Details of the Target

General Information of Target

Target ID LDTP06128
Target Name RNA-binding protein 39 (RBM39)
Gene Name RBM39
Gene ID 9584
Synonyms
HCC1; RNPC2; RNA-binding protein 39; CAPER alpha; CAPERalpha; Hepatocellular carcinoma protein 1; RNA-binding motif protein 39; RNA-binding region-containing protein 2; Splicing factor HCC1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRD
RERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKL
SRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVR
DVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMAN
NLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSD
SECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLM
ARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQP
LATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPS
IAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus speckle
Function
RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
Uniprot ID
Q14498
Ensemble ID
ENST00000253363.11
HGNC ID
HGNC:15923
ChEMBL ID
CHEMBL4680031

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.A422E DBIA    Probe Info 
HCC1806 Insertion: p.T367DfsTer50 DBIA    Probe Info 
HCT116 SNV: p.R87Ter DBIA    Probe Info 
HEC1 SNV: p.A197T DBIA    Probe Info 
HEC1B SNV: p.A197T .
HT115 SNV: p.R57Q DBIA    Probe Info 
HUH28 SNV: p.S410L DBIA    Probe Info 
IGROV1 SNV: p.L160P DBIA    Probe Info 
NUGC3 SNV: p.Q280Ter DBIA    Probe Info 
PEO1 SNV: p.V418F DBIA    Probe Info 
REH SNV: p.G383S DBIA    Probe Info 
SW756 SNV: p.E231Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.54  LDD0448  [1]
P8
 Probe Info  		1.71  LDD0455  [1]
W1
 Probe Info  		10.21  LDD0235  [2]
C-Sul
 Probe Info  		3.95  LDD0066  [3]
TH211
 Probe Info  		Y293(20.00); Y464(5.75)  LDD0257  [4]
TH216
 Probe Info  		Y464(18.16)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K322(1.37)  LDD0274  [6]
STPyne
 Probe Info  		K119(8.58); K178(9.55); K232(9.09); K322(5.82)  LDD0277  [6]
Probe 1
 Probe Info  		Y99(73.52); Y475(26.82)  LDD3495  [7]
BTD
 Probe Info  		C157(0.78)  LDD2107  [8]
HHS-475
 Probe Info  		Y293(0.76); Y475(0.93); Y464(1.04)  LDD0264  [9]
HHS-465
 Probe Info  		Y253(6.77); Y293(6.49); Y464(8.66)  LDD2237  [10]
DBIA
 Probe Info  		C478(1.64); C303(1.46)  LDD0080  [11]
5E-2FA
 Probe Info  		H492(0.00); H258(0.00); H512(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K322(0.00); K178(0.00); K291(0.00); K119(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H492(0.00); H258(0.00); H28(0.00); H512(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C478(0.00); C303(0.00); C157(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C303(0.00); C157(0.00); C478(0.00)  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C478(0.00); C303(0.00); C157(0.00)  LDD0037  [14]
TFBX
 Probe Info  		C157(0.00); C303(0.00)  LDD0027  [17]
Compound 10
 Probe Info  		C303(0.00); C478(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C303(0.00); C478(0.00)  LDD2213  [18]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		N.A.  LDD0010  [19]
SF
 Probe Info  		Y99(0.00); Y475(0.00)  LDD0028  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1c-yne
 Probe Info  		K477(0.00); K306(0.00)  LDD0228  [22]
1d-yne
 Probe Info  		N.A.  LDD0357  [22]
Acrolein
 Probe Info  		C303(0.00); H28(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		C303(0.00); H28(0.00)  LDD0218  [23]
NAIA_5
 Probe Info  		C478(0.00); C303(0.00); C157(0.00)  LDD2223  [24]
HHS-482
 Probe Info  		Y198(0.86); Y253(0.81); Y293(0.88); Y464(0.79)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C100
 Probe Info  		5.28  LDD1789  [25]
C107
 Probe Info  		14.03  LDD1794  [25]
C112
 Probe Info  		17.27  LDD1799  [25]
C219
 Probe Info  		17.51  LDD1893  [25]
C220
 Probe Info  		11.79  LDD1894  [25]
C228
 Probe Info  		21.26  LDD1901  [25]
C233
 Probe Info  		9.25  LDD1906  [25]
FFF probe13
 Probe Info  		6.95  LDD0475  [26]
FFF probe3
 Probe Info  		6.24  LDD0464  [26]
FFF probe4
 Probe Info  		5.35  LDD0466  [26]
STS-2
 Probe Info  		N.A.  LDD0139  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C157(1.14)  LDD2117  [8]
 LDCM0214  AC1 HCT 116 C157(1.09); C303(0.99); C478(0.65)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C157(1.05); C303(1.12); C478(0.55)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C157(1.04); C303(1.00); C478(0.70)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C157(0.75); C303(1.10); C478(0.69)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C157(0.70); C303(1.01); C478(0.75)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C157(0.67); C303(1.13); C478(0.80)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C157(0.82); C303(0.99); C478(0.80)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C157(0.73); C303(1.05); C478(0.74)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C157(0.73); C303(0.99); C478(0.76)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C157(0.97); C303(1.02); C478(1.02)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C157(0.86); C303(1.08); C478(0.80)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C157(0.71); C303(1.03); C478(0.72)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C157(1.05); C303(1.06); C478(0.51)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C157(0.84); C303(1.04); C478(0.63)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C157(0.95); C303(1.06); C478(0.68)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C157(0.83); C303(1.04); C478(0.75)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C157(1.18); C303(1.03); C454(1.08); C478(0.95)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C157(1.03); C303(1.14); C454(1.02); C478(1.05)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C157(0.89); C303(1.08); C454(0.83); C478(1.00)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C157(1.02); C303(1.15); C454(1.21); C478(0.96)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C157(1.03); C303(1.00); C454(1.28); C478(1.01)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C157(0.96); C303(1.15); C454(1.34); C478(1.03)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C157(1.07); C303(1.04); C454(1.45); C478(1.09)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C157(0.94); C303(0.88); C478(0.65)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C157(1.00); C303(1.00); C454(0.94); C478(1.49)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C157(1.17); C303(1.00); C454(1.06); C478(1.40)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C157(0.85); C303(1.07); C454(1.30); C478(1.09)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C157(1.05); C303(0.99); C454(1.03); C478(1.31)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C157(1.20); C303(1.08); C454(1.23); C478(1.23)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C157(0.99); C303(1.14); C454(1.15); C478(1.16)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C157(0.97); C303(1.21); C454(1.12); C478(1.23)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C157(1.11); C303(1.06); C454(1.45); C478(1.13)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C303(1.10); C478(0.71)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C303(1.23); C478(1.86)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C303(1.14); C478(1.74)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C303(0.99); C478(2.74)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C303(1.14); C478(0.91)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C303(0.88); C478(0.92)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C303(1.11); C478(0.96)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C303(1.11); C478(0.72)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C303(0.94); C478(0.68)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C303(1.12); C478(0.70)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C303(1.28); C478(0.76)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C303(1.22); C478(1.09)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C157(1.20); C303(0.96); C478(0.62)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C303(1.43); C478(0.95)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C303(1.32); C478(0.87)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C303(1.02); C478(0.74)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C478(0.63); C157(0.70); C303(1.06)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C157(0.78); C478(0.86); C303(0.92)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C157(0.50); C478(0.92); C303(0.95)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C157(0.57); C478(0.65); C303(0.95)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C157(0.80); C303(0.98); C478(1.26)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C478(0.67); C303(0.95); C157(0.98)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C478(0.66); C157(0.71); C303(0.89)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C478(0.63); C303(1.17); C157(1.17)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C478(0.90); C303(0.99); C157(1.12)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C157(0.71); C478(0.81); C303(1.07)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C478(0.72); C157(0.74); C303(0.92)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C478(0.49); C157(0.78); C303(0.99)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C157(0.75); C303(0.94); C478(0.83)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C157(0.99); C303(1.06); C478(0.62)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C157(0.53); C303(0.95); C478(0.74)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C157(0.71); C303(0.95); C478(0.66)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C303(0.94); C157(1.01); C454(1.02); C478(1.43)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C478(0.76); C157(0.83); C303(0.92); C454(1.41)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C303(0.92); C157(0.92); C454(1.29); C478(1.36)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C478(0.75); C157(0.94); C303(0.95)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C303(0.90); C157(0.95); C454(1.06); C478(1.23)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C303(0.87); C157(0.99); C454(1.01); C478(1.02)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C303(0.83); C157(1.00); C454(1.06); C478(1.07)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C303(0.86); C157(0.89); C454(0.92); C478(1.09)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C303(0.93); C454(0.95); C157(0.99); C478(1.68)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C303(0.91); C157(1.00); C478(1.01)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C478(0.77); C157(0.82); C303(0.91)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C478(0.84); C157(0.87); C303(0.95)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C157(0.75); C478(0.76); C303(0.96)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C157(0.83); C478(0.91); C303(1.04)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C478(0.74); C303(0.91); C157(1.13)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C478(0.72); C157(0.80); C303(1.01)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C478(0.67); C303(0.91); C157(0.91)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C478(0.65); C157(0.75); C303(1.12)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C478(0.80); C157(0.86); C303(0.93)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C478(0.78); C303(0.96); C157(1.00)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C157(0.78); C478(0.88); C303(0.90)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C478(0.91); C303(1.03); C157(1.09)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C157(0.69); C478(0.86); C303(0.98)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C157(0.60); C478(0.92); C303(1.08)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C478(0.65); C157(0.73); C303(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C478(0.74); C303(0.95); C157(1.11)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C157(0.69); C478(0.74); C303(1.04)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C478(0.77); C303(0.94); C157(1.09)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C157(0.73); C478(0.82); C303(1.08)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C478(0.77); C303(1.10); C157(1.17)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C478(0.70); C157(0.76); C303(1.11)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C478(0.67); C157(0.75); C303(0.91)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C157(0.92); C478(0.97); C303(1.08)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C157(0.80); C478(0.87); C303(0.95)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C157(0.75); C478(0.77); C303(1.00)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C478(0.78); C157(0.80); C303(1.10)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C478(0.64); C303(1.01); C157(1.32)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C157(0.82); C478(1.10); C303(1.15)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C157(0.87); C303(1.07); C478(1.16)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C157(0.83); C478(0.95); C303(1.08)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C157(0.86); C478(0.91); C303(0.92)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C157(0.88); C478(0.90); C303(1.06)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C303(0.88); C157(0.92); C478(0.95)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C157(0.93); C478(0.95); C303(1.00)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C478(0.70); C303(1.02); C157(1.08); C454(1.27)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C478(0.82); C454(0.98); C303(1.00); C157(1.20)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C478(0.64); C157(0.94); C454(1.04); C303(1.06)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C478(0.67); C157(0.99); C303(1.01)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C478(0.64); C157(0.90); C454(0.99); C303(1.16)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C478(0.63); C157(1.09); C454(1.10); C303(1.11)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C478(0.77); C157(0.98); C303(1.02); C454(1.09)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C478(0.64); C454(0.99); C303(1.00); C157(1.08)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C478(0.72); C157(0.93); C454(1.10); C303(1.12)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C478(0.59); C157(0.80); C454(0.95); C303(1.17)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C478(0.74); C157(0.78); C454(0.99); C303(1.12)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C478(0.55); C157(0.67); C454(1.04); C303(1.06)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C478(0.79); C303(1.16); C157(1.18)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C478(0.96); C303(1.00); C157(1.15)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C478(0.58); C303(0.96); C157(1.12)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C478(0.64); C157(0.87); C303(1.15)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C478(0.89); C157(0.99); C303(1.00)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C478(1.02); C303(1.09); C157(1.20)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C478(0.87); C303(1.15); C157(1.15)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C478(0.81); C157(1.14); C303(1.27)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C478(0.84); C157(1.14); C303(1.25)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C478(0.92); C303(0.94); C157(1.21)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C478(1.01); C303(1.03); C157(1.23)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C478(0.96); C157(1.07); C303(1.09)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C478(0.92); C303(1.12); C157(1.12)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C478(0.54); C303(1.12); C157(1.13)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C478(0.88); C303(0.99); C157(1.14)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C478(0.72); C303(0.92); C157(0.99)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C478(0.71); C157(1.08); C303(1.20)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C454(0.75); C157(0.87); C478(0.89); C303(1.03)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C454(0.62); C478(0.79); C157(0.91); C303(1.02)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C478(0.74); C454(0.79); C157(0.85); C303(1.02)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C157(0.78); C454(0.86); C303(1.04); C478(1.08)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C303(0.93); C454(0.99); C478(1.05); C157(1.06)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C157(0.83); C454(0.88); C303(0.91); C478(1.18)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C454(0.93); C157(0.98); C303(1.04); C478(1.15)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C157(0.85); C303(1.01); C454(1.11); C478(1.26)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C157(0.96); C303(0.98); C454(1.00); C478(1.01)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C454(0.88); C303(0.95); C157(0.96); C478(0.98)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C454(0.73); C157(0.93); C478(0.96); C303(1.05)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C157(0.95); C478(1.04); C454(1.06); C303(1.09)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C303(0.93); C478(1.03); C454(1.18); C157(1.19)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C303(0.99); C157(1.05); C478(1.09); C454(1.23)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C478(0.95); C157(0.99); C303(1.04); C454(1.16)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C478(0.61); C157(0.63); C303(1.08)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C478(0.77); C157(0.82); C303(1.05)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C157(1.09); C303(1.17); C478(0.65)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C478(0.55); C303(1.05); C157(1.09)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C478(0.53); C303(1.21); C157(1.22)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C303(1.11)  LDD2171  [11]
 LDCM0108  Chloroacetamide HeLa C303(0.00); H28(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C478(0.87)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C303(0.86); C157(0.95); C478(1.19)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C478(0.74); C303(0.88); C157(0.96)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C478(0.69); C157(0.86); C303(0.94)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C478(0.62); C157(1.12); C303(1.14)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C303(0.86); C478(1.00); C157(1.21)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C303(0.87); C478(0.91); C157(1.20)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C478(0.95); C157(1.16); C303(1.22)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C478(0.75); C157(0.85); C303(0.90); C454(1.22)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C478(0.73); C157(0.87); C303(0.98); C454(1.17)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C478(0.73); C157(0.86); C303(0.96); C454(1.10)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C478(0.75); C157(0.85); C303(1.09); C454(1.27)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C157(0.82); C303(0.96); C454(0.98); C478(1.00)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C478(0.63); C157(0.80); C303(0.84)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C157(0.84); C454(0.88); C303(0.91); C478(1.00)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C454(0.81); C157(0.88); C303(0.95); C478(0.96)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C478(0.79); C157(0.85); C303(0.94)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C478(0.77); C157(0.86); C303(1.08)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C478(0.82); C157(0.94); C303(0.95)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C478(0.76); C157(0.80); C303(1.04)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C478(0.67); C157(0.89); C303(0.99)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C478(0.83); C157(0.90); C303(1.02)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C478(0.83); C157(0.83); C303(0.94)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C157(0.55); C478(0.81); C303(0.88)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C478(0.74); C303(0.91); C157(0.93)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C478(0.78); C157(1.01); C303(1.01)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C478(0.73); C303(0.91); C157(0.91)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C478(0.83); C157(0.92); C303(1.03)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C478(0.78); C157(0.85); C303(0.96)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C478(0.82); C157(0.85); C303(1.09)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C478(0.67); C303(1.02); C157(1.14); C454(1.15)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C478(0.68); C454(0.83); C303(0.92); C157(0.99)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C478(0.71); C454(0.84); C303(1.00); C157(1.09)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C478(0.78); C303(1.01); C157(1.07); C454(1.28)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C478(0.82); C303(0.89); C157(1.09)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C303(0.98); C478(1.02); C157(1.14)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C478(0.70); C303(0.85); C157(1.22)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C478(0.83); C157(1.02); C303(1.04)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C478(0.96); C157(1.00); C303(1.00); C454(1.09)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C478(0.88); C303(1.01); C454(1.24); C157(1.36)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C478(0.93); C303(1.00); C157(1.13); C454(1.15)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C303(0.86); C157(0.89); C478(0.93)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C478(1.01); C303(1.03); C157(1.15); C454(1.16)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C478(0.85); C303(0.87); C454(1.05); C157(1.12)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C454(0.71); C478(0.92); C157(1.20); C303(1.23)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C454(0.59); C478(1.04); C303(1.09); C157(1.14)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C157(1.11); C303(1.06); C454(1.19); C478(0.95)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C157(1.20); C303(0.94); C454(1.02); C478(0.81)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C157(1.28); C303(0.96); C454(0.86); C478(0.89)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C157(1.17); C303(0.89); C454(1.04); C478(0.79)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C157(1.10); C303(1.04); C454(1.20); C478(0.86)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C157(1.34); C303(0.98); C454(0.95); C478(0.83)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C157(0.94); C303(0.87); C478(0.92)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C157(1.24); C303(1.07); C454(1.22); C478(0.88)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C303(0.98); C454(1.11); C478(1.07)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C157(0.75); C303(1.12); C454(1.01); C478(0.74)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C157(0.56); C303(1.01); C454(1.07); C478(0.97)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C157(0.95); C303(1.00); C454(1.09); C478(0.93)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C157(0.64); C303(1.09); C454(0.83); C478(1.19)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C157(1.55); C303(1.01); C454(0.93); C478(1.32)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C157(1.03); C303(1.07); C454(0.87); C478(1.28)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C157(0.59); C303(1.08); C454(1.12); C478(0.89)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C157(1.18); C303(0.85); C478(0.94)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C157(0.85); C303(0.94); C454(0.79); C478(1.18)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C157(1.40); C303(0.99); C454(0.99); C478(1.17)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C157(1.28); C303(1.15); C454(0.79); C478(0.95)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C157(0.86); C303(1.03); C454(1.21); C478(1.25)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C157(0.80); C303(1.04); C454(1.06); C478(1.02)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C157(0.79); C303(1.01); C454(1.02); C478(0.83)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C157(1.22); C303(0.87); C454(1.06); C478(1.75)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C157(1.03); C303(0.83); C454(0.91); C478(1.64)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C157(1.10); C303(0.82); C454(1.06); C478(2.06)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C157(1.27); C303(0.99); C454(1.78); C478(2.76)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C157(1.05); C303(0.86); C478(0.98)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C157(0.88); C303(0.83); C454(1.12); C478(1.89)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C157(0.93); C303(0.86); C454(1.46); C478(1.84)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C157(1.05); C303(0.86); C454(1.25); C478(1.59)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C157(0.76); C303(0.83); C454(0.64); C478(2.39)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C157(0.95); C303(0.82); C454(1.08); C478(2.18)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C157(1.16); C303(0.79); C454(1.29); C478(2.41)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C157(0.76); C303(0.85); C454(0.94); C478(1.31)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C157(1.00); C303(0.86); C454(0.73); C478(1.68)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C157(0.91); C303(0.79); C454(1.26); C478(2.03)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C157(0.89); C303(0.90); C454(1.40); C478(1.59)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C157(0.98); C303(0.88); C478(0.70)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C157(0.93); C303(0.82); C454(1.34); C478(1.82)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C157(0.94); C454(0.92); C478(0.87)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C157(0.88); C454(0.94); C478(0.75)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C157(0.91); C454(0.78); C478(0.66)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C157(1.07); C454(1.10); C478(0.66)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C157(0.92); C454(0.84); C478(0.75)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C157(0.87); C454(1.00); C478(0.62)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C157(0.89); C454(0.77); C478(0.68)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C157(0.98); C454(0.60); C478(0.73)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C157(0.95); C454(0.55); C478(0.72)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C157(0.93); C303(0.89); C478(0.67)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C157(1.15); C454(0.81); C478(0.69)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C157(0.96); C454(0.79); C478(0.60)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C157(0.88); C454(1.01); C478(0.60)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C157(1.00); C454(0.81); C478(0.73)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C157(1.03); C454(0.80); C478(0.82)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C303(1.04); C478(0.90)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C303(1.06); C478(1.21)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C303(1.00); C478(0.89)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C303(1.01); C478(0.98)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C157(0.98); C303(0.84); C478(0.71)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C303(1.03); C478(1.11)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C303(1.01); C478(0.94)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C303(1.03); C478(0.96)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C303(0.94); C478(0.81)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C303(0.96); C478(0.85)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C303(0.98); C478(1.12)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C303(1.01); C478(0.95)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C303(0.97); C478(0.89)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C303(1.03); C478(0.80)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C303(0.99); C478(0.85)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C157(1.12); C303(0.97); C478(0.98)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C303(0.94); C478(1.55)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C157(1.21); C303(0.99); C478(0.87)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C157(1.26); C303(0.98); C478(1.02)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C157(1.19); C303(0.93); C478(1.04)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C157(1.03); C303(0.95); C478(0.94)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C157(0.91); C303(0.89); C478(0.80)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C157(1.15); C303(0.95); C478(0.75)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C157(0.90); C303(0.96); C478(0.87)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C157(0.98); C303(0.98); C478(0.70)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C157(0.97); C303(0.89); C478(0.72)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C478(0.93); C303(0.99)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C478(1.54)  LDD1702  [8]
 LDCM0625  F8 Ramos C303(1.11); C478(0.48)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C303(1.25); C478(0.37)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C303(0.63); C478(0.21)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C303(1.19); C478(0.46)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C478(0.78)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C303(0.97); C478(0.90)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C303(1.01); C478(0.40)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C303(1.95); C478(0.39)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C303(1.30); C478(0.48)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C478(0.47)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C478(1.12)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C303(0.81); C478(0.57)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C478(0.93)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C303(0.88); C478(0.32)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C157(1.11); C454(0.90); C478(0.53)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C303(1.68); C478(0.91)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C303(0.85); C478(0.57)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C157(1.22); C303(1.00); C454(0.52); C478(1.13)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C303(1.22); C478(1.31)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C303(1.04); C478(0.50)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C303(0.69); C478(0.45)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C303(0.71); C478(0.38)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y293(0.76); Y475(0.93); Y464(1.04)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y293(0.37); Y475(0.85); Y464(0.95)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y475(0.79); Y464(1.15); Y293(2.36)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y293(0.28); Y475(0.84); Y464(1.22)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y293(0.53); Y475(0.85); Y464(2.28)  LDD0268  [9]
 LDCM0022  KB02 HCT 116 C478(1.64); C303(1.46)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C478(4.35); C303(1.44)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C478(2.01); C303(1.46)  LDD0082  [11]
 LDCM0109  NEM HeLa H457(0.00); H28(0.00)  LDD0223  [23]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C157(0.78)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C157(0.59)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C157(1.03)  LDD2111  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C157(0.79)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C157(0.93)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C157(1.06)  LDD2127  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C157(0.93)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C157(1.03)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C157(0.77)  LDD2140  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C157(1.23)  LDD2144  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C157(1.06)  LDD2150  [8]
 LDCM0021  THZ1 HCT 116 C303(1.11)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
Casein kinase II subunit beta (CSNK2B) Casein kinase 2 subunit beta family P67870
SRSF protein kinase 1 (SRPK1) CMGC Ser/Thr protein kinase family Q96SB4
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Peptidyl-prolyl cis-trans isomerase G (PPIG) . Q13427
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase complex subunit SAP18 (SAP18) SAP18 family O00422
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 22 (ZBTB22) Krueppel C2H2-type zinc-finger protein family O15209
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Max-like protein X (MLX) . Q9UH92
Nuclear autoantigen Sp-100 (SP100) . P23497
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein FAM200A (FAM200A) FAM200 family Q8TCP9
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
KH homology domain-containing protein 4 (KHDC4) KHDC4 family Q7Z7F0
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Serine/arginine-rich splicing factor 11 (SRSF11) Splicing factor SR family Q05519
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) Splicing factor SR family Q8WXA9
INO80 complex subunit B (INO80B) . Q9C086
Poly(rC)-binding protein 1 (PCBP1) . Q15365
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

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2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578