Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P8  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 33 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04876  Actin, cytoplasmic 1 (ACTB) 10.0
 LDTP03242  Adenosylhomocysteinase (AHCY) 10.0
 LDTP03591  Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1) 10.0
 LDTP04886  Cell division control protein 42 homolog (CDC42) 10.0
 LDTP02616  Creatine kinase B-type (CKB) 10.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 10.0
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 10.0
 LDTP03907  Malate dehydrogenase, cytoplasmic (MDH1) 10.0
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) 10.0
 LDTP03764  Myosin-9 (MYH9) 10.0
 LDTP12752  NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) 10.0
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 10.0
 LDTP12444  Xaa-Pro aminopeptidase 1 (XPNPEP1) 10.0
 LDTP05073  Actin, alpha skeletal muscle (ACTA1) 8.2
 LDTP02774  Phosphoglycerate mutase 2 (PGAM2) 5.3
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) 4.1
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 3.5
 LDTP03915  Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) 3.2
 LDTP03976  Aldo-keto reductase family 1 member C3 (AKR1C3) 2.9
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 2.4
 LDTP15029  Putative elongation factor 1-alpha-like 3 (EEF1A1P5) 2.2
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 2.2
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 2.2
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 1.9
 LDTP02733  Pyruvate kinase PKM (PKM) 1.9
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 1.9
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) 1.8
 LDTP02672  Elongation factor 2 (EEF2) 1.7
 LDTP05911  Serine/threonine-protein kinase PRP4 homolog (PRPF4B) 1.7
 LDTP01807  Argininosuccinate synthase (ASS1) 1.7
 LDTP04851  Triosephosphate isomerase (TPI1) 1.7
 LDTP00952  Germinal-center associated nuclear protein (MCM3AP) 1.6
 LDTP05028  Peptidyl-prolyl cis-trans isomerase A (PPIA) 1.5
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02010  Annexin A1 (ANXA1) 10.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) 10.0
 LDTP06165  Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) 10.0
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 10.0
 LDTP05832  Urea transporter 1 (SLC14A1) 10.0
 LDTP05252  Clathrin heavy chain 1 (CLTC) 6.4
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) 4.5
 LDTP02307  Annexin A5 (ANXA5) 4.2
 LDTP03385  14-3-3 protein theta (YWHAQ) 3.5
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 1.8
 LDTP03107  Filamin-A (FLNA) 1.7
 LDTP05231  Cytochrome c (CYCS) 1.5
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17677  Olfactory receptor 8H2 (OR8H2) 10.0
Other
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05729  A-kinase anchor protein 6 (AKAP6) 10.0
 LDTP00843  Alpha-actinin-4 (ACTN4) 10.0
 LDTP09815  Dedicator of cytokinesis protein 2 (DOCK2) 10.0
 LDTP02053  Heat shock protein beta-1 (HSPB1) 10.0
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 10.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 10.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 10.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 10.0
 LDTP03658  Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) 10.0
 LDTP15396  Leucine-rich single-pass membrane protein 2 (LSMEM2) 10.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP03620  Protein S100-A11 (S100A11) 10.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) 10.0
 LDTP10650  Serpin B11 (SERPINB11) 10.0
 LDTP04970  Small ribosomal subunit protein uS11 (RPS14) 10.0
 LDTP04965  Small ribosomal subunit protein uS8 (RPS15A) 10.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 10.0
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP02297  Vimentin (VIM) 10.0
 LDTP14045  Disheveled-associated activator of morphogenesis 1 (DAAM1) 9.5
 LDTP09562  Splicing factor U2AF 26 kDa subunit (U2AF1L4) 6.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) 4.5
 LDTP05014  Small ribosomal subunit protein eS26 (RPS26) 4.2
 LDTP06598  Fascin (FSCN1) 3.7
 LDTP03575  Protein S100-A7 (S100A7) 3.3
 LDTP03618  14-3-3 protein sigma (SFN) 2.8
 LDTP03367  Elongation factor 1-gamma (EEF1G) 2.7
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) 2.7
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19) 2.6
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 2.5
 LDTP02341  Galectin-1 (LGALS1) 2.4
 LDTP01932  Prelamin-A/C (LMNA) 2.1
 LDTP11705  Bromodomain-containing protein 8 (BRD8) 2.1
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 1.9
 LDTP02205  Tubulin beta chain (TUBB) 1.9
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) 1.8
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) 1.8
 LDTP06128  RNA-binding protein 39 (RBM39) 1.7
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) 1.7
 LDTP02152  Protein S100-A9 (S100A9) 1.6

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.