Details of the Target

General Information of Target

Target ID LDTP05196
Target Name Large ribosomal subunit protein eL19 (RPL19)
Gene Name RPL19
Gene ID 6143
Synonyms
Large ribosomal subunit protein eL19; 60S ribosomal protein L19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSR
ARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMY
HSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAK
KEEIIKTLSKEEETKK
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL19 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P84098
Ensemble ID
ENST00000225430.9
HGNC ID
HGNC:10312

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		1.67  LDD0450  [2]
P8
 Probe Info  		2.56  LDD0455  [2]
A-EBA
 Probe Info  		3.03  LDD0215  [3]
C-Sul
 Probe Info  		4.05  LDD0066  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K46(0.00); K82(0.00); K92(0.00)  LDD0273  [6]
AZ-9
 Probe Info  		6.94  LDD2154  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
ATP probe
 Probe Info  		K21(0.00); K46(0.00); K144(0.00); K146(0.00)  LDD0199  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
1d-yne
 Probe Info  		K20(0.00); K21(0.00)  LDD0356  [11]
SF
 Probe Info  		K46(0.00); K190(0.00); Y124(0.00); K82(0.00)  LDD0028  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Ox-W18
 Probe Info  		W95(0.00); W23(0.00)  LDD2175  [15]
Acrolein
 Probe Info  		H143(0.00); H75(0.00); H141(0.00); H118(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		H143(0.00); H58(0.00); H75(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		H143(0.00); H58(0.00); H141(0.00)  LDD0218  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
HHS-482
 Probe Info  		Y120(1.03); Y124(1.00)  LDD2239  [19]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C193
 Probe Info  		5.43  LDD1869  [20]
DA-2
 Probe Info  		N.A.  LDD0071  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0151  AZ-11 HeLa 6.94  LDD2154  [7]
 LDCM0108  Chloroacetamide HeLa H141(0.00); H143(0.00); H58(0.00); H75(0.00)  LDD0222  [16]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0107  IAA HeLa H75(0.00); H58(0.00); H143(0.00); H141(0.00)  LDD0221  [16]
 LDCM0109  NEM HeLa H118(0.00); H141(0.00); H143(0.00); H75(0.00)  LDD0223  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-3-phenyllactic Acid . DB02494
Anisomycin . DB07374
Puromycin . DB08437

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.