Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name AZ-9  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
Competitor Name AZ-11  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 10.0
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 10.0
 LDTP01767  Aldehyde dehydrogenase 1A1 (ALDH1A1) 10.0
 LDTP17326  Aspartate beta-hydroxylase domain-containing protein 2 (ASPHD2) 10.0
 LDTP04552  Biliverdin reductase A (BLVRA) 10.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.0
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) 10.0
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 10.0
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 10.0
 LDTP14854  Inorganic pyrophosphatase (PPA1) 10.0
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) 10.0
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 10.0
 LDTP03169  Nucleoside diphosphate kinase B (NME2) 10.0
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 10.0
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 10.0
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) 10.0
 LDTP02733  Pyruvate kinase PKM (PKM) 10.0
 LDTP07929  Staphylococcal nuclease domain-containing protein 1 (SND1) 10.0
 LDTP05007  GTP-binding nuclear protein Ran (RAN) 9.6
 LDTP03222  Tryptophan--tRNA ligase, cytoplasmic (WARS1) 7.6
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) 7.4
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04969  14-3-3 protein epsilon (YWHAE) 10.0
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 10.0
 LDTP02010  Annexin A1 (ANXA1) 10.0
 LDTP03107  Filamin-A (FLNA) 10.0
 LDTP02929  Galectin-3 (LGALS3) 10.0
 LDTP09949  Transportin-1 (TNPO1) 10.0
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 9.7
 LDTP02199  Annexin A2 (ANXA2) 9.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03624  Neural cell adhesion molecule L1 (L1CAM) 10.0
Other
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02631  Alpha-actinin-1 (ACTN1) 10.0
 LDTP02101  Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) 10.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 10.0
 LDTP02674  Keratin, type I cytoskeletal 10 (KRT10) 10.0
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1) 10.0
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 10.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 10.0
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) 10.0
 LDTP05360  Large ribosomal subunit protein eL20 (RPL18A) 10.0
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6) 10.0
 LDTP03899  Large ribosomal subunit protein uL13 (RPL13A) 10.0
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) 10.0
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP01557  RasGAP-activating-like protein 1 (RASAL1) 10.0
 LDTP13746  Serine/arginine repetitive matrix protein 2 (SRRM2) 10.0
 LDTP05197  Serine/arginine-rich splicing factor 3 (SRSF3) 10.0
 LDTP19820  Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2) 10.0
 LDTP04109  Small ribosomal subunit protein uS4 (RPS9) 10.0
 LDTP05036  Transformer-2 protein homolog beta (TRA2B) 10.0
 LDTP02205  Tubulin beta chain (TUBB) 10.0
 LDTP02292  U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) 10.0
 LDTP03354  Large ribosomal subunit protein eL13 (RPL13) 8.0
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19) 6.9
 LDTP17097  Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2) 6.4
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 6.0
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) 5.4
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) 5.3

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.