Details of the Target

General Information of Target

Target ID LDTP03169
Target Name Nucleoside diphosphate kinase B (NME2)
Gene Name NME2
Gene ID 4831
Synonyms
NM23B; Nucleoside diphosphate kinase B; NDK B; NDP kinase B; EC 2.7.4.6; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; EC 2.7.13.3; nm23-H2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPF
FPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
Target Bioclass
Enzyme
Family
NDK family
Subcellular location
Cytoplasm
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity.
Uniprot ID
P22392
Ensemble ID
ENST00000393190.4
HGNC ID
HGNC:7850
ChEMBL ID
CHEMBL2160

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC26 SNV: p.A10V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.96  LDD0402  [1]
Jackson_1
 Probe Info  		10.44  LDD0122  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		6.32  LDD0242  [3]
TH211
 Probe Info  		Y67(5.12)  LDD0257  [4]
STPyne
 Probe Info  		K100(7.35); K12(7.44); K124(6.72); K39(7.47)  LDD0277  [5]
ONAyne
 Probe Info  		K49(0.00); K124(0.00)  LDD0273  [5]
DBIA
 Probe Info  		C94(2.13)  LDD3312  [6]
BTD
 Probe Info  		C109(2.74)  LDD1700  [7]
AZ-9
 Probe Info  		10.00  LDD2154  [8]
AHL-Pu-1
 Probe Info  		C109(2.25)  LDD0169  [9]
HHS-482
 Probe Info  		Y67(1.51)  LDD0285  [10]
HHS-465
 Probe Info  		Y67(1.54)  LDD2237  [11]
5E-2FA
 Probe Info  		H47(0.00); H51(0.00); H118(0.00); H147(0.00)  LDD2235  [12]
AMP probe
 Probe Info  		N.A.  LDD0200  [13]
ATP probe
 Probe Info  		K124(0.00); K49(0.00); K128(0.00); K135(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C145(0.00); C109(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C109(0.00); C145(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		K100(0.00); K128(0.00); K49(0.00); K124(0.00)  LDD0035  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
KY-26
 Probe Info  		N.A.  LDD0301  [20]
1d-yne
 Probe Info  		N.A.  LDD0356  [21]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K12(0.00); K100(0.00); K56(0.00); K49(0.00)  LDD0010  [19]
SF
 Probe Info  		K12(0.00); K49(0.00); K100(0.00); K124(0.00)  LDD0028  [22]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C109(0.00); C145(0.00)  LDD0018  [23]
Ox-W18
 Probe Info  		W78(0.00); W149(0.00)  LDD2175  [24]
1c-yne
 Probe Info  		K128(0.00); K135(0.00); K85(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C109(0.00); H118(0.00); H147(0.00); H51(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		C109(0.00); H47(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		H118(0.00); H47(0.00); C109(0.00); C145(0.00)  LDD0218  [25]
W1
 Probe Info  		N.A.  LDD0236  [26]
AOyne
 Probe Info  		14.20  LDD0443  [27]
NAIA_5
 Probe Info  		N.A.  LDD2223  [28]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0068  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C145(0.90)  LDD2112  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C145(0.89)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C145(1.47)  LDD2117  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C109(2.25)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C145(0.91); C109(0.87)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C145(0.89); C109(0.90)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C145(0.85); C109(0.93)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C145(0.79); C109(0.85)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C145(1.03); C109(0.93)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C145(0.82); C109(0.94)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C145(1.00); C109(0.90)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C145(0.87); C109(0.94)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C145(0.62); C109(0.82)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C145(1.05); C109(0.93)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C145(0.84); C109(0.92)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C145(0.97); C109(0.98)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C145(1.02); C109(1.00)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C145(0.88); C109(1.02)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C145(0.96); C109(1.00)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C145(0.95); C109(0.83)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C145(0.92); C109(0.93)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C145(0.85); C109(0.95)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C145(0.88); C109(0.89)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C145(0.95); C109(1.01)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C145(0.88); C109(0.87)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C145(1.06); C109(0.97)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C145(0.91); C109(0.95)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C145(0.87); C109(0.94)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C145(0.87); C109(0.84)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C145(0.90); C109(0.89)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C145(0.84); C109(0.91)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C145(0.99); C109(0.87)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C145(1.00); C109(1.02)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C145(0.99); C109(0.97)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C145(0.85); C109(0.91)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C145(0.96); C109(0.89)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C145(0.94); C109(0.93)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C145(0.90); C109(0.84)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C145(0.94); C109(0.90)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C145(0.75); C109(0.91)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C145(1.01); C109(0.82)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C145(0.97); C109(0.99)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C145(0.93); C109(0.95)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C145(0.88); C109(0.87)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C145(0.89); C109(0.94)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C145(0.74); C109(0.84)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C145(0.98); C109(1.06)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C145(0.84); C109(0.91)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C145(0.88); C109(0.96)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C145(0.76); C109(0.84)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C145(0.92); C109(1.02)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C145(0.93); C109(0.92)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C145(0.78); C109(0.90)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C145(0.87); C109(0.92)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C145(0.77); C109(0.81)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C145(0.75); C109(0.94)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C145(0.83); C109(0.97)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C145(0.92); C109(0.94)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C145(0.96); C109(0.85)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C145(0.80); C109(0.98)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C145(0.91); C109(0.92)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C145(0.83); C109(0.89)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C145(0.88); C109(0.95)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C145(0.96); C109(0.97)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C145(1.04); C109(0.98)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C145(0.95); C109(1.01)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C145(0.95); C109(0.83)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C145(0.98); C109(0.97)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 12.63  LDD0403  [1]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [8]
 LDCM0108  Chloroacetamide HeLa C109(0.00); H118(0.00); H47(0.00); C145(0.00)  LDD0222  [25]
 LDCM0367  CL1 HEK-293T C145(0.85); C109(0.90)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C145(0.89); C109(0.81)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C145(0.94); C109(0.89)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C145(0.91); C109(0.90)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C145(0.88); C109(0.86)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C145(0.90); C109(0.94)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C145(0.95); C109(0.97)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C145(0.86); C109(0.94)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C145(0.89); C109(0.95)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C145(0.81); C109(0.94)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C145(0.81); C109(0.92)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C145(0.90); C109(0.89)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C145(1.09); C109(0.99)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C145(0.74); C109(0.83)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C145(0.97); C109(0.89)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C145(0.90); C109(0.93)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C145(0.95); C109(0.88)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C145(0.90); C109(0.79)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C145(0.91); C109(0.91)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C145(0.81); C109(0.92)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C145(0.86); C109(0.88)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C145(0.78); C109(0.85)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C145(0.94); C109(0.91)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C145(0.88); C109(0.86)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C145(0.95); C109(0.94)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C145(0.83); C109(0.88)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C145(0.75); C109(0.90)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C145(0.75); C109(0.83)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C145(0.82); C109(0.85)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C145(0.71); C109(0.93)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C145(0.79); C109(0.83)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C145(0.75); C109(0.92)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C145(0.79); C109(0.89)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C145(0.70); C109(0.87)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C145(0.81); C109(0.92)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C145(0.82); C109(0.85)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C145(0.80); C109(0.89)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C145(0.79); C109(0.68)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C145(0.76); C109(0.83)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C145(0.82); C109(0.98)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C145(0.95); C109(0.94)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C145(0.93); C109(0.93)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C145(0.87); C109(0.95)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C145(0.99); C109(0.92)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C145(1.07); C109(0.99)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C145(0.97); C109(1.04)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C145(0.83); C109(0.84)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C145(0.81); C109(0.92)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C145(0.84); C109(0.94)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C145(0.99); C109(0.99)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C145(0.99); C109(0.96)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C145(0.85); C109(0.99)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C145(0.95); C109(0.97)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C145(0.77); C109(0.91)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C145(0.86); C109(0.97)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C145(0.75); C109(0.81)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C145(0.95); C109(0.99)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C145(0.93); C109(1.09)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C145(0.84); C109(0.95)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C145(0.89); C109(0.92)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C145(0.98); C109(0.83)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C145(0.83); C109(0.81)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C145(1.06); C109(0.97)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C145(0.99); C109(0.88)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C145(1.08); C109(0.99)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C145(1.04); C109(1.03)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C145(1.00); C109(0.95)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C145(0.86); C109(1.00)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C145(0.99); C109(1.16)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C145(0.96); C109(1.08)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C145(0.95); C109(1.14)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C145(0.80); C109(0.95)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C145(0.84); C109(0.83)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C145(0.80); C109(0.87)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C145(0.90); C109(0.86)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C145(0.81); C109(0.80)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C145(0.76); C109(0.80)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C145(0.80); C109(0.97)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C145(0.94); C109(0.94)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C145(0.94); C109(0.89)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C145(0.87); C109(0.96)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C145(0.80); C109(0.98)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C145(0.74); C109(0.73)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C145(0.97); C109(0.94)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C145(0.83); C109(0.88)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C145(0.86); C109(0.93)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C145(0.80); C109(0.99)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C145(0.85); C109(0.87)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C145(0.92); C109(0.85)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C145(0.86); C109(0.90)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C145(0.84); C109(1.00)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C145(1.05); C109(0.89)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C145(0.83); C109(0.99)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C145(0.85); C109(1.00)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C145(1.02); C109(1.00)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C145(0.94); C109(1.11)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C145(0.98); C109(0.96)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C145(0.88); C109(0.89)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C145(0.91); C109(0.95)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C145(0.87); C109(0.94)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C145(0.78); C109(0.78)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C145(0.93); C109(0.92)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C145(0.99); C109(1.06)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C145(0.74); C109(0.66)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C145(1.12); C109(0.97)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C145(0.90); C109(0.95)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C145(1.04); C109(1.06)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C145(0.92); C109(1.10)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C145(0.95); C109(1.02)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C145(0.74); C109(0.89)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C145(0.68); C109(0.90)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C145(0.70); C109(0.89)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C145(0.75); C109(0.90)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C145(0.77); C109(0.88)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C145(1.02); C109(0.96)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C145(0.58); C109(0.76)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C145(0.71); C109(0.98)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C145(0.91); C109(0.84)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C145(0.82); C109(0.95)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C145(0.87); C109(0.91)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C145(0.72); C109(0.82)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C145(0.79); C109(0.86)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C145(0.85); C109(0.89)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C145(0.92); C109(0.89)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C145(0.81); C109(0.85)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C145(0.75); C109(0.94)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C109(3.18); C145(1.05)  LDD1702  [7]
 LDCM0625  F8 Ramos C145(0.70)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C145(0.38)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C145(0.13)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C145(0.44)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C145(1.31)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C145(0.88)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C145(0.32)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C145(0.86)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C145(0.67)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C145(1.40)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C145(1.60)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C145(0.98)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C145(0.80)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C145(0.47)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C145(0.91); C109(0.98)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C145(1.18)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C145(0.73)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C145(0.89); C109(0.98)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C145(1.90)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C145(1.40)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C145(0.64)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C145(0.34)  LDD2188  [31]
 LDCM0107  IAA HeLa H118(0.00); H51(0.00); C109(0.00); H147(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y67(1.51)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y67(1.79)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y67(0.93)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y67(2.19)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y67(1.99)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y67(0.18)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y67(1.06)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y67(0.60)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C145(0.96); C109(0.93)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C145(0.93); C109(0.95)  LDD1497  [30]
 LDCM0024  KB05 HMCB C94(2.13)  LDD3312  [6]
 LDCM0109  NEM HeLa H118(0.00); H51(0.00); C109(0.00); H147(0.00)  LDD0223  [25]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C145(1.62)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C109(2.62)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C145(0.16)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C109(0.76)  LDD2098  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C145(0.70)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C145(0.74); C109(0.42)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C145(1.32)  LDD2107  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C109(0.47)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C145(1.52)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C145(0.64)  LDD2114  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C145(0.27)  LDD2116  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C145(2.12)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C109(0.73)  LDD2120  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C145(0.22)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C145(1.84)  LDD2125  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C145(1.74)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C145(1.64)  LDD2135  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C109(2.74)  LDD1700  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C145(0.51)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C145(0.95)  LDD2146  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C109(1.00)  LDD2149  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C145(0.22)  LDD2151  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C145(0.84)  LDD2207  [32]
 LDCM0112  W16 Hep-G2 D57(1.16); R58(1.17)  LDD0239  [26]
 LDCM0113  W17 Hep-G2 K39(0.99)  LDD0240  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyclovir Small molecular drug DB00787
Adefovir Dipivoxil Small molecular drug DB00718
Adenosine Small molecular drug DB00640
Decitabine Small molecular drug DB01262
Lamivudine Small molecular drug DB00709
Tenofovir Alafenamide Small molecular drug DB09299
Tenofovir Disoproxil Small molecular drug DB00300
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Tenofovir Small molecular drug DB14126

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.