Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0151
Competitor Name
AZ-11
Synonyms
3-(4-methoxyphenyl)-2H-azirine
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 147.17
Lipid-water partition coefficient (xlogp) 1.5
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C9H9NO
IUPAC Name
3-(4-methoxyphenyl)-2H-azirine
Canonical SMILES
COC1=CC=C(C=C1)C2=NC2
InChI
InChI=1S/C9H9NO/c1-11-8-4-2-7(3-5-8)9-6-10-9/h2-5H,6H2,1H3
InChIKey
VCGKHYBNHSSOHT-UHFFFAOYSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
AZ-9
 Probe Info  		10 uM Human endocervical adenocarcinoma cells (HeLa) [1]

Target(s) List of this Competitor

23 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) LDTP09477 10.00  LDD2155 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 10.00  LDD2154 
ADP-ribosylation factor 5 (ARF5) LDTP05193 10.00  LDD2154 
Aldehyde dehydrogenase 1A1 (ALDH1A1) LDTP01767 10.00  LDD2154 
Aspartate beta-hydroxylase domain-containing protein 2 (ASPHD2) LDTP17326 10.00  LDD2154 
Biliverdin reductase A (BLVRA) LDTP04552 10.00  LDD2154 
Cytochrome b5 type B (CYB5B) LDTP00697 10.00  LDD2154 
E3 ubiquitin-protein ligase UBR5 (UBR5) LDTP01495 10.00  LDD2154 
Glycine--tRNA ligase (GARS1) LDTP03946 10.00  LDD2155 
GTP-binding nuclear protein Ran (RAN) LDTP05007 9.61  LDD2154 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 10.00  LDD2154 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 10.00  LDD2154 
Inorganic pyrophosphatase (PPA1) LDTP14854 10.00  LDD2154 
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) LDTP01005 10.00  LDD2154 
Neutral alpha-glucosidase AB (GANAB) LDTP06192 10.00  LDD2154 
Nucleoside diphosphate kinase B (NME2) LDTP03169 10.00  LDD2154 
Probable ATP-dependent RNA helicase DDX17 (DDX17) LDTP09899 10.00  LDD2154 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 10.00  LDD2154 
Pyruvate carboxylase, mitochondrial (PC) LDTP02576 10.00  LDD2154 
Pyruvate kinase PKM (PKM) LDTP02733 10.00  LDD2154 
Staphylococcal nuclease domain-containing protein 1 (SND1) LDTP07929 10.00  LDD2154 
Tryptophan--tRNA ligase, cytoplasmic (WARS1) LDTP03222 7.61  LDD2154 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 7.39  LDD2154 
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⏷ Show the Full List of 23 Enzyme
9 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 10.00  LDD2154 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 10.00  LDD2154 
Annexin A1 (ANXA1) LDTP02010 10.00  LDD2154 
Annexin A2 (ANXA2) LDTP02199 9.62  LDD2154 
Filamin-A (FLNA) LDTP03107 10.00  LDD2154 
Galectin-3 (LGALS3) LDTP02929 10.00  LDD2154 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 9.66  LDD2154 
Statherin (STATH) LDTP01976 10.00  LDD2155 
Transportin-1 (TNPO1) LDTP09949 10.00  LDD2154 
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⏷ Show the Full List of 9 Transporter and channel
1 Immunoglobulin Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Neural cell adhesion molecule L1 (L1CAM) LDTP03624 10.00  LDD2154 
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30 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Alpha-actinin-1 (ACTN1) LDTP02631 10.00  LDD2154 
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) LDTP02101 10.00  LDD2154 
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) LDTP03027 10.00  LDD2155 
Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2) LDTP17097 6.37  LDD2154 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 10.00  LDD2154 
Keratin, type I cytoskeletal 10 (KRT10) LDTP02674 10.00  LDD2154 
Keratin, type II cytoskeletal 1 (KRT1) LDTP02031 10.00  LDD2154 
Keratin, type II cytoskeletal 8 (KRT8) LDTP02125 10.00  LDD2154 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 10.00  LDD2154 
Large ribosomal subunit protein eL13 (RPL13) LDTP03354 8.02  LDD2154 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 10.00  LDD2154 
Large ribosomal subunit protein eL19 (RPL19) LDTP05196 6.94  LDD2154 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 10.00  LDD2154 
Large ribosomal subunit protein eL32 (RPL32) LDTP05025 5.34  LDD2154 
Large ribosomal subunit protein eL6 (RPL6) LDTP05378 10.00  LDD2154 
Large ribosomal subunit protein uL13 (RPL13A) LDTP03899 10.00  LDD2154 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 5.39  LDD2154 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 10.00  LDD2154 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 10.00  LDD2154 
Prelamin-A/C (LMNA) LDTP01932 10.00  LDD2154 
RasGAP-activating-like protein 1 (RASAL1) LDTP01557 10.00  LDD2154 
Ribosomal L1 domain-containing protein 1 (RSL1D1) LDTP01379 10.00  LDD2155 
Serine/arginine repetitive matrix protein 2 (SRRM2) LDTP13746 10.00  LDD2154 
Serine/arginine-rich splicing factor 3 (SRSF3) LDTP05197 10.00  LDD2154 
Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2) LDTP19820 10.00  LDD2154 
Small ribosomal subunit protein uS4 (RPS9) LDTP04109 10.00  LDD2154 
Transformer-2 protein homolog beta (TRA2B) LDTP05036 10.00  LDD2154 
Tropomyosin alpha-4 chain (TPM4) LDTP05068 5.99  LDD2154 
Tubulin beta chain (TUBB) LDTP02205 10.00  LDD2154 
U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) LDTP02292 10.00  LDD2154 
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⏷ Show the Full List of 30 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 10 uM
Quantitative Method Isotope tag
Experimemt Name ISO-TOP ABPP
Competitor Name AZ-11
Competitor Concentration 20 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)
Interaction Atlas ID  LDD2154  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 10 uM
Quantitative Method Isotope tag
Experimemt Name ISO-TOP ABPP
Competitor Name AZ-11
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)
Interaction Atlas ID  LDD2155  Download The Altas

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.