Details of the Target

General Information of Target

Target ID LDTP02929
Target Name Galectin-3 (LGALS3)
Gene Name LGALS3
Gene ID 3958
Synonyms
MAC2; Galectin-3; Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
TTD ID
T72038
Uniprot ID
P17931
DrugMap ID
TTFPQV7
Ensemble ID
ENST00000254301.14
HGNC ID
HGNC:6563
ChEMBL ID
CHEMBL4531

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K176(1.30); K196(7.75); K199(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y221(8.31)  LDD3495  [2]
BTD
 Probe Info  		C173(1.73)  LDD1700  [3]
AZ-9
 Probe Info  		10.00  LDD2154  [4]
HHS-482
 Probe Info  		Y221(0.88)  LDD0285  [5]
DBIA
 Probe Info  		C173(0.47)  LDD0531  [6]
5E-2FA
 Probe Info  		H158(0.00); H208(0.00); H217(0.00)  LDD2235  [7]
m-APA
 Probe Info  		H208(0.00); H217(0.00); H158(0.00)  LDD2231  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Acrolein
 Probe Info  		H208(0.00); C173(0.00)  LDD0217  [10]
MPP-AC
 Probe Info  		N.A.  LDD0428  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
TER-AC
 Probe Info  		N.A.  LDD0426  [11]
TPP-AC
 Probe Info  		N.A.  LDD0427  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C173(0.28)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C173(0.38)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C173(0.86)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C173(0.62)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C173(1.17)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C173(0.47)  LDD0531  [6]
 LDCM0216  AC100 HCT 116 C173(0.78)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C173(0.77)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C173(0.73)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C173(0.69)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C173(0.69)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C173(0.69)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C173(0.68)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C173(0.72)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C173(0.70)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C173(0.72)  LDD0542  [6]
 LDCM0227  AC110 HCT 116 C173(0.67)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C173(0.67)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C173(0.67)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C173(1.15)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C173(0.91)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C173(0.77)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C173(1.10)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C173(1.42)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C173(1.23)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C173(0.96)  LDD0553  [6]
 LDCM0238  AC120 HCT 116 C173(1.17)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C173(1.66)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C173(1.04)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C173(0.73)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C173(1.27)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C173(1.11)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C173(1.02)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C173(1.30)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C173(0.74)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C173(0.74)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C173(1.52)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C173(1.17)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C173(0.96)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C173(0.77)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C173(0.93)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C173(0.64)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C173(0.79)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C173(0.87)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C173(1.01)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C173(0.89)  LDD1137  [6]
 LDCM0260  AC140 PaTu 8988t C173(1.02)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C173(0.89)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C173(1.07)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C173(0.70)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C173(0.66)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C173(0.95)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C173(0.46)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C173(0.68)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C173(0.56)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C173(0.56)  LDD1148  [6]
 LDCM0271  AC150 PaTu 8988t C173(0.51)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C173(0.46)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C173(0.50)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C173(0.55)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C173(0.48)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C173(0.54)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C173(0.39)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C173(0.47)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C173(1.08)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C173(0.70)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C173(1.15)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C173(0.74)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C173(1.30)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C173(0.85)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C173(1.19)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C173(1.06)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C173(1.41)  LDD0601  [6]
 LDCM0290  AC3 HCT 116 C173(0.78)  LDD0607  [6]
 LDCM0296  AC35 HCT 116 C173(0.98)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C173(0.96)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C173(0.88)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C173(0.99)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C173(0.78)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C173(0.54)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C173(1.09)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C173(0.98)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C173(0.96)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C173(0.89)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C173(1.05)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C173(0.99)  LDD0624  [6]
 LDCM0312  AC5 HCT 116 C173(0.62)  LDD0629  [6]
 LDCM0320  AC57 HCT 116 C173(0.86)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C173(0.73)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C173(1.27)  LDD0639  [6]
 LDCM0324  AC60 HCT 116 C173(0.82)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C173(0.78)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C173(1.04)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C173(1.01)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C173(1.10)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C173(0.70)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C173(0.74)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C173(0.89)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C173(0.96)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C173(0.61)  LDD0650  [6]
 LDCM0335  AC70 HCT 116 C173(0.65)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C173(1.25)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C173(0.77)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C173(0.61)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C173(0.56)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C173(0.56)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C173(0.89)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C173(0.74)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C173(0.77)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C173(1.10)  LDD0661  [6]
 LDCM0346  AC80 HCT 116 C173(1.00)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C173(1.33)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C173(0.34)  LDD0665  [6]
 LDCM0365  AC98 HCT 116 C173(0.52)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C173(0.78)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C173(0.48)  LDD2138  [3]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [4]
 LDCM0498  BS-3668 MDA-MB-231 C173(1.74)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H158(0.00); C173(0.00); H208(0.00)  LDD0222  [10]
 LDCM0369  CL100 HCT 116 C173(0.75)  LDD0686  [6]
 LDCM0374  CL105 HCT 116 C173(0.75)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C173(0.38)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C173(0.65)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C173(0.64)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C173(0.92)  LDD0695  [6]
 LDCM0380  CL110 HCT 116 C173(0.73)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C173(0.95)  LDD0698  [6]
 LDCM0387  CL117 HCT 116 C173(1.13)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C173(0.98)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C173(0.94)  LDD0706  [6]
 LDCM0391  CL120 HCT 116 C173(1.03)  LDD0708  [6]
 LDCM0396  CL125 HCT 116 C173(0.74)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C173(0.79)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C173(0.80)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C173(0.87)  LDD0716  [6]
 LDCM0403  CL16 HCT 116 C173(0.75)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C173(0.55)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C173(0.34)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C173(0.51)  LDD0723  [6]
 LDCM0408  CL20 HCT 116 C173(0.59)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C173(0.48)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C173(0.44)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C173(0.71)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C173(0.55)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C173(0.51)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C173(0.72)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C173(0.64)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C173(0.41)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C173(0.41)  LDD0734  [6]
 LDCM0419  CL30 HCT 116 C173(0.61)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C173(0.84)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C173(0.84)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C173(0.73)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C173(0.70)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C173(0.77)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C173(0.72)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C173(0.78)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C173(0.92)  LDD0745  [6]
 LDCM0430  CL40 HCT 116 C173(0.67)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C173(0.83)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C173(0.71)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C173(0.77)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C173(0.79)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C173(0.74)  LDD0752  [6]
 LDCM0453  CL61 HCT 116 C173(0.95)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C173(0.84)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C173(0.64)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C173(0.61)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C173(0.80)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C173(0.60)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C173(0.68)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C173(0.52)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C173(0.94)  LDD0778  [6]
 LDCM0463  CL70 HCT 116 C173(0.58)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C173(0.67)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C173(0.83)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C173(0.69)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C173(0.67)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C173(0.90)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C173(1.38)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C173(1.50)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C173(1.23)  LDD0789  [6]
 LDCM0474  CL80 HCT 116 C173(0.97)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C173(1.89)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C173(1.84)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C173(1.02)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C173(1.24)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C173(1.03)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C173(2.41)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C173(1.54)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C173(0.89)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C173(1.12)  LDD0800  [6]
 LDCM0485  CL90 HCT 116 C173(1.21)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C173(0.85)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C173(0.76)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C173(0.69)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C173(0.53)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C173(0.54)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C173(0.72)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C173(0.76)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C173(0.84)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C173(0.76)  LDD0811  [6]
 LDCM0468  Fragment33 HCT 116 C173(0.71)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C173(0.57)  LDD0744  [6]
 LDCM0107  IAA HeLa H158(0.00); H208(0.00)  LDD0221  [10]
 LDCM0123  JWB131 DM93 Y221(0.88)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y221(0.40)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y221(0.91)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y221(2.66)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y221(2.16)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y221(0.99)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y221(0.65)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y221(0.72)  LDD0292  [5]
 LDCM0022  KB02 42-MG-BA C173(1.67)  LDD2244  [14]
 LDCM0023  KB03 42-MG-BA C173(1.93)  LDD2661  [14]
 LDCM0024  KB05 IGR37 C173(3.01)  LDD3314  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C173(0.55)  LDD2121  [3]
 LDCM0109  NEM HeLa H158(0.00); H208(0.00)  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C173(1.00)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C173(0.95)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C173(0.84)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C173(0.84)  LDD2099  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C173(0.64)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C173(0.48)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C173(0.78)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C173(0.28)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C173(0.89)  LDD2109  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C173(0.26)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C173(2.55)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C173(0.96)  LDD2120  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C173(0.05)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C173(0.63)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C173(0.05)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C173(0.72)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C173(0.99)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C173(0.90)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C173(1.13)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C173(0.87)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C173(0.81)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C173(1.73)  LDD1700  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C173(0.70)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C173(1.25)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C173(2.59)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C173(0.20)  LDD2145  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C173(6.54)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C173(0.38)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C173(0.49)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C173(2.76)  LDD2151  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C173(0.88)  LDD2153  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chitinase-3-like protein 1 (CHI3L1) Glycosyl hydrolase 18 family P36222
Matrilysin (MMP7) Peptidase M10A family P09237
Peptidyl-prolyl cis-trans isomerase G (PPIG) . Q13427
T-cell differentiation antigen CD6 (CD6) . P30203
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MHC class I polypeptide-related sequence A (MICA) MHC class I family Q29983
Natural cytotoxicity triggering receptor 3 (NCR3) Natural cytotoxicity receptor (NCR) family O14931
CD166 antigen (ALCAM) . Q13740
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-13 receptor subunit alpha-2 (IL13RA2) Type I cytokine receptor family Q14627
Endoglin (ENG) . P17813
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Calcium-responsive transactivator (SS18L1) SS18 family O75177
Programmed cell death 6-interacting protein (PDCD6IP) . Q8WUM4
Proline-rich protein 13 (PRR13) . Q9NZ81

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lactose Small molecular drug DB04465
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gr-md-02 Protein D06BKH
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2,3,5,6-tetrafluoro-4-methoxy-benzamide Small molecular drug D0HB9G
2356-tetrafluoro-4-methoxy-benzamide Small molecular drug DB01827
Pfffff Small molecular drug D03CDB

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840