Details of the Target

General Information of Target

Target ID LDTP02631
Target Name Alpha-actinin-1 (ACTN1)
Gene Name ACTN1
Gene ID 87
Synonyms
Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
Target Bioclass
Other
Family
Alpha-actinin family
Subcellular location
Cytoplasm, cytoskeleton
Function F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Uniprot ID
P12814
Ensemble ID
ENST00000193403.10
HGNC ID
HGNC:163

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		3.47  LDD0451  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		5.38  LDD0244  [3]
N1
 Probe Info  		7.20  LDD0242  [3]
TH211
 Probe Info  		Y681(20.00)  LDD0260  [4]
ONAyne
 Probe Info  		K327(0.82); K420(1.08); K89(0.89)  LDD0274  [5]
STPyne
 Probe Info  		K198(8.75); K413(1.18); K420(10.00); K47(7.69)  LDD0277  [5]
OPA-S-S-alkyne
 Probe Info  		K492(0.91); K47(0.93); K741(1.15)  LDD3494  [6]
Probe 1
 Probe Info  		Y279(24.62); Y422(4.87)  LDD3495  [7]
DBIA
 Probe Info  		C180(2.48); C370(1.60)  LDD3310  [8]
JZ128-DTB
 Probe Info  		C263(0.00); C370(0.00); C860(0.00); C332(0.00)  LDD0462  [9]
AZ-9
 Probe Info  		10.00  LDD2154  [10]
AHL-Pu-1
 Probe Info  		C154(2.26)  LDD0168  [11]
HHS-482
 Probe Info  		Y215(0.37); Y582(0.74); Y681(1.22)  LDD0285  [12]
HHS-475
 Probe Info  		Y422(0.54); Y708(0.64); Y467(0.74); Y215(0.84)  LDD0264  [13]
HHS-465
 Probe Info  		Y215(1.88); Y582(10.00)  LDD2237  [14]
5E-2FA
 Probe Info  		H762(0.00); H757(0.00); H670(0.00); H661(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K47(0.00); K478(0.00)  LDD0199  [16]
1d-yne
 Probe Info  		N.A.  LDD0358  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C774(0.00); C332(0.00); C180(0.00); C154(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
IPIAA_H
 Probe Info  		C180(0.00); C154(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C332(0.00); C480(0.00); C154(0.00); C180(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C774(0.00); C180(0.00); C480(0.00); C370(0.00)  LDD0037  [18]
BTD
 Probe Info  		C263(0.00); C332(0.00); C480(0.00)  LDD0004  [21]
IPM
 Probe Info  		C332(0.00); C263(0.00)  LDD0025  [22]
JW-RF-010
 Probe Info  		C332(0.00); C860(0.00)  LDD0026  [22]
WYneC
 Probe Info  		N.A.  LDD0014  [21]
WYneN
 Probe Info  		C332(0.00); C154(0.00)  LDD0021  [21]
WYneO
 Probe Info  		C480(0.00); C370(0.00)  LDD0022  [21]
aHNE
 Probe Info  		N.A.  LDD0001  [21]
NHS
 Probe Info  		K31(0.00); K436(0.00)  LDD0010  [21]
NPM
 Probe Info  		N.A.  LDD0016  [21]
PF-06672131
 Probe Info  		C370(0.00); C480(0.00)  LDD0017  [23]
SF
 Probe Info  		K89(0.00); Y708(0.00)  LDD0028  [24]
TFBX
 Probe Info  		C263(0.00); C860(0.00); C480(0.00); C332(0.00)  LDD0148  [22]
VSF
 Probe Info  		C370(0.00); C332(0.00); C480(0.00)  LDD0007  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
Ox-W18
 Probe Info  		W289(0.00); W296(0.00); W409(0.00)  LDD2175  [26]
1c-yne
 Probe Info  		K502(0.00); K214(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C370(0.00); C180(0.00); H572(0.00); H622(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [27]
Methacrolein
 Probe Info  		C370(0.00); C180(0.00); C480(0.00)  LDD0218  [27]
W1
 Probe Info  		N.A.  LDD0236  [28]
m-APA
 Probe Info  		N.A.  LDD0404  [29]
MPP-AC
 Probe Info  		N.A.  LDD0428  [30]
NAIA_5
 Probe Info  		C180(0.00); C480(0.00); C370(0.00)  LDD2223  [31]
TPP-AC
 Probe Info  		N.A.  LDD0427  [30]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		6.74  LDD0473  [32]
FFF probe13
 Probe Info  		15.29  LDD0475  [32]
FFF probe14
 Probe Info  		12.64  LDD0477  [32]
FFF probe3
 Probe Info  		5.45  LDD0464  [32]
JN0003
 Probe Info  		6.09  LDD0469  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
DA-2
 Probe Info  		N.A.  LDD0071  [35]
OEA-DA
 Probe Info  		3.54  LDD0046  [36]
STS-1
 Probe Info  		N.A.  LDD0068  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C480(0.83); C180(0.51)  LDD2142  [38]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C480(0.86); C180(0.64); C370(1.00)  LDD2112  [38]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C480(0.72); C180(0.52)  LDD2095  [38]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C480(0.81); C370(1.00)  LDD2130  [38]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C480(1.12)  LDD2117  [38]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C180(1.64)  LDD2103  [38]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C480(0.59); C370(0.44)  LDD2132  [38]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C480(0.60); C180(0.82)  LDD2131  [38]
 LDCM0025  4SU-RNA HEK-293T C154(2.26)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C180(2.05)  LDD0169  [11]
 LDCM0561  Abegg_cp(-)-10 HeLa C480(2.47)  LDD0312  [22]
 LDCM0214  AC1 HEK-293T C370(1.02); C480(0.94)  LDD1507  [39]
 LDCM0215  AC10 HEK-293T C370(0.99); C480(1.07)  LDD1508  [39]
 LDCM0226  AC11 HEK-293T C370(0.90); C480(1.00)  LDD1509  [39]
 LDCM0237  AC12 HEK-293T C370(0.96); C480(0.91)  LDD1510  [39]
 LDCM0259  AC14 HEK-293T C370(1.03); C480(0.96)  LDD1512  [39]
 LDCM0270  AC15 HEK-293T C370(0.95); C480(0.93)  LDD1513  [39]
 LDCM0276  AC17 HEK-293T C370(0.99); C480(0.94)  LDD1515  [39]
 LDCM0277  AC18 HEK-293T C370(0.96); C480(1.19)  LDD1516  [39]
 LDCM0278  AC19 HEK-293T C370(0.81); C480(0.47)  LDD1517  [39]
 LDCM0279  AC2 HEK-293T C370(1.13); C480(1.04)  LDD1518  [39]
 LDCM0280  AC20 HEK-293T C370(0.96); C480(0.94)  LDD1519  [39]
 LDCM0281  AC21 HEK-293T C370(1.09); C480(1.03); C180(0.94)  LDD1520  [39]
 LDCM0282  AC22 HEK-293T C370(1.04); C480(0.94)  LDD1521  [39]
 LDCM0283  AC23 HEK-293T C370(1.02); C480(1.02)  LDD1522  [39]
 LDCM0284  AC24 HEK-293T C370(1.01); C480(1.01)  LDD1523  [39]
 LDCM0285  AC25 HEK-293T C370(0.97); C480(0.99)  LDD1524  [39]
 LDCM0286  AC26 HEK-293T C370(0.96); C480(1.06)  LDD1525  [39]
 LDCM0287  AC27 HEK-293T C370(1.01); C480(1.01)  LDD1526  [39]
 LDCM0288  AC28 HEK-293T C370(0.99); C480(0.97)  LDD1527  [39]
 LDCM0289  AC29 HEK-293T C370(1.03); C480(1.00); C180(0.96)  LDD1528  [39]
 LDCM0290  AC3 HEK-293T C370(1.04); C480(0.98)  LDD1529  [39]
 LDCM0291  AC30 HEK-293T C370(1.00); C480(0.96)  LDD1530  [39]
 LDCM0292  AC31 HEK-293T C370(1.07); C480(1.05)  LDD1531  [39]
 LDCM0293  AC32 HEK-293T C370(0.99); C480(0.96)  LDD1532  [39]
 LDCM0294  AC33 HEK-293T C370(0.92); C480(0.98)  LDD1533  [39]
 LDCM0295  AC34 HEK-293T C370(1.02); C480(1.06)  LDD1534  [39]
 LDCM0296  AC35 HEK-293T C370(0.91); C480(0.97)  LDD1535  [39]
 LDCM0297  AC36 HEK-293T C370(0.91); C480(0.90)  LDD1536  [39]
 LDCM0298  AC37 HEK-293T C370(1.06); C480(0.98); C180(1.01)  LDD1537  [39]
 LDCM0299  AC38 HEK-293T C370(0.98); C480(1.05)  LDD1538  [39]
 LDCM0300  AC39 HEK-293T C370(0.87); C480(1.04)  LDD1539  [39]
 LDCM0301  AC4 HEK-293T C370(0.97); C480(0.89)  LDD1540  [39]
 LDCM0302  AC40 HEK-293T C370(0.85); C480(0.96)  LDD1541  [39]
 LDCM0303  AC41 HEK-293T C370(0.98); C480(1.03)  LDD1542  [39]
 LDCM0304  AC42 HEK-293T C370(0.99); C480(1.08)  LDD1543  [39]
 LDCM0305  AC43 HEK-293T C370(0.91); C480(0.96)  LDD1544  [39]
 LDCM0306  AC44 HEK-293T C370(0.98); C480(0.90)  LDD1545  [39]
 LDCM0307  AC45 HEK-293T C370(1.06); C480(0.87); C180(1.02)  LDD1546  [39]
 LDCM0308  AC46 HEK-293T C370(0.92); C480(0.98)  LDD1547  [39]
 LDCM0309  AC47 HEK-293T C370(0.97); C480(1.00)  LDD1548  [39]
 LDCM0310  AC48 HEK-293T C370(0.96); C480(0.94)  LDD1549  [39]
 LDCM0311  AC49 HEK-293T C370(0.96); C480(0.96)  LDD1550  [39]
 LDCM0312  AC5 HEK-293T C370(1.12); C480(0.91); C180(1.08)  LDD1551  [39]
 LDCM0313  AC50 HEK-293T C370(0.92); C480(1.10)  LDD1552  [39]
 LDCM0314  AC51 HEK-293T C370(1.06); C480(0.96)  LDD1553  [39]
 LDCM0315  AC52 HEK-293T C370(1.01); C480(0.92)  LDD1554  [39]
 LDCM0316  AC53 HEK-293T C370(1.06); C480(0.92); C180(0.97)  LDD1555  [39]
 LDCM0317  AC54 HEK-293T C370(0.94); C480(1.01)  LDD1556  [39]
 LDCM0318  AC55 HEK-293T C370(0.89); C480(1.05)  LDD1557  [39]
 LDCM0319  AC56 HEK-293T C370(0.93); C480(1.01)  LDD1558  [39]
 LDCM0320  AC57 HEK-293T C370(1.03); C480(0.92)  LDD1559  [39]
 LDCM0321  AC58 HEK-293T C370(1.00); C480(1.08)  LDD1560  [39]
 LDCM0322  AC59 HEK-293T C370(0.97); C480(0.99)  LDD1561  [39]
 LDCM0323  AC6 HEK-293T C370(1.03); C480(0.90)  LDD1562  [39]
 LDCM0324  AC60 HEK-293T C370(0.92); C480(0.90)  LDD1563  [39]
 LDCM0325  AC61 HEK-293T C370(1.04); C480(0.86); C180(0.98)  LDD1564  [39]
 LDCM0326  AC62 HEK-293T C370(1.01); C480(0.95)  LDD1565  [39]
 LDCM0327  AC63 HEK-293T C370(0.92); C480(0.92)  LDD1566  [39]
 LDCM0328  AC64 HEK-293T C370(1.01); C480(0.95)  LDD1567  [39]
 LDCM0334  AC7 HEK-293T C370(1.03); C480(1.03)  LDD1568  [39]
 LDCM0345  AC8 HEK-293T C370(1.00); C480(0.99)  LDD1569  [39]
 LDCM0545  Acetamide MDA-MB-231 C180(1.10)  LDD2138  [38]
 LDCM0248  AKOS034007472 HEK-293T C370(1.12); C480(0.93); C180(0.96)  LDD1511  [39]
 LDCM0356  AKOS034007680 HEK-293T C370(0.99); C480(0.98)  LDD1570  [39]
 LDCM0275  AKOS034007705 HEK-293T C370(0.94); C480(0.98)  LDD1514  [39]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [29]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [10]
 LDCM0498  BS-3668 MDA-MB-231 C180(0.97); C370(0.99)  LDD2091  [38]
 LDCM0630  CCW28-3 231MFP C370(2.42); C480(1.59); C154(1.17)  LDD2214  [40]
 LDCM0108  Chloroacetamide HeLa C370(0.00); C480(0.00); H622(0.00); C180(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C370(1.71)  LDD2227  [31]
 LDCM0367  CL1 HEK-293T C370(1.01); C480(1.06); C180(0.95)  LDD1571  [39]
 LDCM0368  CL10 HEK-293T C370(0.80); C480(0.87)  LDD1572  [39]
 LDCM0369  CL100 HEK-293T C370(1.03); C480(0.88)  LDD1573  [39]
 LDCM0370  CL101 HEK-293T C370(1.01); C480(0.99); C180(0.96)  LDD1574  [39]
 LDCM0371  CL102 HEK-293T C370(0.89); C480(0.87)  LDD1575  [39]
 LDCM0372  CL103 HEK-293T C370(1.01); C480(1.00)  LDD1576  [39]
 LDCM0373  CL104 HEK-293T C370(1.03); C480(0.70)  LDD1577  [39]
 LDCM0374  CL105 HEK-293T C370(1.05); C480(0.98); C180(1.03)  LDD1578  [39]
 LDCM0375  CL106 HEK-293T C370(0.87); C480(0.97)  LDD1579  [39]
 LDCM0376  CL107 HEK-293T C370(1.03); C480(1.08)  LDD1580  [39]
 LDCM0377  CL108 HEK-293T C370(0.99); C480(0.96)  LDD1581  [39]
 LDCM0378  CL109 HEK-293T C370(1.03); C480(0.99); C180(0.91)  LDD1582  [39]
 LDCM0379  CL11 HEK-293T C370(0.99); C480(0.94)  LDD1583  [39]
 LDCM0380  CL110 HEK-293T C370(0.88); C480(0.87)  LDD1584  [39]
 LDCM0381  CL111 HEK-293T C370(1.01); C480(1.03)  LDD1585  [39]
 LDCM0382  CL112 HEK-293T C370(0.99); C480(0.95)  LDD1586  [39]
 LDCM0383  CL113 HEK-293T C370(1.01); C480(1.11); C180(0.98)  LDD1587  [39]
 LDCM0384  CL114 HEK-293T C370(0.82); C480(0.85)  LDD1588  [39]
 LDCM0385  CL115 HEK-293T C370(0.96); C480(1.03)  LDD1589  [39]
 LDCM0386  CL116 HEK-293T C370(1.02); C480(0.95)  LDD1590  [39]
 LDCM0387  CL117 HEK-293T C370(0.93); C480(1.01); C180(1.01)  LDD1591  [39]
 LDCM0388  CL118 HEK-293T C370(0.89); C480(0.93)  LDD1592  [39]
 LDCM0389  CL119 HEK-293T C370(1.02); C480(1.05)  LDD1593  [39]
 LDCM0390  CL12 HEK-293T C370(0.95); C480(0.92)  LDD1594  [39]
 LDCM0391  CL120 HEK-293T C370(1.04); C480(1.04)  LDD1595  [39]
 LDCM0392  CL121 HEK-293T C370(0.99); C480(0.97); C180(1.01)  LDD1596  [39]
 LDCM0393  CL122 HEK-293T C370(0.92); C480(0.91)  LDD1597  [39]
 LDCM0394  CL123 HEK-293T C370(0.85); C480(0.87)  LDD1598  [39]
 LDCM0395  CL124 HEK-293T C370(1.01); C480(1.04)  LDD1599  [39]
 LDCM0396  CL125 HEK-293T C370(1.00); C480(0.98); C180(1.17)  LDD1600  [39]
 LDCM0397  CL126 HEK-293T C370(0.90); C480(0.91)  LDD1601  [39]
 LDCM0398  CL127 HEK-293T C370(0.96); C480(1.05)  LDD1602  [39]
 LDCM0399  CL128 HEK-293T C370(1.02); C480(0.95)  LDD1603  [39]
 LDCM0400  CL13 HEK-293T C370(1.01); C480(1.00); C180(0.90)  LDD1604  [39]
 LDCM0401  CL14 HEK-293T C370(0.91); C480(0.98)  LDD1605  [39]
 LDCM0402  CL15 HEK-293T C370(0.91); C480(0.95)  LDD1606  [39]
 LDCM0403  CL16 HEK-293T C370(1.10); C480(1.06)  LDD1607  [39]
 LDCM0404  CL17 HEK-293T C370(0.88); C480(0.86)  LDD1608  [39]
 LDCM0405  CL18 HEK-293T C370(1.03); C480(1.10)  LDD1609  [39]
 LDCM0406  CL19 HEK-293T C370(0.92); C480(1.00)  LDD1610  [39]
 LDCM0407  CL2 HEK-293T C370(0.99); C480(1.00)  LDD1611  [39]
 LDCM0408  CL20 HEK-293T C370(1.07); C480(0.99)  LDD1612  [39]
 LDCM0409  CL21 HEK-293T C370(1.00); C480(0.85); C180(0.82)  LDD1613  [39]
 LDCM0410  CL22 HEK-293T C370(0.88); C480(1.10)  LDD1614  [39]
 LDCM0411  CL23 HEK-293T C370(0.98); C480(0.98)  LDD1615  [39]
 LDCM0412  CL24 HEK-293T C370(1.03); C480(0.99)  LDD1616  [39]
 LDCM0413  CL25 HEK-293T C370(0.91); C480(0.93); C180(0.99)  LDD1617  [39]
 LDCM0414  CL26 HEK-293T C370(0.95); C480(1.02)  LDD1618  [39]
 LDCM0415  CL27 HEK-293T C370(1.02); C480(1.04)  LDD1619  [39]
 LDCM0416  CL28 HEK-293T C370(0.99); C480(1.02)  LDD1620  [39]
 LDCM0417  CL29 HEK-293T C370(1.06); C480(0.99)  LDD1621  [39]
 LDCM0418  CL3 HEK-293T C370(1.05); C480(1.02)  LDD1622  [39]
 LDCM0419  CL30 HEK-293T C370(1.01); C480(1.25)  LDD1623  [39]
 LDCM0420  CL31 HEK-293T C370(0.85); C480(0.88)  LDD1624  [39]
 LDCM0421  CL32 HEK-293T C370(1.05); C480(0.97)  LDD1625  [39]
 LDCM0422  CL33 HEK-293T C370(0.86); C480(0.78); C180(0.71)  LDD1626  [39]
 LDCM0423  CL34 HEK-293T C370(0.98); C480(1.00)  LDD1627  [39]
 LDCM0424  CL35 HEK-293T C370(1.01); C480(1.03)  LDD1628  [39]
 LDCM0425  CL36 HEK-293T C370(0.95); C480(0.99)  LDD1629  [39]
 LDCM0426  CL37 HEK-293T C370(1.08); C480(1.03); C180(1.10)  LDD1630  [39]
 LDCM0428  CL39 HEK-293T C370(0.98); C480(0.97)  LDD1632  [39]
 LDCM0429  CL4 HEK-293T C370(1.06); C480(1.06)  LDD1633  [39]
 LDCM0430  CL40 HEK-293T C370(1.02); C480(1.02)  LDD1634  [39]
 LDCM0431  CL41 HEK-293T C370(1.07); C480(0.92)  LDD1635  [39]
 LDCM0432  CL42 HEK-293T C370(1.05); C480(1.05)  LDD1636  [39]
 LDCM0433  CL43 HEK-293T C370(1.02); C480(0.98)  LDD1637  [39]
 LDCM0434  CL44 HEK-293T C370(1.01); C480(0.91)  LDD1638  [39]
 LDCM0435  CL45 HEK-293T C370(0.96); C480(0.94); C180(0.83)  LDD1639  [39]
 LDCM0436  CL46 HEK-293T C370(0.99); C480(0.98)  LDD1640  [39]
 LDCM0437  CL47 HEK-293T C370(0.96); C480(1.04)  LDD1641  [39]
 LDCM0438  CL48 HEK-293T C370(1.01); C480(1.00)  LDD1642  [39]
 LDCM0439  CL49 HEK-293T C370(0.99); C480(1.01); C180(1.19)  LDD1643  [39]
 LDCM0440  CL5 HEK-293T C370(1.07); C480(1.10)  LDD1644  [39]
 LDCM0441  CL50 HEK-293T C370(0.91); C480(0.94)  LDD1645  [39]
 LDCM0443  CL52 HEK-293T C370(1.08); C480(1.05)  LDD1646  [39]
 LDCM0444  CL53 HEK-293T C370(0.94); C480(0.87)  LDD1647  [39]
 LDCM0445  CL54 HEK-293T C370(0.90); C480(1.31)  LDD1648  [39]
 LDCM0446  CL55 HEK-293T C370(0.98); C480(0.95)  LDD1649  [39]
 LDCM0447  CL56 HEK-293T C370(0.92); C480(0.91)  LDD1650  [39]
 LDCM0448  CL57 HEK-293T C370(0.87); C480(0.80); C180(0.83)  LDD1651  [39]
 LDCM0449  CL58 HEK-293T C370(0.94); C480(0.99)  LDD1652  [39]
 LDCM0450  CL59 HEK-293T C370(1.03); C480(0.91)  LDD1653  [39]
 LDCM0451  CL6 HEK-293T C370(0.98); C480(1.17)  LDD1654  [39]
 LDCM0452  CL60 HEK-293T C370(1.00); C480(0.93)  LDD1655  [39]
 LDCM0453  CL61 HEK-293T C370(1.06); C480(1.08); C180(1.10)  LDD1656  [39]
 LDCM0454  CL62 HEK-293T C370(0.95); C480(0.99)  LDD1657  [39]
 LDCM0455  CL63 HEK-293T C370(1.02); C480(1.12)  LDD1658  [39]
 LDCM0456  CL64 HEK-293T C370(0.97); C480(0.92)  LDD1659  [39]
 LDCM0457  CL65 HEK-293T C370(0.93); C480(1.01)  LDD1660  [39]
 LDCM0458  CL66 HEK-293T C370(1.08); C480(0.99)  LDD1661  [39]
 LDCM0459  CL67 HEK-293T C370(0.88); C480(0.96)  LDD1662  [39]
 LDCM0460  CL68 HEK-293T C370(1.00); C480(0.96)  LDD1663  [39]
 LDCM0461  CL69 HEK-293T C370(1.03); C480(0.90); C180(0.88)  LDD1664  [39]
 LDCM0462  CL7 HEK-293T C370(0.96); C480(0.98)  LDD1665  [39]
 LDCM0463  CL70 HEK-293T C370(0.99); C480(0.97)  LDD1666  [39]
 LDCM0464  CL71 HEK-293T C370(1.02); C480(0.89)  LDD1667  [39]
 LDCM0465  CL72 HEK-293T C370(0.98); C480(0.99)  LDD1668  [39]
 LDCM0466  CL73 HEK-293T C370(0.98); C480(0.99); C180(1.09)  LDD1669  [39]
 LDCM0467  CL74 HEK-293T C370(1.00); C480(0.98)  LDD1670  [39]
 LDCM0469  CL76 HEK-293T C370(1.06); C480(1.06)  LDD1672  [39]
 LDCM0470  CL77 HEK-293T C370(0.97); C480(0.92)  LDD1673  [39]
 LDCM0471  CL78 HEK-293T C370(1.12); C480(1.28)  LDD1674  [39]
 LDCM0472  CL79 HEK-293T C370(0.87); C480(0.98)  LDD1675  [39]
 LDCM0473  CL8 HEK-293T C370(0.78); C480(0.65)  LDD1676  [39]
 LDCM0474  CL80 HEK-293T C370(1.05); C480(1.01)  LDD1677  [39]
 LDCM0475  CL81 HEK-293T C370(1.19); C480(0.98); C180(0.90)  LDD1678  [39]
 LDCM0476  CL82 HEK-293T C370(1.08); C480(1.03)  LDD1679  [39]
 LDCM0477  CL83 HEK-293T C370(1.01); C480(0.95)  LDD1680  [39]
 LDCM0478  CL84 HEK-293T C370(0.92); C480(0.96)  LDD1681  [39]
 LDCM0479  CL85 HEK-293T C370(0.95); C480(1.08); C180(1.12)  LDD1682  [39]
 LDCM0480  CL86 HEK-293T C370(1.02); C480(0.98)  LDD1683  [39]
 LDCM0481  CL87 HEK-293T C370(0.99); C480(0.96)  LDD1684  [39]
 LDCM0482  CL88 HEK-293T C370(1.11); C480(1.02)  LDD1685  [39]
 LDCM0483  CL89 HEK-293T C370(1.01); C480(1.09)  LDD1686  [39]
 LDCM0484  CL9 HEK-293T C370(1.11); C480(0.96); C180(0.87)  LDD1687  [39]
 LDCM0485  CL90 HEK-293T C370(0.76); C480(0.82)  LDD1688  [39]
 LDCM0486  CL91 HEK-293T C370(0.89); C480(1.00)  LDD1689  [39]
 LDCM0487  CL92 HEK-293T C370(1.00); C480(0.85)  LDD1690  [39]
 LDCM0488  CL93 HEK-293T C370(1.04); C480(0.91); C180(0.96)  LDD1691  [39]
 LDCM0489  CL94 HEK-293T C370(1.00); C480(1.04)  LDD1692  [39]
 LDCM0490  CL95 HEK-293T C370(0.81); C480(0.76)  LDD1693  [39]
 LDCM0491  CL96 HEK-293T C370(0.88); C480(0.88)  LDD1694  [39]
 LDCM0492  CL97 HEK-293T C370(0.92); C480(0.96); C180(0.97)  LDD1695  [39]
 LDCM0493  CL98 HEK-293T C370(0.89); C480(0.94)  LDD1696  [39]
 LDCM0494  CL99 HEK-293T C370(0.95); C480(0.99)  LDD1697  [39]
 LDCM0495  E2913 HEK-293T C370(1.05); C480(1.02)  LDD1698  [39]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C370(0.84)  LDD1702  [38]
 LDCM0572  Fragment10 MDA-MB-231 C370(1.19)  LDD1389  [41]
 LDCM0573  Fragment11 MDA-MB-231 C370(1.09)  LDD1391  [41]
 LDCM0574  Fragment12 MDA-MB-231 C370(1.11)  LDD1393  [41]
 LDCM0575  Fragment13 MDA-MB-231 C370(0.98)  LDD1395  [41]
 LDCM0576  Fragment14 MDA-MB-231 C370(1.00)  LDD1397  [41]
 LDCM0577  Fragment15 MDA-MB-231 C370(0.98)  LDD1399  [41]
 LDCM0579  Fragment20 MDA-MB-231 C370(1.05)  LDD1402  [41]
 LDCM0580  Fragment21 MDA-MB-231 C370(0.98)  LDD1404  [41]
 LDCM0581  Fragment22 MDA-MB-231 C370(1.01)  LDD1406  [41]
 LDCM0582  Fragment23 MDA-MB-231 C370(8.17)  LDD1408  [41]
 LDCM0584  Fragment25 MDA-MB-231 C370(0.92)  LDD1411  [41]
 LDCM0578  Fragment27 MDA-MB-231 C370(1.00)  LDD1401  [41]
 LDCM0586  Fragment28 MDA-MB-231 C370(0.88)  LDD1415  [41]
 LDCM0587  Fragment29 MDA-MB-231 C370(1.27)  LDD1417  [41]
 LDCM0589  Fragment31 MDA-MB-231 C370(1.05)  LDD1421  [41]
 LDCM0590  Fragment32 MDA-MB-231 C370(1.06)  LDD1423  [41]
 LDCM0468  Fragment33 MDA-MB-231 C370(0.77)  LDD1425  [41]
 LDCM0596  Fragment38 MDA-MB-231 C370(1.04)  LDD1433  [41]
 LDCM0597  Fragment39 MDA-MB-231 C370(1.00)  LDD1435  [41]
 LDCM0566  Fragment4 MDA-MB-231 C370(1.07)  LDD1378  [41]
 LDCM0599  Fragment41 MDA-MB-231 C370(5.24)  LDD1438  [41]
 LDCM0601  Fragment43 MDA-MB-231 C370(1.01)  LDD1441  [41]
 LDCM0602  Fragment44 MDA-MB-231 C370(0.78)  LDD1443  [41]
 LDCM0603  Fragment45 MDA-MB-231 C370(1.22)  LDD1444  [41]
 LDCM0604  Fragment46 MDA-MB-231 C370(0.88)  LDD1445  [41]
 LDCM0605  Fragment47 MDA-MB-231 C370(1.09)  LDD1446  [41]
 LDCM0607  Fragment49 MDA-MB-231 C370(4.95)  LDD1448  [41]
 LDCM0608  Fragment50 MDA-MB-231 C370(0.85)  LDD1449  [41]
 LDCM0427  Fragment51 MDA-MB-231 C370(0.70)  LDD1450  [41]
 LDCM0610  Fragment52 MDA-MB-231 C370(0.90)  LDD1452  [41]
 LDCM0611  Fragment53 MDA-MB-231 C370(0.80)  LDD1454  [41]
 LDCM0612  Fragment54 MDA-MB-231 C370(1.26)  LDD1456  [41]
 LDCM0614  Fragment56 MDA-MB-231 C370(0.84)  LDD1458  [41]
 LDCM0568  Fragment6 MDA-MB-231 C370(1.19)  LDD1382  [41]
 LDCM0569  Fragment7 MDA-MB-231 C370(0.98)  LDD1383  [41]
 LDCM0570  Fragment8 MDA-MB-231 C370(0.95)  LDD1385  [41]
 LDCM0571  Fragment9 MDA-MB-231 C370(0.86)  LDD1387  [41]
 LDCM0116  HHS-0101 DM93 Y422(0.54); Y708(0.64); Y467(0.74); Y215(0.84)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y708(0.56); Y422(0.78); Y681(0.86); Y582(0.93)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y422(0.42); Y708(0.61); Y215(0.62); Y246(0.84)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y708(0.63); Y422(0.72); Y215(0.90); Y582(0.90)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y422(0.35); Y708(0.68); Y681(0.89); Y246(1.02)  LDD0268  [13]
 LDCM0107  IAA HeLa C370(0.00); H622(0.00); H762(0.00); H186(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y215(0.37); Y582(0.74); Y681(1.22)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y215(0.24); Y582(0.79); Y681(1.08)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y215(0.71); Y582(0.74); Y681(0.99)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y215(5.34); Y582(2.95); Y681(4.31)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y215(1.34); Y582(1.35); Y681(5.19)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y215(0.23); Y582(1.58); Y681(2.22)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y215(0.87); Y582(0.59); Y681(1.35)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y215(1.71); Y582(0.67); Y681(2.03)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 C263(0.00); C370(0.00); C860(0.00); C332(0.00)  LDD0462  [9]
 LDCM0022  KB02 MDA-MB-231 C370(1.34)  LDD1374  [41]
 LDCM0023  KB03 MDA-MB-231 C370(1.16)  LDD1376  [41]
 LDCM0024  KB05 COLO792 C180(2.48); C370(1.60)  LDD3310  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C180(1.02)  LDD2102  [38]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C480(1.02); C180(0.75)  LDD2121  [38]
 LDCM0109  NEM HeLa H622(0.00); H572(0.00); H757(0.00); H762(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C480(1.03); C180(0.95); C370(1.13)  LDD2089  [38]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C480(1.10)  LDD2092  [38]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C480(1.16)  LDD2094  [38]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C480(0.91)  LDD2098  [38]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C480(0.90)  LDD2099  [38]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C480(0.46); C180(0.41); C370(0.82)  LDD2100  [38]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C480(0.85); C180(0.38); C370(0.68)  LDD2104  [38]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C480(1.44); C180(1.89)  LDD2105  [38]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C180(0.36); C370(0.66)  LDD2106  [38]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C480(0.99)  LDD2107  [38]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C480(0.70)  LDD2108  [38]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C480(0.86)  LDD2109  [38]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C180(0.65); C370(0.97)  LDD2110  [38]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C480(1.01)  LDD2111  [38]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C480(0.62); C180(0.59); C370(0.64)  LDD2114  [38]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C480(1.28)  LDD2119  [38]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C180(0.81)  LDD2120  [38]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C480(0.98)  LDD2123  [38]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C480(1.01)  LDD2125  [38]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C480(1.01)  LDD2129  [38]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C480(0.90)  LDD2135  [38]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C480(1.04)  LDD2136  [38]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C480(0.73); C180(0.45); C370(0.94)  LDD2141  [38]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C180(0.94)  LDD2143  [38]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C180(0.17); C370(1.32)  LDD2145  [38]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C480(1.04)  LDD2146  [38]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C480(0.67); C180(1.08)  LDD2150  [38]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2'-5'-oligoadenylate synthase 1 (OAS1) 2-5A synthase family P00973
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Titin (TTN) CAMK Ser/Thr protein kinase family Q8WZ42
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Thioredoxin (TXN) Thioredoxin family P10599
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family Q9Y223
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) Calcium channel alpha-1 subunit (TC 1.A.1.11) family Q13936
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein ARX (ARX) Paired homeobox family Q96QS3
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) EIF-2-alpha family P05198
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Myozenin-2 (MYOZ2) Myozenin family Q9NPC6
Synaptopodin (SYNPO) Synaptopodin family Q8N3V7
Amyloid protein-binding protein 2 (APPBP2) . Q92624
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
MICAL-like protein 2 (MICALL2) . Q8IY33
PDZ and LIM domain protein 4 (PDLIM4) . P50479
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Human Calcitonin . DB06773

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD039908 , PXD029761
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