Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name TFBX  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Abegg_cp(-)-10  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12893  Maspardin (SPG21) C204 7.6
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 6.3
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1347 4.5
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) C34 3.9
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 3.3
 LDTP03258  Thymidylate kinase (DTYMK) C31 3.2
 LDTP11759  Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL) C385 3.2
 LDTP05957  Ras-related protein Rab-31 (RAB31) C49 2.7
 LDTP03842  Squalene synthase (FDFT1) C147 2.7
 LDTP01265  E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) C1906 2.6
 LDTP11990  Cytosolic iron-sulfur assembly component 3 (CIAO3) C179 2.5
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) C1335 2.5
 LDTP07672  E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) C397 2.5
 LDTP05716  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) C229 2.4
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C702 2.4
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C305 2.4
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C1148 2.1
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) C192 2.1
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) C347 2.0
 LDTP02642  X-ray repair cross-complementing protein 5 (XRCC5) C249 .
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04393  Annexin A11 (ANXA11) C384 3.9
 LDTP00287  Exocyst complex component 5 (EXOC5) C111 3.2
 LDTP04501  Importin subunit alpha-1 (KPNA2) C133 2.6
 LDTP07058  Transmembrane protein 201 (TMEM201) C124 2.6
 LDTP09515  Importin-4 (IPO4) C350 2.3
 LDTP05252  Clathrin heavy chain 1 (CLTC) C1102 2.3
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 2.2
 LDTP03107  Filamin-A (FLNA) C2199 2.1
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04989  TATA box-binding protein-like 1 (TBPL1) C139 2.4
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C486 2.2
Other
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14980  RRP12-like protein (RRP12) C839 10.0
 LDTP13035  CTTNBP2 N-terminal-like protein (CTTNBP2NL) C76 6.5
 LDTP06174  Pumilio homolog 1 (PUM1) C1179 5.8
 LDTP11331  Sideroflexin-3 (SFXN3) C189 4.8
 LDTP10308  Dynein light chain 2, cytoplasmic (DYNLL2) C56 4.1
 LDTP16285  Transducin beta-like protein 2 (TBL2) C44 3.6
 LDTP00078  CCR4-NOT transcription complex subunit 1 (CNOT1) C624 3.6
 LDTP14426  TRAF-type zinc finger domain-containing protein 1 (TRAFD1) C267 2.9
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) C92 2.7
 LDTP16934  Protein POLR1D, isoform 2 (POLR1D) C37 2.6
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C125 2.6
 LDTP02631  Alpha-actinin-1 (ACTN1) C480 2.5
 LDTP05421  Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) C919 2.5
 LDTP06186  Protein RRP5 homolog (PDCD11) C361 2.4
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) C92 2.4
 LDTP10822  Protein IWS1 homolog (IWS1) C749 2.4
 LDTP00843  Alpha-actinin-4 (ACTN4) C499 2.4
 LDTP05778  Chromobox protein homolog 3 (CBX3) C177 2.4
 LDTP12596  Protein diaphanous homolog 3 (DIAPH3) C1125 2.4
 LDTP03030  Annexin A7 (ANXA7) C413 2.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C658 2.2
 LDTP05734  Protein flightless-1 homolog (FLII) C289 2.1
 LDTP07221  Myomegalin (PDE4DIP) C617 2.1
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 2.1
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) C1396 2.1
 LDTP07335  Rho GTPase-activating protein 17 (ARHGAP17) C43 2.1
 LDTP04321  Transcription initiation factor TFIID subunit 6 (TAF6) C130 2.1
 LDTP08735  Spartin (SPART) C562 2.1
 LDTP10529  Leucine-rich repeat protein 1 (LRR1) C246 2.0
 LDTP06176  Mediator of DNA damage checkpoint protein 1 (MDC1) C2042 2.0

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255