Details of the Target

General Information of Target

Target ID LDTP04989
Target Name TATA box-binding protein-like 1 (TBPL1)
Gene Name TBPL1
Gene ID 9519
Synonyms
TLF; TLP; TLP21; TRF2; TRP; TATA box-binding protein-like 1; TBP-like 1; 21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATI
WSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEF
TKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFE
SRKEIL
Target Bioclass
Transcription factor
Family
TBP family
Subcellular location
Cytoplasm
Function
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
Uniprot ID
P62380
Ensemble ID
ENST00000237264.9
HGNC ID
HGNC:11589

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C68(2.31)  LDD3323  [1]
BTD
 Probe Info  		C24(0.39)  LDD2096  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C68(0.00); C139(0.00); C109(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C68(0.00); C139(0.00); C109(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
TFBX
 Probe Info  		C139(0.00); C68(0.00)  LDD0027  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
NAIA_5
 Probe Info  		C68(0.00); C139(0.00); C18(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0561  Abegg_cp(-)-10 HeLa C139(2.37)  LDD0312  [4]
 LDCM0215  AC10 HEK-293T C139(1.11)  LDD1508  [7]
 LDCM0277  AC18 HEK-293T C139(0.86)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C139(0.93)  LDD1518  [7]
 LDCM0286  AC26 HEK-293T C139(0.96)  LDD1525  [7]
 LDCM0295  AC34 HEK-293T C139(1.15)  LDD1534  [7]
 LDCM0304  AC42 HEK-293T C139(1.12)  LDD1543  [7]
 LDCM0313  AC50 HEK-293T C139(0.98)  LDD1552  [7]
 LDCM0321  AC58 HEK-293T C139(0.92)  LDD1560  [7]
 LDCM0108  Chloroacetamide HeLa C68(0.00); C139(0.00)  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C139(0.90)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C139(1.14)  LDD1571  [7]
 LDCM0370  CL101 HEK-293T C139(1.16)  LDD1574  [7]
 LDCM0372  CL103 HEK-293T C139(1.04)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C139(1.14)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C139(1.08)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C139(1.12)  LDD1582  [7]
 LDCM0381  CL111 HEK-293T C139(1.08)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C139(1.20)  LDD1587  [7]
 LDCM0385  CL115 HEK-293T C139(1.18)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C139(1.12)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C139(1.11)  LDD1593  [7]
 LDCM0392  CL121 HEK-293T C139(1.17)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C139(1.08)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C139(1.01)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C139(0.86)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C139(1.07)  LDD1604  [7]
 LDCM0402  CL15 HEK-293T C139(0.95)  LDD1606  [7]
 LDCM0405  CL18 HEK-293T C139(1.06)  LDD1609  [7]
 LDCM0413  CL25 HEK-293T C139(0.92)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C139(1.03)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C139(1.03)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C139(1.09)  LDD1623  [7]
 LDCM0426  CL37 HEK-293T C139(1.02)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C139(1.15)  LDD1632  [7]
 LDCM0432  CL42 HEK-293T C139(0.99)  LDD1636  [7]
 LDCM0439  CL49 HEK-293T C139(1.07)  LDD1643  [7]
 LDCM0445  CL54 HEK-293T C139(0.97)  LDD1648  [7]
 LDCM0451  CL6 HEK-293T C139(0.86)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C139(1.07)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C139(1.11)  LDD1658  [7]
 LDCM0458  CL66 HEK-293T C139(1.11)  LDD1661  [7]
 LDCM0466  CL73 HEK-293T C139(0.96)  LDD1669  [7]
 LDCM0471  CL78 HEK-293T C139(1.16)  LDD1674  [7]
 LDCM0479  CL85 HEK-293T C139(0.90)  LDD1682  [7]
 LDCM0481  CL87 HEK-293T C139(0.96)  LDD1684  [7]
 LDCM0485  CL90 HEK-293T C139(0.76)  LDD1688  [7]
 LDCM0492  CL97 HEK-293T C139(1.07)  LDD1695  [7]
 LDCM0494  CL99 HEK-293T C139(0.98)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C139(1.27)  LDD1698  [7]
 LDCM0573  Fragment11 Ramos C139(2.81)  LDD2190  [8]
 LDCM0576  Fragment14 Ramos C139(0.63)  LDD2193  [8]
 LDCM0586  Fragment28 Ramos C139(0.37)  LDD2198  [8]
 LDCM0468  Fragment33 HEK-293T C139(1.03)  LDD1671  [7]
 LDCM0566  Fragment4 Ramos C139(1.00)  LDD2184  [8]
 LDCM0569  Fragment7 Ramos C139(0.72)  LDD2186  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C139(0.90)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C139(1.01)  LDD1497  [7]
 LDCM0024  KB05 SKMEL24 C68(2.31)  LDD3323  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C24(0.39)  LDD2096  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C24(1.03)  LDD2116  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C24(0.65)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C24(0.58)  LDD2124  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C24(0.56)  LDD2126  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C24(0.72)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C24(0.68)  LDD2151  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Progranulin (GRN) Granulin family P28799
U6 snRNA-associated Sm-like protein LSm5 (LSM5) SnRNP Sm proteins family Q9Y4Y9
Transcription initiation factor IIA subunit 1 (GTF2A1) TFIIA subunit 1 family P52655
Troponin T, slow skeletal muscle (TNNT1) Troponin T family P13805
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578