Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0561
Competitor Name
Abegg_cp(-)-10
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 344.4
Lipid-water partition coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C20H24O5
IUPAC Name
(1S,2S,5R,11S,14S)-5-ethenyl-2,9-dihydroxy-5,11-dimethyl-8-oxotetracyclo[8.5.0.01,14.02,7]pentadeca-6,9-diene-11-carboxylic acid
Canonical SMILES
CC1(CCC2(C(=C1)C(=O)C(=C3C24CC4CCC3(C)C(=O)O)O)O)C=C
InChI
InChI=1S/C20H24O5/c1-4-17(2)7-8-20(25)12(10-17)13(21)14(22)15-18(3,16(23)24)6-5-11-9-19(11,15)20/h4,10-11,22,25H,1,5-9H2,2-3H3,(H,23,24)/t11-,17-,18-,19-,20+/m0/s1
InChIKey
PTUXWFGKOJMZET-ZWIBCXMYSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 2 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IPM
 Probe Info  		100 uM Human endocervical adenocarcinoma cell lysate (HeLa) [1]
TFBX
 Probe Info  		100 uM Human endocervical adenocarcinoma cell lysate (HeLa) [1]

Target(s) List of this Competitor

23 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) LDTP05716 2.40  LDD0312 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 2.09  LDD0312 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 2.06  LDD0312 
Cytosolic iron-sulfur assembly component 3 (CIAO3) LDTP11990 2.53  LDD0312 
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) LDTP04103 2.36  LDD0312 
E3 SUMO-protein ligase RanBP2 (RANBP2) LDTP04310 2.46  LDD0312 
E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) LDTP07672 2.46  LDD0312 
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) LDTP01265 2.55  LDD0312 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 2.04  LDD0311 
Maspardin (SPG21) LDTP12893 7.62  LDD0312 
Nuclear pore complex protein Nup98-Nup96 (NUP98) LDTP04547 4.51  LDD0312 
Probable ATP-dependent RNA helicase DDX52 (DDX52) LDTP13904 2.33  LDD0311 
Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL) LDTP11759 3.16  LDD0312 
Ras-related protein Rab-31 (RAB31) LDTP05957 2.74  LDD0312 
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) LDTP05917 3.88  LDD0312 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 6.33  LDD0312 
Squalene synthase (FDFT1) LDTP03842 2.73  LDD0312 
Thymidylate kinase (DTYMK) LDTP03258 3.17  LDD0312 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 2.01  LDD0312 
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) LDTP09962 2.40  LDD0312 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 3.29  LDD0312 
Unconventional myosin-XVIIIa (MYO18A) LDTP09819 2.14  LDD0311 
X-ray repair cross-complementing protein 5 (XRCC5) LDTP02642 0.00  LDD0312 
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⏷ Show the Full List of 23 Enzyme
9 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Annexin A11 (ANXA11) LDTP04393 3.87  LDD0312 
Clathrin heavy chain 1 (CLTC) LDTP05252 2.27  LDD0312 
Exocyst complex component 5 (EXOC5) LDTP00287 3.15  LDD0312 
Filamin-A (FLNA) LDTP03107 2.05  LDD0312 
Importin subunit alpha-1 (KPNA2) LDTP04501 2.64  LDD0312 
Importin-4 (IPO4) LDTP09515 2.32  LDD0312 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 2.17  LDD0312 
Transmembrane protein 201 (TMEM201) LDTP07058 2.58  LDD0312 
Unconventional myosin-Ic (MYO1C) LDTP00196 2.29  LDD0311 
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⏷ Show the Full List of 9 Transporter and channel
3 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Protein polybromo-1 (PBRM1) LDTP08216 2.15  LDD0311 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 2.20  LDD0312 
TATA box-binding protein-like 1 (TBPL1) LDTP04989 2.37  LDD0312 
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32 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Alpha-actinin-1 (ACTN1) LDTP02631 2.47  LDD0312 
Alpha-actinin-4 (ACTN4) LDTP00843 2.39  LDD0312 
Annexin A7 (ANXA7) LDTP03030 2.18  LDD0312 
CCR4-NOT transcription complex subunit 1 (CNOT1) LDTP00078 3.64  LDD0312 
Chromobox protein homolog 3 (CBX3) LDTP05778 2.37  LDD0312 
Cold shock domain-containing protein E1 (CSDE1) LDTP01252 3.18  LDD0311 
CTTNBP2 N-terminal-like protein (CTTNBP2NL) LDTP13035 6.47  LDD0312 
Dynein light chain 2, cytoplasmic (DYNLL2) LDTP10308 4.07  LDD0312 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 2.46  LDD0312 
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) LDTP06255 2.12  LDD0312 
Integrin beta-5 (ITGB5) LDTP02941 2.14  LDD0311 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 2.17  LDD0312 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 2.59  LDD0312 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 2.13  LDD0312 
Leucine-rich repeat protein 1 (LRR1) LDTP10529 2.04  LDD0312 
Lipoma-preferred partner (LPP) LDTP09969 2.09  LDD0311 
Mediator of DNA damage checkpoint protein 1 (MDC1) LDTP06176 2.03  LDD0312 
Myomegalin (PDE4DIP) LDTP07221 2.14  LDD0312 
Protein diaphanous homolog 3 (DIAPH3) LDTP12596 2.36  LDD0312 
Protein flightless-1 homolog (FLII) LDTP05734 2.14  LDD0312 
Protein IWS1 homolog (IWS1) LDTP10822 2.40  LDD0312 
Protein POLR1D, isoform 2 (POLR1D) LDTP16934 2.59  LDD0312 
Protein RRP5 homolog (PDCD11) LDTP06186 2.45  LDD0312 
Pumilio homolog 1 (PUM1) LDTP06174 5.76  LDD0312 
Rho GTPase-activating protein 17 (ARHGAP17) LDTP07335 2.09  LDD0312 
RRP12-like protein (RRP12) LDTP14980 10.01  LDD0312 
Sideroflexin-3 (SFXN3) LDTP11331 4.80  LDD0312 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 2.73; 2.41  LDD0312 
Spartin (SPART) LDTP08735 2.06  LDD0312 
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) LDTP14426 2.93  LDD0312 
Transcription initiation factor TFIID subunit 6 (TAF6) LDTP04321 2.07  LDD0312 
Transducin beta-like protein 2 (TBL2) LDTP16285 2.02  LDD0311 
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⏷ Show the Full List of 32 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method LFQ
Competitor Name Abegg_cp(-)-10
Competitor Concentration 30 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)
Interaction Atlas ID  LDD0311  Download The Altas
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method LFQ
Competitor Name Abegg_cp(-)-10
Competitor Concentration 30 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)
Interaction Atlas ID  LDD0312  Download The Altas

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255