Details of the Target

General Information of Target

Target ID LDTP10529
Target Name Leucine-rich repeat protein 1 (LRR1)
Gene Name LRR1
Gene ID 122769
Synonyms
PPIL5; Leucine-rich repeat protein 1; 4-1BB-mediated-signaling molecule; 4-1BBlrr; LRR-repeat protein 1; LRR-1; Peptidylprolyl isomerase-like 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEP
PPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFS
LDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQA
AGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKE
WLQLTMYS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.
Uniprot ID
Q96L50
Ensemble ID
ENST00000298288.11
HGNC ID
HGNC:19742

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.R27G .
DANG SNV: p.R335S .
HCT116 SNV: p.H381R DBIA    Probe Info 
MOLT4 SNV: p.Q270Ter .
PF382 SNV: p.L199P .
U937 SNV: p.S178R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C357(1.05)  LDD2110  [1]
DBIA
 Probe Info  		C114(0.94)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
SF
 Probe Info  		N.A.  LDD0028  [6]
TFBX
 Probe Info  		C246(0.00); C33(0.00)  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0561  Abegg_cp(-)-10 HeLa C246(2.04)  LDD0312  [5]
 LDCM0214  AC1 HCT 116 C114(0.94)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C114(0.93); C266(1.06); C91(0.92); C33(0.94)  LDD1508  [9]
 LDCM0216  AC100 HCT 116 C114(1.60); C266(0.81)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C114(1.54); C266(0.89)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C114(1.31); C266(0.79)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C114(1.56); C266(1.05)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C114(1.33); C266(1.07)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C114(1.51); C266(1.15)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C114(1.61); C266(0.99)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C114(1.45); C266(1.16)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C114(1.92); C266(0.93)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C114(1.40); C266(0.92)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C114(0.94); C266(1.07); C91(0.86); C33(1.02)  LDD1509  [9]
 LDCM0227  AC110 HCT 116 C114(1.45); C266(0.88)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C114(1.54); C266(0.97)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C114(1.77); C266(0.93)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C114(0.87)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C114(0.84)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C114(0.89)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C114(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C114(0.89)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C114(0.89)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C114(1.02)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C114(1.10); C91(1.03); C33(1.11)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C114(0.89)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C114(0.76)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C114(0.84)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C114(0.76)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C114(0.78)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C114(0.88)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C114(0.80)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C114(0.76)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C114(0.92); C246(1.18)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C114(1.07); C246(1.05)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C114(1.21); C246(0.98)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C114(1.19); C246(1.07)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C114(1.23); C246(1.15)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C114(1.12); C246(1.03)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C114(1.53); C246(1.11)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C114(1.20); C246(0.99)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C114(1.38); C246(1.14)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C114(1.29); C246(1.13)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C114(1.56); C246(1.06)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C114(1.41); C246(1.09)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C114(1.05); C91(0.83)  LDD1512  [9]
 LDCM0260  AC140 HCT 116 C114(1.59); C246(1.17)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C114(1.94); C246(1.15)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C114(1.45); C246(1.11)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C246(0.83); C266(1.10)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C266(0.85); C246(0.92)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C266(0.90); C246(1.08)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C246(0.98); C266(1.14)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C246(0.83); C266(0.94)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C246(0.97); C266(1.30)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C246(0.88); C266(1.02)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C114(1.09); C33(1.00)  LDD1513  [9]
 LDCM0271  AC150 HCT 116 C246(0.97); C266(1.03)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C246(1.05); C266(1.22)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C246(1.00); C266(1.04)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C266(0.96); C246(0.96)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C246(1.04); C266(0.98)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C246(0.91); C266(0.99)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C246(0.94); C266(0.83)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C246(1.07); C266(0.98)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C114(1.03); C91(0.81); C33(0.99)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C114(1.07); C266(1.09); C91(0.93); C33(0.88)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C114(1.01); C266(0.88); C91(0.71); C33(0.96)  LDD1517  [9]
 LDCM0279  AC2 HCT 116 C114(0.97)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C114(0.99); C91(0.90); C33(1.18)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C114(1.01); C266(0.96); C91(0.96)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C114(1.00); C91(0.92)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C114(1.03); C33(0.96)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C114(1.05); C266(0.99); C91(1.02)  LDD1523  [9]
 LDCM0285  AC25 HCT 116 C246(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C246(1.12)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C246(1.24)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C246(0.89)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C246(0.89)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C114(0.94)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C246(0.78)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C246(1.28)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C246(1.34)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C246(0.95)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C246(0.89)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C114(0.88); C246(1.29)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C114(1.07); C246(1.09)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C246(0.97); C114(1.01)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C114(1.12); C246(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C114(0.97); C246(1.65)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C114(0.86)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C246(1.10); C114(1.15)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C246(1.01); C114(1.12)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C114(1.13); C246(1.33)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C246(1.05); C114(1.12)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C246(0.96); C114(0.96)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C246(0.91); C114(1.01)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C114(1.12); C91(0.84)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C114(1.00); C33(0.94)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C114(0.99); C266(1.09); C91(1.07)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C114(0.95); C91(0.83); C33(0.99)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C114(0.86)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C114(1.04); C266(0.96); C91(0.86); C33(1.02)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C114(0.90); C266(1.03); C91(0.87); C33(1.15)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C114(0.98); C91(0.82); C33(0.94)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C114(1.10); C266(0.95); C91(0.90)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C114(1.06); C91(0.83)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C114(1.05); C33(1.01)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C114(0.93); C266(1.06); C91(1.02)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C114(1.18); C91(0.87); C33(1.00)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C114(1.00); C266(1.07); C91(0.89); C33(0.89)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C114(0.75); C266(1.10); C91(0.87); C33(1.03)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C114(1.03); C91(0.99)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C114(1.09); C91(0.97); C33(1.02)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C114(1.06); C266(0.98); C91(0.87)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C114(1.05); C91(0.84)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C114(1.12); C33(1.04)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C114(0.98); C266(1.02); C91(1.07)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C114(1.07); C33(0.95)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C114(0.95); C266(1.02); C91(0.95)  LDD1569  [9]
 LDCM0349  AC83 HCT 116 C114(1.46)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C114(1.37)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C114(1.26)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C114(1.43)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C114(1.13)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C114(1.32)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C114(1.32)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C114(1.21)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C114(1.36)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C114(1.38)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C114(1.21)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C114(1.17)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C114(1.26)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C114(1.19)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C114(1.46)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C266(0.82); C114(1.61)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C266(0.91); C114(1.49)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C114(1.04); C266(1.07); C91(1.03)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C114(1.13); C91(0.81); C33(1.02)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C114(0.97); C266(1.04); C91(1.12)  LDD1514  [9]
 LDCM0367  CL1 HCT 116 C266(1.23)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C266(0.99)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C114(0.96)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C114(1.12); C266(1.07); C91(1.08)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C114(1.20); C91(0.79)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C114(1.02); C91(0.68)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C114(1.00); C266(1.04); C91(0.84); C33(0.96)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C114(1.15); C266(1.17); C91(1.05)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C114(1.02); C91(0.77)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C114(1.21); C91(0.66)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C114(1.03); C266(0.90); C91(0.82); C33(0.92)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C114(1.10); C266(1.07); C91(1.03)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C266(2.16)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C114(1.16); C91(0.87)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C114(1.40); C91(0.75)  LDD1585  [9]
 LDCM0382  CL112 HCT 116 C246(1.16)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C246(1.07)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C246(0.94)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C246(1.13)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C246(1.09)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C114(1.10); C246(1.22)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C246(1.00); C114(1.00)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C246(1.05); C114(1.08)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C266(1.06)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C246(1.07); C114(1.17)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C114(1.07); C266(1.02); C91(0.99)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C114(1.06); C91(0.78)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C114(0.95); C91(0.68)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C114(1.22); C266(0.97); C91(0.90); C33(0.83)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C114(1.05); C266(1.01); C91(1.13)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C114(0.91); C91(0.93)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C114(1.12); C91(0.70)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C114(1.15); C266(0.93); C91(0.86); C33(0.88)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C266(1.20)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C266(0.96)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C266(1.66)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C114(1.02); C266(1.04); C91(1.02); C33(0.96)  LDD1607  [9]
 LDCM0404  CL17 HCT 116 C114(1.09)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C114(0.98)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C114(1.07)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C266(1.15)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C114(1.19)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C114(1.24)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C114(1.03)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C114(1.27)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C114(0.98)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C114(0.98)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C114(1.00)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C114(1.02)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C114(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C114(1.10)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C266(0.84)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C114(1.00)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C114(0.94)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C114(1.13); C91(1.29); C33(0.92)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C114(1.29); C266(1.16); C91(1.33)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C114(1.16); C91(1.63)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C114(1.05); C33(1.16)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C114(1.03); C266(1.06); C91(0.65)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C114(1.08); C266(0.98); C91(1.04)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C114(1.07); C91(0.81)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C266(1.79)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C114(1.03); C266(1.06); C91(0.92); C33(1.02)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C114(1.17); C91(0.90); C33(1.14)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C114(1.12); C266(0.99); C91(1.08); C33(0.95)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C114(0.88); C266(0.91); C91(1.03); C33(1.06)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C114(1.06); C91(1.12); C33(1.14)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C114(1.07); C266(1.49); C91(1.64)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C266(1.33)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C266(1.41)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C266(1.18)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C266(1.30)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C266(1.34)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C266(1.68)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C266(1.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C266(1.40)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C266(1.79)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C266(1.36)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C266(1.23)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C266(1.28)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C266(1.87)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C266(1.15)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C266(1.23)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C266(1.22)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C266(1.46)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C114(0.99); C266(1.02); C91(0.99)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C114(1.31); C91(0.89)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C114(1.05); C91(0.85)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C114(1.10); C266(1.51); C91(0.85); C33(0.93)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C114(1.03); C91(0.93); C33(0.88)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C114(1.05); C266(1.04); C91(1.19); C33(1.02)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C114(0.87); C266(1.00); C91(0.86); C33(0.98)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C114(0.95); C91(1.43); C33(1.09)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C114(1.06); C266(0.86); C91(1.44)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C266(1.44)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C114(1.07); C91(1.57)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C114(1.15); C33(0.91)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C114(0.94); C266(1.10); C91(0.72)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C114(1.03); C266(1.34); C91(1.12)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C114(0.99); C91(0.78)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C114(1.13); C266(1.01); C91(0.90); C33(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C114(1.14); C91(0.78); C33(0.88)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C114(0.98); C266(0.98); C91(1.01); C33(1.12)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C114(1.05); C266(0.94); C91(0.90); C33(1.00)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C266(1.18)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C114(1.01); C91(1.49); C33(1.07)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C114(1.14); C266(1.16); C91(1.49)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C114(1.09); C91(1.42)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C114(1.07); C33(0.85)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C114(1.09); C266(1.09); C91(0.71)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C114(1.13); C266(1.02); C91(1.08)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C114(0.97); C91(0.78)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C114(0.97); C91(0.93)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C114(1.01); C266(0.90); C91(0.85); C33(0.79)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C114(1.01); C91(0.90); C33(0.88)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C266(1.44)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C114(1.56); C266(0.94); C91(0.96); C33(0.87)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C114(0.91)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C114(0.90)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C114(0.84)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C114(1.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C114(1.14)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C114(0.93)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C114(0.95)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C114(0.95)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C114(0.93)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C114(0.96); C91(0.74)  LDD1698  [9]
 LDCM0625  F8 Ramos C33(0.76); C114(1.36); C266(1.53)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C33(0.62)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C114(13.99)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C33(0.79); C114(1.11)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C33(1.01); C114(1.03); C266(1.26)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C33(0.30); C114(0.68); C266(0.86)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C33(0.88); C114(1.71)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C33(0.98); C114(1.03); C266(0.89)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C33(0.73); C114(1.12); C266(0.85)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C33(0.82); C114(1.13); C266(0.91)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C33(0.87); C114(0.76); C266(1.41)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C33(0.85); C114(0.95); C266(1.35)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C33(0.97); C114(0.96); C266(0.79)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C33(0.69); C114(1.92)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C114(1.09); C91(0.80)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C33(0.74); C114(0.72); C266(0.92)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C33(1.00); C114(1.08); C266(1.94)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C114(1.04); C91(0.78)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C114(0.92); C266(0.97)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C33(0.97); C114(0.98); C266(1.03)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C33(0.87); C114(1.46)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C33(0.67)  LDD2188  [10]
 LDCM0022  KB02 Ramos 8.19  LDD0431  [11]
 LDCM0023  KB03 HEK-293T C33(0.95); C91(0.98); C114(0.94)  LDD1497  [9]
 LDCM0024  KB05 NALM-6 C246(2.13)  LDD3339  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C357(1.05)  LDD2110  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) Phosphoglycerate mutase family Q16877
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840