Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
Competitor Name KB02  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) 20.0
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 20.0
 LDTP03985  Caspase-2 (CASP2) 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 20.0
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 20.0
 LDTP03496  Protein PML (PML) 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 20.0
 LDTP06211  Caspase-8 (CASP8) 19.3
 LDTP05409  Antigen peptide transporter 2 (TAP2) 19.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) 18.8
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) 18.8
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) 17.0
 LDTP01776  Superoxide dismutase [Cu-Zn] (SOD1) 15.1
 LDTP00042  Probable ribonuclease ZC3H12D (ZC3H12D) 12.6
 LDTP05480  Amidophosphoribosyltransferase (PPAT) 12.3
 LDTP03564  DNA-directed RNA polymerase II subunit RPB2 (POLR2B) 12.1
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) 9.5
 LDTP12552  Lymphoid-specific helicase (HELLS) 8.1
 LDTP00693  Ribosomal RNA-processing protein 8 (RRP8) 7.4
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) 7.2
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 6.6
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 6.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) 5.9
 LDTP08687  tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) 5.6
 LDTP11639  RNA exonuclease 4 (REXO4) 5.5
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 5.5
 LDTP15427  Ribonuclease P protein subunit p25-like protein (RPP25L) 4.8
 LDTP04555  Serine/threonine-protein kinase PLK1 (PLK1) 4.8
 LDTP03350  DNA (cytosine-5)-methyltransferase 1 (DNMT1) 4.7
 LDTP06441  Rho-related GTP-binding protein RhoH (RHOH) 4.6
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 4.5
 LDTP04555  Serine/threonine-protein kinase PLK1 (PLK1) 4.3
 LDTP14535  6-phosphogluconolactonase (PGLS) 4.2
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) 4.2
 LDTP01173  RNA/RNP complex-1-interacting phosphatase (DUSP11) 4.1
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) 4.0
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02048  Cellular tumor antigen p53 (TP53) 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 7.0
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 6.7
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) 5.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 5.0
 LDTP04801  Gasdermin-D (GSDMD) 5.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 4.4
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04515  Signal transducer and activator of transcription 2 (STAT2) 20.0
 LDTP05362  Interferon regulatory factor 8 (IRF8) 16.5
 LDTP06354  Interferon regulatory factor 4 (IRF4) 6.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 4.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02593  B-cell antigen receptor complex-associated protein alpha chain (CD79A) 13.1
Other
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10252  Elongator complex protein 4 (ELP4) 20.0
 LDTP13515  Zinc finger protein 346 (ZNF346) 20.0
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 17.1
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 17.0
 LDTP04092  Crk-like protein (CRKL) 15.4
 LDTP12412  Reticulon-4 (RTN4) 14.8
 LDTP06182  Ribosomal RNA processing protein 1 homolog B (RRP1B) 11.0
 LDTP11143  Centromere protein K (CENPK) 10.1
 LDTP14011  Nucleolar complex protein 2 homolog (NOC2L) 8.9
 LDTP10529  Leucine-rich repeat protein 1 (LRR1) 8.2
 LDTP01750  Peroxisomal membrane protein 11B (PEX11B) 7.2
 LDTP15861  Acyl-CoA-binding domain-containing protein 6 (ACBD6) 5.8
 LDTP12155  Pleckstrin homology domain-containing family A member 2 (PLEKHA2) 5.7
 LDTP13583  Targeting protein for Xklp2 (TPX2) 5.7
 LDTP10992  Myeloid differentiation primary response protein MyD88 (MYD88) 5.6
 LDTP05898  Sequestosome-1 (SQSTM1) 5.2
 LDTP00155  MIF4G domain-containing protein (MIF4GD) 5.1
 LDTP01373  SAM and SH3 domain-containing protein 3 (SASH3) 5.0
 LDTP08195  Retrotransposon-derived protein PEG10 (PEG10) 4.9
 LDTP09989  Pre-rRNA-processing protein TSR2 homolog (TSR2) 4.9
 LDTP07605  La-related protein 1 (LARP1) 4.9
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) 4.7
 LDTP08195  Retrotransposon-derived protein PEG10 (PEG10) 4.7
 LDTP00313  Nucleolar protein 56 (NOP56) 4.5
 LDTP13414  ADP-ribosylation factor-binding protein GGA2 (GGA2) 4.3
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) 4.3
 LDTP06282  Polycomb protein SUZ12 (SUZ12) 4.3
 LDTP11131  Ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2) 4.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 4.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 4.1
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) 4.0
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) 4.0

References

1 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.