Target ID	LDTP01776
Target Name	Superoxide dismutase [Cu-Zn] (SOD1)
Gene Name	SOD1
Gene ID	6647
Synonyms	Superoxide dismutase [Cu-Zn]; EC 1.15.1.1; Superoxide dismutase 1; hSod1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Target Type	Successful
Target Bioclass	Enzyme
Family	Cu-Zn superoxide dismutase family
Subcellular location	Cytoplasm
Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
TTD ID	T29024
Uniprot ID	P00441
DrugMap ID	TT6RVLG
Ensemble ID	ENST00000270142.11
HGNC ID	HGNC:11179
ChEMBL ID	CHEMBL2354

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
FBPP2  Probe Info			677.32	LDD0318	[1]
FBP2  Probe Info			5.36	LDD0323	[1]
AZ-9  Probe Info			E22(1.06); D12(1.15); E133(0.96); E134(1.05)	LDD2208	[2]
m-APA  Probe Info			15.00	LDD0403	[3]
BTD  Probe Info			C7(0.63)	LDD2089	[4]
DBIA  Probe Info			C147(1.12)	LDD0613	[5]
AMP probe  Probe Info			N.A.	LDD0200	[6]
ATP probe  Probe Info			K123(0.00); K4(0.00); K24(0.00); K31(0.00)	LDD0199	[6]
4-Iodoacetamidophenylacetylene  Probe Info			C112(0.00); C58(0.00); C147(0.00)	LDD0038	[7]
IA-alkyne  Probe Info			C112(0.00); C147(0.00)	LDD0032	[8]
IPIAA_H  Probe Info			N.A.	LDD0030	[9]
IPIAA_L  Probe Info			C58(0.00); C112(0.00)	LDD0031	[9]
Lodoacetamide azide  Probe Info			C112(0.00); C58(0.00); C147(0.00)	LDD0037	[7]
ATP probe  Probe Info			K10(0.00); K92(0.00); K137(0.00)	LDD0035	[10]
IPM  Probe Info			N.A.	LDD0025	[11]
NAIA_4  Probe Info			C7(0.00); C112(0.00)	LDD2226	[12]
Compound 10  Probe Info			C112(0.00); C58(0.00)	LDD2216	[13]
Compound 11  Probe Info			C112(0.00); C58(0.00)	LDD2213	[13]
Phosphinate-6  Probe Info			C112(0.00); C58(0.00); C147(0.00)	LDD0018	[14]
1c-yne  Probe Info			N.A.	LDD0228	[15]
Acrolein  Probe Info			C112(0.00); H111(0.00); C147(0.00)	LDD0217	[16]
Methacrolein  Probe Info			N.A.	LDD0218	[16]
AOyne  Probe Info			7.40	LDD0443	[17]
NAIA_5  Probe Info			C58(0.00); C112(0.00)	LDD2223	[12]

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C7(0.77); C147(0.48)	LDD2095	[4]
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C7(0.91)	LDD2130	[4]
LDCM0539	3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C7(0.41)	LDD2132	[4]
LDCM0538	4-(Cyanoacetyl)morpholine	MDA-MB-231	C7(1.07); C147(0.86)	LDD2131	[4]
LDCM0214	AC1	HEK-293T	C147(0.93); C112(1.39)	LDD1507	[18]
LDCM0215	AC10	HEK-293T	C147(0.91); C112(1.19)	LDD1508	[18]
LDCM0216	AC100	HEK-293T	C147(1.46)	LDD0814	[5]
LDCM0217	AC101	HEK-293T	C147(1.35)	LDD0815	[5]
LDCM0218	AC102	HEK-293T	C147(1.39)	LDD0816	[5]
LDCM0219	AC103	HEK-293T	C147(1.58)	LDD0817	[5]
LDCM0220	AC104	HEK-293T	C147(1.60)	LDD0818	[5]
LDCM0221	AC105	HEK-293T	C147(1.18)	LDD0819	[5]
LDCM0222	AC106	HEK-293T	C147(1.08)	LDD0820	[5]
LDCM0223	AC107	HEK-293T	C147(1.37)	LDD0821	[5]
LDCM0224	AC108	HEK-293T	C147(1.29)	LDD0822	[5]
LDCM0225	AC109	HEK-293T	C147(1.39)	LDD0823	[5]
LDCM0226	AC11	HEK-293T	C147(1.10); C112(1.58); C58(1.11)	LDD1509	[18]
LDCM0227	AC110	HEK-293T	C147(1.37)	LDD0825	[5]
LDCM0228	AC111	HEK-293T	C147(1.03)	LDD0826	[5]
LDCM0229	AC112	HEK-293T	C147(1.03)	LDD0827	[5]
LDCM0230	AC113	HEK-293T	C147(0.93)	LDD0828	[5]
LDCM0231	AC114	HEK-293T	C147(0.95)	LDD0829	[5]
LDCM0232	AC115	HEK-293T	C147(1.05)	LDD0830	[5]
LDCM0233	AC116	HEK-293T	C147(0.78)	LDD0831	[5]
LDCM0234	AC117	HEK-293T	C147(1.07)	LDD0832	[5]
LDCM0235	AC118	HEK-293T	C147(1.30)	LDD0833	[5]
LDCM0236	AC119	HEK-293T	C147(1.09)	LDD0834	[5]
LDCM0237	AC12	HEK-293T	C147(1.04); C112(1.46)	LDD1510	[18]
LDCM0238	AC120	HEK-293T	C147(1.23)	LDD0836	[5]
LDCM0239	AC121	HEK-293T	C147(1.31)	LDD0837	[5]
LDCM0240	AC122	HEK-293T	C147(1.35)	LDD0838	[5]
LDCM0241	AC123	HEK-293T	C147(1.17)	LDD0839	[5]
LDCM0242	AC124	HEK-293T	C147(1.52)	LDD0840	[5]
LDCM0243	AC125	HEK-293T	C147(1.34)	LDD0841	[5]
LDCM0244	AC126	HEK-293T	C147(1.51)	LDD0842	[5]
LDCM0245	AC127	HEK-293T	C147(1.34)	LDD0843	[5]
LDCM0246	AC128	HEK-293T	C147(1.21)	LDD0844	[5]
LDCM0247	AC129	HEK-293T	C147(1.57)	LDD0845	[5]
LDCM0249	AC130	HEK-293T	C147(5.06)	LDD0847	[5]
LDCM0250	AC131	HEK-293T	C147(1.06)	LDD0848	[5]
LDCM0251	AC132	HEK-293T	C147(1.55)	LDD0849	[5]
LDCM0252	AC133	HEK-293T	C147(1.77)	LDD0850	[5]
LDCM0253	AC134	HEK-293T	C147(1.15)	LDD0851	[5]
LDCM0254	AC135	HEK-293T	C147(1.16)	LDD0852	[5]
LDCM0255	AC136	HEK-293T	C147(3.39)	LDD0853	[5]
LDCM0256	AC137	HEK-293T	C147(1.17)	LDD0854	[5]
LDCM0257	AC138	HEK-293T	C147(1.25)	LDD0855	[5]
LDCM0258	AC139	HEK-293T	C147(1.42)	LDD0856	[5]
LDCM0259	AC14	HEK-293T	C147(0.87); C112(1.18)	LDD1512	[18]
LDCM0260	AC140	HEK-293T	C147(1.19)	LDD0858	[5]
LDCM0261	AC141	HEK-293T	C147(1.25)	LDD0859	[5]
LDCM0262	AC142	HEK-293T	C147(1.08)	LDD0860	[5]
LDCM0263	AC143	HEK-293T	C147(1.26)	LDD0861	[5]
LDCM0264	AC144	HEK-293T	C147(1.93)	LDD0862	[5]
LDCM0265	AC145	HEK-293T	C147(2.38)	LDD0863	[5]
LDCM0266	AC146	HEK-293T	C147(1.01)	LDD0864	[5]
LDCM0267	AC147	HEK-293T	C147(0.61)	LDD0865	[5]
LDCM0268	AC148	HEK-293T	C147(1.39)	LDD0866	[5]
LDCM0269	AC149	HEK-293T	C147(1.28)	LDD0867	[5]
LDCM0270	AC15	HEK-293T	C147(1.00); C112(1.64)	LDD1513	[18]
LDCM0271	AC150	HEK-293T	C147(1.58)	LDD0869	[5]
LDCM0272	AC151	HEK-293T	C147(1.79)	LDD0870	[5]
LDCM0273	AC152	HEK-293T	C147(1.37)	LDD0871	[5]
LDCM0274	AC153	HEK-293T	C147(1.43)	LDD0872	[5]
LDCM0621	AC154	HEK-293T	C147(1.17)	LDD2162	[5]
LDCM0622	AC155	HEK-293T	C147(1.50)	LDD2163	[5]
LDCM0623	AC156	HEK-293T	C147(1.46)	LDD2164	[5]
LDCM0624	AC157	HEK-293T	C147(1.33)	LDD2165	[5]
LDCM0276	AC17	HEK-293T	C147(1.09); C112(1.54)	LDD1515	[18]
LDCM0277	AC18	HEK-293T	C147(1.18); C112(1.38)	LDD1516	[18]
LDCM0278	AC19	HEK-293T	C147(1.72); C112(1.90); C58(1.01)	LDD1517	[18]
LDCM0279	AC2	HEK-293T	C147(1.05); C112(1.37)	LDD1518	[18]
LDCM0280	AC20	HEK-293T	C147(1.22); C112(1.66)	LDD1519	[18]
LDCM0281	AC21	HEK-293T	C147(1.31); C112(1.52)	LDD1520	[18]
LDCM0282	AC22	HEK-293T	C147(1.07); C112(1.29)	LDD1521	[18]
LDCM0283	AC23	HEK-293T	C147(1.13); C112(2.06)	LDD1522	[18]
LDCM0284	AC24	HEK-293T	C147(1.00); C112(1.40)	LDD1523	[18]
LDCM0285	AC25	HEK-293T	C147(1.12); C112(1.51)	LDD1524	[18]
LDCM0286	AC26	HEK-293T	C147(1.14); C112(1.18)	LDD1525	[18]
LDCM0287	AC27	HEK-293T	C147(1.14); C112(1.79); C58(1.04)	LDD1526	[18]
LDCM0288	AC28	HEK-293T	C147(1.10); C112(1.42)	LDD1527	[18]
LDCM0289	AC29	HEK-293T	C147(1.20); C112(1.22)	LDD1528	[18]
LDCM0290	AC3	HEK-293T	C147(0.94); C112(1.42); C58(1.11)	LDD1529	[18]
LDCM0291	AC30	HEK-293T	C147(0.95); C112(1.05)	LDD1530	[18]
LDCM0292	AC31	HEK-293T	C147(1.22); C112(1.69)	LDD1531	[18]
LDCM0293	AC32	HEK-293T	C147(0.97); C112(1.59)	LDD1532	[18]
LDCM0294	AC33	HEK-293T	C147(1.22); C112(1.58)	LDD1533	[18]
LDCM0295	AC34	HEK-293T	C147(1.07); C112(1.52)	LDD1534	[18]
LDCM0296	AC35	HCT 116	C147(1.12)	LDD0613	[5]
LDCM0297	AC36	HCT 116	C147(1.34)	LDD0614	[5]
LDCM0298	AC37	HCT 116	C147(1.20)	LDD0615	[5]
LDCM0299	AC38	HCT 116	C147(1.33)	LDD0616	[5]
LDCM0300	AC39	HCT 116	C147(1.23)	LDD0617	[5]
LDCM0301	AC4	HEK-293T	C147(0.90); C112(1.24)	LDD1540	[18]
LDCM0302	AC40	HCT 116	C147(1.16)	LDD0619	[5]
LDCM0303	AC41	HCT 116	C147(1.28)	LDD0620	[5]
LDCM0304	AC42	HCT 116	C147(1.25)	LDD0621	[5]
LDCM0305	AC43	HCT 116	C147(1.53)	LDD0622	[5]
LDCM0306	AC44	HCT 116	C147(1.24)	LDD0623	[5]
LDCM0307	AC45	HCT 116	C147(1.25)	LDD0624	[5]
LDCM0308	AC46	HEK-293T	C147(0.96); C112(1.19)	LDD1547	[18]
LDCM0309	AC47	HEK-293T	C147(1.09); C112(1.95)	LDD1548	[18]
LDCM0310	AC48	HEK-293T	C147(0.98); C112(1.59)	LDD1549	[18]
LDCM0311	AC49	HEK-293T	C147(1.11); C112(1.42)	LDD1550	[18]
LDCM0312	AC5	HEK-293T	C147(0.98); C112(1.26)	LDD1551	[18]
LDCM0313	AC50	HEK-293T	C147(1.07); C112(1.40)	LDD1552	[18]
LDCM0314	AC51	HEK-293T	C147(0.98); C112(2.17); C58(0.97)	LDD1553	[18]
LDCM0315	AC52	HEK-293T	C147(1.15); C112(1.39)	LDD1554	[18]
LDCM0316	AC53	HEK-293T	C147(1.09); C112(1.70)	LDD1555	[18]
LDCM0317	AC54	HEK-293T	C147(1.02); C112(1.25)	LDD1556	[18]
LDCM0318	AC55	HEK-293T	C147(0.93); C112(1.86)	LDD1557	[18]
LDCM0319	AC56	HEK-293T	C147(0.94); C112(1.46)	LDD1558	[18]
LDCM0320	AC57	HEK-293T	C147(1.25)	LDD0918	[5]
LDCM0321	AC58	HEK-293T	C147(0.93)	LDD0919	[5]
LDCM0322	AC59	HEK-293T	C147(1.29)	LDD0920	[5]
LDCM0323	AC6	HEK-293T	C147(0.87); C112(1.14)	LDD1562	[18]
LDCM0324	AC60	HEK-293T	C147(1.17)	LDD0922	[5]
LDCM0325	AC61	HEK-293T	C147(1.01)	LDD0923	[5]
LDCM0326	AC62	HEK-293T	C147(1.00)	LDD0924	[5]
LDCM0327	AC63	HEK-293T	C147(1.24)	LDD0925	[5]
LDCM0328	AC64	HEK-293T	C147(1.07)	LDD0926	[5]
LDCM0329	AC65	HEK-293T	C147(1.13)	LDD0927	[5]
LDCM0330	AC66	HEK-293T	C147(1.49)	LDD0928	[5]
LDCM0331	AC67	HEK-293T	C147(1.08)	LDD0929	[5]
LDCM0334	AC7	HEK-293T	C147(0.92); C112(1.49)	LDD1568	[18]
LDCM0345	AC8	HEK-293T	C147(0.95); C112(1.34)	LDD1569	[18]
LDCM0349	AC83	HCT 116	C147(1.00)	LDD0666	[5]
LDCM0350	AC84	HCT 116	C147(1.10)	LDD0667	[5]
LDCM0351	AC85	HCT 116	C147(0.85)	LDD0668	[5]
LDCM0352	AC86	HCT 116	C147(0.99)	LDD0669	[5]
LDCM0353	AC87	HCT 116	C147(0.99)	LDD0670	[5]
LDCM0354	AC88	HCT 116	C147(0.89)	LDD0671	[5]
LDCM0355	AC89	HCT 116	C147(0.92)	LDD0672	[5]
LDCM0357	AC90	HCT 116	C147(0.99)	LDD0674	[5]
LDCM0358	AC91	HCT 116	C147(0.87)	LDD0675	[5]
LDCM0359	AC92	HCT 116	C147(0.95)	LDD0676	[5]
LDCM0360	AC93	HCT 116	C147(0.89)	LDD0677	[5]
LDCM0361	AC94	HCT 116	C147(0.85)	LDD0678	[5]
LDCM0362	AC95	HCT 116	C147(0.90)	LDD0679	[5]
LDCM0363	AC96	HCT 116	C147(0.78)	LDD0680	[5]
LDCM0364	AC97	HCT 116	C147(0.76)	LDD0681	[5]
LDCM0365	AC98	HEK-293T	C147(1.35)	LDD0963	[5]
LDCM0366	AC99	HEK-293T	C147(1.75)	LDD0964	[5]
LDCM0545	Acetamide	MDA-MB-231	C7(0.39)	LDD2138	[4]
LDCM0248	AKOS034007472	HEK-293T	C147(1.02); C112(1.41)	LDD1511	[18]
LDCM0356	AKOS034007680	HEK-293T	C147(0.97); C112(1.53)	LDD1570	[18]
LDCM0275	AKOS034007705	HEK-293T	C147(0.85); C112(1.37)	LDD1514	[18]
LDCM0156	Aniline	NCI-H1299	15.00	LDD0403	[3]
LDCM0498	BS-3668	MDA-MB-231	C7(0.68); C147(0.87)	LDD2091	[4]
LDCM0108	Chloroacetamide	HeLa	C112(0.00); C58(0.00); C7(0.00); C147(0.00)	LDD0222	[16]
LDCM0632	CL-Sc	Hep-G2	C112(1.19)	LDD2227	[12]
LDCM0367	CL1	HCT 116	C147(1.17)	LDD0684	[5]
LDCM0368	CL10	HCT 116	C147(1.14)	LDD0685	[5]
LDCM0369	CL100	HEK-293T	C147(0.92); C112(1.41); C58(0.99)	LDD1573	[18]
LDCM0370	CL101	HEK-293T	C147(0.79); C112(1.36); C58(0.96)	LDD1574	[18]
LDCM0371	CL102	HEK-293T	C147(0.90); C112(1.20)	LDD1575	[18]
LDCM0372	CL103	HEK-293T	C147(0.97); C112(1.66)	LDD1576	[18]
LDCM0373	CL104	HEK-293T	C147(0.74); C112(1.31); C58(1.00)	LDD1577	[18]
LDCM0374	CL105	HEK-293T	C147(0.94); C112(1.38); C58(1.06)	LDD1578	[18]
LDCM0375	CL106	HEK-293T	C147(0.89); C112(1.64)	LDD1579	[18]
LDCM0376	CL107	HEK-293T	C147(1.00); C112(1.58)	LDD1580	[18]
LDCM0377	CL108	HEK-293T	C147(0.87); C112(1.73); C58(0.89)	LDD1581	[18]
LDCM0378	CL109	HEK-293T	C147(1.06); C112(1.32); C58(0.94)	LDD1582	[18]
LDCM0379	CL11	HCT 116	C147(0.84)	LDD0696	[5]
LDCM0380	CL110	HEK-293T	C147(1.01); C112(1.45)	LDD1584	[18]
LDCM0381	CL111	HEK-293T	C147(0.97); C112(1.40)	LDD1585	[18]
LDCM0382	CL112	HEK-293T	C147(0.93); C112(1.87); C58(0.94)	LDD1586	[18]
LDCM0383	CL113	HEK-293T	C147(1.13); C112(1.52); C58(1.14)	LDD1587	[18]
LDCM0384	CL114	HEK-293T	C147(1.01); C112(1.46)	LDD1588	[18]
LDCM0385	CL115	HEK-293T	C147(1.08); C112(1.57)	LDD1589	[18]
LDCM0386	CL116	HEK-293T	C147(0.81); C112(2.21); C58(1.07)	LDD1590	[18]
LDCM0387	CL117	HCT 116	C147(1.53)	LDD0704	[5]
LDCM0388	CL118	HCT 116	C147(1.74)	LDD0705	[5]
LDCM0389	CL119	HCT 116	C147(1.81)	LDD0706	[5]
LDCM0390	CL12	HCT 116	C147(1.12)	LDD0707	[5]
LDCM0391	CL120	HCT 116	C147(1.64)	LDD0708	[5]
LDCM0392	CL121	HEK-293T	C147(1.02); C112(1.52); C58(1.06)	LDD1596	[18]
LDCM0393	CL122	HEK-293T	C147(1.07); C112(1.81)	LDD1597	[18]
LDCM0394	CL123	HEK-293T	C147(0.96); C112(1.52)	LDD1598	[18]
LDCM0395	CL124	HEK-293T	C147(0.83); C112(1.75); C58(0.90)	LDD1599	[18]
LDCM0396	CL125	HEK-293T	C147(1.04)	LDD0994	[5]
LDCM0397	CL126	HEK-293T	C147(1.62)	LDD0995	[5]
LDCM0398	CL127	HEK-293T	C147(1.01)	LDD0996	[5]
LDCM0399	CL128	HEK-293T	C147(1.43)	LDD0997	[5]
LDCM0400	CL13	HCT 116	C147(1.27)	LDD0717	[5]
LDCM0401	CL14	HCT 116	C147(1.13)	LDD0718	[5]
LDCM0402	CL15	HCT 116	C147(1.11)	LDD0719	[5]
LDCM0403	CL16	HEK-293T	C147(0.97); C112(1.95); C58(1.05)	LDD1607	[18]
LDCM0404	CL17	HEK-293T	C147(0.95); C112(1.47)	LDD1608	[18]
LDCM0405	CL18	HEK-293T	C147(1.03); C112(1.40)	LDD1609	[18]
LDCM0406	CL19	HEK-293T	C147(1.17); C112(1.97); C58(1.21)	LDD1610	[18]
LDCM0407	CL2	HCT 116	C147(1.01)	LDD0724	[5]
LDCM0408	CL20	HEK-293T	C147(1.04); C112(1.57)	LDD1612	[18]
LDCM0409	CL21	HEK-293T	C147(1.00); C112(1.82)	LDD1613	[18]
LDCM0410	CL22	HEK-293T	C147(0.97); C112(1.42)	LDD1614	[18]
LDCM0411	CL23	HEK-293T	C147(1.02); C112(2.07)	LDD1615	[18]
LDCM0412	CL24	HEK-293T	C147(0.90); C112(1.48)	LDD1616	[18]
LDCM0413	CL25	HEK-293T	C147(0.98); C112(1.43); C58(0.96)	LDD1617	[18]
LDCM0414	CL26	HEK-293T	C147(1.11); C112(2.40)	LDD1618	[18]
LDCM0415	CL27	HEK-293T	C147(0.97); C112(1.71)	LDD1619	[18]
LDCM0416	CL28	HEK-293T	C147(0.85); C112(1.84); C58(1.04)	LDD1620	[18]
LDCM0417	CL29	HEK-293T	C147(1.02); C112(1.62)	LDD1621	[18]
LDCM0418	CL3	HCT 116	C147(1.02)	LDD0735	[5]
LDCM0419	CL30	HEK-293T	C147(1.07); C112(1.39)	LDD1623	[18]
LDCM0420	CL31	HEK-293T	C147(1.07); C112(1.79); C58(0.90)	LDD1624	[18]
LDCM0421	CL32	HEK-293T	C147(1.21); C112(1.56)	LDD1625	[18]
LDCM0422	CL33	HEK-293T	C147(0.85); C112(1.40)	LDD1626	[18]
LDCM0423	CL34	HEK-293T	C147(0.90); C112(1.47)	LDD1627	[18]
LDCM0424	CL35	HEK-293T	C147(1.04); C112(2.31)	LDD1628	[18]
LDCM0425	CL36	HEK-293T	C147(0.97); C112(1.82)	LDD1629	[18]
LDCM0426	CL37	HEK-293T	C147(1.10); C112(1.48); C58(1.10)	LDD1630	[18]
LDCM0428	CL39	HEK-293T	C147(1.06); C112(2.00)	LDD1632	[18]
LDCM0429	CL4	HCT 116	C147(1.42)	LDD0746	[5]
LDCM0430	CL40	HEK-293T	C147(0.98); C112(2.69); C58(0.94)	LDD1634	[18]
LDCM0431	CL41	HEK-293T	C147(1.18); C112(1.69)	LDD1635	[18]
LDCM0432	CL42	HEK-293T	C147(1.34); C112(1.20)	LDD1636	[18]
LDCM0433	CL43	HEK-293T	C147(1.18); C112(1.95); C58(0.96)	LDD1637	[18]
LDCM0434	CL44	HEK-293T	C147(1.21); C112(1.61)	LDD1638	[18]
LDCM0435	CL45	HEK-293T	C147(1.08); C112(1.49)	LDD1639	[18]
LDCM0436	CL46	HEK-293T	C147(1.05); C112(1.40)	LDD1640	[18]
LDCM0437	CL47	HEK-293T	C147(1.12); C112(2.29)	LDD1641	[18]
LDCM0438	CL48	HEK-293T	C147(1.02); C112(1.97)	LDD1642	[18]
LDCM0439	CL49	HEK-293T	C147(0.82); C112(1.32); C58(1.06)	LDD1643	[18]
LDCM0440	CL5	HCT 116	C147(0.93)	LDD0757	[5]
LDCM0441	CL50	HEK-293T	C147(1.01); C112(2.11)	LDD1645	[18]
LDCM0443	CL52	HEK-293T	C147(0.88); C112(1.67); C58(0.97)	LDD1646	[18]
LDCM0444	CL53	HEK-293T	C147(0.98); C112(1.51)	LDD1647	[18]
LDCM0445	CL54	HEK-293T	C147(0.88); C112(1.10)	LDD1648	[18]
LDCM0446	CL55	HEK-293T	C147(1.16); C112(1.81); C58(1.06)	LDD1649	[18]
LDCM0447	CL56	HEK-293T	C147(1.08); C112(1.58)	LDD1650	[18]
LDCM0448	CL57	HEK-293T	C147(1.14); C112(1.50)	LDD1651	[18]
LDCM0449	CL58	HEK-293T	C147(0.92); C112(1.30)	LDD1652	[18]
LDCM0450	CL59	HEK-293T	C147(0.97); C112(2.38)	LDD1653	[18]
LDCM0451	CL6	HCT 116	C147(1.17)	LDD0768	[5]
LDCM0452	CL60	HEK-293T	C147(1.16); C112(1.92)	LDD1655	[18]
LDCM0453	CL61	HCT 116	C147(1.01)	LDD0770	[5]
LDCM0454	CL62	HCT 116	C147(1.13)	LDD0771	[5]
LDCM0455	CL63	HCT 116	C147(1.16)	LDD0772	[5]
LDCM0456	CL64	HCT 116	C147(1.43)	LDD0773	[5]
LDCM0457	CL65	HCT 116	C147(1.08)	LDD0774	[5]
LDCM0458	CL66	HCT 116	C147(1.44)	LDD0775	[5]
LDCM0459	CL67	HCT 116	C147(1.66)	LDD0776	[5]
LDCM0460	CL68	HCT 116	C147(1.24)	LDD0777	[5]
LDCM0461	CL69	HCT 116	C147(1.13)	LDD0778	[5]
LDCM0462	CL7	HCT 116	C147(1.07)	LDD0779	[5]
LDCM0463	CL70	HCT 116	C147(1.11)	LDD0780	[5]
LDCM0464	CL71	HCT 116	C147(1.10)	LDD0781	[5]
LDCM0465	CL72	HCT 116	C147(0.97)	LDD0782	[5]
LDCM0466	CL73	HCT 116	C147(1.05)	LDD0783	[5]
LDCM0467	CL74	HCT 116	C147(1.00)	LDD0784	[5]
LDCM0469	CL76	HEK-293T	C147(0.75); C112(1.46); C58(0.85)	LDD1672	[18]
LDCM0470	CL77	HEK-293T	C147(1.16); C112(1.41)	LDD1673	[18]
LDCM0471	CL78	HEK-293T	C147(0.99); C112(1.14)	LDD1674	[18]
LDCM0472	CL79	HEK-293T	C147(1.02); C112(1.63); C58(0.96)	LDD1675	[18]
LDCM0473	CL8	HCT 116	C147(0.93)	LDD0790	[5]
LDCM0474	CL80	HEK-293T	C147(0.99); C112(1.35)	LDD1677	[18]
LDCM0475	CL81	HEK-293T	C147(1.01); C112(1.80)	LDD1678	[18]
LDCM0476	CL82	HEK-293T	C147(0.84); C112(1.20)	LDD1679	[18]
LDCM0477	CL83	HEK-293T	C147(1.17); C112(1.83)	LDD1680	[18]
LDCM0478	CL84	HEK-293T	C147(1.09); C112(1.41)	LDD1681	[18]
LDCM0479	CL85	HEK-293T	C147(1.15); C112(1.35); C58(0.95)	LDD1682	[18]
LDCM0480	CL86	HEK-293T	C147(1.03); C112(1.56)	LDD1683	[18]
LDCM0481	CL87	HEK-293T	C147(0.99); C112(1.33)	LDD1684	[18]
LDCM0482	CL88	HEK-293T	C147(0.88); C112(1.98); C58(0.96)	LDD1685	[18]
LDCM0483	CL89	HEK-293T	C147(1.21); C112(1.56)	LDD1686	[18]
LDCM0484	CL9	HCT 116	C147(1.63)	LDD0801	[5]
LDCM0485	CL90	HEK-293T	C147(0.81); C112(1.25)	LDD1688	[18]
LDCM0486	CL91	HEK-293T	C147(1.11); C112(1.50); C58(1.05)	LDD1689	[18]
LDCM0487	CL92	HEK-293T	C147(0.98); C112(1.69)	LDD1690	[18]
LDCM0488	CL93	HEK-293T	C147(0.93); C112(1.57)	LDD1691	[18]
LDCM0489	CL94	HEK-293T	C147(0.95); C112(1.38)	LDD1692	[18]
LDCM0490	CL95	HEK-293T	C147(0.98); C112(1.81)	LDD1693	[18]
LDCM0491	CL96	HEK-293T	C147(1.03); C112(1.37)	LDD1694	[18]
LDCM0492	CL97	HEK-293T	C147(0.84); C112(1.23); C58(0.99)	LDD1695	[18]
LDCM0493	CL98	HEK-293T	C147(0.84); C112(1.33)	LDD1696	[18]
LDCM0494	CL99	HEK-293T	C147(1.13); C112(1.34)	LDD1697	[18]
LDCM0495	E2913	HEK-293T	C147(0.91); C112(1.92)	LDD1698	[18]
LDCM0573	Fragment11	Ramos	C112(1.62)	LDD2190	[19]
LDCM0575	Fragment13	Ramos	C147(0.77)	LDD2192	[19]
LDCM0576	Fragment14	Ramos	C147(1.15); C112(0.72)	LDD2193	[19]
LDCM0580	Fragment21	Ramos	C147(1.53)	LDD2195	[19]
LDCM0578	Fragment27	Ramos	C147(0.97)	LDD2197	[19]
LDCM0586	Fragment28	Ramos	C147(1.51)	LDD2198	[19]
LDCM0588	Fragment30	Ramos	C147(1.02)	LDD2199	[19]
LDCM0468	Fragment33	HCT 116	C147(1.16)	LDD0785	[5]
LDCM0596	Fragment38	Ramos	C147(0.54)	LDD2203	[19]
LDCM0566	Fragment4	Ramos	C112(0.74)	LDD2184	[19]
LDCM0427	Fragment51	HEK-293T	C147(1.17); C112(2.20)	LDD1631	[18]
LDCM0610	Fragment52	Ramos	C147(0.74)	LDD2204	[19]
LDCM0614	Fragment56	Ramos	C147(0.79)	LDD2205	[19]
LDCM0569	Fragment7	Ramos	C112(0.42)	LDD2186	[19]
LDCM0107	IAA	HeLa	H111(0.00); C147(0.00)	LDD0221	[16]
LDCM0022	KB02	Ramos	15.05	LDD0431	[20]
LDCM0023	KB03	HEK-293T	C147(1.02); C112(1.06); C58(1.11)	LDD1497	[18]
LDCM0024	KB05	IGR37	C7(0.76)	LDD3314	[21]
LDCM0169	KB63	Ramos	4.84	LDD0432	[20]
LDCM0528	N-(4-bromophenyl)-2-cyano-N-phenylacetamide	MDA-MB-231	C147(1.10)	LDD2121	[4]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[16]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C7(0.63)	LDD2089	[4]
LDCM0131	RA190	MM1.R	C147(1.18); C112(1.07)	LDD0304	[22]

Protein name				Family	Uniprot ID
26S proteasome regulatory subunit 4 (PSMC1)				AAA ATPase family	P62191
26S proteasome regulatory subunit 6A (PSMC3)				AAA ATPase family	P17980
Lysine--tRNA ligase (KARS1)				Class-II aminoacyl-tRNA synthetase family	Q15046
Copper chaperone for superoxide dismutase (CCS)				Cu-Zn superoxide dismutase family	O14618
Superoxide dismutase [Cu-Zn] (SOD1)				Cu-Zn superoxide dismutase family	P00441
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				Glyceraldehyde-3-phosphate dehydrogenase family	P04406
Ribonuclease P protein subunit p25 (RPP25)				Histone-like Alba family	Q9BUL9
L-lactate dehydrogenase A-like 6B (LDHAL6B)				LDH family	Q9BYZ2
Ubiquitin thioesterase OTUB1 (OTUB1)				Peptidase C65 family	Q96FW1
MPN domain-containing protein (MPND)				Peptidase M67 family	Q8N594
Peroxiredoxin-5, mitochondrial (PRDX5)				Peroxiredoxin family	P30044
E3 ubiquitin-protein ligase RNF19A (RNF19A)				RBR family	Q9NV58
ADP-ribosylation factor-like protein 16 (ARL16)				Arf family	Q0P5N6
RING finger protein 112 (RNF112)				GB1/RHD3 GTPase family	Q9ULX5
E3 ubiquitin-protein ligase CBL-B (CBLB)				.	Q13191
Thioredoxin-related transmembrane protein 1 (TMX1)				.	Q9H3N1

Protein name				Family	Uniprot ID
Apoptosis regulator Bcl-2 (BCL2)				Bcl-2 family	P10415
Bcl-2 homologous antagonist/killer (BAK1)				Bcl-2 family	Q16611
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)				WD repeat G protein beta family	P62879
Integrin beta-1-binding protein 1 (ITGB1BP1)				.	O14713

Protein name				Family	Uniprot ID
Homeobox protein Hox-C4 (HOXC4)				Antp homeobox family	P09017
Transcription factor Sp6 (SP6)				Sp1 C2H2-type zinc-finger protein family	Q3SY56
Pre-B-cell leukemia transcription factor 4 (PBX4)				TALE/PBX homeobox family	Q9BYU1
Zinc finger protein ZXDC (ZXDC)				ZXD family	Q2QGD7

Protein name				Family	Uniprot ID
Annexin A8 (ANXA8)				Annexin family	P13928
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)				BACURD family	Q13829
Beta-crystallin A2 (CRYBA2)				Beta/gamma-crystallin family	P53672
Complement component C9 (C9)				Complement C6/C7/C8/C9 family	P02748
26S proteasome complex subunit SEM1 (SEM1)				DSS1/SEM1 family	P60896
Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)				Dynein light intermediate chain family	Q8TCX1
Elongation factor 1-delta (EEF1D)				EF-1-beta/EF-1-delta family	P29692
Splicing factor 3B subunit 3 (SF3B3)				RSE1 family	Q15393
U6 snRNA-associated Sm-like protein LSm8 (LSM8)				SnRNP Sm proteins family	O95777
Tubulin beta chain (TUBB)				Tubulin family	P07437
Polyubiquitin-B (UBB)				Ubiquitin family	P0CG47
Small ribosomal subunit protein uS2 (RPSA)				Universal ribosomal protein uS2 family	P08865
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)				WD repeat EBI family	Q9BZK7
Histone-binding protein RBBP4 (RBBP4)				WD repeat RBAP46/RBAP48/MSI1 family	Q09028
Disabled homolog 2 (DAB2)				.	P98082
Enkurin (ENKUR)				.	Q8TC29
G-protein-signaling modulator 3 (GPSM3)				.	Q9Y4H4
Ligand of Numb protein X 2 (LNX2)				.	Q8N448
PDZK1-interacting protein 1 (PDZK1IP1)				.	Q13113
Protein MGARP (MGARP)				.	Q8TDB4
RING1 and YY1-binding protein (RYBP)				.	Q8N488
SH3 and cysteine-rich domain-containing protein 3 (STAC3)				.	Q96MF2
Spermatogenesis-associated protein 22 (SPATA22)				.	Q8NHS9
Superkiller complex protein 8 (SKIC8)				.	Q9GZS3
Uncharacterized protein C6orf141 (C6orf141)				.	Q5SZD1
Zinc finger matrin-type protein 2 (ZMAT2)				.	Q96NC0

Drug Name				Drug Type	External ID
Cannabidiol				Small molecular drug	DB09061
Cisplatin				Small molecular drug	DB00515
Dopamine				Small molecular drug	DB00988
Isoprenaline				Small molecular drug	DB01064
Vitamin E				Small molecular drug	DB00163
Alpha-tocopherol Succinate				.	DB14001
Benzoyl Peroxide				.	DB09096
Copper				.	DB09130
D-alpha-tocopherol Acetate				.	DB14002
Zinc				.	DB01593
Zinc Acetate				.	DB14487
Zinc Chloride				.	DB14533
Zinc Sulfate Unspecified Form				.	DB14548

Drug Name				Drug Type	External ID
Biib067				Antisense oligonucleotide	D0I1CQ
Coprexa				Small molecular drug	D06WPM

Drug Name				Drug Type	External ID
Atn-224				Small molecular drug	D0T8MA
Methoxyestradiol				Small molecular drug	D0D9NZ
Tempol				Small molecular drug	D04GZS
Apn-201				.	D0HE9J
Midismase				.	D09IUR
Pc-sod				.	D0U6PJ
Superoxide Dismutase				.	D05RTV

Drug Name				Drug Type	External ID
Euk-189				Small molecular drug	D06VAQ

Drug Name				Drug Type	External ID
Aeol-10150				.	D0G1EH

Drug Name				Drug Type	External ID
Acetate Ion				Small molecular drug	D0F2ME
Arimoclomol				Small molecular drug	DB05025
Nabiximols				Small molecular drug	DB14011
5-fluorouridine				.	DB01629
Ec-sod				.	D02TFB
Medical Cannabis				.	DB14009
Polaprezinc				.	DB09221
S-oxy-l-cysteine				.	DB03382
Tdi-0060				.	D0BT4P
Tdi-0079				.	D05SCQ
Tdi-0107				.	D0W7DP
Vlts-582				.	D0LE6M

Drug Name				Drug Type	External ID
Euk-207				Small molecular drug	D0U1FZ
Pegorgotein				Small molecular drug	D0N4SU
M-40401				.	D0U0PV

1	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
2	2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
5	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
8	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
10	Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22. Mass spectrometry data entry: PXD006095 , PXD006096
11	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
12	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
13	Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20. Mass spectrometry data entry: PXD022279
14	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
15	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
19	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
20	2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
21	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
22	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.