Probe ID	LDPC0053
Probe Name	FBP2
Probe Type	ABPP Probe
Structure
	2D MOL
Ro5 Violations (Lipinski): 0	Molecular Weight (mw)		215.296
	Lipid-water partition coefficient (xlogp)		2.2934
	Rotatable Bond Count (rotbonds)		5
	Hydrogen Bond Donor Count (hbonddonor)		1
	Hydrogen Bond Acceptor Count (hbondacc)		2
Chemical Identifiers	Formula C14H17NO Canonical SMILES C#CCCCOc1ccc(C2CC2N)cc1 InChI InChI=1S/C14H17NO/c1-2-3-4-9-16-12-7-5-11(6-8-12)13-10-14(13)15/h1,5-8,13-14H,3-4,9-10,15H2/t13?,14-/m0/s1 InChIKey PVWDOGIKWILKGI-KZUDCZAMSA-N

51 Enzyme Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID Acid ceramidase (ASAH1) LDTP05905 2.63  LDD0317  Adenosylhomocysteinase (AHCY) LDTP03242 2.04  LDD0323  ADP-ribosylation factor-like protein 2 (ARL2) LDTP03805 2.79  LDD0323  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 2.01  LDD0317  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 2.76  LDD0320  Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 2.70  LDD0317  Amine oxidase [flavin-containing] A (MAOA) LDTP03109 3.56  LDD0317  Arsenite methyltransferase (AS3MT) LDTP12188 2.08  LDD0317  Atlastin-3 (ATL3) LDTP07362 2.62  LDD0317  Cathepsin B (CTSB) LDTP02223 2.14  LDD0323  Cathepsin D (CTSD) LDTP02198 2.44  LDD0053  CTD nuclear envelope phosphatase 1 (CTDNEP1) LDTP01616 3.14  LDD0317  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) LDTP04144 2.74  LDD0323  Cytochrome b5 type B (CYB5B) LDTP00697 19.34  LDD0317  Deoxyribonuclease-2-alpha (DNASE2) LDTP00185 5.63  LDD0323  Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) LDTP03669 2.03  LDD0323  Deubiquitinase OTUD6B (OTUD6B) LDTP08942 2.34  LDD0323  Endothelin-converting enzyme 1 (ECE1) LDTP04008 2.47  LDD0323  Eukaryotic elongation factor 2 kinase (EEF2K) LDTP00268 4.17  LDD0323  Ferroptosis suppressor protein 1 (AIFM2) LDTP11124 2.80  LDD0323  Glucosidase 2 subunit beta (PRKCSH) LDTP02718 2.60  LDD0323  Glutathione S-transferase omega-1 (GSTO1) LDTP05128 2.99  LDD0317  Heme oxygenase 2 (HMOX2) LDTP03540 42.55  LDD0317  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 3.92  LDD0317  Long-chain fatty acid transport protein 2 (SLC27A2) LDTP00496 2.20  LDD0323  Long-chain fatty acid transport protein 3 (SLC27A3) LDTP07028 2.23  LDD0317  Monoacylglycerol lipase ABHD6 (ABHD6) LDTP11261 9.06  LDD0317  Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 2.03  LDD0323  Patatin-like phospholipase domain-containing protein 4 (PNPLA4) LDTP03945 14.99  LDD0317  Peptidyl-prolyl cis-trans isomerase FKBP3 (FKBP3) LDTP05255 2.09  LDD0323  Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 2.11  LDD0323  Phosphatidylserine synthase 2 (PTDSS2) LDTP11284 3.15  LDD0317  Probable glutathione peroxidase 8 (GPX8) LDTP09495 2.20  LDD0323  Procathepsin L (CTSL) LDTP02217 6.87  LDD0317  Prostaglandin E synthase 2 (PTGES2) LDTP12040 26.00  LDD0317  Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) LDTP00253 2.33  LDD0323  Ras-related protein Rab-31 (RAB31) LDTP05957 2.05  LDD0323  Retinaldehyde dehydrogenase 3 (ALDH1A3) LDTP04134 14.75  LDD0317  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 2.62  LDD0317  Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 2.40  LDD0323  Signal peptidase complex subunit 2 (SPCS2) LDTP06270 2.17  LDD0317  Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 3.95  LDD0317  Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 5.55  LDD0317  Sulfhydryl oxidase 2 (QSOX2) LDTP07813 2.31  LDD0323  Superoxide dismutase [Cu-Zn] (SOD1) LDTP01776 5.36  LDD0323  Telomerase RNA component interacting RNase (TRIR) LDTP11055 5.77  LDD0323  Ubiquitin thioesterase otulin (OTULIN) LDTP10133 2.07  LDD0323  Ubiquitin-conjugating enzyme E2 T (UBE2T) LDTP12348 3.78  LDD0323  Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) LDTP05853 2.34  LDD0323  Ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) LDTP06482 2.72  LDD0323  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 2.14  LDD0317  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 51 Enzyme
34 Transporter and channel Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID Annexin A5 (ANXA5) LDTP02307 3.82  LDD0323  ATP synthase subunit d, mitochondrial (ATP5PD) LDTP14509 2.56  LDD0317  ATP synthase subunit O, mitochondrial (ATP5PO) LDTP04150 2.03  LDD0323  Bax inhibitor 1 (TMBIM6) LDTP04663 2.90  LDD0320  Bone marrow stromal antigen 2 (BST2) LDTP05631 37.85  LDD0323  Calnexin (CANX) LDTP03405 2.14  LDD0323  Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 2.37  LDD0323  Clathrin light chain A (CLTA) LDTP02352 2.35  LDD0323  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) LDTP05510 3.36  LDD0323  Cytochrome c (CYCS) LDTP05231 3.00  LDD0323  Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 2.74  LDD0317  Gasdermin-E (GSDME) LDTP00970 2.56  LDD0317  Integrin beta-1 (ITGB1) LDTP02122 2.51  LDD0317  Lysosome membrane protein 2 (SCARB2) LDTP06034 4.43  LDD0317  Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 4.04  LDD0317  Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 2.01  LDD0323  Methylosome subunit pICln (CLNS1A) LDTP04597 3.71  LDD0323  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.24  LDD0317  Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 2.22  LDD0317  NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 4.19  LDD0323  Pannexin-1 (PANX1) LDTP10754 2.46  LDD0317  PRA1 family protein 2 (PRAF2) LDTP01060 3.45  LDD0317  Protein S100-A16 (S100A16) LDTP10313 2.45  LDD0323  Reticulon-1 (RTN1) LDTP06633 4.52  LDD0317  Scavenger receptor class B member 1 (SCARB1) LDTP09547 3.08  LDD0323  Secretory carrier-associated membrane protein 1 (SCAMP1) LDTP00546 2.06  LDD0317  Sorting nexin-1 (SNX1) LDTP05938 3.06  LDD0323  Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 2.20  LDD0317  Transmembrane emp24 domain-containing protein 1 (TMED1) LDTP05875 3.53  LDD0317  Transmembrane protein 126A (TMEM126A) LDTP15948 3.06  LDD0317  Transport and Golgi organization protein 1 homolog (MIA3) LDTP07002 2.38  LDD0323  Vesicle-associated membrane protein 3 (VAMP3) LDTP06490 4.37  LDD0317  Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 3.91  LDD0317  Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 2.17  LDD0317  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 34 Transporter and channel
4 Transcription factor Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID High mobility group protein B2 (HMGB2) LDTP03363 2.42  LDD0323  Leucine zipper transcription factor-like protein 1 (LZTFL1) LDTP12394 3.33  LDD0323  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) LDTP09996 2.14  LDD0323  Zinc finger CCCH domain-containing protein 4 (ZC3H4) LDTP13718 2.05  LDD0323  ------------------------------------------------------------------------------------
4 Immunoglobulin Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID Basigin (BSG) LDTP03772 5.11  LDD0323  CD166 antigen (ALCAM) LDTP05973 2.30  LDD0053  Cell surface glycoprotein MUC18 (MCAM) LDTP04020 2.10  LDD0323  Neural cell adhesion molecule 1 (NCAM1) LDTP02666 2.30  LDD0317  ------------------------------------------------------------------------------------
69 Other Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID 26S proteasome non-ATPase regulatory subunit 10 (PSMD10) LDTP01323 2.96  LDD0323  A-kinase anchor protein 8 (AKAP8) LDTP00880 2.37  LDD0323  A-kinase anchor protein 9 (AKAP9) LDTP11033 19.75  LDD0320  Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 3.09  LDD0323  Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) LDTP09843 2.08  LDD0323  Armadillo repeat-containing X-linked protein 2 (ARMCX2) LDTP17517 3.17  LDD0320  Barrier-to-autointegration factor (BANF1) LDTP01250 6.97  LDD0317  Bcl-2-associated transcription factor 1 (BCLAF1) LDTP12826 2.12  LDD0323  Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) LDTP09196 2.78  LDD0320  Cadherin-2 (CDH2) LDTP02977 2.59  LDD0317  Calmodulin-3 (CALM3) LDTP02443 12.28  LDD0317  CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 2.92  LDD0317  Charged multivesicular body protein 1b (CHMP1B) LDTP07984 6.41  LDD0323  Charged multivesicular body protein 7 (CHMP7) LDTP09589 2.53  LDD0323  Clusterin (CLU) LDTP02526 2.70  LDD0323  Coiled-coil domain-containing protein 6 (CCDC6) LDTP06515 2.07  LDD0323  DNA replication complex GINS protein PSF2 (GINS2) LDTP13802 3.36  LDD0323  DNA replication complex GINS protein PSF3 (GINS3) LDTP11139 2.94  LDD0323  Drebrin (DBN1) LDTP06588 2.13  LDD0323  Dynactin subunit 2 (DCTN2) LDTP05922 4.79  LDD0323  EKC/KEOPS complex subunit GON7 (GON7) LDTP11418 3.57  LDD0323  Emerin (EMD) LDTP04356 2.22  LDD0323  Endoplasmin (HSP90B1) LDTP02734 2.17  LDD0323  Eukaryotic translation initiation factor 4B (EIF4B) LDTP03247 3.46  LDD0323  Eukaryotic translation initiation factor 4H (EIF4H) LDTP06301 2.05  LDD0323  Glycine cleavage system H protein, mitochondrial (GCSH) LDTP03227 3.03  LDD0323  Golgi reassembly-stacking protein 2 (GORASP2) LDTP12073 2.43  LDD0323  GrpE protein homolog 1, mitochondrial (GRPEL1) LDTP12144 2.03  LDD0323  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) LDTP14747 3.70  LDD0317  Histone-binding protein RBBP4 (RBBP4) LDTP05590 2.07  LDD0323  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 5.73  LDD0317  LRP chaperone MESD (MESD) LDTP06191 3.49  LDD0323  Lupus La protein (SSB) LDTP02116 3.33  LDD0323  MICOS complex subunit MIC19 (CHCHD3) LDTP12764 2.67  LDD0323  Microtubule-associated protein RP/EB family member 1 (MAPRE1) LDTP06444 2.14  LDD0323  Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 3.13  LDD0323  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 2.56  LDD0317  Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) LDTP08874 3.26  LDD0323  Myosin regulatory light chain 12A (MYL12A) LDTP02982 2.79  LDD0323  Myristoylated alanine-rich C-kinase substrate (MARCKS) LDTP03503 2.45  LDD0317  Nuclear autoantigenic sperm protein (NASP) LDTP04241 2.59  LDD0323  Nucleolar and spindle-associated protein 1 (NUSAP1) LDTP11408 2.34  LDD0323  OCIA domain-containing protein 1 (OCIAD1) LDTP12755 3.81  LDD0317  ORM1-like protein 1 (ORMDL1) LDTP12978 3.62  LDD0320  Perilipin-3 (PLIN3) LDTP01021 2.15  LDD0317  Peroxiredoxin-like 2A (PRXL2A) LDTP11140 3.84  LDD0317  Polyglutamine-binding protein 1 (PQBP1) LDTP01057 8.81  LDD0323  Prohibitin-2 (PHB2) LDTP10924 3.45  LDD0317  Proteasome activator complex subunit 1 (PSME1) LDTP05484 2.63  LDD0323  Protein FAM234A (FAM234A) LDTP15958 2.83  LDD0323  Protein LSM14 homolog B (LSM14B) LDTP11350 3.46  LDD0323  Protein SET (SET) LDTP05277 3.54  LDD0323  Ran-specific GTPase-activating protein (RANBP1) LDTP04049 2.12  LDD0323  Replication termination factor 2 (RTF2) LDTP11434 3.35  LDD0323  Reticulon-3 (RTN3) LDTP01522 6.08  LDD0317  Reticulon-4 (RTN4) LDTP12412 5.99  LDD0317  RUS family member 1 (RUSF1) LDTP10357 10.87  LDD0317  SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) LDTP11804 4.25  LDD0323  Small ribosomal subunit protein mS23 (MRPS23) LDTP13985 3.54  LDD0053  Spliceosome-associated protein CWC15 homolog (CWC15) LDTP12951 3.18  LDD0323  Stathmin-2 (STMN2) LDTP09967 4.02  LDD0317  Syntaxin-12 (STX12) LDTP08389 2.18  LDD0317  Transforming acidic coiled-coil-containing protein 3 (TACC3) LDTP14228 2.86  LDD0323  Tropomyosin alpha-4 chain (TPM4) LDTP05068 2.03  LDD0323  Tumor protein D54 (TPD52L2) LDTP00759 4.22  LDD0317  Ubiquitin-like protein 4A (UBL4A) LDTP02570 3.06  LDD0323  Ubiquitin-like protein ISG15 (ISG15) LDTP02092 2.23  LDD0323  Vimentin (VIM) LDTP02297 2.09  LDD0323  Zinc finger CCCH domain-containing protein 11A (ZC3H11A) LDTP01143 2.19  LDD0323  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 69 Other

Competitor ID	Name	Concentration		Cell-system	Ref
LDCM0008	Tranylcypromine	1 mM		Human neuroblastoma cells (SH-SY5Y)	[1]

1	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580