Details of the Target

General Information of Target

Target ID LDTP00496
Target Name Long-chain fatty acid transport protein 2 (SLC27A2)
Gene Name SLC27A2
Gene ID 11001
Synonyms
ACSVL1; FACVL1; FATP2; VLACS; Long-chain fatty acid transport protein 2; Arachidonate--CoA ligase; EC 6.2.1.15; Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; EC 6.2.1.3; Phytanate--CoA ligase; EC 6.2.1.24; Solute carrier family 27 member 2; THCA-CoA ligase; EC 6.2.1.7; Very long-chain acyl-CoA synthetase; VLACS; VLCS; EC 6.2.1.-; Very long-chain-fatty-acid-CoA ligase
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFL
EKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWL
WLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIY
YVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQ
RIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDD
CRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYE
FYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKG
EVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDR
VGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGK
KLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAK
MYVPMTEDIYNAISAKTLKL
Target Bioclass
Enzyme
Family
ATP-dependent AMP-binding enzyme family
Subcellular location
Endoplasmic reticulum membrane
Function
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake . Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake . Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. May contribute to the synthesis of sphingosine-1-phosphate. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo.; [Isoform 1]: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol.; [Isoform 2]: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
Uniprot ID
O14975
Ensemble ID
ENST00000267842.10
HGNC ID
HGNC:10996
ChEMBL ID
CHEMBL4326

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.F461L .
NCIH2172 SNV: p.Y311C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.20  LDD0323  [1]
DBIA
 Probe Info  		C301(1.03); C414(1.04)  LDD0531  [2]
IA-alkyne
 Probe Info  		C320(0.00); C427(0.00); C414(0.00); C301(0.00)  LDD0162  [3]
BTD
 Probe Info  		N.A.  LDD0004  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		C320(0.00); C427(0.00)  LDD0148  [5]
YN-1
 Probe Info  		N.A.  LDD0447  [6]
Acrolein
 Probe Info  		C427(0.00); C414(0.00)  LDD0217  [7]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		7.84  LDD1733  [8]
C094
 Probe Info  		28.44  LDD1785  [8]
C197
 Probe Info  		5.03  LDD1873  [8]
FFF probe11
 Probe Info  		15.52  LDD0472  [9]
FFF probe3
 Probe Info  		11.92  LDD0465  [9]
STS-1
 Probe Info  		N.A.  LDD0136  [10]
STS-2
 Probe Info  		N.A.  LDD0138  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
DA-2
 Probe Info  		N.A.  LDD0072  [12]
OEA-DA
 Probe Info  		4.80  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C301(1.03); C414(1.04)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C301(0.67); C320(0.70); C414(0.48)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C301(0.51)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C301(0.52)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C301(0.39)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C301(0.15)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C301(0.19)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C301(0.19)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C301(0.20)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C301(0.17)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C301(0.61)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C301(0.72)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C301(0.58); C320(0.61); C414(0.43)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C301(0.55)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C301(0.51)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C301(0.24)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C301(0.83)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C301(0.42)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C301(0.22)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C301(0.20)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C301(0.43)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C301(1.08)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C301(0.57)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C301(0.89); C320(0.85); C414(0.76)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C301(0.41)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C301(0.89)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C301(0.89)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C301(0.79)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C301(0.73)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C301(0.71)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C301(0.24)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C301(0.28)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C301(0.40); C414(0.75)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C301(1.07); C414(0.92)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C301(0.53); C414(1.11)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C301(1.29); C414(0.93)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C301(1.90); C414(1.02)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C301(0.72); C414(0.94)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C301(0.58); C414(1.03)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C301(0.65); C414(0.93)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C301(0.83); C414(1.01)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C301(1.25); C414(1.07)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C301(0.97); C414(1.08)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C301(1.00); C414(1.18)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C301(0.72); C320(0.64); C414(0.58)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C301(0.66); C414(1.00)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C301(0.80); C414(0.97)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C301(1.91); C414(0.97)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C301(0.83); C414(1.25)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C301(0.32); C414(0.71)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C301(0.59); C414(1.07)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C301(0.47); C414(1.00)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C301(0.31); C414(0.63)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C301(0.20); C414(0.63)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C301(0.28); C414(0.68)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C414(0.47); C301(0.61); C320(0.70)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C301(1.03); C414(1.11)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C301(0.78); C414(1.08)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C301(0.25); C414(0.55)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C301(0.20); C414(0.65)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C301(0.37); C414(0.74)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C301(0.41); C414(0.74)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C301(1.03); C414(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C301(0.98); C414(1.16)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C320(0.85); C301(0.97)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C320(0.48); C301(0.54)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C301(0.65); C320(0.90)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C414(1.04); C301(1.46)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C301(0.85); C320(1.22)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C320(0.70); C301(0.77)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C301(0.94); C320(1.36)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C301(0.79); C320(0.83)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C320(0.84); C301(1.09)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C414(0.92); C320(1.04); C133(0.95); C149(0.95)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C414(0.98); C133(1.29); C149(0.95)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C427(0.84); C414(0.96); C320(1.05); C133(0.92)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C427(1.07); C320(0.98); C133(0.94); C149(0.93)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C427(0.97); C414(1.31); C320(1.00); C149(1.01)  LDD1528  [14]
 LDCM0290  AC3 HCT 116 C414(1.03); C301(1.08)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C427(1.01); C414(1.08); C320(1.07); C133(0.96)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C427(1.08); C357(1.01); C133(1.01); C149(1.03)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C427(0.87); C320(1.01); C133(1.22); C149(1.02)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C414(0.99); C320(1.03); C133(0.91); C149(1.08)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C414(1.00); C133(1.11); C149(1.07)  LDD1534  [14]
 LDCM0296  AC35 HCT 116 C301(1.43); C414(1.98); C320(3.45)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C301(1.41); C414(1.88); C320(3.28)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C301(1.48); C414(1.53); C320(1.76)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C301(1.43); C414(1.54); C320(1.71)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C414(1.07); C320(1.11); C301(1.17)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C414(0.87); C301(0.98)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C301(0.72); C414(0.75); C320(0.92)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C320(1.05); C301(1.21); C414(1.45)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C414(0.94); C301(1.01); C320(1.03)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C414(1.13); C301(1.18); C320(1.63)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C414(0.97); C301(0.99); C320(1.10)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C414(0.73); C301(0.76); C320(0.77)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C320(0.63); C301(1.09); C414(1.20)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C320(0.70); C414(0.92); C301(0.97)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C301(1.44); C320(1.55); C414(1.60)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C320(0.45); C301(0.49); C414(0.52)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C414(0.89); C301(1.12)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C320(0.40); C301(0.46); C414(0.53)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C320(1.18); C301(1.49); C414(2.32)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C320(0.48); C414(0.79); C301(0.85)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C320(0.52); C414(0.55); C301(0.59)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C320(0.41); C301(0.50); C414(0.54)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C320(0.38); C301(0.47); C414(0.54)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C320(0.32); C301(0.50); C414(0.59)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C414(0.20); C301(0.44)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C414(0.20); C301(0.35)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C414(0.14); C301(0.31)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C414(0.45); C320(0.53); C301(0.62)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C414(0.25); C301(0.50)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C414(0.48); C301(0.66)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C414(0.16); C301(0.26)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C414(0.24); C301(0.51)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C414(0.15); C301(0.30)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C414(0.25); C301(0.61)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C414(0.28); C301(0.64)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C414(0.17); C301(0.33)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C301(0.69); C414(0.76)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C301(0.50); C414(0.64)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C414(0.72); C320(0.86); C301(0.91)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C301(0.35); C414(0.52)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C414(0.95); C301(1.02)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C301(0.50); C414(0.65)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C301(0.40); C414(0.62)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C301(0.38); C414(0.66)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C301(0.40); C414(0.72)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C301(0.42); C414(0.61)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C301(0.45); C414(0.65)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C414(0.99); C301(1.02)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C414(0.75); C301(0.79)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C414(0.49); C301(0.69); C320(0.91)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C301(0.45); C414(0.59)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C301(0.86); C414(1.06)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C301(0.42); C414(0.68)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C414(0.26); C301(0.55)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C414(0.30); C301(0.58)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C414(0.53); C301(0.88)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C414(0.57); C301(0.84)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C414(0.97); C301(0.98)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C414(0.60); C301(0.92)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C414(0.34); C301(0.67)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C414(1.81); C301(2.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C414(0.25); C301(0.54)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C414(0.26); C301(0.54)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C414(0.51); C301(0.76)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C414(0.62); C301(0.95)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C414(0.90); C301(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C414(0.44); C301(0.71)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C414(0.30); C301(0.60)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C301(0.09)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C301(0.66)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C301(1.02); C320(1.35); C414(0.85)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C414(0.65); C301(0.85); C320(1.00)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C414(0.16); C301(0.21); C320(0.24)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C301(1.05)  LDD2171  [2]
 LDCM0108  Chloroacetamide HeLa C427(0.00); H96(0.00); C301(0.00); C320(0.00)  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C414(1.16); C301(1.20); C320(1.28)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C301(0.37); C414(0.57); C320(0.98)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C414(0.93); C301(1.13)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C414(0.38); C320(0.48); C301(0.53)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C414(0.89); C301(0.97); C320(1.04)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C414(0.71); C301(0.86); C320(0.90)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C414(0.69); C301(0.89); C320(1.03)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C320(0.58); C301(0.62)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C320(0.29); C301(0.32)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C301(0.35); C320(0.38)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C320(0.26); C301(0.28)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C320(0.55); C301(0.75)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C301(0.33); C414(0.57); C320(0.75)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C301(0.42); C320(0.54)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C320(0.70); C301(0.71)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C427(0.77); C414(0.91); C320(1.01); C133(1.06)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C427(0.95); C414(1.07); C320(1.14); C149(1.13)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C427(0.90); C414(0.86); C320(1.16); C133(1.05)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C427(1.01); C414(0.92); C320(1.02); C133(0.87)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C427(0.84); C414(0.98); C320(1.04); C133(1.00)  LDD1590  [14]
 LDCM0387  CL117 HCT 116 C301(0.64); C414(0.70); C320(0.81)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C301(1.09); C414(1.21); C320(1.25)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C414(0.82); C301(0.89); C320(0.91)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C301(0.28); C414(0.62); C320(1.15)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C414(1.25); C320(1.33); C301(1.35)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C301(0.60); C320(0.63); C414(0.76)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C301(0.74); C320(0.82); C414(0.84)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C320(0.32); C414(0.53); C301(0.54)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C320(0.42); C301(0.51); C414(0.55)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C414(0.68); C301(1.01)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C414(0.55); C301(0.78)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C414(0.58); C301(0.78)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C414(0.16); C301(0.36)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C301(0.48); C414(0.63); C320(0.97)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C301(0.78); C320(0.80); C414(0.84)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C301(0.60); C414(0.81); C320(1.50)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C414(0.75); C301(0.75)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C301(0.82); C414(0.83)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C301(0.75); C414(0.83)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C301(0.56); C414(0.82)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C301(0.95); C414(0.98); C320(1.29)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C301(0.29); C414(0.69)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C301(0.25); C414(0.62)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C301(0.24); C414(0.68)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C301(0.44); C414(0.55)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C301(0.24); C414(0.59)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C301(0.29); C414(0.56)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C301(0.45); C414(0.59)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C301(0.59); C414(0.74)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C301(0.39); C414(0.57)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C301(0.37); C414(0.61)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C301(0.72); C320(0.94); C414(0.94)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C301(0.71); C414(0.77)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C301(0.69); C414(1.12)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C301(0.66); C414(1.01)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C301(0.59); C414(0.89)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C301(0.31); C414(1.22)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C301(0.31); C414(1.01)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C301(0.36); C414(0.87)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C301(0.30); C414(1.02)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C301(0.31); C414(0.76)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C301(0.73); C320(1.30); C414(0.86)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C301(0.38); C414(0.97)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C301(0.43); C414(0.96)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C301(0.29); C414(0.96)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C301(0.31); C414(0.84)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C301(0.44); C414(0.97)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C301(0.39); C414(0.98)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C301(0.75)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C301(0.65)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C301(0.74)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C301(0.92)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C301(0.61); C320(1.34); C414(0.81)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C301(1.28)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C301(1.11)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C301(0.78)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C301(0.78)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C301(0.83)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C301(1.02)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C301(0.72)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C301(0.68)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C301(1.11)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C301(1.13)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C301(0.67); C320(2.25); C414(0.77)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C301(1.30)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C301(0.89); C414(0.84)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C301(0.76); C414(0.86)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C301(0.64); C414(0.62)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C301(0.38); C414(0.38)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C301(0.68); C414(0.73)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C301(0.24); C414(0.29)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C301(0.37); C414(0.33)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C301(0.59); C414(0.58)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C301(0.72); C414(0.94)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C301(0.37); C320(0.96); C414(0.63)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C301(0.56); C414(0.71)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C301(0.43); C414(0.44)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C301(0.90); C414(0.78)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C301(0.61); C414(0.52)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C301(0.43); C414(0.47)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C301(0.57); C414(0.92)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C301(0.51); C414(1.10)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C301(0.48); C414(0.86)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C301(0.26); C414(0.51)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C301(0.25); C320(0.75); C414(0.50)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C301(0.63); C414(1.04)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C301(0.38); C414(0.69)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C301(0.21); C414(0.41)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C301(0.26); C414(0.45)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C301(0.21); C414(0.47)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C301(0.42); C414(0.77)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C301(0.62); C414(0.91)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C301(0.44); C414(0.53)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C301(0.24); C414(0.45)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C301(0.21); C414(0.49)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C301(0.44); C320(0.98); C414(0.63)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C301(0.54); C414(1.11)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C301(1.02); C414(0.95)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C301(1.32); C414(0.94)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C301(1.01); C414(1.02)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C301(0.88); C414(0.81)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C301(0.85); C414(0.81)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C301(1.04); C414(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C301(1.21); C414(0.93)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C301(1.00); C414(0.92)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C301(1.01); C414(0.77)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C427(0.97); C414(1.03); C320(1.09); C133(0.90)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C301(0.49); C414(0.47)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C301(0.28); C414(0.85)  LDD0744  [2]
 LDCM0107  IAA HeLa H96(0.00); C427(0.00)  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C320(1.01); C414(0.98); C149(1.08); C146(0.96)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C320(1.03); C414(1.03); C149(0.96); C146(0.85)  LDD1497  [14]
 LDCM0024  KB05 Hs 936.T C427(1.11)  LDD3313  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C320(0.35)  LDD2127  [16]
 LDCM0021  THZ1 HCT 116 C301(1.05)  LDD2173  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bempedoic Acid Small molecular drug DB11936

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761