Details of the Target

General Information of Target

Target ID LDTP12394
Target Name Leucine zipper transcription factor-like protein 1 (LZTFL1)
Gene Name LZTFL1
Gene ID 54585
Synonyms
Leucine zipper transcription factor-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTL
LHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDC
TSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPV
PTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFV
LQRQPRCWEASVEDLLNDQVTLHSIRPREENDLGPAGTVDSSQGQGYLEEKAAPCCPAHL
AFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSL
LFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVV
LRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA
Target Bioclass
Transcription factor
Family
LZTFL1 family
Subcellular location
Cytoplasm
Function
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Uniprot ID
Q9NQ48
Ensemble ID
ENST00000296135.11
HGNC ID
HGNC:6741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.N198S .
EFO27 Deletion: p.N232TfsTer30 .
NCIH661 SNV: p.M274I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		3.33  LDD0323  [1]
STPyne
 Probe Info  		K244(10.00); K259(4.05); K264(0.98); K275(3.39)  LDD0277  [2]
HHS-475
 Probe Info  		Y271(1.90)  LDD0268  [3]
DBIA
 Probe Info  		C35(1.59)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C35(0.85)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C35(1.14)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C35(1.12)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C35(1.02)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C35(1.01)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C35(1.03)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C35(0.96)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C35(1.07)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C35(1.07)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C35(0.95)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C35(1.02)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C35(1.05)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C35(1.11)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C35(1.04)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C35(1.04)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C35(1.08)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C35(0.83)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C35(0.82)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C35(0.93)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C35(0.98)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C35(1.32)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C35(1.03)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C35(0.95)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C35(1.13)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C35(0.76)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C35(1.75)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C35(0.89)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C35(0.94)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C35(1.34)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C35(0.78)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C35(0.87)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C35(1.06)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C35(1.13)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C35(0.87)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C35(1.08)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C35(0.81)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C35(0.83)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C35(1.07)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C35(1.07)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C35(0.95)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C35(0.99)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C35(0.92)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C35(0.85)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C35(1.08)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C35(0.86)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C35(0.94)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C35(0.96)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C35(0.93)  LDD0579  [4]
 LDCM0270  AC15 HCT 116 C35(0.93)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C35(1.06)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C35(1.05)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C35(1.07)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C35(0.89)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C35(1.07)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C35(1.05)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C35(1.03)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C35(1.11)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C35(1.10)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C35(1.23)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C35(0.92)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C35(0.99)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C35(1.10)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C35(0.99)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C35(0.80)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C35(1.00)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C35(1.18)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C35(1.05)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C35(1.07)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C35(1.01)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C35(1.04)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C35(1.00)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C35(0.75)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C35(1.06)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C35(0.97)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C35(0.99)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C35(0.99)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C35(0.78)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C35(0.94)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C35(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C35(0.83)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C35(0.70)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C35(1.04)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C35(1.10)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C35(1.11)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C35(1.10)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C35(0.82)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C35(0.82)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C35(0.99)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C35(1.14)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C35(0.92)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C35(1.25)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C35(1.26)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C35(0.99)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C35(0.88)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C35(0.77)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C35(0.89)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C35(1.00)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C35(1.08)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C35(0.88)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C35(0.83)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C35(0.89)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C35(0.89)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C35(0.92)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C35(0.96)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C35(1.02)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C35(0.85)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C35(0.90)  LDD0931  [4]
 LDCM0334  AC7 HCT 116 C35(0.92)  LDD0651  [4]
 LDCM0335  AC70 HEK-293T C35(1.05)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C35(0.87)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C35(0.93)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C35(0.90)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C35(1.06)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C35(0.92)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C35(0.92)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C35(1.02)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C35(0.89)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C35(0.93)  LDD0942  [4]
 LDCM0345  AC8 HCT 116 C35(0.92)  LDD0662  [4]
 LDCM0346  AC80 HEK-293T C35(0.80)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C35(0.79)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C35(1.02)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C35(1.02)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C35(0.97)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C35(0.82)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C35(0.95)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C35(0.97)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C35(1.07)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C35(0.96)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C35(1.07)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C35(1.03)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C35(1.03)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C35(0.85)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C35(0.94)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C35(0.81)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C35(0.96)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C35(1.03)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C35(1.06)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C35(0.99)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C35(1.15)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C35(1.04)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C35(1.00)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C35(1.04)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C35(1.02)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C35(0.96)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C35(0.91)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C35(0.88)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C35(0.94)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C35(0.83)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C35(1.07)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C35(1.15)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C35(1.13)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C35(1.02)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C35(0.91)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C35(1.21)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C35(0.95)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C35(0.84)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C35(0.97)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C35(1.13)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C35(0.96)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C35(0.96)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C35(1.16)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C35(1.07)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C35(0.90)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C35(1.18)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C35(1.21)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C35(1.02)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C35(1.00)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C35(1.06)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C35(0.97)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C35(1.02)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C35(0.90)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C35(0.70)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C35(0.85)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C35(0.82)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C35(1.18)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C35(1.03)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C35(0.97)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C35(0.92)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C35(0.79)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C35(0.79)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C35(1.07)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C35(0.95)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C35(0.97)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C35(0.92)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C35(1.01)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C35(1.03)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C35(0.76)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C35(0.82)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C35(1.02)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C35(0.89)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C35(1.01)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C35(0.96)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C35(0.96)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C35(1.27)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C35(0.80)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C35(1.06)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C35(0.80)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C35(0.65)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C35(0.84)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C35(0.77)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C35(0.85)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C35(0.77)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C35(1.04)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C35(0.97)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C35(0.70)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C35(1.00)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C35(0.98)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C35(0.99)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C35(0.71)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C35(0.91)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C35(0.97)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C35(0.96)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C35(0.94)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C35(1.04)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C35(1.06)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C35(0.80)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C35(0.87)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C35(1.01)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C35(0.75)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C35(0.88)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C35(0.79)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C35(0.84)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C35(0.93)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C35(0.95)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C35(0.94)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C35(0.90)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C35(1.14)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C35(0.88)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C35(1.06)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C35(1.31)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C35(1.18)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C35(1.15)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C35(1.27)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C35(1.38)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C35(1.04)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C35(1.17)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C35(1.12)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C35(1.23)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C35(1.08)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C35(1.10)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C35(1.05)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C35(1.10)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C35(1.17)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C35(1.06)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C35(1.13)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C35(1.05)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C35(1.20)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C35(1.18)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C35(1.27)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C35(1.24)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C35(1.03)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C35(1.21)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C35(1.12)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C35(1.27)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C35(1.38)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C35(1.03)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C35(1.10)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C35(1.10)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C35(0.85)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C35(0.85)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C35(0.93)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C35(0.85)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C35(0.86)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C35(0.77)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C35(0.76)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C35(0.95)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C35(0.84)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C35(0.95)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C35(1.22)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C35(1.39)  LDD1025  [4]
 LDCM0120  HHS-0701 DM93 Y271(1.90)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C35(1.59)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C35(2.57)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C35(3.79)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
E3 ubiquitin-protein ligase TRIM68 (TRIM68) TRIM/RBCC family Q6AZZ1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein PTHB1 (BBS9) . Q3SYG4
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MOB kinase activator 1A (MOB1A) MOB1/phocein family Q9H8S9
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402