Details of the Target
General Information of Target
Target ID | LDTP02570 | |||||
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Target Name | Ubiquitin-like protein 4A (UBL4A) | |||||
Gene Name | UBL4A | |||||
Gene ID | 8266 | |||||
Synonyms |
DXS254E; GDX; UBL4; Ubiquitin-like protein 4A; Ubiquitin-like protein GDX |
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3D Structure | ||||||
Sequence |
MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYS
IGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQ RDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK |
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Target Bioclass |
Other
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Subcellular location |
Cytoplasm, cytosol
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Function |
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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FBP2 Probe Info |
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3.06 | LDD0323 | [1] | |
STPyne Probe Info |
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K66(10.00); K72(6.55) | LDD0277 | [2] | |
DBIA Probe Info |
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C13(1.15) | LDD1492 | [3] | |
ATP probe Probe Info |
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K66(0.00); K72(0.00) | LDD0199 | [4] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
C001 Probe Info |
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5.94 | LDD1711 | [5] | |
C003 Probe Info |
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13.45 | LDD1713 | [5] | |
C004 Probe Info |
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8.00 | LDD1714 | [5] | |
C007 Probe Info |
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5.39 | LDD1716 | [5] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C13(0.83) | LDD1507 | [3] |
LDCM0226 | AC11 | HEK-293T | C13(0.93) | LDD1509 | [3] |
LDCM0237 | AC12 | HEK-293T | C13(0.86) | LDD1510 | [3] |
LDCM0259 | AC14 | HEK-293T | C13(0.99) | LDD1512 | [3] |
LDCM0270 | AC15 | HEK-293T | C13(0.96) | LDD1513 | [3] |
LDCM0276 | AC17 | HEK-293T | C13(0.94) | LDD1515 | [3] |
LDCM0278 | AC19 | HEK-293T | C13(0.79) | LDD1517 | [3] |
LDCM0280 | AC20 | HEK-293T | C13(0.98) | LDD1519 | [3] |
LDCM0281 | AC21 | HEK-293T | C13(1.03) | LDD1520 | [3] |
LDCM0282 | AC22 | HEK-293T | C13(1.10) | LDD1521 | [3] |
LDCM0283 | AC23 | HEK-293T | C13(0.96) | LDD1522 | [3] |
LDCM0284 | AC24 | HEK-293T | C13(0.96) | LDD1523 | [3] |
LDCM0285 | AC25 | HEK-293T | C13(0.98) | LDD1524 | [3] |
LDCM0287 | AC27 | HEK-293T | C13(0.89) | LDD1526 | [3] |
LDCM0288 | AC28 | HEK-293T | C13(0.75) | LDD1527 | [3] |
LDCM0289 | AC29 | HEK-293T | C13(1.04) | LDD1528 | [3] |
LDCM0290 | AC3 | HEK-293T | C13(1.01) | LDD1529 | [3] |
LDCM0291 | AC30 | HEK-293T | C13(1.02) | LDD1530 | [3] |
LDCM0292 | AC31 | HEK-293T | C13(0.94) | LDD1531 | [3] |
LDCM0293 | AC32 | HEK-293T | C13(0.97) | LDD1532 | [3] |
LDCM0294 | AC33 | HEK-293T | C13(0.95) | LDD1533 | [3] |
LDCM0296 | AC35 | HEK-293T | C13(0.95) | LDD1535 | [3] |
LDCM0297 | AC36 | HEK-293T | C13(1.18) | LDD1536 | [3] |
LDCM0298 | AC37 | HEK-293T | C13(1.10) | LDD1537 | [3] |
LDCM0299 | AC38 | HEK-293T | C13(1.14) | LDD1538 | [3] |
LDCM0300 | AC39 | HEK-293T | C13(0.98) | LDD1539 | [3] |
LDCM0301 | AC4 | HEK-293T | C13(0.88) | LDD1540 | [3] |
LDCM0302 | AC40 | HEK-293T | C13(0.92) | LDD1541 | [3] |
LDCM0303 | AC41 | HEK-293T | C13(0.94) | LDD1542 | [3] |
LDCM0305 | AC43 | HEK-293T | C13(0.86) | LDD1544 | [3] |
LDCM0306 | AC44 | HEK-293T | C13(0.95) | LDD1545 | [3] |
LDCM0307 | AC45 | HEK-293T | C13(1.06) | LDD1546 | [3] |
LDCM0308 | AC46 | HEK-293T | C13(1.11) | LDD1547 | [3] |
LDCM0309 | AC47 | HEK-293T | C13(0.93) | LDD1548 | [3] |
LDCM0310 | AC48 | HEK-293T | C13(1.05) | LDD1549 | [3] |
LDCM0311 | AC49 | HEK-293T | C13(0.92) | LDD1550 | [3] |
LDCM0312 | AC5 | HEK-293T | C13(1.03) | LDD1551 | [3] |
LDCM0314 | AC51 | HEK-293T | C13(0.94) | LDD1553 | [3] |
LDCM0315 | AC52 | HEK-293T | C13(0.94) | LDD1554 | [3] |
LDCM0316 | AC53 | HEK-293T | C13(1.01) | LDD1555 | [3] |
LDCM0317 | AC54 | HEK-293T | C13(1.05) | LDD1556 | [3] |
LDCM0318 | AC55 | HEK-293T | C13(0.96) | LDD1557 | [3] |
LDCM0319 | AC56 | HEK-293T | C13(0.97) | LDD1558 | [3] |
LDCM0320 | AC57 | HEK-293T | C13(0.85) | LDD1559 | [3] |
LDCM0322 | AC59 | HEK-293T | C13(0.98) | LDD1561 | [3] |
LDCM0323 | AC6 | HEK-293T | C13(1.06) | LDD1562 | [3] |
LDCM0324 | AC60 | HEK-293T | C13(0.82) | LDD1563 | [3] |
LDCM0325 | AC61 | HEK-293T | C13(1.08) | LDD1564 | [3] |
LDCM0326 | AC62 | HEK-293T | C13(1.08) | LDD1565 | [3] |
LDCM0327 | AC63 | HEK-293T | C13(0.95) | LDD1566 | [3] |
LDCM0328 | AC64 | HEK-293T | C13(1.03) | LDD1567 | [3] |
LDCM0334 | AC7 | HEK-293T | C13(1.01) | LDD1568 | [3] |
LDCM0345 | AC8 | HEK-293T | C13(1.02) | LDD1569 | [3] |
LDCM0248 | AKOS034007472 | HEK-293T | C13(1.03) | LDD1511 | [3] |
LDCM0356 | AKOS034007680 | HEK-293T | C13(0.82) | LDD1570 | [3] |
LDCM0275 | AKOS034007705 | HEK-293T | C13(0.94) | LDD1514 | [3] |
LDCM0367 | CL1 | HEK-293T | C13(0.93) | LDD1571 | [3] |
LDCM0368 | CL10 | HEK-293T | C13(0.87) | LDD1572 | [3] |
LDCM0369 | CL100 | HEK-293T | C13(0.83) | LDD1573 | [3] |
LDCM0370 | CL101 | HEK-293T | C13(0.94) | LDD1574 | [3] |
LDCM0371 | CL102 | HEK-293T | C13(0.87) | LDD1575 | [3] |
LDCM0372 | CL103 | HEK-293T | C13(0.81) | LDD1576 | [3] |
LDCM0373 | CL104 | HEK-293T | C13(0.98) | LDD1577 | [3] |
LDCM0374 | CL105 | HEK-293T | C13(0.94) | LDD1578 | [3] |
LDCM0375 | CL106 | HEK-293T | C13(0.93) | LDD1579 | [3] |
LDCM0376 | CL107 | HEK-293T | C13(0.79) | LDD1580 | [3] |
LDCM0377 | CL108 | HEK-293T | C13(0.99) | LDD1581 | [3] |
LDCM0378 | CL109 | HEK-293T | C13(0.96) | LDD1582 | [3] |
LDCM0379 | CL11 | HEK-293T | C13(1.05) | LDD1583 | [3] |
LDCM0380 | CL110 | HEK-293T | C13(0.95) | LDD1584 | [3] |
LDCM0381 | CL111 | HEK-293T | C13(0.84) | LDD1585 | [3] |
LDCM0382 | CL112 | HEK-293T | C13(1.00) | LDD1586 | [3] |
LDCM0383 | CL113 | HEK-293T | C13(1.01) | LDD1587 | [3] |
LDCM0384 | CL114 | HEK-293T | C13(0.87) | LDD1588 | [3] |
LDCM0385 | CL115 | HEK-293T | C13(0.86) | LDD1589 | [3] |
LDCM0386 | CL116 | HEK-293T | C13(1.02) | LDD1590 | [3] |
LDCM0387 | CL117 | HEK-293T | C13(1.09) | LDD1591 | [3] |
LDCM0388 | CL118 | HEK-293T | C13(0.98) | LDD1592 | [3] |
LDCM0389 | CL119 | HEK-293T | C13(0.82) | LDD1593 | [3] |
LDCM0390 | CL12 | HEK-293T | C13(0.93) | LDD1594 | [3] |
LDCM0391 | CL120 | HEK-293T | C13(0.92) | LDD1595 | [3] |
LDCM0392 | CL121 | HEK-293T | C13(0.97) | LDD1596 | [3] |
LDCM0393 | CL122 | HEK-293T | C13(1.09) | LDD1597 | [3] |
LDCM0394 | CL123 | HEK-293T | C13(0.77) | LDD1598 | [3] |
LDCM0395 | CL124 | HEK-293T | C13(0.89) | LDD1599 | [3] |
LDCM0396 | CL125 | HEK-293T | C13(1.01) | LDD1600 | [3] |
LDCM0397 | CL126 | HEK-293T | C13(0.98) | LDD1601 | [3] |
LDCM0398 | CL127 | HEK-293T | C13(0.80) | LDD1602 | [3] |
LDCM0399 | CL128 | HEK-293T | C13(0.97) | LDD1603 | [3] |
LDCM0400 | CL13 | HEK-293T | C13(0.99) | LDD1604 | [3] |
LDCM0401 | CL14 | HEK-293T | C13(1.00) | LDD1605 | [3] |
LDCM0402 | CL15 | HEK-293T | C13(0.75) | LDD1606 | [3] |
LDCM0403 | CL16 | HEK-293T | C13(0.87) | LDD1607 | [3] |
LDCM0404 | CL17 | HEK-293T | C13(0.88) | LDD1608 | [3] |
LDCM0406 | CL19 | HEK-293T | C13(1.10) | LDD1610 | [3] |
LDCM0407 | CL2 | HEK-293T | C13(1.11) | LDD1611 | [3] |
LDCM0408 | CL20 | HEK-293T | C13(0.95) | LDD1612 | [3] |
LDCM0409 | CL21 | HEK-293T | C13(0.98) | LDD1613 | [3] |
LDCM0410 | CL22 | HEK-293T | C13(0.99) | LDD1614 | [3] |
LDCM0411 | CL23 | HEK-293T | C13(0.99) | LDD1615 | [3] |
LDCM0412 | CL24 | HEK-293T | C13(1.05) | LDD1616 | [3] |
LDCM0413 | CL25 | HEK-293T | C13(0.92) | LDD1617 | [3] |
LDCM0414 | CL26 | HEK-293T | C13(1.00) | LDD1618 | [3] |
LDCM0415 | CL27 | HEK-293T | C13(0.87) | LDD1619 | [3] |
LDCM0416 | CL28 | HEK-293T | C13(1.07) | LDD1620 | [3] |
LDCM0417 | CL29 | HEK-293T | C13(0.98) | LDD1621 | [3] |
LDCM0418 | CL3 | HEK-293T | C13(0.81) | LDD1622 | [3] |
LDCM0420 | CL31 | HEK-293T | C13(1.02) | LDD1624 | [3] |
LDCM0421 | CL32 | HEK-293T | C13(1.03) | LDD1625 | [3] |
LDCM0422 | CL33 | HEK-293T | C13(0.84) | LDD1626 | [3] |
LDCM0423 | CL34 | HEK-293T | C13(0.88) | LDD1627 | [3] |
LDCM0424 | CL35 | HEK-293T | C13(1.06) | LDD1628 | [3] |
LDCM0425 | CL36 | HEK-293T | C13(0.95) | LDD1629 | [3] |
LDCM0426 | CL37 | HEK-293T | C13(1.04) | LDD1630 | [3] |
LDCM0428 | CL39 | HEK-293T | C13(0.82) | LDD1632 | [3] |
LDCM0429 | CL4 | HEK-293T | C13(0.94) | LDD1633 | [3] |
LDCM0430 | CL40 | HEK-293T | C13(1.09) | LDD1634 | [3] |
LDCM0431 | CL41 | HEK-293T | C13(0.92) | LDD1635 | [3] |
LDCM0433 | CL43 | HEK-293T | C13(1.08) | LDD1637 | [3] |
LDCM0434 | CL44 | HEK-293T | C13(0.80) | LDD1638 | [3] |
LDCM0435 | CL45 | HEK-293T | C13(0.91) | LDD1639 | [3] |
LDCM0436 | CL46 | HEK-293T | C13(1.06) | LDD1640 | [3] |
LDCM0437 | CL47 | HEK-293T | C13(0.91) | LDD1641 | [3] |
LDCM0438 | CL48 | HEK-293T | C13(1.04) | LDD1642 | [3] |
LDCM0439 | CL49 | HEK-293T | C13(1.05) | LDD1643 | [3] |
LDCM0440 | CL5 | HEK-293T | C13(1.03) | LDD1644 | [3] |
LDCM0441 | CL50 | HEK-293T | C13(0.97) | LDD1645 | [3] |
LDCM0443 | CL52 | HEK-293T | C13(1.06) | LDD1646 | [3] |
LDCM0444 | CL53 | HEK-293T | C13(0.83) | LDD1647 | [3] |
LDCM0446 | CL55 | HEK-293T | C13(0.96) | LDD1649 | [3] |
LDCM0447 | CL56 | HEK-293T | C13(0.90) | LDD1650 | [3] |
LDCM0448 | CL57 | HEK-293T | C13(1.02) | LDD1651 | [3] |
LDCM0449 | CL58 | HEK-293T | C13(1.02) | LDD1652 | [3] |
LDCM0450 | CL59 | HEK-293T | C13(0.93) | LDD1653 | [3] |
LDCM0452 | CL60 | HEK-293T | C13(1.01) | LDD1655 | [3] |
LDCM0453 | CL61 | HEK-293T | C13(1.03) | LDD1656 | [3] |
LDCM0454 | CL62 | HEK-293T | C13(1.04) | LDD1657 | [3] |
LDCM0455 | CL63 | HEK-293T | C13(0.93) | LDD1658 | [3] |
LDCM0456 | CL64 | HEK-293T | C13(0.97) | LDD1659 | [3] |
LDCM0457 | CL65 | HEK-293T | C13(0.97) | LDD1660 | [3] |
LDCM0459 | CL67 | HEK-293T | C13(1.13) | LDD1662 | [3] |
LDCM0460 | CL68 | HEK-293T | C13(1.00) | LDD1663 | [3] |
LDCM0461 | CL69 | HEK-293T | C13(1.14) | LDD1664 | [3] |
LDCM0462 | CL7 | HEK-293T | C13(0.93) | LDD1665 | [3] |
LDCM0463 | CL70 | HEK-293T | C13(1.02) | LDD1666 | [3] |
LDCM0464 | CL71 | HEK-293T | C13(1.04) | LDD1667 | [3] |
LDCM0465 | CL72 | HEK-293T | C13(1.08) | LDD1668 | [3] |
LDCM0466 | CL73 | HEK-293T | C13(0.98) | LDD1669 | [3] |
LDCM0467 | CL74 | HEK-293T | C13(1.06) | LDD1670 | [3] |
LDCM0469 | CL76 | HEK-293T | C13(1.07) | LDD1672 | [3] |
LDCM0470 | CL77 | HEK-293T | C13(0.75) | LDD1673 | [3] |
LDCM0472 | CL79 | HEK-293T | C13(1.17) | LDD1675 | [3] |
LDCM0473 | CL8 | HEK-293T | C13(0.63) | LDD1676 | [3] |
LDCM0474 | CL80 | HEK-293T | C13(1.02) | LDD1677 | [3] |
LDCM0475 | CL81 | HEK-293T | C13(1.04) | LDD1678 | [3] |
LDCM0476 | CL82 | HEK-293T | C13(1.09) | LDD1679 | [3] |
LDCM0477 | CL83 | HEK-293T | C13(0.94) | LDD1680 | [3] |
LDCM0478 | CL84 | HEK-293T | C13(1.04) | LDD1681 | [3] |
LDCM0479 | CL85 | HEK-293T | C13(0.94) | LDD1682 | [3] |
LDCM0480 | CL86 | HEK-293T | C13(1.05) | LDD1683 | [3] |
LDCM0481 | CL87 | HEK-293T | C13(0.79) | LDD1684 | [3] |
LDCM0482 | CL88 | HEK-293T | C13(0.96) | LDD1685 | [3] |
LDCM0483 | CL89 | HEK-293T | C13(0.93) | LDD1686 | [3] |
LDCM0484 | CL9 | HEK-293T | C13(0.97) | LDD1687 | [3] |
LDCM0486 | CL91 | HEK-293T | C13(1.13) | LDD1689 | [3] |
LDCM0487 | CL92 | HEK-293T | C13(0.81) | LDD1690 | [3] |
LDCM0488 | CL93 | HEK-293T | C13(0.98) | LDD1691 | [3] |
LDCM0489 | CL94 | HEK-293T | C13(1.00) | LDD1692 | [3] |
LDCM0490 | CL95 | HEK-293T | C13(0.71) | LDD1693 | [3] |
LDCM0491 | CL96 | HEK-293T | C13(0.73) | LDD1694 | [3] |
LDCM0492 | CL97 | HEK-293T | C13(0.70) | LDD1695 | [3] |
LDCM0493 | CL98 | HEK-293T | C13(0.99) | LDD1696 | [3] |
LDCM0494 | CL99 | HEK-293T | C13(0.73) | LDD1697 | [3] |
LDCM0495 | E2913 | HEK-293T | C13(0.83) | LDD1698 | [3] |
LDCM0468 | Fragment33 | HEK-293T | C13(0.82) | LDD1671 | [3] |
LDCM0427 | Fragment51 | HEK-293T | C13(1.00) | LDD1631 | [3] |
LDCM0022 | KB02 | HEK-293T | C13(1.15) | LDD1492 | [3] |
LDCM0023 | KB03 | HEK-293T | C13(1.04) | LDD1497 | [3] |
LDCM0024 | KB05 | HEK-293T | C13(1.03) | LDD1502 | [3] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transcription factor
Protein name | Family | Uniprot ID | |||
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Homeobox protein MOX-2 (MEOX2) | . | P50222 |
Other
References