Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C003  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 23.9
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 22.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 21.3
 LDTP04689  Adenosine kinase (ADK) 20.4
 LDTP02757  Cytochrome b-c1 complex subunit 7 (UQCRB) 17.9
 LDTP04552  Biliverdin reductase A (BLVRA) 17.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 16.1
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 15.9
 LDTP10583  E3 SUMO-protein ligase NSE2 (NSMCE2) 15.2
 LDTP10329  Ceramide synthase 2 (CERS2) 14.9
 LDTP03842  Squalene synthase (FDFT1) 14.9
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 14.5
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 14.4
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 14.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 14.0
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 14.0
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 13.6
 LDTP09965  Cullin-5 (CUL5) 13.4
 LDTP02055  Thymidylate synthase (TYMS) 13.2
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 13.0
 LDTP12691  Pyridoxine-5'-phosphate oxidase (PNPO) 12.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 12.8
 LDTP11788  EH domain-containing protein 4 (EHD4) 12.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.8
 LDTP06111  UDP-glucose 4-epimerase (GALE) 12.8
 LDTP06427  Translin (TSN) 12.6
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 12.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 12.0
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 29.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 28.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 18.1
 LDTP11116  45 kDa calcium-binding protein (SDF4) 15.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 15.3
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 15.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 14.5
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 13.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 13.4
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 13.0
 LDTP04969  14-3-3 protein epsilon (YWHAE) 12.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.5
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 15.2
 LDTP05235  Transcription factor A, mitochondrial (TFAM) 13.7
 LDTP02749  POU domain, class 2, transcription factor 1 (POU2F1) 13.1
 LDTP12309  High mobility group protein 20A (HMG20A) 12.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 15.3
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01067  Endothelial differentiation-related factor 1 (EDF1) 33.4
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 24.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 22.8
 LDTP11076  Apolipoprotein L2 (APOL2) 22.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 22.2
 LDTP02869  Stathmin (STMN1) 21.6
 LDTP02297  Vimentin (VIM) 19.4
 LDTP00573  Prefoldin subunit 6 (PFDN6) 18.3
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 17.4
 LDTP10857  c-Myc-binding protein (MYCBP) 16.9
 LDTP12729  Required for meiotic nuclear division protein 1 homolog (RMND1) 16.4
 LDTP03926  Centrin-2 (CETN2) 16.2
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 16.1
 LDTP11134  DNA replication complex GINS protein SLD5 (GINS4) 15.8
 LDTP03721  Radixin (RDX) 15.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 15.2
 LDTP04703  Tumor protein D52 (TPD52) 15.1
 LDTP05400  Lamin-B2 (LMNB2) 14.8
 LDTP16193  Craniofacial development protein 1 (CFDP1) 14.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 14.6
 LDTP01361  DnaJ homolog subfamily C member 8 (DNAJC8) 14.5
 LDTP10908  Protein S100-A13 (S100A13) 14.4
 LDTP06386  Splicing factor 3B subunit 4 (SF3B4) 14.0
 LDTP01932  Prelamin-A/C (LMNA) 13.9
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 13.9
 LDTP00887  Calumenin (CALU) 13.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 13.8
 LDTP05763  Liprin-alpha-1 (PPFIA1) 13.6
 LDTP12388  Putative RNA-binding protein Luc7-like 1 (LUC7L) 13.6
 LDTP02181  Neurofilament medium polypeptide (NEFM) 13.5
 LDTP00829  Regulator of G-protein signaling 10 (RGS10) 13.5
 LDTP02570  Ubiquitin-like protein 4A (UBL4A) 13.5
 LDTP10187  Coiled-coil domain-containing protein 124 (CCDC124) 13.3
 LDTP05160  Nucleobindin-2 (NUCB2) 13.0
 LDTP16278  Nucleolar protein 16 (NOP16) 13.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.9
 LDTP08761  NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) 12.9
 LDTP01582  Pre-mRNA-splicing factor SLU7 (SLU7) 12.8
 LDTP03499  Elongation factor 1-delta (EEF1D) 12.6
 LDTP03065  Lamin-B1 (LMNB1) 12.5
 LDTP04974  Small ribosomal subunit protein uS15 (RPS13) 12.4
 LDTP02116  Lupus La protein (SSB) 12.3
 LDTP06527  Alpha-internexin (INA) 12.1
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 12.1
 LDTP06254  Sarcolemmal membrane-associated protein (SLMAP) 12.0
 LDTP02779  Ezrin (EZR) 12.0
 LDTP04668  Microfibrillar-associated protein 1 (MFAP1) 12.0
 LDTP10924  Prohibitin-2 (PHB2) 12.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587