Details of the Target

General Information of Target

Target ID LDTP06386
Target Name Splicing factor 3B subunit 4 (SF3B4)
Gene Name SF3B4
Gene ID 10262
Synonyms
SAP49; Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; Spliceosome-associated protein 49; SAP 49
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVE
FLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTF
SAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKK
DSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPP
GSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGG
MPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGS
PMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRG
PLPQ
Target Bioclass
Other
Family
SF3B4 family
Subcellular location
Nucleus
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs.
Uniprot ID
Q15427
Ensemble ID
ENST00000271628.9
HGNC ID
HGNC:10771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K23(10.00)  LDD0277  [2]
AZ-9
 Probe Info  		E8(10.00)  LDD2209  [3]
Probe 1
 Probe Info  		Y69(18.58)  LDD3495  [4]
m-APA
 Probe Info  		8.42  LDD0403  [5]
DBIA
 Probe Info  		C168(1.26)  LDD1492  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
1c-yne
 Probe Info  		N.A.  LDD0228  [8]
HHS-465
 Probe Info  		K23(0.00); Y16(0.00)  LDD2240  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		14.03  LDD1713  [10]
C007
 Probe Info  		4.96  LDD1716  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C168(0.88)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C168(1.03)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C168(1.02)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C168(1.09)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C168(1.10)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C168(1.13)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C168(1.00)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C168(0.93)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C168(0.90)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C168(1.01)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C168(1.20)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C168(0.99)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C168(1.21)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C168(1.19)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C168(1.08)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C168(0.89)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C168(0.89)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C168(0.96)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C168(1.01)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C168(0.93)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C168(0.93)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C168(0.96)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C168(0.83)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C168(1.06)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C168(1.21)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C168(1.06)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C168(1.13)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C168(1.23)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C168(0.92)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C168(1.13)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C168(1.18)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C168(0.93)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C168(1.13)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C168(1.05)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C168(0.96)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C168(1.28)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C168(1.12)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C168(0.99)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C168(1.09)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C168(1.19)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C168(1.19)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C168(1.00)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C168(1.01)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C168(0.94)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C168(1.04)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C168(1.25)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C168(1.19)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C168(1.18)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C168(1.07)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C168(1.09)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C168(1.04)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C168(1.03)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C168(1.10)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C168(1.06)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C168(1.00)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C168(0.99)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C168(1.12)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C168(1.01)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C168(0.99)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C168(1.02)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C168(0.96)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C168(1.10)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C168(1.02)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C168(1.15)  LDD1514  [6]
 LDCM0156  Aniline NCI-H1299 8.42  LDD0403  [5]
 LDCM0367  CL1 HEK-293T C168(0.85)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C168(0.79)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C168(0.90)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C168(0.88)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C168(0.85)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C168(1.25)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C168(1.05)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C168(1.04)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C168(0.91)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C168(1.17)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C168(1.06)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C168(0.84)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C168(0.87)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C168(0.74)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C168(0.90)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C168(0.88)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C168(1.02)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C168(0.87)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C168(1.07)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C168(1.10)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C168(1.30)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C168(0.88)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C168(1.09)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C168(1.04)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C168(0.99)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C168(1.00)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C168(1.11)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C168(1.01)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C168(1.02)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C168(1.29)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C168(1.03)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C168(1.12)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C168(1.09)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C168(1.12)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C168(1.08)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C168(1.16)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C168(1.10)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C168(0.90)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C168(0.97)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C168(1.07)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C168(1.00)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C168(1.09)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C168(0.91)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C168(0.97)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C168(1.00)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C168(1.03)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C168(1.21)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C168(1.23)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C168(1.12)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C168(1.13)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C168(0.99)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C168(1.08)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C168(1.05)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C168(0.95)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C168(1.00)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C168(0.74)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C168(0.89)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C168(0.98)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C168(0.93)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C168(1.33)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C168(1.41)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C168(1.03)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C168(1.29)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C168(1.04)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C168(1.06)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C168(1.06)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C168(0.95)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C168(0.89)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C168(0.99)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C168(0.89)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C168(1.19)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C168(1.05)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C168(1.04)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C168(1.22)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C168(1.00)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C168(0.99)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C168(0.77)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C168(0.92)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C168(1.02)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C168(0.79)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C168(0.88)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C168(1.00)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C168(0.88)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C168(1.17)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C168(1.23)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C168(1.15)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C168(1.30)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C168(1.01)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C168(1.22)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C168(0.92)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C168(0.95)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C168(1.10)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C168(1.02)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C168(0.96)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C168(0.94)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C168(0.95)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C168(1.43)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C168(0.99)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C168(1.04)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C168(1.13)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C168(0.83)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C168(0.84)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C168(0.92)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C168(0.65)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C168(0.93)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C168(0.95)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C168(0.78)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C168(0.89)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C168(0.89)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C168(1.53)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C168(1.37)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C168(1.24)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C168(1.24)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C168(1.28)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C168(0.82)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C168(0.79)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C168(1.16)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C168(1.06)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C168(0.91)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C168(1.07)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C168(0.76)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C168(1.00)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C168(0.81)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C168(0.86)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C168(1.05)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C168(1.37)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C168(1.05)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C168(1.12)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C168(1.26)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C168(1.09)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C168(1.33)  LDD1502  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 9 (PRMT9) Protein arginine N-methyltransferase family Q6P2P2
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Methyltransferase-like protein 17, mitochondrial (METTL17) Rsm22 family Q9H7H0
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Tyrosine-protein kinase FRK (FRK) Tyr protein kinase family P42685
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2) Classic translation factor GTPase family Q15029
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 3 (ZNF3) Krueppel C2H2-type zinc-finger protein family P17036
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Protein transport protein Sec24D (SEC24D) SEC23/SEC24 family O94855
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Calcium-responsive transactivator (SS18L1) SS18 family O75177
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Cytoplasmic protein NCK2 (NCK2) . O43639
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
NEDD8 ultimate buster 1 (NUB1) . Q9Y5A7
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Protein TFG (TFG) . Q92734
RNA-binding protein 10 (RBM10) . P98175
Splicing factor 3B subunit 2 (SF3B2) . Q13435
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) . P57075
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
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5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.