Details of the Target

General Information of Target

Target ID LDTP00573
Target Name Prefoldin subunit 6 (PFDN6)
Gene Name PFDN6
Gene ID 10471
Synonyms
HKE2; PFD6; Prefoldin subunit 6; Protein Ke2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLL
GPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQA
AKAGAPGKA
Target Bioclass
Other
Family
Prefoldin subunit beta family
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Uniprot ID
O15212
Ensemble ID
ENST00000374606.10
HGNC ID
HGNC:4926

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y16(5.39)  LDD0257  [1]
ONAyne
 Probe Info  		K122(6.78)  LDD0274  [2]
AZ-9
 Probe Info  		E114(0.77)  LDD2208  [3]
Probe 1
 Probe Info  		Y16(140.32); Y82(19.61); Y90(44.51)  LDD3495  [4]
HHS-482
 Probe Info  		Y16(1.20)  LDD0287  [5]
HHS-475
 Probe Info  		Y16(0.89); Y82(0.99)  LDD0264  [6]
HHS-465
 Probe Info  		Y16(10.00); Y82(8.79)  LDD2237  [7]
ATP probe
 Probe Info  		K21(0.00); K25(0.00); K66(0.00); K8(0.00)  LDD0199  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		18.25  LDD1713  [11]
C056
 Probe Info  		18.64  LDD1753  [11]
C158
 Probe Info  		9.99  LDD1838  [11]
C249
 Probe Info  		16.45  LDD1922  [11]
C284
 Probe Info  		21.71  LDD1954  [11]
C296
 Probe Info  		12.55  LDD1966  [11]
C305
 Probe Info  		10.06  LDD1974  [11]
C313
 Probe Info  		13.55  LDD1980  [11]
C314
 Probe Info  		14.83  LDD1981  [11]
C326
 Probe Info  		11.00  LDD1990  [11]
C349
 Probe Info  		10.34  LDD2010  [11]
C350
 Probe Info  		24.25  LDD2011  [11]
C354
 Probe Info  		9.06  LDD2015  [11]
C355
 Probe Info  		24.25  LDD2016  [11]
C361
 Probe Info  		18.51  LDD2022  [11]
C362
 Probe Info  		30.70  LDD2023  [11]
C364
 Probe Info  		17.75  LDD2025  [11]
C391
 Probe Info  		16.45  LDD2050  [11]
C397
 Probe Info  		10.48  LDD2056  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y16(0.89); Y82(0.99)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y16(0.78); Y82(0.86)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y16(0.77); Y82(0.91)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y16(0.80); Y82(0.87)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y16(0.83); Y82(0.93)  LDD0268  [6]
 LDCM0125  JWB146 DM93 Y16(1.20)  LDD0287  [5]
 LDCM0127  JWB152 DM93 Y16(0.69)  LDD0289  [5]
 LDCM0129  JWB202 DM93 Y16(0.37)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y16(0.21)  LDD0292  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
F-box only protein 2 (FBXO2) . Q9UK22
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCAAT/enhancer-binding protein gamma (CEBPG) BZIP family P53567
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen B4 (MAGEB4) . O15481

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587