Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C391  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 88 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 62.7
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 56.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 55.7
 LDTP01803  Adenosine deaminase (ADA) 48.5
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 48.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 41.9
 LDTP05246  Cyclin-dependent kinase 16 (CDK16) 41.4
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 38.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 38.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 37.8
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 36.3
 LDTP10583  E3 SUMO-protein ligase NSE2 (NSMCE2) 34.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 34.5
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 34.3
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) 33.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 32.4
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 31.8
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 30.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 28.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 27.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 25.6
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 25.5
 LDTP03816  Oxidized purine nucleoside triphosphate hydrolase (NUDT1) 24.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 24.3
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 23.4
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 23.1
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 23.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 22.8
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 22.5
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 22.2
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 21.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 21.3
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 21.0
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 20.5
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 20.4
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 20.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 19.8
 LDTP08322  Valacyclovir hydrolase (BPHL) 19.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 19.6
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 19.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 18.8
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 18.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 18.4
 LDTP03787  Choline kinase alpha (CHKA) 17.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 17.9
 LDTP12061  Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) 17.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 17.5
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 17.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 17.1
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 16.8
 LDTP02149  Cyclin-dependent kinase 1 (CDK1) 16.7
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 16.6
 LDTP04318  Glycogen synthase kinase-3 alpha (GSK3A) 16.6
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 16.1
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 16.1
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 16.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 15.9
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 15.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.6
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 15.3
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 15.3
 LDTP05245  Cyclin-dependent kinase 5 (CDK5) 15.2
 LDTP02539  Lysosomal acid phosphatase (ACP2) 15.2
 LDTP00150  Acyl-coenzyme A diphosphatase NUDT19 (NUDT19) 15.1
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 15.1
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 15.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 14.9
 LDTP11535  Ras-related protein Rab-34 (RAB34) 14.7
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 14.5
 LDTP03842  Squalene synthase (FDFT1) 14.5
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 14.2
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 14.1
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 14.1
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 14.1
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 14.1
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 14.0
 LDTP05881  Rho-associated protein kinase 1 (ROCK1) 13.7
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 13.5
 LDTP01368  Triple functional domain protein (TRIO) 13.3
 LDTP14075  AFG3-like protein 2 (AFG3L2) 13.2
 LDTP02260  Beta-glucuronidase (GUSB) 13.2
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 13.2
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 13.2
 LDTP04689  Adenosine kinase (ADK) 13.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 12.6
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 12.4
 LDTP10020  Ras-related protein Rab-24 (RAB24) 12.4
Transporter and channel
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 62.2
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 54.2
 LDTP01804  ATP synthase subunit a (MT-ATP6) 53.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 53.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 49.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 47.8
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 44.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 40.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 31.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 31.3
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 31.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 28.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 27.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 26.9
 LDTP05900  Metaxin-1 (MTX1) 26.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 23.1
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 22.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 22.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 21.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 21.1
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 21.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 21.0
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 20.4
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 20.4
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 18.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.6
 LDTP07236  Protein GPR107 (GPR107) 18.5
 LDTP01056  Coiled-coil domain-containing protein 22 (CCDC22) 18.0
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 17.8
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.3
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 16.9
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 16.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 16.8
 LDTP07667  Transmembrane protein 205 (TMEM205) 15.8
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 15.7
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 15.5
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 14.9
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 14.4
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 13.7
 LDTP06581  Occludin (OCLN) 13.5
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 13.3
 LDTP11607  Exportin-4 (XPO4) 13.1
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 13.1
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 12.8
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 12.5
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 12.4
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09694  Paraspeckle component 1 (PSPC1) 25.1
 LDTP05065  Y-box-binding protein 1 (YBX1) 16.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 13.4
Other
Click to Show/Hide to Show 107 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 99.7
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 59.3
 LDTP05160  Nucleobindin-2 (NUCB2) 56.9
 LDTP06097  Reticulocalbin-2 (RCN2) 52.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 48.5
 LDTP02297  Vimentin (VIM) 44.9
 LDTP02913  Desmin (DES) 43.4
 LDTP02180  Neurofilament light polypeptide (NEFL) 37.8
 LDTP13630  Neudesin (NENF) 35.3
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 34.1
 LDTP05375  Nucleobindin-1 (NUCB1) 33.6
 LDTP05226  RNA-binding protein 3 (RBM3) 31.3
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 28.8
 LDTP01652  Centrosomal protein 43 (CEP43) 28.2
 LDTP08795  GH3 domain-containing protein (GHDC) 27.7
 LDTP18883  Protein CEBPZOS (CEBPZOS) 27.1
 LDTP05277  Protein SET (SET) 26.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 25.6
 LDTP06948  Protein YIF1B (YIF1B) 24.4
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 23.6
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 23.1
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 22.9
 LDTP06527  Alpha-internexin (INA) 22.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 21.9
 LDTP00887  Calumenin (CALU) 21.7
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 21.4
 LDTP09069  Kinetochore protein Spc24 (SPC24) 21.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 21.1
 LDTP01661  Synaptosomal-associated protein 29 (SNAP29) 20.8
 LDTP04091  Adapter molecule crk (CRK) 20.1
 LDTP08000  Dymeclin (DYM) 20.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 20.0
 LDTP19963  TraB domain-containing protein (TRABD) 19.4
 LDTP12591  Kinesin light chain 4 (KLC4) 19.3
 LDTP00417  Programmed cell death protein 5 (PDCD5) 19.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 18.6
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 18.5
 LDTP02181  Neurofilament medium polypeptide (NEFM) 18.4
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 18.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 18.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 17.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 17.8
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 17.4
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 17.4
 LDTP16006  Optic atrophy 3 protein (OPA3) 17.3
 LDTP01932  Prelamin-A/C (LMNA) 17.3
 LDTP15728  Large ribosomal subunit protein mL48 (MRPL48) 17.1
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 16.4
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 16.4
 LDTP00573  Prefoldin subunit 6 (PFDN6) 16.4
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 16.4
 LDTP10452  Conserved oligomeric Golgi complex subunit 3 (COG3) 16.2
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 15.7
 LDTP01711  Protein ecdysoneless homolog (ECD) 15.7
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 15.6
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 15.2
 LDTP05789  DnaJ homolog subfamily C member 3 (DNAJC3) 15.1
 LDTP09049  NHL repeat-containing protein 2 (NHLRC2) 15.1
 LDTP04558  Arfaptin-1 (ARFIP1) 14.9
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 14.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 14.7
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 14.5
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) 14.4
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 14.3
 LDTP03775  RNA-binding protein FUS (FUS) 14.1
 LDTP07348  Cytospin-A (SPECC1L) 14.0
 LDTP09850  Proline-rich protein PRCC (PRCC) 14.0
 LDTP13086  Syntaxin-18 (STX18) 14.0
 LDTP05400  Lamin-B2 (LMNB2) 13.9
 LDTP05800  Serine/arginine-rich splicing factor 9 (SRSF9) 13.9
 LDTP08594  Negative elongation factor C/D (NELFCD) 13.8
 LDTP10822  Protein IWS1 homolog (IWS1) 13.8
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 13.8
 LDTP10857  c-Myc-binding protein (MYCBP) 13.7
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 13.7
 LDTP01167  Reticulon-2 (RTN2) 13.7
 LDTP13273  Ubiquilin-2 (UBQLN2) 13.7
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 13.6
 LDTP04668  Microfibrillar-associated protein 1 (MFAP1) 13.6
 LDTP11643  Superkiller complex protein 8 (SKIC8) 13.6
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 13.5
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 13.5
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 13.5
 LDTP08448  ELKS/Rab6-interacting/CAST family member 1 (ERC1) 13.4
 LDTP06868  Angiomotin (AMOT) 13.2
 LDTP09920  Golgi apparatus protein 1 (GLG1) 13.2
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 13.2
 LDTP04356  Emerin (EMD) 13.1
 LDTP10056  Protein FAM162A (FAM162A) 13.1
 LDTP05036  Transformer-2 protein homolog beta (TRA2B) 13.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 13.0
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 12.7
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) 12.7
 LDTP03465  General transcription factor IIE subunit 1 (GTF2E1) 12.6
 LDTP09183  Periphilin-1 (PPHLN1) 12.6
 LDTP00280  Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) 12.6
 LDTP15398  Protein FAM177A1 (FAM177A1) 12.6
 LDTP10203  RalBP1-associated Eps domain-containing protein 1 (REPS1) 12.6
 LDTP05985  Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) 12.6
 LDTP05937  Transformer-2 protein homolog alpha (TRA2A) 12.6
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 12.6
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 12.5
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 12.5
 LDTP03065  Lamin-B1 (LMNB1) 12.5
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 12.5
 LDTP13309  Prefoldin subunit 2 (PFDN2) 12.5
 LDTP05763  Liprin-alpha-1 (PPFIA1) 12.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587