Details of the Target

General Information of Target

Target ID LDTP01368
Target Name Triple functional domain protein (TRIO)
Gene Name TRIO
Gene ID 7204
Synonyms
Triple functional domain protein; EC 2.7.11.1; PTPRF-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM
KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC
KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI
LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG
NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR
QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL
EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL
HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV
RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI
KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN
LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT
HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS
EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY
VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI
QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF
QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL
IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG
RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG
QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS
SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG
EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK
MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED
PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP
VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA
QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV
SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL
TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR
IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE
GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP
LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG
KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI
LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK
KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE
TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI
AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR
AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC
VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA
VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET
CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. Plays a key role in the regulation of neurite outgrowth and lamellipodia formation. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses. May act as a regulator of adipogenesis.
Uniprot ID
O75962
Ensemble ID
ENST00000344204.9
HGNC ID
HGNC:12303
ChEMBL ID
CHEMBL4523153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.S2325R DBIA    Probe Info 
A3KAW SNV: p.S52F; p.L2847P .
AN3CA SNV: p.L2971M .
CAL33 Deletion: p.L853del DBIA    Probe Info 
CHL1 SNV: p.A2594V .
DU145 SNV: p.E1592K DBIA    Probe Info 
FADU SNV: p.D1865Y DBIA    Probe Info 
HCT15 SNV: p.R1783W .
HDMYZ SNV: p.I2489T DBIA    Probe Info 
HLF Substitution: p.G2312V DBIA    Probe Info 
HT115 SNV: p.R131C; p.S939L .
IPC298 SNV: p.R2346Ter; p.F2485L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.I2158SfsTer63
SNV: p.Q1173Ter		 .
JEKO1 SNV: p.T1610P .
JURKAT SNV: p.R400C; p.R2496Ter .
KYSE410 Substitution: p.S2375F .
LN229 SNV: p.G2803S .
LNCaP clone FGC SNV: p.A1823V DBIA    Probe Info 
MDAMB231 SNV: p.L600V; p.K2789E .
MEWO SNV: p.P2350L; p.F2473S .
MOLT4 SNV: p.V2617I .
NCIH1155 SNV: p.R1643W DBIA    Probe Info 
NCIH2172 SNV: p.P2677A DBIA    Probe Info 
NCIH2286 SNV: p.R924H; p.G2380C .
NCIH446 SNV: p.V907L .
OPM2 SNV: p.F124L .
OVK18 Insertion: p.V1781RfsTer108;p.L2031FfsTer9
SNV: p.Q2538Ter		 DBIA    Probe Info 
REH SNV: p.A2381T .
RKO SNV: p.W3049R DBIA    Probe Info 
RL952 SNV: p.A2601T .
SNGM SNV: p.R662H .
SNU1 SNV: p.R317Q; p.N1253S DBIA    Probe Info 
SUPT1 SNV: p.M1297L DBIA    Probe Info 
SW480 SNV: p.P1872L .
SW756 SNV: p.S2769L DBIA    Probe Info 
TE4 SNV: p.G2300R .
THP1 SNV: p.V1793M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.74  LDD0402  [2]
STPyne
 Probe Info  		K1431(10.00); K1568(6.87); K2112(10.00); K264(8.47)  LDD0277  [3]
BTD
 Probe Info  		C1220(3.33)  LDD1700  [4]
DBIA
 Probe Info  		C1713(1.26); C1717(1.26); C3028(1.03); C1041(1.03)  LDD0078  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		C2813(0.00); C2880(0.00); C1024(0.00); C1220(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C2327(0.00); H911(0.00); C1024(0.00)  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		13.40  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		25.28  LDD1877  [13]
C391
 Probe Info  		13.27  LDD2050  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1041(0.75); C113(0.95); C120(0.95); C1442(1.27)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1041(0.64); C113(1.03); C1137(0.68); C120(1.03)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1041(0.47); C113(0.72); C120(0.72); C1442(0.60)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1041(0.44); C113(0.77); C120(0.77); C1442(0.66)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1041(0.56); C113(0.76); C120(0.76); C1442(0.64)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1041(0.59); C113(0.85); C120(0.85); C1442(0.72)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1041(0.44); C113(0.81); C120(0.81); C1442(0.63)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1041(0.67); C113(0.73); C120(0.73); C1442(0.79)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1041(0.57); C113(0.75); C120(0.75); C1442(0.84)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1041(0.55); C113(0.82); C120(0.82); C1442(0.91)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1041(0.57); C113(0.72); C120(0.72); C1442(0.81)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1041(0.48); C113(0.79); C120(0.79); C1442(0.71)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1041(0.72); C113(0.76); C1137(0.82); C120(0.76)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1041(0.44); C113(0.77); C120(0.77); C1442(0.77)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1041(0.50); C113(0.77); C120(0.77); C1442(0.78)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1041(0.51); C113(0.79); C120(0.79); C1442(0.86)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1041(0.98); C1137(0.91); C1713(1.02); C1717(1.02)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1041(1.08); C1137(0.85); C1713(1.26); C1717(1.26)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1041(0.89); C1137(1.10); C1713(1.36); C1717(1.36)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1041(0.87); C1137(0.99); C1713(1.18); C1717(1.18)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1041(0.88); C1137(1.30); C1713(1.12); C1717(1.12)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1041(1.08); C1137(0.92); C1713(0.96); C1717(0.96)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1041(1.21); C1137(1.35); C1713(0.91); C1717(0.91)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1041(0.66); C113(1.09); C1137(0.73); C120(1.09)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1041(0.82); C1137(1.49); C1713(1.35); C1717(1.35)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1041(0.89); C1137(0.89); C1713(1.00); C1717(1.00)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1041(0.97); C1137(1.11); C1713(0.83); C1717(0.83)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1041(0.92); C1137(0.64); C1713(1.06); C1717(1.06)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1041(1.06); C1137(1.18); C1713(1.02); C1717(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1041(1.02); C1137(0.94); C1713(0.99); C1717(0.99)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1041(0.81); C1137(0.87); C1713(1.00); C1717(1.00)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1041(1.03); C1137(1.11); C1713(0.86); C1717(0.86)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1713(0.69); C1717(0.69); C2224(1.44); C2234(1.44)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1713(0.71); C1717(0.71); C2224(1.28); C2234(1.28)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1713(0.65); C1717(0.65); C2224(1.48); C2234(1.48)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1713(1.13); C1717(1.13); C2224(1.29); C2234(1.29)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1713(0.76); C1717(0.76); C2224(1.16); C2234(1.16)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1713(0.73); C1717(0.73); C2224(1.50); C2234(1.50)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1713(1.37); C1717(1.37); C2224(1.57); C2234(1.57)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1713(0.76); C1717(0.76); C2224(1.71); C2234(1.71)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1713(0.97); C1717(0.97); C2224(1.39); C2234(1.39)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1713(0.98); C1717(0.98); C2224(1.41); C2234(1.41)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1713(1.55); C1717(1.55); C2224(1.34); C2234(1.34)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1713(1.30); C1717(1.30); C2224(1.42); C2234(1.42)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1041(0.60); C113(0.89); C1137(0.70); C120(0.89)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1713(1.48); C1717(1.48); C2224(1.26); C2234(1.26)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1713(1.44); C1717(1.44); C2224(1.36); C2234(1.36)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1713(0.99); C1717(0.99); C2224(1.33); C2234(1.33)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C339(0.87); C1442(0.90); C1443(0.90); C1713(0.96)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C113(0.83); C120(0.83); C339(0.86); C1713(0.88)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C339(0.83); C2880(0.92); C1713(0.93); C1717(0.93)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C339(0.88); C113(0.96); C120(0.96); C1713(1.04)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C339(0.88); C113(0.99); C120(0.99); C2880(1.01)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C2880(0.93); C339(1.11); C1713(1.12); C1717(1.12)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C113(0.93); C120(0.93); C339(0.94); C2880(1.05)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1041(0.49); C113(0.78); C120(0.78); C2142(0.85)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C339(0.87); C113(0.93); C120(0.93); C2880(1.01)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C339(0.81); C113(0.87); C120(0.87); C1442(0.96)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C339(0.87); C2880(1.03); C1442(1.04); C1443(1.04)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1713(1.14); C1717(1.14); C113(1.16); C120(1.16)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C113(1.14); C120(1.14); C1442(1.07); C1443(1.07)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C113(0.91); C120(0.91); C1442(0.90); C1443(0.90)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C113(1.02); C120(1.02); C1442(1.00); C1443(1.00)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C113(1.09); C120(1.09); C1442(0.92); C1443(0.92)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1713(0.56); C1717(0.56); C1442(0.91); C1443(0.91)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C2142(0.46); C1137(0.76); C1207(1.03); C1442(1.04)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C2142(0.66); C1442(0.92); C1443(0.92); C465(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1041(0.86); C339(1.01); C2222(1.02); C2234(1.02)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1442(0.76); C1443(0.76); C1137(0.77); C2142(0.85)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C2142(0.61); C1442(0.75); C1443(0.75); C1713(0.86)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C2142(0.64); C1713(0.68); C1717(0.68); C1207(0.83)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1442(0.79); C1443(0.79); C1207(0.79); C2142(0.82)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1442(0.90); C1443(0.90); C1207(0.92); C1713(0.95)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C113(0.80); C120(0.80); C2234(0.83); C2880(0.85)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C2880(0.86); C113(0.90); C120(0.90); C1442(0.95)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C113(0.94); C120(0.94); C2234(0.97); C1442(0.97)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C2142(0.83); C1041(0.88); C1207(0.93); C113(1.00)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1442(0.90); C1443(0.90); C1041(1.04); C113(1.07)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1041(0.92); C1713(0.96); C1717(0.96); C339(1.00)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1442(0.91); C1443(0.91); C2142(0.91); C1041(0.92)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1442(0.94); C1443(0.94); C2142(0.94); C1041(0.94)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1041(0.84); C1442(0.92); C1443(0.92); C113(0.98)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1041(0.80); C1442(0.93); C1443(0.93); C2234(0.95)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1041(0.81); C1442(0.89); C1443(0.89); C2234(1.00)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1442(0.85); C1443(0.85); C465(0.91); C1137(0.93)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1442(0.88); C1443(0.88); C339(0.90); C1137(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C339(0.85); C1207(0.87); C465(0.94); C1041(0.96)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1207(0.85); C1137(0.91); C1041(0.93); C1442(0.95)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1041(0.99); C1137(1.00); C1207(1.00); C339(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1041(0.82); C1713(0.87); C1717(0.87); C339(1.04)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C339(0.91); C1041(1.01); C2224(1.04); C2234(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C339(0.94); C1207(0.97); C465(0.99); C1041(1.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C339(0.96); C1137(0.96); C1442(1.04); C1443(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1041(0.93); C339(0.99); C465(1.02); C1442(1.09)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C339(0.91); C1041(0.96); C1137(1.01); C465(1.10)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C339(0.94); C1041(0.99); C1207(1.08); C465(1.09)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1713(0.86); C465(0.93); C1137(0.95); C339(1.04)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1713(0.76); C465(0.95); C1137(1.00); C1442(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C1713(0.80); C339(1.01); C1041(1.02); C1137(1.03)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1041(0.58); C1713(0.92); C339(0.96); C1137(1.09)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1041(0.89); C1713(0.93); C1717(0.93); C339(1.03)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C1713(0.91); C1041(0.94); C339(1.03); C1137(1.04)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1041(0.75); C339(1.00); C1713(1.00); C1137(1.07)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1713(0.76); C1041(0.77); C1137(0.93); C339(1.01)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C1041(0.75); C339(0.97); C465(1.01); C1137(1.07)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C1713(0.76); C1041(0.94); C339(1.07); C1442(1.12)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1041(0.82); C1713(1.09); C465(1.09); C339(1.10)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1041(0.72); C1137(0.91); C339(0.99); C1713(0.99)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1442(0.87); C1443(0.87); C1713(0.91); C1717(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1442(0.87); C1443(0.87); C1041(0.98); C113(1.06)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1442(0.94); C1443(0.94); C1041(0.98); C1713(1.01)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1137(0.72); C1041(0.78); C113(0.80); C120(0.80)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1442(0.86); C1443(0.86); C1041(0.90); C113(0.99)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1442(0.86); C1443(0.86); C1041(0.91); C1713(0.91)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1713(0.88); C1717(0.88); C1041(0.98); C1442(1.08)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1713(0.78); C1717(0.78); C1041(0.87); C113(0.93)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1713(0.79); C1717(0.79); C1442(1.11); C1443(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1713(1.00); C1717(1.00); C1041(1.10); C113(1.24)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1713(0.92); C1717(0.92); C1041(1.06); C113(1.19)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1041(1.07); C1713(1.10); C1717(1.10); C113(1.24)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C465(0.92); C339(0.92); C1041(1.08); C1713(1.33)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C339(1.06); C1041(1.09); C465(1.17); C1713(1.27)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1041(0.76); C1137(0.79); C113(0.85); C120(0.85)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C339(1.00); C1713(1.17); C1717(1.17); C1041(1.26)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1713(1.02); C1717(1.02); C339(1.06); C1041(1.19)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C339(1.06); C1041(1.14); C1713(1.22); C1717(1.22)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C339(1.12); C1041(1.53); C1713(1.55); C1717(1.55)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C339(1.11); C1041(1.27); C1713(1.28); C1717(1.28)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C339(1.02); C1041(1.24); C1713(1.55); C1717(1.55)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1713(1.03); C1717(1.03); C339(1.07); C1041(1.19)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C339(1.02); C1041(1.08); C465(1.20); C1713(1.49)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C339(0.97); C1041(1.04); C1713(1.21); C1717(1.21)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C339(1.02); C1041(1.09); C1713(1.17); C1717(1.17)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C2142(0.66); C1137(0.77); C1442(0.79); C1443(0.79)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1041(1.02); C339(1.07); C1713(1.22); C1717(1.22)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C339(0.98); C1041(1.12); C1713(1.62); C1717(1.62)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C339(1.06); C1041(1.57); C1713(1.80); C1717(1.80)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1041(0.90); C339(1.23); C465(1.24); C1713(1.32)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1041(0.91); C465(1.15); C339(1.26); C1713(1.31)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1041(0.87); C465(1.03); C339(1.12); C1713(1.25)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1041(0.95); C465(1.13); C1713(1.15); C1717(1.15)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1041(0.88); C465(1.02); C1713(1.11); C1717(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1041(1.03); C465(1.06); C339(1.16); C1713(1.26)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1041(0.93); C465(1.05); C339(1.10); C1713(1.28)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1713(0.85); C1717(0.85); C465(0.95); C1041(1.05)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1041(0.98); C339(1.24); C465(1.26); C1713(1.28)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C465(1.17); C1041(1.17); C339(1.20); C1713(1.29)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C465(0.96); C1041(1.03); C1713(1.06); C1717(1.06)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1041(0.96); C465(0.98); C1713(1.12); C1717(1.12)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C465(0.85); C1041(0.94); C339(1.02); C1713(1.47)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C465(1.05); C1041(1.07); C339(1.22); C1713(1.48)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1041(0.91); C465(1.15); C339(1.24); C1713(1.29)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1041(0.57); C113(0.78); C120(0.78); C1442(0.84)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C2224(0.49); C1041(0.51); C1442(0.58); C1443(0.58)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1041(0.60); C113(1.21); C1137(0.82); C120(1.21)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1041(0.59); C113(0.74); C120(0.74); C339(0.90)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1041(0.56); C1713(1.00); C339(1.02); C1717(1.03)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 13.56  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C1713(1.26); C1717(1.26); C3028(1.03); C1041(1.03)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C2327(0.00); C1024(0.00); C640(0.00); C339(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C2136(1.63); C2813(0.72)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C2224(0.87); C2234(0.87); C1442(0.92); C1443(0.92)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C339(0.92); C1041(0.96); C113(0.99); C120(0.99)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1041(0.78); C1713(0.93); C1717(0.93); C339(0.96)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1041(0.68); C1137(0.83); C339(0.85); C113(0.98)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1137(0.62); C1041(0.63); C113(0.73); C120(0.73)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C113(0.78); C120(0.78); C2142(0.84); C339(0.93)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1041(0.62); C113(0.87); C120(0.87); C339(0.90)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1713(0.77); C1717(0.77); C2142(0.89); C1442(0.90)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1713(0.80); C1717(0.80); C2142(0.96); C1442(1.01)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1713(0.80); C1717(0.80); C1442(0.92); C1443(0.92)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1713(0.60); C1717(0.60); C1442(0.95); C1443(0.95)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C2142(0.77); C1713(0.82); C1717(0.82); C1442(0.83)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1041(0.79); C339(0.97); C1442(1.13); C1443(1.13)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C2142(0.80); C1207(0.91); C1442(0.93); C1443(0.93)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C2142(0.73); C1442(0.81); C1443(0.81); C1207(0.86)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C2142(0.76); C1442(0.82); C1443(0.82); C2880(0.85)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1041(0.81); C1442(0.84); C1443(0.84); C113(0.85)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1442(0.74); C1443(0.74); C1207(0.91); C113(0.95)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C2142(0.74); C1442(0.81); C1443(0.81); C1041(0.85)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1041(0.88); C2142(0.94); C1442(0.97); C1443(0.97)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C339(0.95); C1041(1.07); C2224(1.27); C2234(1.27)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1442(1.03); C1443(1.03); C339(1.04); C1207(1.05)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1137(0.99); C339(1.01); C465(1.04); C1207(1.07)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1041(0.87); C1717(0.95); C1713(0.97); C1442(1.07)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1207(0.96); C339(0.99); C465(1.03); C1041(1.04)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1041(0.86); C339(0.99); C465(1.08); C1137(1.10)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1041(0.76); C339(1.00); C1137(1.01); C465(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1137(0.76); C1713(0.79); C1041(0.81); C339(0.88)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1713(0.77); C1137(0.82); C1041(0.87); C465(1.10)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1713(0.89); C1717(0.89); C1442(0.90); C1443(0.90)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C465(0.95); C1041(0.97); C113(1.01); C120(1.01)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1442(0.92); C1443(0.92); C1041(0.96); C465(0.98)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1041(1.01); C113(1.06); C120(1.06); C1442(1.06)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1041(0.81); C339(0.91); C1442(1.10); C1443(1.10)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1041(0.79); C1442(0.91); C1443(0.91); C339(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C339(0.89); C1041(0.91); C1442(0.96); C1443(0.96)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C339(0.81); C113(0.91); C120(0.91); C2224(0.98)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C339(0.85); C113(0.92); C120(0.92); C1713(0.98)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C2224(0.83); C2234(0.83); C113(0.89); C120(0.89)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C339(0.96); C113(0.99); C120(0.99); C2880(1.01)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1442(0.83); C1443(0.83); C1041(0.89); C339(0.93)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C339(0.87); C1713(1.04); C1717(1.04); C465(1.08)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C339(0.89); C1041(0.96); C113(1.04); C120(1.04)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C2880(0.71); C1041(0.94); C339(1.25); C113(1.36)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C339(0.91); C2224(0.95); C2234(0.95); C113(0.97)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1041(1.08); C113(1.03); C120(1.03); C1713(0.97)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1041(1.07); C113(0.90); C120(0.90); C1713(1.11)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1041(1.02); C113(0.95); C120(0.95); C1713(1.22)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1041(1.06); C113(0.94); C120(0.94); C1713(1.02)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1041(1.18); C113(1.00); C120(1.00); C1713(1.20)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1041(1.01); C113(1.12); C120(1.12); C1713(0.98)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1041(0.74); C113(1.08); C120(1.08); C1442(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1041(1.29); C113(1.00); C120(1.00); C1713(1.04)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1041(1.00); C1442(0.93); C1443(0.93); C1713(1.02)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1442(1.04); C1443(1.04); C1713(1.59); C1717(1.27)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1442(0.89); C1443(0.89); C1713(2.22); C1717(1.54)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1442(1.06); C1443(1.06); C1713(1.83); C1717(1.33)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1442(1.05); C1443(1.05); C1713(0.80); C1717(0.98)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1442(0.99); C1443(0.99); C1713(1.55); C1717(1.50)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1442(1.16); C1443(1.16); C1713(1.04); C1717(1.19)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1442(1.02); C1443(1.02); C1713(1.27); C1717(1.15)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1041(0.86); C113(1.11); C120(1.11); C1442(0.98)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1442(0.99); C1443(0.99); C1713(1.83); C1717(1.62)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1442(0.93); C1443(0.93); C1713(3.04); C1717(2.04)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1442(1.15); C1443(1.15); C1713(1.65); C1717(1.38)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1442(1.10); C1443(1.10); C1713(1.24); C1717(1.07)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1442(0.97); C1443(0.97); C1713(0.87); C1717(1.02)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1442(1.05); C1443(1.05); C1713(0.74); C1717(0.91)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1041(1.75); C113(0.80); C120(0.80); C1442(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1041(1.03); C113(0.99); C120(0.99); C1442(0.88)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1041(1.41); C113(0.94); C120(0.94); C1442(0.91)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1041(1.49); C113(0.79); C120(0.79); C1442(0.87)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1041(0.99); C113(1.12); C120(1.12); C1442(0.96)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1041(1.27); C113(0.82); C120(0.82); C1442(0.83)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1041(1.26); C113(0.86); C120(0.86); C1442(0.93)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1041(1.50); C113(0.91); C120(0.91); C1442(0.93)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1041(0.73); C113(0.75); C120(0.75); C1442(0.86)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1041(1.00); C113(0.80); C120(0.80); C1442(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1041(0.97); C113(0.84); C120(0.84); C1442(0.92)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1041(0.78); C113(0.85); C120(0.85); C1442(0.89)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1041(0.94); C113(0.85); C120(0.85); C1442(0.82)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1041(0.98); C113(0.77); C120(0.77); C1442(0.94)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1041(0.93); C113(0.82); C120(0.82); C1442(0.94)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1041(1.01); C113(0.87); C120(0.87); C1442(0.99)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1041(1.55); C113(0.92); C120(0.92); C1442(0.85)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1041(1.07); C113(1.44); C120(1.44); C1442(1.06)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1041(0.83); C113(1.02); C120(1.02); C1442(1.01)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1041(0.84); C113(1.03); C120(1.03); C1442(1.13)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1041(1.01); C113(1.12); C120(1.12); C1442(1.11)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1041(0.92); C113(1.05); C120(1.05); C1442(1.08)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1041(1.05); C113(0.99); C120(0.99); C1442(1.25)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1041(0.87); C113(1.24); C120(1.24); C1442(1.01)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1041(0.95); C113(1.15); C120(1.15); C1442(1.18)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1041(0.85); C113(0.74); C120(0.74); C1442(1.11)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1041(1.03); C113(1.19); C120(1.19); C1442(1.06)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1041(0.98); C113(1.05); C120(1.05); C1442(1.04)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1041(0.83); C113(1.05); C120(1.05); C1442(1.08)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1041(1.04); C113(1.34); C120(1.34); C1442(0.97)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1041(0.77); C113(1.05); C120(1.05); C1442(0.91)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1041(1.03); C113(0.88); C120(0.88); C1442(1.03)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1041(0.97); C1713(1.67); C1717(1.37); C2222(1.27)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1041(1.07); C1713(2.65); C1717(1.89); C2222(1.13)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1041(0.93); C1713(1.51); C1717(1.42); C2222(1.31)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1041(0.96); C1713(1.31); C1717(1.19); C2222(1.48)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1041(1.02); C113(1.13); C120(1.13); C1442(1.04)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1041(0.83); C1713(1.08); C1717(1.06); C2222(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1041(0.95); C1713(1.07); C1717(1.04); C2222(1.33)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1041(0.81); C1713(0.92); C1717(0.89); C2222(2.05)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1041(1.02); C1713(1.42); C1717(1.27); C2222(1.71)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1041(0.84); C1713(1.58); C1717(1.45); C2222(1.97)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1041(0.81); C1713(1.98); C1717(1.63); C2222(1.30)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1041(0.94); C1713(1.66); C1717(1.37); C2222(1.31)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1041(0.87); C1713(1.66); C1717(1.34); C2222(1.43)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1041(0.84); C1713(1.62); C1717(1.27); C2222(1.58)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1041(0.88); C1713(1.32); C1717(1.16); C2222(1.88)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1041(0.94); C113(1.07); C120(1.07); C1442(0.89)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1041(0.83); C1713(2.16); C1717(1.66); C2222(1.36)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1041(0.93); C113(1.11); C120(1.11); C1442(1.06)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1041(1.00); C113(1.02); C120(1.02); C1442(0.80)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1041(0.86); C113(1.06); C120(1.06); C1442(0.99)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1041(0.87); C113(0.93); C120(0.93); C1442(1.25)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1041(0.78); C113(0.99); C120(0.99); C1442(0.91)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1041(0.97); C113(0.99); C120(0.99); C1442(1.03)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1041(0.93); C113(0.96); C120(0.96); C1442(0.97)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1041(0.87); C113(1.01); C120(1.01); C1442(1.32)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1041(0.80); C113(1.06); C120(1.06); C1442(1.43)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C2142(1.25); C2880(0.82); C1207(0.88)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C1041(0.93); C113(1.16); C120(1.16); C1442(1.07)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1442(1.19); C1443(1.19); C1713(1.28); C1717(1.43)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C465(1.36); C2222(1.58); C2224(1.58)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C465(1.51); C2222(1.36); C2224(1.36)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C465(1.40); C2222(1.28); C2224(1.28)  LDD0082  [5]
 LDCM0109  NEM HeLa H961(0.00); H886(0.00); H911(0.00); H451(0.00)  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1220(1.27)  LDD2093  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C2142(1.12)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1220(1.03)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2142(0.99)  LDD2109  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1220(2.11)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2142(0.54)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1220(1.43)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2142(1.17); C2909(0.72)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C2142(1.30)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1220(1.05)  LDD2129  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1220(3.33)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1220(1.02); C2142(0.75)  LDD2140  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1220(1.13)  LDD2149  [4]
 LDCM0021  THZ1 HCT 116 C465(1.53)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402