Details of the Target

General Information of Target

Target ID LDTP05789
Target Name DnaJ homolog subfamily C member 3 (DNAJC3)
Gene Name DNAJC3
Gene ID 5611
Synonyms
P58IPK; PRKRI; DnaJ homolog subfamily C member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQF
HAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGK
LDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKI
LEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHEL
SLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPS
IAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAI
QDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQ
WHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHR
SWNSWQGFNPFSSGGPFRFKFHFN
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Uniprot ID
Q13217
Ensemble ID
ENST00000602402.6
HGNC ID
HGNC:9439

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y262(12.87)  LDD0259  [1]
IPM
 Probe Info  		C313(0.00); C315(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y226(8.40); Y284(127.04); Y304(9.47)  LDD3495  [3]
BTD
 Probe Info  		C197(2.42)  LDD1700  [4]
DBIA
 Probe Info  		C197(13.72)  LDD0209  [5]
HHS-482
 Probe Info  		Y262(1.11)  LDD0285  [6]
HHS-475
 Probe Info  		Y262(1.18)  LDD0264  [7]
HHS-465
 Probe Info  		Y262(5.05)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K416(0.00); K117(0.00); K120(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C184(0.00); C329(0.00)  LDD0037  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C258(0.00); C248(0.00); C184(0.00); C329(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.23  LDD1725  [16]
C158
 Probe Info  		8.88  LDD1838  [16]
C391
 Probe Info  		15.14  LDD2050  [16]
STS-1
 Probe Info  		N.A.  LDD0136  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C197(0.32); C313(0.99)  LDD2142  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C197(1.30)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C313(1.01)  LDD0531  [18]
 LDCM0215  AC10 HEK-293T C184(1.06); C315(0.99)  LDD1508  [19]
 LDCM0216  AC100 HCT 116 C313(0.73)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C313(0.80)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C313(0.60)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C313(0.51)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C313(0.55)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C313(0.60)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C313(0.58)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C313(0.51)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C313(0.66)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C313(0.69)  LDD0542  [18]
 LDCM0226  AC11 HEK-293T C184(1.11)  LDD1509  [19]
 LDCM0227  AC110 HCT 116 C313(0.63)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C313(0.67)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C313(0.55)  LDD0546  [18]
 LDCM0230  AC113 PaTu 8988t C184(1.07)  LDD1109  [18]
 LDCM0231  AC114 PaTu 8988t C184(1.07)  LDD1110  [18]
 LDCM0232  AC115 PaTu 8988t C184(1.01)  LDD1111  [18]
 LDCM0233  AC116 PaTu 8988t C184(0.97)  LDD1112  [18]
 LDCM0234  AC117 PaTu 8988t C184(0.95)  LDD1113  [18]
 LDCM0235  AC118 PaTu 8988t C184(1.01)  LDD1114  [18]
 LDCM0236  AC119 PaTu 8988t C184(0.89)  LDD1115  [18]
 LDCM0237  AC12 HEK-293T C329(0.96); C184(0.95); C315(0.86)  LDD1510  [19]
 LDCM0238  AC120 PaTu 8988t C184(0.87)  LDD1117  [18]
 LDCM0239  AC121 PaTu 8988t C184(0.69)  LDD1118  [18]
 LDCM0240  AC122 PaTu 8988t C184(1.07)  LDD1119  [18]
 LDCM0241  AC123 PaTu 8988t C184(0.94)  LDD1120  [18]
 LDCM0242  AC124 PaTu 8988t C184(0.66)  LDD1121  [18]
 LDCM0243  AC125 PaTu 8988t C184(0.90)  LDD1122  [18]
 LDCM0244  AC126 PaTu 8988t C184(1.04)  LDD1123  [18]
 LDCM0245  AC127 PaTu 8988t C184(0.76)  LDD1124  [18]
 LDCM0246  AC128 HCT 116 C313(0.36)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C313(1.20)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C313(0.69)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C313(1.56)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C313(1.11)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C313(0.77)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C313(0.67)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C313(0.73)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C313(0.88)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C313(1.10)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C313(0.84)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C313(0.84)  LDD0575  [18]
 LDCM0259  AC14 HEK-293T C329(1.04); C184(1.07)  LDD1512  [19]
 LDCM0260  AC140 HCT 116 C313(0.66)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C313(0.92)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C313(1.26)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C313(1.05)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C313(0.89)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C313(1.01)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C313(1.03)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C313(0.89)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C313(0.74)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C313(0.88)  LDD0586  [18]
 LDCM0270  AC15 HEK-293T C329(0.93); C184(1.15); C315(0.97)  LDD1513  [19]
 LDCM0271  AC150 HCT 116 C313(0.91)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C313(0.91)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C313(0.87)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C313(0.65)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C313(0.90)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C313(0.80)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C313(0.85)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C313(0.78)  LDD2161  [18]
 LDCM0276  AC17 PaTu 8988t C184(0.85)  LDD1155  [18]
 LDCM0277  AC18 PaTu 8988t C184(0.77)  LDD1156  [18]
 LDCM0278  AC19 PaTu 8988t C184(1.15)  LDD1157  [18]
 LDCM0279  AC2 HCT 116 C313(0.80)  LDD0596  [18]
 LDCM0280  AC20 PaTu 8988t C184(0.87)  LDD1159  [18]
 LDCM0281  AC21 PaTu 8988t C184(1.13)  LDD1160  [18]
 LDCM0282  AC22 PaTu 8988t C184(0.96)  LDD1161  [18]
 LDCM0283  AC23 PaTu 8988t C184(0.92)  LDD1162  [18]
 LDCM0284  AC24 PaTu 8988t C184(0.88)  LDD1163  [18]
 LDCM0285  AC25 PaTu 8988t C184(1.05)  LDD1164  [18]
 LDCM0286  AC26 PaTu 8988t C184(0.97)  LDD1165  [18]
 LDCM0287  AC27 PaTu 8988t C184(1.00)  LDD1166  [18]
 LDCM0288  AC28 PaTu 8988t C184(0.75)  LDD1167  [18]
 LDCM0289  AC29 PaTu 8988t C184(1.07)  LDD1168  [18]
 LDCM0290  AC3 HCT 116 C313(0.88)  LDD0607  [18]
 LDCM0291  AC30 PaTu 8988t C184(1.32)  LDD1170  [18]
 LDCM0292  AC31 PaTu 8988t C184(1.07)  LDD1171  [18]
 LDCM0293  AC32 PaTu 8988t C184(0.77)  LDD1172  [18]
 LDCM0294  AC33 PaTu 8988t C184(0.76)  LDD1173  [18]
 LDCM0295  AC34 PaTu 8988t C184(0.99)  LDD1174  [18]
 LDCM0296  AC35 HEK-293T C184(1.09)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C329(1.01); C184(0.89); C315(0.95)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C184(1.03); C315(1.16)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C329(0.95); C184(1.19)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C329(0.88); C184(1.01); C315(0.93)  LDD1539  [19]
 LDCM0301  AC4 HCT 116 C313(1.01)  LDD0618  [18]
 LDCM0302  AC40 HEK-293T C329(1.08); C184(1.05)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C184(0.84)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C184(1.06); C315(0.99)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C184(0.99)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C329(0.94); C184(0.94); C315(0.89)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C184(1.01); C315(1.10)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C313(0.81)  LDD0906  [18]
 LDCM0309  AC47 HEK-293T C313(0.68)  LDD0907  [18]
 LDCM0310  AC48 HEK-293T C313(1.16)  LDD0908  [18]
 LDCM0311  AC49 HEK-293T C313(1.05)  LDD0909  [18]
 LDCM0312  AC5 HCT 116 C313(0.84)  LDD0629  [18]
 LDCM0313  AC50 HEK-293T C313(0.73)  LDD0911  [18]
 LDCM0314  AC51 HEK-293T C313(0.75)  LDD0912  [18]
 LDCM0315  AC52 HEK-293T C313(0.67)  LDD0913  [18]
 LDCM0316  AC53 HEK-293T C313(1.09)  LDD0914  [18]
 LDCM0317  AC54 HEK-293T C313(0.83)  LDD0915  [18]
 LDCM0318  AC55 HEK-293T C313(0.96)  LDD0916  [18]
 LDCM0319  AC56 HEK-293T C313(0.80)  LDD0917  [18]
 LDCM0320  AC57 HEK-293T C313(0.93)  LDD0918  [18]
 LDCM0321  AC58 HEK-293T C313(0.65)  LDD0919  [18]
 LDCM0322  AC59 HEK-293T C313(0.85)  LDD0920  [18]
 LDCM0323  AC6 HEK-293T C329(1.00); C184(1.04)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C313(0.83)  LDD0922  [18]
 LDCM0325  AC61 HEK-293T C313(0.75)  LDD0923  [18]
 LDCM0326  AC62 HEK-293T C313(0.93)  LDD0924  [18]
 LDCM0327  AC63 HEK-293T C313(0.81)  LDD0925  [18]
 LDCM0328  AC64 HEK-293T C313(1.01)  LDD0926  [18]
 LDCM0329  AC65 HEK-293T C313(0.95)  LDD0927  [18]
 LDCM0330  AC66 HEK-293T C313(0.73)  LDD0928  [18]
 LDCM0331  AC67 HEK-293T C313(0.59)  LDD0929  [18]
 LDCM0332  AC68 HCT 116 C313(0.60)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C313(0.45)  LDD0650  [18]
 LDCM0334  AC7 HEK-293T C329(1.05); C184(1.02); C315(0.97)  LDD1568  [19]
 LDCM0335  AC70 HCT 116 C313(0.39)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C313(0.90)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C313(0.56)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C313(0.33)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C313(0.36)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C313(0.36)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C313(0.39)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C313(0.35)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C313(0.69)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C313(0.70)  LDD0661  [18]
 LDCM0345  AC8 HEK-293T C329(1.06); C184(0.91)  LDD1569  [19]
 LDCM0346  AC80 HCT 116 C313(0.45)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C313(0.79)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C313(0.28)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C313(0.36)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C313(0.37)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C313(0.67)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C313(0.75)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C313(0.84)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C313(0.69)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C313(0.45)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C313(1.47)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C313(0.31)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C313(0.31)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C313(0.63)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C313(0.71)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C313(0.81)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C313(0.46)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C313(0.37)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C313(0.42)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C313(0.74)  LDD0683  [18]
 LDCM0248  AKOS034007472 HEK-293T C184(1.09); C315(1.06)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C184(0.96)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C329(1.00); C184(1.06)  LDD1514  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C313(0.87)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C313(1.18)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C313(0.80)  LDD0686  [18]
 LDCM0370  CL101 HEK-293T C329(0.98); C313(0.95)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C315(1.03)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C184(1.00); C315(0.96)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C184(0.86); C313(0.99)  LDD1577  [19]
 LDCM0374  CL105 PaTu 8988t C184(0.82)  LDD1253  [18]
 LDCM0375  CL106 PaTu 8988t C184(0.99)  LDD1254  [18]
 LDCM0376  CL107 PaTu 8988t C184(0.76)  LDD1255  [18]
 LDCM0377  CL108 PaTu 8988t C184(1.45)  LDD1256  [18]
 LDCM0378  CL109 PaTu 8988t C184(1.01)  LDD1257  [18]
 LDCM0379  CL11 HCT 116 C313(0.94)  LDD0696  [18]
 LDCM0380  CL110 PaTu 8988t C184(1.00)  LDD1259  [18]
 LDCM0381  CL111 PaTu 8988t C184(0.98)  LDD1260  [18]
 LDCM0382  CL112 PaTu 8988t C184(0.87)  LDD1261  [18]
 LDCM0383  CL113 PaTu 8988t C184(1.05)  LDD1262  [18]
 LDCM0384  CL114 PaTu 8988t C184(0.82)  LDD1263  [18]
 LDCM0385  CL115 PaTu 8988t C184(0.80)  LDD1264  [18]
 LDCM0386  CL116 PaTu 8988t C184(1.01)  LDD1265  [18]
 LDCM0387  CL117 HEK-293T C329(1.09); C313(1.02)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C315(0.99)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C184(1.05); C315(1.10)  LDD1593  [19]
 LDCM0390  CL12 HCT 116 C313(0.86)  LDD0707  [18]
 LDCM0391  CL120 HEK-293T C184(0.89); C313(1.04)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C313(0.79)  LDD0990  [18]
 LDCM0393  CL122 HEK-293T C313(0.60)  LDD0991  [18]
 LDCM0394  CL123 HEK-293T C313(0.98)  LDD0992  [18]
 LDCM0395  CL124 HEK-293T C313(1.26)  LDD0993  [18]
 LDCM0396  CL125 HEK-293T C313(0.70)  LDD0994  [18]
 LDCM0397  CL126 HEK-293T C313(1.56)  LDD0995  [18]
 LDCM0398  CL127 HEK-293T C313(1.02)  LDD0996  [18]
 LDCM0399  CL128 HEK-293T C313(0.81)  LDD0997  [18]
 LDCM0400  CL13 HCT 116 C313(0.72)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C313(1.04)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C313(0.69)  LDD0719  [18]
 LDCM0403  CL16 HEK-293T C184(0.93); C313(1.07)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C184(0.93)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C184(1.12); C315(0.87)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C184(1.04)  LDD1610  [19]
 LDCM0407  CL2 HCT 116 C313(1.04)  LDD0724  [18]
 LDCM0408  CL20 HEK-293T C329(0.98); C184(0.95); C315(0.69)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C184(1.12); C315(0.83)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C329(0.93); C184(1.08)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C329(0.97); C184(1.05); C315(0.82)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C329(1.07); C184(0.97)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C329(0.97); C313(1.00)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C315(0.88)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C184(1.09); C315(1.04)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C184(0.98); C313(1.03)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C184(0.89)  LDD1621  [19]
 LDCM0418  CL3 HCT 116 C313(1.49)  LDD0735  [18]
 LDCM0419  CL30 HEK-293T C184(1.18); C315(0.93)  LDD1623  [19]
 LDCM0420  CL31 HCT 116 C313(0.97)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C313(0.93)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C313(0.67)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C313(0.71)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C313(0.58)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C313(0.62)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C313(0.53)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C313(0.63)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C313(0.98)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C313(0.67)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C313(0.75)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C313(0.64)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C313(0.57)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C313(0.62)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C313(0.58)  LDD0752  [18]
 LDCM0436  CL46 PaTu 8988t C184(0.90)  LDD1315  [18]
 LDCM0437  CL47 PaTu 8988t C184(0.91)  LDD1316  [18]
 LDCM0438  CL48 PaTu 8988t C184(1.16)  LDD1317  [18]
 LDCM0439  CL49 PaTu 8988t C184(0.87)  LDD1318  [18]
 LDCM0440  CL5 HCT 116 C313(1.54)  LDD0757  [18]
 LDCM0441  CL50 PaTu 8988t C184(0.61)  LDD1320  [18]
 LDCM0442  CL51 PaTu 8988t C184(0.87)  LDD1321  [18]
 LDCM0443  CL52 PaTu 8988t C184(0.98)  LDD1322  [18]
 LDCM0444  CL53 PaTu 8988t C184(0.55)  LDD1323  [18]
 LDCM0445  CL54 PaTu 8988t C184(0.57)  LDD1324  [18]
 LDCM0446  CL55 PaTu 8988t C184(0.78)  LDD1325  [18]
 LDCM0447  CL56 PaTu 8988t C184(1.07)  LDD1326  [18]
 LDCM0448  CL57 PaTu 8988t C184(0.29)  LDD1327  [18]
 LDCM0449  CL58 PaTu 8988t C184(0.47)  LDD1328  [18]
 LDCM0450  CL59 PaTu 8988t C184(0.32)  LDD1329  [18]
 LDCM0451  CL6 HCT 116 C313(0.97)  LDD0768  [18]
 LDCM0452  CL60 PaTu 8988t C184(0.30)  LDD1331  [18]
 LDCM0453  CL61 HCT 116 C313(0.90)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C313(0.80)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C313(0.94)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C313(0.69)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C313(0.82)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C313(0.94)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C313(0.85)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C313(0.83)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C313(0.71)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C313(0.95)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C313(0.59)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C313(0.59)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C313(0.55)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C313(0.99)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C313(0.74)  LDD0784  [18]
 LDCM0469  CL76 PaTu 8988t C184(1.01)  LDD1348  [18]
 LDCM0470  CL77 PaTu 8988t C184(0.86)  LDD1349  [18]
 LDCM0471  CL78 PaTu 8988t C184(0.88)  LDD1350  [18]
 LDCM0472  CL79 PaTu 8988t C184(1.00)  LDD1351  [18]
 LDCM0473  CL8 HCT 116 C313(1.20)  LDD0790  [18]
 LDCM0474  CL80 PaTu 8988t C184(0.91)  LDD1353  [18]
 LDCM0475  CL81 PaTu 8988t C184(0.72)  LDD1354  [18]
 LDCM0476  CL82 PaTu 8988t C184(0.80)  LDD1355  [18]
 LDCM0477  CL83 PaTu 8988t C184(0.81)  LDD1356  [18]
 LDCM0478  CL84 PaTu 8988t C184(0.60)  LDD1357  [18]
 LDCM0479  CL85 PaTu 8988t C184(0.93)  LDD1358  [18]
 LDCM0480  CL86 PaTu 8988t C184(0.86)  LDD1359  [18]
 LDCM0481  CL87 PaTu 8988t C184(0.56)  LDD1360  [18]
 LDCM0482  CL88 PaTu 8988t C184(0.66)  LDD1361  [18]
 LDCM0483  CL89 PaTu 8988t C184(0.61)  LDD1362  [18]
 LDCM0484  CL9 HCT 116 C313(0.63)  LDD0801  [18]
 LDCM0485  CL90 PaTu 8988t C184(0.67)  LDD1364  [18]
 LDCM0486  CL91 HCT 116 C313(1.04)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C313(1.00)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C313(0.81)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C313(0.86)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C313(0.95)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C313(1.04)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C313(0.91)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C313(1.04)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C313(0.94)  LDD0811  [18]
 LDCM0495  E2913 HEK-293T C184(0.98); C315(1.11)  LDD1698  [19]
 LDCM0468  Fragment33 HCT 116 C313(0.58)  LDD0785  [18]
 LDCM0427  Fragment51 HCT 116 C313(0.41)  LDD0744  [18]
 LDCM0116  HHS-0101 DM93 Y262(1.18)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y262(0.70)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y262(0.95)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y262(0.71)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y262(0.61)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0123  JWB131 DM93 Y262(1.11)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y262(1.20)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y262(1.00)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y262(2.88)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y262(2.72)  LDD0289  [6]
 LDCM0129  JWB202 DM93 Y262(1.32)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y262(1.30)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C329(0.87)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C197(13.72)  LDD0209  [5]
 LDCM0024  KB05 HMCB C258(1.81)  LDD3312  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C197(0.70)  LDD2102  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [13]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C313(2.07)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C197(1.39)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C197(1.21)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C197(0.72)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C197(0.90)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C197(0.50)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C197(1.16); C315(1.19)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C197(1.33)  LDD2108  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C197(1.06)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C313(0.53)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C315(0.47)  LDD2115  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C197(0.90); C315(0.43); C313(0.64)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C197(0.84)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C197(0.85)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C197(0.19)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C197(1.00)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C197(1.01); C315(0.37); C313(0.65)  LDD2128  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C197(0.81)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C197(0.51)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C315(0.82); C313(0.72)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C197(1.10)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C315(0.82)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C197(2.42)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C197(0.85)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C197(0.99)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C197(1.09); C315(0.48); C313(0.53)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C197(3.17); C313(0.98)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C197(0.68)  LDD2145  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C197(1.78); C315(0.60)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C197(0.65)  LDD2148  [4]

References

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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840