Details of the Target

General Information of Target

Target ID LDTP14717
Target Name ATP synthase subunit e, mitochondrial (ATP5ME)
Gene Name ATP5ME
Gene ID 521
Synonyms
ATP5I; ATP5K; ATP synthase subunit e, mitochondrial; ATPase subunit e; ATP synthase membrane subunit e) [Cleaved into: ATP synthase subunit e, mitochondrial, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQSIIKNIWIPMKPYYTKVYQEIWIGMGLMGFIVYKIRAADKRSKALKASAPAPGHH
Target Bioclass
Transporter and channel
Family
ATPase e subunit family
Subcellular location
Mitochondrion
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Uniprot ID
P56385
Ensemble ID
ENST00000304312.5
HGNC ID
HGNC:846

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y32(20.00); Y30(18.34)  LDD0260  [1]
C-Sul
 Probe Info  		5.93  LDD0066  [2]
TH216
 Probe Info  		Y32(15.34)  LDD0259  [1]
STPyne
 Probe Info  		K34(4.17); K50(10.00); K55(7.81)  LDD0277  [3]
AZ-9
 Probe Info  		E60(1.16)  LDD2208  [4]
ONAyne
 Probe Info  		K34(0.00); K48(0.00)  LDD0273  [3]
SF
 Probe Info  		N.A.  LDD0028  [5]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.21  LDD1728  [6]
C040
 Probe Info  		14.12  LDD1740  [6]
C041
 Probe Info  		6.23  LDD1741  [6]
C055
 Probe Info  		14.83  LDD1752  [6]
C056
 Probe Info  		17.39  LDD1753  [6]
C063
 Probe Info  		10.06  LDD1760  [6]
C092
 Probe Info  		18.51  LDD1783  [6]
C094
 Probe Info  		27.67  LDD1785  [6]
C106
 Probe Info  		17.15  LDD1793  [6]
C112
 Probe Info  		21.11  LDD1799  [6]
C134
 Probe Info  		25.99  LDD1816  [6]
C143
 Probe Info  		13.00  LDD1825  [6]
C201
 Probe Info  		24.76  LDD1877  [6]
C210
 Probe Info  		49.87  LDD1884  [6]
C231
 Probe Info  		21.26  LDD1904  [6]
C235
 Probe Info  		22.94  LDD1908  [6]
C238
 Probe Info  		11.55  LDD1911  [6]
C289
 Probe Info  		42.22  LDD1959  [6]
C293
 Probe Info  		17.27  LDD1963  [6]
C343
 Probe Info  		11.63  LDD2005  [6]
C349
 Probe Info  		10.41  LDD2010  [6]
C350
 Probe Info  		38.59  LDD2011  [6]
C355
 Probe Info  		24.59  LDD2016  [6]
C356
 Probe Info  		7.94  LDD2017  [6]
C362
 Probe Info  		34.06  LDD2023  [6]
C388
 Probe Info  		49.18  LDD2047  [6]
C390
 Probe Info  		22.63  LDD2049  [6]
C391
 Probe Info  		16.91  LDD2050  [6]
C407
 Probe Info  		13.45  LDD2064  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587