Details of the Probe

General Information of Probe

Probe ID
LDPC0300
Probe Name
C040
Synonyms
Z4282859628
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 407.4
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C18H20F3N7O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[5-methyl-1-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]pyrazol-3-yl]propanamide
Canonical SMILES
CC1=CC(=NN1CN2C(=CC(=N2)NC(=O)CCC3(N=N3)CCC#C)C)C(F)(F)F
InChI
InChI=1S/C18H20F3N7O/c1-4-5-7-17(25-26-17)8-6-16(29)22-15-10-13(3)28(24-15)11-27-12(2)9-14(23-27)18(19,20)21/h1,9-10H,5-8,11H2,2-3H3,(H,22,24,29)
InChIKey
BYBNOWROURJYCC-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

190 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 8.11  LDD1740 
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 6.82  LDD1740 
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 38.05  LDD1740 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 11.88  LDD1740 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 10.20  LDD1740 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 7.73  LDD1740 
Acid ceramidase (ASAH1) LDTP05905 13.45  LDD1740 
Acyl-CoA 6-desaturase (FADS2) LDTP01699 6.68  LDD1740 
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) LDTP09814 9.78  LDD1740 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 7.57  LDD1740 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 15.03  LDD1740 
Adenosine kinase (ADK) LDTP04689 41.36  LDD1740 
ADP-dependent glucokinase (ADPGK) LDTP11127 19.56  LDD1740 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 31.12  LDD1740 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 13.93  LDD1740 
Atlastin-2 (ATL2) LDTP09251 9.92  LDD1740 
ATP synthase membrane subunit K, mitochondrial (ATP5MK) LDTP10432 9.71  LDD1740 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 7.31  LDD1740 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 9.38  LDD1740 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.21  LDD1740 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 9.99  LDD1740 
ATPase family AAA domain-containing protein 3B (ATAD3B) LDTP07154 9.71  LDD1740 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 8.69  LDD1740 
Beta-galactosidase (GLB1) LDTP02837 10.06  LDD1740 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 12.73  LDD1740 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 27.10  LDD1740 
Calcium-transporting ATPase type 2C member 1 (ATP2C1) LDTP05228 8.11  LDD1740 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 33.36  LDD1740 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 8.00  LDD1740 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 8.11  LDD1740 
Catechol O-methyltransferase (COMT) LDTP03145 14.03  LDD1740 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 19.97  LDD1740 
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) LDTP00416 6.96  LDD1740 
Ceramide synthase 1 (CERS1) LDTP03394 26.91  LDD1740 
Ceramide synthase 2 (CERS2) LDTP10329 30.91  LDD1740 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 11.00  LDD1740 
COP9 signalosome complex subunit 6 (COPS6) LDTP07966 8.57  LDD1740 
Cullin-4A (CUL4A) LDTP05949 6.45  LDD1740 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 41.64  LDD1740 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 41.36  LDD1740 
Cytochrome b5 type B (CYB5B) LDTP00697 36.00  LDD1740 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 16.56  LDD1740 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 29.24  LDD1740 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 7.84  LDD1740 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 22.01  LDD1740 
Dehydrogenase/reductase SDR family member 13 (DHRS13) LDTP15154 8.28  LDD1740 
Dehydrogenase/reductase SDR family member 7B (DHRS7B) LDTP07402 8.51  LDD1740 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 12.47  LDD1740 
Delta(24)-sterol reductase (DHCR24) LDTP06375 13.93  LDD1740 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 11.47  LDD1740 
Diacylglycerol kinase epsilon (DGKE) LDTP04506 23.59  LDD1740 
Diacylglycerol lipase-beta (DAGLB) LDTP09095 13.27  LDD1740 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 8.82  LDD1740 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 23.26  LDD1740 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 11.79  LDD1740 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 15.89  LDD1740 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 10.13  LDD1740 
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) LDTP12757 9.25  LDD1740 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 17.15  LDD1740 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 7.36  LDD1740 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) LDTP13466 10.85  LDD1740 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 15.14  LDD1740 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 13.64  LDD1740 
Epoxide hydrolase 1 (EPHX1) LDTP02175 7.36  LDD1740 
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) LDTP09063 6.82  LDD1740 
Exonuclease 1 (EXO1) LDTP13751 9.19  LDD1740 
Gamma-adducin (ADD3) LDTP13204 10.41  LDD1740 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 6.73  LDD1740 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 6.82  LDD1740 
GPI-anchor transamidase (PIGK) LDTP09835 6.54  LDD1740 
GTP-binding protein SAR1a (SAR1A) LDTP12470 11.79  LDD1740 
GTP-binding protein SAR1b (SAR1B) LDTP14231 12.13  LDD1740 
Heme oxygenase 1 (HMOX1) LDTP02359 66.72  LDD1740 
Heme oxygenase 2 (HMOX2) LDTP03540 54.19  LDD1740 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 26.17  LDD1740 
Hexokinase-2 (HK2) LDTP04531 7.31  LDD1740 
Holocytochrome c-type synthase (HCCS) LDTP04581 7.67  LDD1740 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 22.78  LDD1740 
Ketosamine-3-kinase (FN3KRP) LDTP16025 6.82  LDD1740 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 15.56  LDD1740 
Lathosterol oxidase (SC5D) LDTP01329 10.93  LDD1740 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 18.51  LDD1740 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 18.25  LDD1740 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 14.12  LDD1740 
Lysocardiolipin acyltransferase 1 (LCLAT1) LDTP07679 6.45  LDD1740 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 20.82  LDD1740 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 11.08  LDD1740 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 8.11  LDD1740 
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) LDTP03858 6.36  LDD1740 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.34  LDD1740 
Lysosomal alpha-glucosidase (GAA) LDTP02486 6.45  LDD1740 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 21.11  LDD1740 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 14.52  LDD1740 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) LDTP10930 19.03  LDD1740 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 13.64  LDD1740 
Minor histocompatibility antigen H13 (HM13) LDTP09396 10.27  LDD1740 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 9.78  LDD1740 
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) LDTP10038 16.68  LDD1740 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 8.51  LDD1740 
Mitofusin-1 (MFN1) LDTP08530 7.11  LDD1740 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 9.51  LDD1740 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 7.78  LDD1740 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 10.70  LDD1740 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 30.70  LDD1740 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 54.57  LDD1740 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 48.50  LDD1740 
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) LDTP01515 9.06  LDD1740 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 29.04  LDD1740 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 6.50  LDD1740 
NADH-cytochrome b5 reductase 3 (CYB5R3) LDTP01770 6.36  LDD1740 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 13.55  LDD1740 
NADPH--cytochrome P450 reductase (POR) LDTP02848 9.00  LDD1740 
Neurolysin, mitochondrial (NLN) LDTP11494 17.75  LDD1740 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 13.55  LDD1740 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 17.51  LDD1740 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 13.74  LDD1740 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 12.21  LDD1740 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 6.68  LDD1740 
Phosphatidate cytidylyltransferase 2 (CDS2) LDTP01649 8.22  LDD1740 
Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) LDTP11209 7.62  LDD1740 
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) LDTP12608 8.11  LDD1740 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 8.00  LDD1740 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 11.79  LDD1740 
Phosphatidylserine synthase 2 (PTDSS2) LDTP11284 8.82  LDD1740 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 9.92  LDD1740 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 11.08  LDD1740 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 45.57  LDD1740 
Presenilin-associated rhomboid-like protein, mitochondrial (PARL) LDTP11852 9.99  LDD1740 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 9.32  LDD1740 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 15.45  LDD1740 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 7.57  LDD1740 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 15.45  LDD1740 
Prostaglandin reductase 1 (PTGR1) LDTP06227 8.75  LDD1740 
Prostaglandin reductase 2 (PTGR2) LDTP08979 16.34  LDD1740 
Prostaglandin reductase 3 (PTGR3) LDTP15422 16.80  LDD1740 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 21.86  LDD1740 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 9.19  LDD1740 
Protein farnesyltransferase subunit beta (FNTB) LDTP04247 7.01  LDD1740 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 6.59  LDD1740 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 6.77  LDD1740 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 19.16  LDD1740 
Pseudouridylate synthase RPUSD2 (RPUSD2) LDTP15370 8.28  LDD1740 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 10.20  LDD1740 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 7.73  LDD1740 
Rab-like protein 3 (RABL3) LDTP06986 12.04  LDD1740 
Ras-related protein Rab-10 (RAB10) LDTP04895 6.50  LDD1740 
Ras-related protein Rab-11B (RAB11B) LDTP06501 13.55  LDD1740 
Ras-related protein Rab-1B (RAB1B) LDTP11733 8.69  LDD1740 
Ras-related protein Rab-24 (RAB24) LDTP10020 13.36  LDD1740 
Ras-related protein Rab-2A (RAB2A) LDTP04892 7.46  LDD1740 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 13.55  LDD1740 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 8.69  LDD1740 
Retinol dehydrogenase 13 (RDH13) LDTP09061 11.96  LDD1740 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 7.21  LDD1740 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 8.75  LDD1740 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 16.56  LDD1740 
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) LDTP00890 6.54  LDD1740 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 8.28  LDD1740 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 9.78  LDD1740 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 14.93  LDD1740 
SCY1-like protein 2 (SCYL2) LDTP07529 11.24  LDD1740 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 6.54  LDD1740 
Serine/threonine-protein kinase VRK2 (VRK2) LDTP08378 8.17  LDD1740 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 9.85  LDD1740 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 51.27  LDD1740 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 10.34  LDD1740 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 7.73  LDD1740 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 8.51  LDD1740 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 20.39  LDD1740 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 15.14  LDD1740 
Squalene monooxygenase (SQLE) LDTP06142 19.43  LDD1740 
Squalene synthase (FDFT1) LDTP03842 15.45  LDD1740 
Stearoyl-CoA desaturase (SCD) LDTP00344 14.22  LDD1740 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 7.06  LDD1740 
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) LDTP06455 7.46  LDD1740 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 8.46  LDD1740 
Sulfhydryl oxidase 2 (QSOX2) LDTP07813 7.62  LDD1740 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 11.24  LDD1740 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 7.78  LDD1740 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 14.12  LDD1740 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 10.20  LDD1740 
Ubiquitin carboxyl-terminal hydrolase 28 (USP28) LDTP10785 8.82  LDD1740 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 19.16  LDD1740 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 11.47  LDD1740 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 10.13  LDD1740 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 32.67  LDD1740 
Vesicle transport protein GOT1B (GOLT1B) LDTP13986 8.63  LDD1740 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 13.09  LDD1740 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 16.68  LDD1740 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 6.36  LDD1740 
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⏷ Show the Full List of 190 Enzyme
141 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 11.79  LDD1740 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 17.27  LDD1740 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 9.38  LDD1740 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 7.73  LDD1740 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 10.20  LDD1740 
Amyloid-beta precursor protein (APP) LDTP02071 7.78  LDD1740 
Anoctamin-10 (ANO10) LDTP12704 21.86  LDD1740 
Anoctamin-6 (ANO6) LDTP06855 13.00  LDD1740 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 18.38  LDD1740 
ATP synthase subunit e, mitochondrial (ATP5ME) LDTP14717 14.12  LDD1740 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 38.59  LDD1740 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 7.26  LDD1740 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 9.06  LDD1740 
BRI3-binding protein (BRI3BP) LDTP15648 39.95  LDD1740 
Calcium load-activated calcium channel (TMCO1) LDTP13599 8.88  LDD1740 
Calnexin (CANX) LDTP03405 7.16  LDD1740 
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) LDTP08469 12.21  LDD1740 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 28.44  LDD1740 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 99.73  LDD1740 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 24.42  LDD1740 
Derlin-1 (DERL1) LDTP11245 24.76  LDD1740 
Endophilin-B1 (SH3GLB1) LDTP13953 9.13  LDD1740 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 14.72  LDD1740 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 19.56  LDD1740 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 23.43  LDD1740 
Etoposide-induced protein 2.4 homolog (EI24) LDTP00405 9.58  LDD1740 
Exocyst complex component 1 (EXOC1) LDTP12661 9.45  LDD1740 
Flotillin-1 (FLOT1) LDTP01366 7.94  LDD1740 
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) LDTP00882 9.25  LDD1740 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 29.04  LDD1740 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 8.75  LDD1740 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 11.47  LDD1740 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 10.56  LDD1740 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 8.28  LDD1740 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 9.92  LDD1740 
Importin subunit alpha-1 (KPNA2) LDTP04501 10.70  LDD1740 
Importin-4 (IPO4) LDTP09515 8.00  LDD1740 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 9.45  LDD1740 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 9.51  LDD1740 
Lysosome membrane protein 2 (SCARB2) LDTP06034 25.81  LDD1740 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 6.50  LDD1740 
Magnesium transporter protein 1 (MAGT1) LDTP11732 9.71  LDD1740 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 13.27  LDD1740 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 24.08  LDD1740 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 17.39  LDD1740 
Metal transporter CNNM4 (CNNM4) LDTP07537 6.73  LDD1740 
Metaxin-1 (MTX1) LDTP05900 14.62  LDD1740 
MICOS complex subunit MIC26 (APOO) LDTP11250 8.06  LDD1740 
MICOS complex subunit MIC60 (IMMT) LDTP06660 7.52  LDD1740 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 7.26  LDD1740 
Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) LDTP07439 9.32  LDD1740 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 16.34  LDD1740 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 13.27  LDD1740 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 17.88  LDD1740 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 18.51  LDD1740 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 54.95  LDD1740 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 61.39  LDD1740 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 63.12  LDD1740 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 32.22  LDD1740 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 11.79  LDD1740 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 6.36  LDD1740 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 26.72  LDD1740 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 9.00  LDD1740 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 12.30  LDD1740 
Mitochondrial pyruvate carrier 2 (MPC2) LDTP01631 9.85  LDD1740 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 17.15  LDD1740 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 10.34  LDD1740 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 6.41  LDD1740 
Mpv17-like protein 2 (MPV17L2) LDTP14952 17.63  LDD1740 
Nucleoporin NDC1 (NDC1) LDTP11213 14.42  LDD1740 
Occludin (OCLN) LDTP06581 7.21  LDD1740 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 15.14  LDD1740 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 7.78  LDD1740 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 11.71  LDD1740 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 7.89  LDD1740 
PRA1 family protein 2 (PRAF2) LDTP01060 16.00  LDD1740 
PRA1 family protein 3 (ARL6IP5) LDTP01352 6.41  LDD1740 
Programmed cell death protein 6 (PDCD6) LDTP01180 17.15  LDD1740 
Protein FAM8A1 (FAM8A1) LDTP16190 14.83  LDD1740 
Protein GPR107 (GPR107) LDTP07236 30.06  LDD1740 
Protein RER1 (RER1) LDTP00590 9.65  LDD1740 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 11.55  LDD1740 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 7.57  LDD1740 
Protein tweety homolog 3 (TTYH3) LDTP11615 16.56  LDD1740 
Protein wntless homolog (WLS) LDTP07156 12.04  LDD1740 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 22.78  LDD1740 
Reduced folate transporter (SLC19A1) LDTP03952 7.16  LDD1740 
Reticulon-1 (RTN1) LDTP06633 10.41  LDD1740 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 8.75  LDD1740 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 10.85  LDD1740 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 7.06  LDD1740 
Sideroflexin-2 (SFXN2) LDTP10621 8.28  LDD1740 
Sideroflexin-4 (SFXN4) LDTP07531 20.53  LDD1740 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 20.82  LDD1740 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 24.59  LDD1740 
Sodium bicarbonate cotransporter 3 (SLC4A7) LDTP14275 6.59  LDD1740 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 9.78  LDD1740 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 20.82  LDD1740 
Solute carrier family 25 member 44 (SLC25A44) LDTP15733 13.64  LDD1740 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 15.78  LDD1740 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 9.32  LDD1740 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 12.47  LDD1740 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 6.36  LDD1740 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 20.11  LDD1740 
Stomatin-like protein 2, mitochondrial (STOML2) LDTP13416 6.36  LDD1740 
SUN domain-containing protein 1 (SUN1) LDTP01454 9.00  LDD1740 
SUN domain-containing protein 2 (SUN2) LDTP13256 7.52  LDD1740 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 15.24  LDD1740 
Syntaxin-5 (STX5) LDTP05780 8.88  LDD1740 
Tetraspanin-3 (TSPAN3) LDTP16813 23.75  LDD1740 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 8.82  LDD1740 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 38.59  LDD1740 
Translocation protein SEC62 (SEC62) LDTP15838 10.34  LDD1740 
Translocator protein (TSPO) LDTP03546 11.63  LDD1740 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 99.73  LDD1740 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 8.40  LDD1740 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 12.38  LDD1740 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 13.27  LDD1740 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 10.70  LDD1740 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 6.92  LDD1740 
Transmembrane protein 101 (TMEM101) LDTP15744 8.88  LDD1740 
Transmembrane protein 126A (TMEM126A) LDTP15948 25.99  LDD1740 
Transmembrane protein 14C (TMEM14C) LDTP12979 10.93  LDD1740 
Transmembrane protein 160 (TMEM160) LDTP20002 35.02  LDD1740 
Transmembrane protein 199 (TMEM199) LDTP08881 37.79  LDD1740 
Transmembrane protein 201 (TMEM201) LDTP07058 8.51  LDD1740 
Transmembrane protein 205 (TMEM205) LDTP07667 10.13  LDD1740 
Transmembrane protein 214 (TMEM214) LDTP07477 6.87  LDD1740 
Transmembrane protein 230 (TMEM230) LDTP10065 26.91  LDD1740 
Transmembrane protein 33 (TMEM33) LDTP04787 9.19  LDD1740 
Transmembrane protein 59 (TMEM59) LDTP11406 7.46  LDD1740 
Transmembrane protein 87A (TMEM87A) LDTP15481 20.68  LDD1740 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 20.82  LDD1740 
V-type proton ATPase subunit E 1 (ATP6V1E1) LDTP03811 9.51  LDD1740 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 9.13  LDD1740 
Vang-like protein 1 (VANGL1) LDTP09288 12.91  LDD1740 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 38.32  LDD1740 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 28.44  LDD1740 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 15.03  LDD1740 
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) LDTP11281 11.39  LDD1740 
Wolframin (WFS1) LDTP01380 10.63  LDD1740 
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⏷ Show the Full List of 141 Transporter and channel
3 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 19.03  LDD1740 
SAP30-binding protein (SAP30BP) LDTP13305 6.87  LDD1740 
Y-box-binding protein 1 (YBX1) LDTP05065 8.75  LDD1740 
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3 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 9.71  LDD1740 
Leukocyte surface antigen CD47 (CD47) LDTP05572 7.16  LDD1740 
Neuroplastin (NPTN) LDTP14205 6.59  LDD1740 
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127 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 7.67  LDD1740 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 9.71  LDD1740 
Apolipoprotein L2 (APOL2) LDTP11076 53.45  LDD1740 
Armadillo repeat-containing protein 10 (ARMC10) LDTP08793 9.19  LDD1740 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 13.83  LDD1740 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 10.06  LDD1740 
Calmodulin-3 (CALM3) LDTP02443 9.19  LDD1740 
Calumenin (CALU) LDTP00887 8.57  LDD1740 
Caprin-1 (CAPRIN1) LDTP06121 16.22  LDD1740 
Cell division control protein 45 homolog (CDC45) LDTP01213 7.11  LDD1740 
Centrin-2 (CETN2) LDTP03926 34.78  LDD1740 
Clustered mitochondria protein homolog (CLUH) LDTP14486 11.96  LDD1740 
Coatomer subunit zeta-1 (COPZ1) LDTP04941 7.94  LDD1740 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 7.11  LDD1740 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 11.00  LDD1740 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 38.32  LDD1740 
DDRGK domain-containing protein 1 (DDRGK1) LDTP10403 7.36  LDD1740 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 12.55  LDD1740 
DNA replication complex GINS protein PSF2 (GINS2) LDTP13802 10.56  LDD1740 
DNA replication complex GINS protein SLD5 (GINS4) LDTP11134 7.73  LDD1740 
Dynactin subunit 3 (DCTN3) LDTP01359 14.93  LDD1740 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 11.55  LDD1740 
ELMO domain-containing protein 2 (ELMOD2) LDTP17659 8.69  LDD1740 
Emerin (EMD) LDTP04356 14.83  LDD1740 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 11.55  LDD1740 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 18.51  LDD1740 
Engulfment and cell motility protein 2 (ELMO2) LDTP10469 8.40  LDD1740 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 44.32  LDD1740 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 24.76  LDD1740 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 6.87  LDD1740 
Ganglioside GM2 activator (GM2A) LDTP02927 7.52  LDD1740 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 12.47  LDD1740 
Golgi apparatus protein 1 (GLG1) LDTP09920 7.11  LDD1740 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 19.84  LDD1740 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 13.45  LDD1740 
Golgi to ER traffic protein 4 homolog (GET4) LDTP07964 13.64  LDD1740 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 6.59  LDD1740 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 11.96  LDD1740 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 6.59  LDD1740 
HIG1 domain family member 1A, mitochondrial (HIGD1A) LDTP13797 51.98  LDD1740 
Hippocalcin-like protein 4 (HPCAL4) LDTP13604 6.41  LDD1740 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 8.88  LDD1740 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 8.94  LDD1740 
Integral membrane protein GPR180 (GPR180) LDTP19625 6.92  LDD1740 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 9.58  LDD1740 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 41.93  LDD1740 
Kinetochore protein Spc24 (SPC24) LDTP09069 7.21  LDD1740 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 17.63  LDD1740 
LanC-like protein 2 (LANCL2) LDTP12571 9.38  LDD1740 
Large proline-rich protein BAG6 (BAG6) LDTP04094 9.51  LDD1740 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 34.06  LDD1740 
Lipase maturation factor 2 (LMF2) LDTP15887 7.84  LDD1740 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 20.25  LDD1740 
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) LDTP09644 9.99  LDD1740 
Membralin (TMEM259) LDTP14939 13.74  LDD1740 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 11.00  LDD1740 
MICOS complex subunit MIC27 (APOOL) LDTP07718 8.57  LDD1740 
Mitochondrial fission factor (MFF) LDTP11670 8.51  LDD1740 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 8.82  LDD1740 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 11.47  LDD1740 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 93.05  LDD1740 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 99.73  LDD1740 
Negative elongation factor B (NELFB) LDTP09679 18.90  LDD1740 
Negative elongation factor C/D (NELFCD) LDTP08594 8.28  LDD1740 
Neudesin (NENF) LDTP13630 17.39  LDD1740 
Neuferricin (CYB5D2) LDTP15623 12.64  LDD1740 
Nuclear autoantigenic sperm protein (NASP) LDTP04241 10.56  LDD1740 
Nucleobindin-1 (NUCB1) LDTP05375 43.71  LDD1740 
Nucleobindin-2 (NUCB2) LDTP05160 39.12  LDD1740 
Nucleolar protein 9 (NOP9) LDTP15283 8.69  LDD1740 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 7.31  LDD1740 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 15.78  LDD1740 
OCIA domain-containing protein 2 (OCIAD2) LDTP17157 6.96  LDD1740 
Optic atrophy 3 protein (OPA3) LDTP16006 22.47  LDD1740 
Peroxiredoxin-like 2A (PRXL2A) LDTP11140 8.69  LDD1740 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 10.63  LDD1740 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 22.63  LDD1740 
Prohibitin-2 (PHB2) LDTP10924 15.78  LDD1740 
Proline-rich protein PRCC (PRCC) LDTP09850 8.06  LDD1740 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 7.62  LDD1740 
Protein CEBPZOS (CEBPZOS) LDTP18883 25.99  LDD1740 
Protein FAM114A2 (FAM114A2) LDTP16080 18.64  LDD1740 
Protein FAM162A (FAM162A) LDTP10056 41.36  LDD1740 
Protein FAM177A1 (FAM177A1) LDTP15398 13.36  LDD1740 
Protein FAM3C (FAM3C) LDTP09773 19.29  LDD1740 
Protein Hikeshi (HIKESHI) LDTP06892 14.32  LDD1740 
Protein jagunal homolog 1 (JAGN1) LDTP08904 19.29  LDD1740 
Protein LYRIC (MTDH) LDTP08224 35.75  LDD1740 
Protein unc-119 homolog B (UNC119B) LDTP00105 26.91  LDD1740 
Protein YIF1A (YIF1A) LDTP01494 18.00  LDD1740 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 18.13  LDD1740 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 10.20  LDD1740 
Regulator of microtubule dynamics protein 3 (RMDN3) LDTP10849 7.67  LDD1740 
Reticulocalbin-2 (RCN2) LDTP06097 29.24  LDD1740 
Reticulon-2 (RTN2) LDTP01167 26.17  LDD1740 
Reticulon-3 (RTN3) LDTP01522 41.64  LDD1740 
Reticulon-4 (RTN4) LDTP12412 32.00  LDD1740 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 6.59  LDD1740 
RNA-binding protein EWS (EWSR1) LDTP05318 6.63  LDD1740 
RNA-binding protein FUS (FUS) LDTP03775 7.78  LDD1740 
RUS family member 1 (RUSF1) LDTP10357 12.38  LDD1740 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 15.14  LDD1740 
Small integral membrane protein 12 (SMIM12) LDTP19859 82.71  LDD1740 
Synapse-associated protein 1 (SYAP1) LDTP10062 6.63  LDD1740 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 10.20  LDD1740 
Synaptogyrin-2 (SYNGR2) LDTP00859 18.00  LDD1740 
Syntaxin-10 (STX10) LDTP00986 19.56  LDD1740 
Syntaxin-18 (STX18) LDTP13086 39.12  LDD1740 
Syntaxin-7 (STX7) LDTP00632 7.84  LDD1740 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 8.11  LDD1740 
Tetraspanin-6 (TSPAN6) LDTP14458 19.43  LDD1740 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 9.13  LDD1740 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 34.06  LDD1740 
TraB domain-containing protein (TRABD) LDTP19963 12.13  LDD1740 
Transducin beta-like protein 2 (TBL2) LDTP16285 9.32  LDD1740 
Translocon-associated protein subunit delta (SSR4) LDTP04425 6.50  LDD1740 
Transmembrane emp24 domain-containing protein 4 (TMED4) LDTP08153 6.92  LDD1740 
Transmembrane emp24 domain-containing protein 5 (TMED5) LDTP13967 10.56  LDD1740 
Transmembrane protein 115 (TMEM115) LDTP05685 6.73  LDD1740 
Transmembrane protein 161A (TMEM161A) LDTP12762 7.31  LDD1740 
Transmembrane protein 209 (TMEM209) LDTP18272 6.92  LDD1740 
Transmembrane protein 43 (TMEM43) LDTP11210 7.31  LDD1740 
Trophoblast glycoprotein (TPBG) LDTP05960 13.18  LDD1740 
Type-1 angiotensin II receptor-associated protein (AGTRAP) LDTP07632 8.22  LDD1740 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 13.64  LDD1740 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 10.06  LDD1740 
Vimentin (VIM) LDTP02297 9.45  LDD1740 
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⏷ Show the Full List of 127 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1740 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587