Details of the Target

General Information of Target

Target ID LDTP10059
Target Name PAT complex subunit CCDC47 (CCDC47)
Gene Name CCDC47
Gene ID 57003
Synonyms
PAT complex subunit CCDC47; Calumin; Coiled-coil domain-containing protein 47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPKRAKRRTVEGGSSSVFSMFDQTQIQEFKEAFTVIDQNRDGIIDKEDLRDTFAAMGRL
NVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITGAFKVLDPEGKGTIKKKFL
EELLTTQCDRFSQEEIKNMWAAFPPDVGGNVDYKNICYVITHGDAKDQE
Target Bioclass
Transporter and channel
Family
CCDC47 family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway. Has an essential role in the maintenance of ER organization during embryogenesis.
Uniprot ID
Q96A33
Ensemble ID
ENST00000225726.10
HGNC ID
HGNC:24856

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.E43Q DBIA    Probe Info 
HCC1954 Deletion: p.T92del DBIA    Probe Info 
HCT15 SNV: p.R455M .
IGR1 SNV: p.M1? DBIA    Probe Info 
MOLT4 Deletion: p.A406QfsTer8 IA-alkyne    Probe Info 
OCIAML2 SNV: p.E329D DBIA    Probe Info 
RPMI8226 SNV: p.I150T DBIA    Probe Info 
SW1271 SNV: p.D65N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y293(20.00); Y388(20.00); Y372(9.31)  LDD0260  [1]
ONAyne
 Probe Info  		K419(6.27)  LDD0274  [2]
STPyne
 Probe Info  		K419(4.87)  LDD0277  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
BTD
 Probe Info  		C283(0.77)  LDD2100  [4]
AHL-Pu-1
 Probe Info  		C283(4.87)  LDD0170  [5]
DBIA
 Probe Info  		C209(0.91)  LDD0078  [6]
5E-2FA
 Probe Info  		H332(0.00); H203(0.00)  LDD2235  [7]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C209(0.00); C283(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C283(0.00); C209(0.00)  LDD0037  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		C215(0.00); C209(0.00); C283(0.00); C214(0.00)  LDD0005  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C209(0.00); C283(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 94 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.94  LDD1725  [18]
C022
 Probe Info  		10.85  LDD1728  [18]
C040
 Probe Info  		15.14  LDD1740  [18]
C055
 Probe Info  		14.03  LDD1752  [18]
C056
 Probe Info  		26.54  LDD1753  [18]
C063
 Probe Info  		10.70  LDD1760  [18]
C070
 Probe Info  		9.32  LDD1766  [18]
C091
 Probe Info  		18.00  LDD1782  [18]
C092
 Probe Info  		28.64  LDD1783  [18]
C094
 Probe Info  		37.53  LDD1785  [18]
C095
 Probe Info  		5.24  LDD1786  [18]
C106
 Probe Info  		28.25  LDD1793  [18]
C107
 Probe Info  		5.94  LDD1794  [18]
C112
 Probe Info  		24.93  LDD1799  [18]
C134
 Probe Info  		43.71  LDD1816  [18]
C135
 Probe Info  		11.79  LDD1817  [18]
C141
 Probe Info  		8.88  LDD1823  [18]
C143
 Probe Info  		18.00  LDD1825  [18]
C153
 Probe Info  		18.51  LDD1834  [18]
C159
 Probe Info  		9.38  LDD1839  [18]
C160
 Probe Info  		8.28  LDD1840  [18]
C161
 Probe Info  		19.43  LDD1841  [18]
C166
 Probe Info  		6.96  LDD1846  [18]
C169
 Probe Info  		34.78  LDD1849  [18]
C178
 Probe Info  		20.11  LDD1857  [18]
C187
 Probe Info  		16.11  LDD1865  [18]
C194
 Probe Info  		9.92  LDD1870  [18]
C196
 Probe Info  		13.83  LDD1872  [18]
C198
 Probe Info  		10.56  LDD1874  [18]
C201
 Probe Info  		48.84  LDD1877  [18]
C206
 Probe Info  		16.00  LDD1881  [18]
C210
 Probe Info  		53.45  LDD1884  [18]
C218
 Probe Info  		26.35  LDD1892  [18]
C219
 Probe Info  		6.15  LDD1893  [18]
C220
 Probe Info  		24.25  LDD1894  [18]
C225
 Probe Info  		5.06  LDD1898  [18]
C226
 Probe Info  		5.82  LDD1899  [18]
C228
 Probe Info  		34.30  LDD1901  [18]
C229
 Probe Info  		7.57  LDD1902  [18]
C231
 Probe Info  		37.53  LDD1904  [18]
C232
 Probe Info  		47.84  LDD1905  [18]
C233
 Probe Info  		11.88  LDD1906  [18]
C234
 Probe Info  		7.21  LDD1907  [18]
C235
 Probe Info  		35.51  LDD1908  [18]
C238
 Probe Info  		17.63  LDD1911  [18]
C243
 Probe Info  		13.74  LDD1916  [18]
C246
 Probe Info  		22.01  LDD1919  [18]
C252
 Probe Info  		10.48  LDD1925  [18]
C264
 Probe Info  		21.86  LDD1935  [18]
C265
 Probe Info  		15.03  LDD1936  [18]
C277
 Probe Info  		8.82  LDD1947  [18]
C282
 Probe Info  		14.62  LDD1952  [18]
C285
 Probe Info  		42.22  LDD1955  [18]
C287
 Probe Info  		9.99  LDD1957  [18]
C288
 Probe Info  		6.68  LDD1958  [18]
C289
 Probe Info  		44.02  LDD1959  [18]
C293
 Probe Info  		25.63  LDD1963  [18]
C296
 Probe Info  		18.64  LDD1966  [18]
C299
 Probe Info  		8.40  LDD1968  [18]
C310
 Probe Info  		9.85  LDD1977  [18]
C314
 Probe Info  		13.55  LDD1981  [18]
C322
 Probe Info  		6.15  LDD1988  [18]
C339
 Probe Info  		6.23  LDD2002  [18]
C343
 Probe Info  		15.03  LDD2005  [18]
C349
 Probe Info  		18.51  LDD2010  [18]
C350
 Probe Info  		44.94  LDD2011  [18]
C355
 Probe Info  		33.59  LDD2016  [18]
C356
 Probe Info  		10.27  LDD2017  [18]
C362
 Probe Info  		68.12  LDD2023  [18]
C363
 Probe Info  		21.71  LDD2024  [18]
C364
 Probe Info  		15.67  LDD2025  [18]
C366
 Probe Info  		7.11  LDD2027  [18]
C388
 Probe Info  		99.73  LDD2047  [18]
C390
 Probe Info  		47.18  LDD2049  [18]
C403
 Probe Info  		17.15  LDD2061  [18]
C407
 Probe Info  		18.00  LDD2064  [18]
C413
 Probe Info  		11.96  LDD2069  [18]
C426
 Probe Info  		12.91  LDD2081  [18]
C429
 Probe Info  		12.91  LDD2084  [18]
C431
 Probe Info  		20.97  LDD2086  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		16.70  LDD0477  [19]
FFF probe15
 Probe Info  		5.37  LDD0478  [19]
FFF probe2
 Probe Info  		17.70  LDD0463  [19]
FFF probe3
 Probe Info  		16.23  LDD0464  [19]
FFF probe4
 Probe Info  		12.55  LDD0466  [19]
FFF probe6
 Probe Info  		6.23  LDD0467  [19]
JN0003
 Probe Info  		16.96  LDD0469  [19]
STS-1
 Probe Info  		N.A.  LDD0137  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
A-DA
 Probe Info  		2.38  LDD0145  [22]
OEA-DA
 Probe Info  		20.00  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C215(1.44)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C215(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C283(1.88)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C283(0.89)  LDD2132  [4]
 LDCM0025  4SU-RNA DM93 C283(4.87)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C283(3.07)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C209(0.77); C214(1.00); C215(1.06); C283(1.24)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C209(0.86); C214(0.89); C215(0.89); C283(1.06)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C209(0.83); C214(1.06); C215(1.00); C283(0.67)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C209(0.83); C214(0.91); C215(0.87); C283(0.50)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C209(0.89); C214(0.92); C215(1.00); C283(0.59)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C209(0.70); C214(1.01); C215(0.92); C283(0.51)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C209(0.88); C214(0.99); C215(0.95); C283(0.68)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C209(0.70); C214(0.94); C215(0.95); C283(0.55)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C209(0.80); C214(0.98); C215(0.95); C283(0.53)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C209(0.80); C214(0.95); C215(0.91); C283(0.59)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C209(0.73); C214(1.03); C215(1.06); C283(0.47)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C209(0.81); C214(1.14); C215(1.11); C283(0.60)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C209(0.60); C214(0.85); C215(0.88); C283(0.58)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C209(0.78); C214(0.90); C215(0.90); C283(0.57)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C209(0.72); C214(0.88); C215(0.87); C283(0.57)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C209(0.69); C214(0.89); C215(0.78); C283(0.59)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C209(1.18); C214(1.07); C215(0.98); C283(0.93)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C209(0.87); C214(1.05); C215(0.98); C283(0.99)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C209(0.94); C214(0.97); C215(0.79); C283(1.02)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C209(1.08); C214(0.99); C215(1.05); C283(1.06)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C209(0.74); C214(1.07); C215(0.91); C283(1.20)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C209(0.86); C214(1.06); C215(1.06); C283(1.28)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C209(0.91); C214(0.92); C215(0.99); C283(1.16)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C209(0.87); C214(0.92); C215(0.94); C283(0.98)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C209(0.91); C214(0.90); C215(0.97); C283(1.04)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C209(0.91); C214(1.16); C215(1.16); C283(1.34)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C209(1.00); C214(1.02); C215(1.02); C283(0.84)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C209(0.90); C214(1.15); C215(1.04); C283(1.00)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C209(0.86); C214(1.11); C215(1.18); C283(1.08)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C209(1.11); C214(1.08); C215(1.09); C283(1.13)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C209(0.97); C214(1.12); C215(1.13); C283(0.89)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C209(0.99); C214(1.13); C215(1.11); C283(1.17)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C209(1.89); C214(2.53); C215(2.53); C283(1.33)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C209(1.23); C214(1.62); C215(1.62); C283(1.31)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C209(1.16); C214(1.29); C215(1.29); C283(1.23)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C209(1.81); C214(1.32); C215(1.32); C283(1.16)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C209(0.96); C214(1.16); C215(1.16); C283(0.83)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C209(1.27); C214(1.37); C215(1.37); C283(0.99)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C209(1.11); C214(1.17); C215(1.17); C283(0.85)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C209(1.03); C214(1.18); C215(1.18); C283(0.83)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C209(0.81); C214(0.84); C215(0.84); C283(0.74)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C209(0.78); C214(1.00); C215(1.00); C283(0.75)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C209(0.97); C214(0.86); C215(0.86); C283(0.62)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C209(0.84); C214(0.82); C215(0.82); C283(0.62)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C209(1.07); C214(0.93); C215(0.93); C283(0.91)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C209(0.81); C214(0.88); C215(0.88); C283(0.59)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C209(0.80); C214(0.91); C215(0.91); C283(0.56)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C209(0.81); C214(1.01); C215(1.01); C283(0.82)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C209(0.53); C214(0.94); C215(0.92); C283(0.88)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C209(0.30); C215(1.17); C283(1.18); C214(1.39)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C209(0.58); C283(1.08); C215(1.16); C214(1.16)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C209(0.40); C283(0.91); C215(0.99); C214(1.28)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C209(0.36); C283(0.90); C214(0.96); C215(1.15)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C209(0.27); C215(0.97); C283(1.18); C214(1.44)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C209(0.32); C215(0.90); C283(0.91); C214(1.38)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C209(0.85); C215(0.86); C214(0.87); C283(1.14)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C209(0.60); C215(0.96); C214(1.01); C283(1.04)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C209(0.68); C215(1.06); C214(1.06); C283(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C209(0.55); C215(0.95); C283(1.04); C214(1.17)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C209(0.28); C215(0.76); C214(1.21); C283(1.22)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C209(0.36); C214(1.24); C215(1.11); C283(1.06)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C209(0.45); C214(1.25); C215(1.11); C283(1.05)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C209(0.70); C214(1.13); C215(1.03); C283(1.03)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C209(0.55); C214(1.47); C215(1.36); C283(1.08)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C209(0.90); C215(0.97); C283(1.01); C214(1.03)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C209(0.72); C214(0.83); C215(0.93); C283(1.31)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C209(0.73); C214(0.99); C283(1.05); C215(1.07)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C209(0.75); C214(1.04); C215(1.08); C283(1.27)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C283(0.85); C214(0.96); C215(0.99); C209(1.17)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C209(0.77); C214(0.81); C215(0.87); C283(1.12)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C283(0.82); C214(0.94); C215(0.99); C209(1.05)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C209(0.85); C214(0.97); C215(1.01); C283(1.13)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C283(0.94); C214(0.95); C215(0.98); C209(1.22)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C214(0.90); C215(0.90); C283(1.01); C209(1.14)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C283(0.69); C214(0.83); C215(0.83); C209(1.19)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C283(0.64); C214(0.81); C215(0.81); C209(0.97)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C283(0.63); C214(0.80); C215(0.80); C209(1.00)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C283(0.56); C214(0.77); C215(0.77); C209(1.02)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C209(0.90); C214(1.07); C215(1.11); C283(1.30)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C283(0.52); C214(0.73); C215(0.73); C209(1.21)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C283(0.63); C214(0.83); C215(0.83); C209(1.09)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C283(0.47); C214(0.69); C215(0.69); C209(1.08)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C283(0.69); C214(0.79); C215(0.79); C209(1.00)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C283(0.65); C214(0.80); C215(0.80); C209(1.14)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C214(1.11); C215(1.18)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C215(0.97); C214(0.99)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C214(1.25); C215(1.38)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C214(0.96); C215(0.96)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C214(0.97); C215(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C209(0.74); C214(1.00); C215(1.04); C283(1.48)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C214(0.94); C215(0.95)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C215(0.82); C214(0.82)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C215(0.86); C214(0.89)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C214(0.87); C215(0.89)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C214(1.02); C215(1.09)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C214(1.05); C215(1.15)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C209(0.80); C215(0.88); C214(0.92); C283(0.92)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C209(0.80); C283(0.92); C214(0.98); C215(0.98)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C209(0.50); C215(0.88); C214(0.93); C283(1.01)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C209(0.71); C283(0.71); C215(0.82); C214(0.89)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C209(0.73); C214(1.11); C215(1.17); C283(1.56)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C209(0.67); C283(0.78); C215(0.90); C214(0.93)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C209(0.79); C215(1.01); C214(1.07); C283(1.20)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C209(0.87); C215(0.89); C214(0.93); C283(0.95)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C283(0.74); C209(0.78); C215(0.85); C214(0.89)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C209(0.72); C283(0.90); C215(0.98); C214(1.03)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C283(0.62); C209(0.72); C215(0.93); C214(0.96)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C209(0.66); C283(0.69); C215(0.89); C214(0.94)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C209(0.98); C283(1.12); C214(1.13); C215(1.13)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C209(0.91); C214(0.99); C215(0.99); C283(1.07)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C283(0.85); C214(0.98); C215(0.98); C209(1.26)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C214(0.79); C215(0.79); C209(0.84); C283(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C283(0.75); C214(0.99); C215(0.99); C209(1.38)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C209(0.79); C283(0.98); C214(1.05); C215(1.05)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C283(0.74); C214(0.98); C215(0.98); C209(1.17)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C283(0.72); C214(0.93); C215(0.93); C209(1.33)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C283(0.75); C214(0.96); C215(0.96); C209(1.52)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C209(0.80); C283(0.86); C214(0.94); C215(0.94)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C209(0.64); C283(0.88); C214(0.98); C215(0.98)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C283(0.77); C214(0.92); C215(0.92); C209(0.97)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C283(0.80); C214(1.07); C215(1.07); C209(1.15)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C283(0.72); C209(1.05); C214(1.15); C215(1.15)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C283(0.84); C209(0.86); C214(0.95); C215(0.96)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C283(0.62); C209(0.83); C214(0.96); C215(0.96)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C283(1.08); C214(1.32); C215(1.32); C209(1.39)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C283(0.71); C209(0.97); C214(1.00); C215(1.00)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C283(0.59); C209(0.93); C214(0.99); C215(0.99)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C283(0.60); C209(0.96); C214(1.21); C215(1.21)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C283(0.61); C209(0.91); C214(1.01); C215(1.01)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C283(0.73); C209(0.99); C214(1.22); C215(1.22)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C283(0.68); C209(0.87); C214(0.95); C215(0.95)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C283(0.87); C209(0.94); C214(1.03); C215(1.03)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C283(0.92); C214(1.01); C215(1.01); C209(1.23)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C283(0.76); C215(0.79); C214(0.79); C209(0.79)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C283(0.83); C209(0.89); C214(1.18); C215(1.18)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C214(1.08); C215(1.08); C283(1.26); C209(1.41)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C283(0.70); C209(0.92); C214(1.18); C215(1.18)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C209(0.27); C215(0.70); C283(0.72); C214(0.93)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C209(0.37); C283(0.67); C215(0.75); C214(0.78)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C209(0.33); C283(0.61); C215(0.73); C214(0.80)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C209(0.24); C283(0.71); C215(0.77); C214(1.06)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C209(0.25); C215(0.84); C214(0.92); C283(0.94)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C209(0.25); C215(0.73); C214(0.92); C283(0.95)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C209(0.24); C283(0.69); C215(0.73); C214(0.82)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C209(0.17); C283(0.87); C215(0.91); C214(1.00)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C209(0.30); C283(0.71); C215(0.83); C214(1.02)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C209(0.27); C283(0.68); C215(0.78); C214(1.01)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C209(0.32); C283(0.75); C215(0.83); C214(0.94)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C209(0.51); C283(0.74); C214(0.79); C215(0.86)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C209(0.23); C215(0.90); C283(0.99); C214(1.29)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C209(0.63); C214(0.74); C283(0.75); C215(0.83)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C209(0.22); C283(0.67); C215(0.68); C214(0.83)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C283(0.37); C209(0.52); C215(0.87); C214(1.02)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C283(0.68); C209(0.78); C215(0.90); C214(0.99)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C209(0.84); C214(1.01); C215(1.02); C283(0.88)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C283(0.73); C209(0.76); C214(0.94); C215(0.94)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C209(0.77); C215(0.77); C214(0.78); C283(1.01)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C209(0.91)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C283(0.00); H319(0.00); H422(0.00); C215(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C214(0.91); C215(0.91); C283(1.25); C209(1.38)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C214(0.96); C215(0.96); C283(0.98); C209(0.98)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C209(0.78); C214(0.95); C215(1.01); C283(1.21)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C215(0.84); C214(0.84); C283(1.07); C209(1.11)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C283(0.91); C214(0.98); C215(0.99); C209(1.09)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C283(1.02); C215(1.05); C214(1.06); C209(1.20)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C215(0.96); C214(0.96); C209(1.04); C283(1.05)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C209(0.67); C215(1.13); C214(1.15); C283(1.54)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C209(0.45); C214(1.09); C215(1.20); C283(1.49)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C209(0.67); C215(1.04); C214(1.06); C283(1.35)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C209(0.60); C215(1.09); C214(1.14); C283(1.25)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C209(0.91); C214(0.99); C215(1.03); C283(1.03)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C283(0.86); C209(1.05); C214(1.08); C215(1.08)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C209(0.56); C283(0.99); C215(1.00); C214(1.04)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C209(0.73); C215(0.94); C214(0.95); C283(1.03)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C214(0.87); C215(0.87); C283(0.92); C209(1.21)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C283(0.48); C214(0.74); C215(0.74); C209(1.14)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C283(0.57); C214(0.85); C215(0.85); C209(1.25)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C283(0.61); C214(0.75); C215(0.75); C209(0.98)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C283(0.68); C214(0.78); C215(0.78); C209(1.15)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C215(0.99); C214(0.99)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C215(0.99); C214(1.01)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C215(0.93); C214(0.94)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C283(0.67); C209(0.90); C214(1.04); C215(1.04)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C215(0.83); C214(0.89)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C283(0.80); C209(0.86); C215(0.95); C214(0.99)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C209(0.69); C283(0.78); C215(0.87); C214(0.89)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C283(0.74); C209(0.76); C215(0.87); C214(0.89)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C283(0.69); C209(0.73); C215(0.85); C214(0.90)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C209(0.80); C283(1.01); C214(1.05); C215(1.05)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C214(0.87); C215(0.87); C209(0.92); C283(0.95)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C283(0.81); C214(0.91); C215(0.91); C209(0.94)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C209(0.92); C283(1.24); C214(1.24); C215(1.24)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C283(0.74); C214(0.95); C215(0.95); C209(0.97)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C214(0.96); C215(0.96); C283(1.00); C209(1.08)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C283(0.71); C209(0.96); C214(0.96); C215(0.96)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C283(0.78); C214(0.89); C209(0.93); C215(1.00)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C214(0.80); C215(0.86); C209(0.94); C283(1.22)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C214(0.90); C215(0.90); C283(0.96); C209(1.04)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C214(0.75); C215(0.84); C209(0.84); C283(1.00)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C214(1.01); C215(1.01); C283(1.06); C209(1.23)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C214(0.78); C215(0.82); C283(0.84); C209(0.99)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C209(0.70); C214(0.74); C283(0.86); C215(0.86)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C209(0.78); C214(0.79); C283(0.83); C215(0.93)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C214(0.81); C283(0.83); C215(0.85); C209(1.08)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C283(0.78); C214(0.78); C209(0.83); C215(0.86)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C209(0.85); C214(0.83); C215(0.94); C283(0.66)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C209(1.23); C214(0.81); C215(0.90); C283(0.76)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C209(0.75); C214(0.88); C215(0.98); C283(0.95)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C209(0.74); C214(0.75); C215(0.85); C283(0.70)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C209(1.00); C214(0.74); C215(0.84); C283(0.77)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C209(1.35); C214(1.00); C215(1.00); C283(0.99)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C209(1.06); C214(0.92); C215(1.02); C283(0.85)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C214(0.90); C215(0.85); C283(0.99)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C214(0.86); C215(0.81); C283(0.88)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C214(0.85); C215(0.82); C283(1.00)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C214(0.83); C215(0.78); C283(0.77)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C214(0.82); C215(0.77); C283(0.67)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C214(0.93); C215(0.83); C283(0.73)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C214(0.83); C215(0.78); C283(0.74)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C214(0.82); C215(0.80); C283(0.74)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C209(1.08); C214(0.92); C215(0.92); C283(0.91)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C214(0.92); C215(0.85); C283(0.80)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C214(0.84); C215(0.77); C283(0.80)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C214(0.90); C215(0.82); C283(0.61)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C214(0.86); C215(0.79); C283(0.88)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C214(0.85); C215(0.79); C283(0.81)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C214(0.89); C215(0.83); C283(0.64)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C214(1.06); C215(1.06)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C214(1.01); C215(1.01)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C214(0.98); C215(0.98)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C214(0.96); C215(0.96)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C209(1.17); C214(0.99); C215(0.99); C283(0.90)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C214(1.01); C215(1.01)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C214(0.96); C215(0.96)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C214(0.87); C215(0.87)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C214(0.98); C215(0.98)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C214(0.99); C215(0.99)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C214(1.06); C215(1.06)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C214(0.98); C215(0.98)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C214(1.04); C215(1.04)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C214(1.01); C215(1.01)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C214(1.05); C215(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C209(1.10); C214(0.96); C215(0.96); C283(0.79)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C214(1.04); C215(1.04)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C209(0.80); C214(0.80); C215(0.79)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C209(0.72); C214(0.79); C215(0.73)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C209(0.68); C214(0.72); C215(0.67)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C209(0.67); C214(0.80); C215(0.78)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C209(0.82); C214(0.91); C215(0.86)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C209(0.56); C214(0.79); C215(0.72)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C209(0.93); C214(0.82); C215(0.74)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C209(0.98); C214(0.75); C215(0.67)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C209(0.77); C214(0.76); C215(0.84)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C209(1.03); C214(1.11); C215(1.11); C283(0.68)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C209(0.66); C214(0.76); C215(0.71)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C209(0.82); C214(0.66); C215(0.61)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C209(0.73); C214(0.73); C215(0.68)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C209(1.08); C214(0.77); C215(0.73)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C209(0.91); C214(0.72); C215(0.64)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C209(0.91); C214(1.00); C215(0.91); C283(0.82)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C209(1.10); C214(0.87); C215(0.83); C283(0.90)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C209(0.89); C214(0.94); C215(0.88); C283(0.94)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C209(0.83); C214(0.97); C215(0.92); C283(0.65)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C209(1.17); C214(0.97); C215(0.97); C283(0.56)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C209(0.92); C214(0.92); C215(0.85); C283(0.99)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C209(0.86); C214(1.07); C215(1.00); C283(0.76)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C209(0.90); C214(1.08); C215(1.03); C283(0.58)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C209(0.81); C214(1.07); C215(0.93); C283(0.56)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C209(0.73); C214(0.96); C215(0.89); C283(0.52)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C209(0.94); C214(1.01); C215(0.95); C283(0.82)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C209(0.89); C214(1.08); C215(0.97); C283(0.89)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C209(0.91); C214(1.06); C215(0.99); C283(0.79)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C209(1.00); C214(1.02); C215(0.98); C283(0.62)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C209(0.87); C214(0.92); C215(0.89); C283(0.51)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C209(1.48); C214(0.89); C215(0.89); C283(0.69)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C209(1.16); C214(1.24); C215(1.18); C283(1.16)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C209(0.87); C214(0.92); C215(0.92); C283(1.18)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C209(1.00); C214(1.02); C215(1.02); C283(1.03)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C209(0.90); C214(1.02); C215(1.06); C283(1.33)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C209(0.69); C214(0.99); C215(1.03); C283(1.21)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C209(0.73); C214(0.94); C215(0.92); C283(1.45)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C209(0.82); C214(0.99); C215(1.00); C283(1.26)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C209(0.94); C214(1.01); C215(1.03); C283(1.42)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C209(0.79); C214(1.00); C215(1.03); C283(1.06)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C209(0.75); C214(0.91); C215(0.96); C283(1.26)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C283(1.03); C209(0.94); C214(1.04); C215(1.09)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C209(5.49); C215(4.45); C283(0.86)  LDD1702  [4]
 LDCM0625  F8 Ramos C283(1.40); C209(0.92)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C283(0.79); C209(0.76)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C283(0.38); C209(0.51)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C283(0.94); C209(1.34)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C283(1.00); C209(0.73)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C283(0.97)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C283(0.88)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C283(0.87); C209(0.80)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C283(0.81); C209(0.74)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C283(1.04); C209(0.89)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C283(1.04); C209(0.70)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C283(1.33); C209(0.78)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C209(0.85)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C283(0.84); C209(0.92)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C209(0.77); C214(0.87); C215(0.79)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C283(0.93); C209(0.88)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C283(1.06); C209(1.46)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C214(0.88); C215(0.78); C283(0.62)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C209(0.96)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C283(1.04); C209(0.86)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C283(1.55); C209(1.95)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C283(1.01)  LDD2188  [25]
 LDCM0107  IAA HeLa C215(0.00); C283(0.00)  LDD0221  [14]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HCT 116 C209(1.72)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C209(2.44)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C209(2.12)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C283(0.77)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C283(0.71)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C283(0.92)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C283(0.57)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C283(1.42)  LDD2107  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C283(1.15)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C283(1.66)  LDD2111  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C283(0.61)  LDD2118  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C283(0.38)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C283(0.77); C214(0.50)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C283(1.37)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C283(1.18)  LDD2128  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C283(0.64)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C283(1.63)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C283(1.72)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C283(1.31); C214(0.59)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C283(1.04)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C283(0.72)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C283(2.23)  LDD2144  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C283(0.66)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C215(1.33); C209(1.06)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C209(1.19); C214(0.76); C215(0.76)  LDD2207  [26]
 LDCM0084  Ro 48-8071 A-549 2.38  LDD0145  [22]
 LDCM0111  W14 Hep-G2 C214(1.62)  LDD0238  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
PAT complex subunit Asterix (WDR83OS) Asterix family Q9Y284
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP) . P58753
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 7 (IRF7) IRF family Q92985

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.