Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C339  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 91 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 29.2
 LDTP03842  Squalene synthase (FDFT1) 27.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 26.5
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 26.0
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 25.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 22.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 22.3
 LDTP10329  Ceramide synthase 2 (CERS2) 21.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 20.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 18.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 18.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 16.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 16.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.3
 LDTP05905  Acid ceramidase (ASAH1) 14.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 12.6
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 12.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.6
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 11.1
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 11.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 10.9
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 10.7
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 10.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 10.4
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 10.4
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 10.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.3
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 9.8
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 9.6
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 9.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 8.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 8.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.6
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.4
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 8.3
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 8.3
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.8
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 7.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.5
 LDTP00325  Pirin (PIR) 7.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.3
 LDTP03145  Catechol O-methyltransferase (COMT) 7.2
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 7.1
 LDTP02539  Lysosomal acid phosphatase (ACP2) 7.1
 LDTP00886  Nardilysin (NRDC) 7.0
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 7.0
 LDTP07268  Palmitoyltransferase ZDHHC20 (ZDHHC20) 7.0
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 6.9
 LDTP07292  Metalloreductase STEAP3 (STEAP3) 6.9
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 6.9
 LDTP02837  Beta-galactosidase (GLB1) 6.8
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 6.7
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 6.5
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 6.5
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 6.5
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 6.5
 LDTP00836  ATPase GET3 (GET3) 6.5
 LDTP05409  Antigen peptide transporter 2 (TAP2) 6.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 6.1
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) 6.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 6.1
 LDTP02868  Fumarylacetoacetase (FAH) 6.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 6.1
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 6.0
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 5.9
 LDTP02721  Farnesyl pyrophosphate synthase (FDPS) 5.9
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.8
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 5.7
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 5.7
 LDTP08530  Mitofusin-1 (MFN1) 5.7
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 5.6
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 5.5
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 5.5
 LDTP06142  Squalene monooxygenase (SQLE) 5.4
 LDTP10020  Ras-related protein Rab-24 (RAB24) 5.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 5.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.2
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 5.2
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 5.2
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 5.1
 LDTP06139  Helicase-like transcription factor (HLTF) 5.0
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 5.0
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 5.0
Transporter and channel
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 76.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 37.8
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 36.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 31.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 29.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 26.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 25.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 21.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 21.1
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 18.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 18.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.5
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 16.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 16.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 15.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 15.7
 LDTP15648  BRI3-binding protein (BRI3BP) 15.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 13.5
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.0
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 12.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 12.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 12.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 11.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 11.3
 LDTP11213  Nucleoporin NDC1 (NDC1) 11.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 10.3
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 10.0
 LDTP11245  Derlin-1 (DERL1) 9.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.7
 LDTP07236  Protein GPR107 (GPR107) 9.3
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 9.1
 LDTP05900  Metaxin-1 (MTX1) 8.6
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 8.3
 LDTP12383  Protein GPR108 (GPR108) 7.9
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 7.8
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 7.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.6
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 7.5
 LDTP09203  Nucleoporin Nup37 (NUP37) 7.4
 LDTP01060  PRA1 family protein 2 (PRAF2) 7.3
 LDTP07667  Transmembrane protein 205 (TMEM205) 7.2
 LDTP01366  Flotillin-1 (FLOT1) 7.2
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 7.2
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 6.8
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 6.8
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 6.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 6.2
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 6.2
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 6.1
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 6.0
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 6.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.0
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 5.9
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 5.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 5.7
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 5.7
 LDTP16190  Protein FAM8A1 (FAM8A1) 5.6
 LDTP07058  Transmembrane protein 201 (TMEM201) 5.5
 LDTP10065  Transmembrane protein 230 (TMEM230) 5.4
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 5.3
 LDTP04787  Transmembrane protein 33 (TMEM33) 5.3
 LDTP02071  Amyloid-beta precursor protein (APP) 5.2
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 5.2
 LDTP11250  MICOS complex subunit MIC26 (APOO) 5.1
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 4.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 12.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 8.3
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 77.7
 LDTP11076  Apolipoprotein L2 (APOL2) 58.1
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 37.3
 LDTP08594  Negative elongation factor C/D (NELFCD) 27.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 23.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 22.5
 LDTP01522  Reticulon-3 (RTN3) 19.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 18.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 16.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 14.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 14.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 13.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 12.2
 LDTP00859  Synaptogyrin-2 (SYNGR2) 11.8
 LDTP10056  Protein FAM162A (FAM162A) 11.7
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 11.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 11.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 11.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 10.9
 LDTP16080  Protein FAM114A2 (FAM114A2) 10.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.9
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 9.8
 LDTP12412  Reticulon-4 (RTN4) 9.6
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 9.3
 LDTP19963  TraB domain-containing protein (TRABD) 9.1
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 8.7
 LDTP01932  Prelamin-A/C (LMNA) 8.5
 LDTP05922  Dynactin subunit 2 (DCTN2) 8.5
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 8.3
 LDTP05160  Nucleobindin-2 (NUCB2) 8.2
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.8
 LDTP05375  Nucleobindin-1 (NUCB1) 7.2
 LDTP16285  Transducin beta-like protein 2 (TBL2) 7.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 7.1
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 6.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 6.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 6.7
 LDTP09787  Nicastrin (NCSTN) 6.5
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 6.4
 LDTP09839  Centromere protein I (CENPI) 6.2
 LDTP08224  Protein LYRIC (MTDH) 6.1
 LDTP06097  Reticulocalbin-2 (RCN2) 6.0
 LDTP01638  YEATS domain-containing protein 4 (YEATS4) 5.9
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 5.5
 LDTP12591  Kinesin light chain 4 (KLC4) 5.4
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 5.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 5.2
 LDTP08073  Tetratricopeptide repeat protein 21B (TTC21B) 5.2
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 5.1
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 5.1
 LDTP15623  Neuferricin (CYB5D2) 5.0
 LDTP02297  Vimentin (VIM) 5.0
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587