Details of the Target

General Information of Target

Target ID LDTP00872
Target Name Peroxisomal membrane protein PMP34 (SLC25A17)
Gene Name SLC25A17
Gene ID 10478
Synonyms
PMP34; Peroxisomal membrane protein PMP34; 34 kDa peroxisomal membrane protein; Solute carrier family 25 member 17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEG
LLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT
PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA
IQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPE
NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMG
LKRAHQH
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Cytoplasm
Function
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism.
Uniprot ID
O43808
Ensemble ID
ENST00000435456.7
HGNC ID
HGNC:10987

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y252(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K130(7.50)  LDD0277  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
W1
 Probe Info  		N.A.  LDD0236  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.89  LDD1740  [6]
C056
 Probe Info  		28.84  LDD1753  [6]
C087
 Probe Info  		9.19  LDD1779  [6]
C091
 Probe Info  		12.38  LDD1782  [6]
C092
 Probe Info  		17.75  LDD1783  [6]
C094
 Probe Info  		40.79  LDD1785  [6]
C158
 Probe Info  		11.47  LDD1838  [6]
C161
 Probe Info  		11.39  LDD1841  [6]
C228
 Probe Info  		22.47  LDD1901  [6]
C231
 Probe Info  		11.88  LDD1904  [6]
C235
 Probe Info  		25.11  LDD1908  [6]
C238
 Probe Info  		10.93  LDD1911  [6]
C246
 Probe Info  		12.64  LDD1919  [6]
C282
 Probe Info  		16.56  LDD1952  [6]
C284
 Probe Info  		22.63  LDD1954  [6]
C287
 Probe Info  		8.69  LDD1957  [6]
C289
 Probe Info  		29.45  LDD1959  [6]
C299
 Probe Info  		6.87  LDD1968  [6]
C338
 Probe Info  		20.39  LDD2001  [6]
C339
 Probe Info  		5.98  LDD2002  [6]
C349
 Probe Info  		8.63  LDD2010  [6]
C362
 Probe Info  		52.35  LDD2023  [6]
C363
 Probe Info  		30.06  LDD2024  [6]
C364
 Probe Info  		17.39  LDD2025  [6]
C366
 Probe Info  		8.75  LDD2027  [6]
C367
 Probe Info  		5.66  LDD2028  [6]
C388
 Probe Info  		62.68  LDD2047  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587