Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C299  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 110 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 54.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 36.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 23.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 23.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 23.1
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 23.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.9
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 21.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 19.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 18.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 18.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 18.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 17.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 17.1
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 17.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 15.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.2
 LDTP00836  ATPase GET3 (GET3) 14.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 13.8
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 13.7
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 13.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 13.1
 LDTP10329  Ceramide synthase 2 (CERS2) 12.4
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 12.0
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 11.8
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.6
 LDTP06986  Rab-like protein 3 (RABL3) 11.2
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 10.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 10.6
 LDTP03145  Catechol O-methyltransferase (COMT) 10.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 10.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 9.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 9.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.4
 LDTP04689  Adenosine kinase (ADK) 9.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 8.9
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 8.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.8
 LDTP04531  Hexokinase-2 (HK2) 8.8
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 8.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.8
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 8.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.6
 LDTP02505  Lysosomal protective protein (CTSA) 8.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.4
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 8.2
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 8.2
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.1
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.8
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 7.7
 LDTP02569  Glucose-6-phosphate 1-dehydrogenase (G6PD) 7.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.6
 LDTP03787  Choline kinase alpha (CHKA) 7.6
 LDTP06617  Ceramide glucosyltransferase (UGCG) 7.6
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 7.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.4
 LDTP05905  Acid ceramidase (ASAH1) 7.3
 LDTP10286  Corrinoid adenosyltransferase MMAB (MMAB) 7.3
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 7.3
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 7.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 7.3
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 7.2
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.2
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 7.2
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 7.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 7.1
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 7.0
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 7.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.9
 LDTP10020  Ras-related protein Rab-24 (RAB24) 6.9
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.8
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 6.7
 LDTP06371  GTP-binding protein Rheb (RHEB) 6.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.7
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 6.7
 LDTP06142  Squalene monooxygenase (SQLE) 6.7
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 6.6
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 6.6
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 6.6
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 6.5
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 6.4
 LDTP12154  MYG1 exonuclease (MYG1) 6.4
 LDTP12702  DNA-directed RNA polymerase III subunit RPC2 (POLR3B) 6.4
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 6.4
 LDTP14427  Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) 6.3
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.3
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 6.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.3
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 6.3
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 6.3
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) 6.3
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 6.2
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 6.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 6.1
 LDTP09053  Xyloside xylosyltransferase 1 (XXYLT1) 6.1
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 6.1
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 6.0
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 6.0
 LDTP11733  Ras-related protein Rab-1B (RAB1B) 6.0
 LDTP01769  Dihydrofolate reductase (DHFR) 5.9
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 5.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.9
 LDTP07683  Carboxylesterase 3 (CES3) 5.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 5.8
 LDTP14801  Di-N-acetylchitobiase (CTBS) 5.8
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 5.7
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 5.7
Transporter and channel
Click to Show/Hide to Show 82 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 94.4
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 62.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 35.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 31.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 31.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 29.7
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 29.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 27.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 25.3
 LDTP09180  Zinc transporter 7 (SLC30A7) 25.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 22.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 21.1
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 21.0
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 18.6
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 17.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 16.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 16.1
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 16.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.9
 LDTP15648  BRI3-binding protein (BRI3BP) 15.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 15.1
 LDTP07236  Protein GPR107 (GPR107) 14.3
 LDTP11245  Derlin-1 (DERL1) 13.5
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 13.5
 LDTP02215  Prosaposin (PSAP) 13.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 11.9
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 11.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 11.7
 LDTP15481  Transmembrane protein 87A (TMEM87A) 10.7
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 10.2
 LDTP05900  Metaxin-1 (MTX1) 9.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 9.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 9.3
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 8.9
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 8.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 8.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.7
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 8.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 8.6
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 8.4
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.3
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.3
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 8.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.1
 LDTP10065  Transmembrane protein 230 (TMEM230) 7.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.8
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 7.6
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 7.5
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 7.3
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 7.3
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 7.3
 LDTP11615  Protein tweety homolog 3 (TTYH3) 7.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 7.3
 LDTP14140  Ceramide transfer protein (CERT1) 7.2
 LDTP01804  ATP synthase subunit a (MT-ATP6) 6.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 6.9
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 6.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.8
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 6.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 6.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.7
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 6.6
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 6.6
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 6.4
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 6.3
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 6.2
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 6.1
 LDTP07667  Transmembrane protein 205 (TMEM205) 6.1
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 6.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 6.0
 LDTP01380  Wolframin (WFS1) 5.9
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 5.9
 LDTP07361  Bridge-like lipid transfer protein family member 3A (BLTP3A) 5.9
 LDTP12451  Integral membrane protein 2C (ITM2C) 5.8
 LDTP14970  Metaxin-3 (MTX3) 5.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 5.8
 LDTP03869  Protein Mpv17 (MPV17) 5.7
 LDTP03380  Stomatin (STOM) 5.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.7
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 12.2
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 12.3
Other
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 82.7
 LDTP16078  Heme-binding protein 1 (HEBP1) 81.0
 LDTP11076  Apolipoprotein L2 (APOL2) 37.5
 LDTP18883  Protein CEBPZOS (CEBPZOS) 25.8
 LDTP05160  Nucleobindin-2 (NUCB2) 24.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 18.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 17.9
 LDTP14939  Membralin (TMEM259) 16.8
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 16.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 15.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 15.3
 LDTP01522  Reticulon-3 (RTN3) 15.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 14.3
 LDTP04558  Arfaptin-1 (ARFIP1) 13.8
 LDTP19963  TraB domain-containing protein (TRABD) 13.8
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 12.8
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 12.7
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 12.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 12.1
 LDTP10056  Protein FAM162A (FAM162A) 12.1
 LDTP05375  Nucleobindin-1 (NUCB1) 11.7
 LDTP13086  Syntaxin-18 (STX18) 11.4
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 10.9
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.6
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 10.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 9.7
 LDTP12412  Reticulon-4 (RTN4) 9.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.1
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 8.9
 LDTP14192  MORF4 family-associated protein 1 (MRFAP1) 8.8
 LDTP01167  Reticulon-2 (RTN2) 8.7
 LDTP16285  Transducin beta-like protein 2 (TBL2) 8.6
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 8.4
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 7.7
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 7.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 7.6
 LDTP10357  RUS family member 1 (RUSF1) 7.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 7.0
 LDTP08224  Protein LYRIC (MTDH) 6.6
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 6.5
 LDTP15398  Protein FAM177A1 (FAM177A1) 6.5
 LDTP08094  Wings apart-like protein homolog (WAPL) 6.1
 LDTP15283  Nucleolar protein 9 (NOP9) 6.0
 LDTP10452  Conserved oligomeric Golgi complex subunit 3 (COG3) 6.0
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 6.0
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 5.9
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 5.7
 LDTP13630  Neudesin (NENF) 5.7
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 5.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587