Details of the Target

General Information of Target

Target ID LDTP00262
Target Name Acetyl-coenzyme A transporter 1 (SLC33A1)
Gene Name SLC33A1
Gene ID 9197
Synonyms
ACATN; AT1; Acetyl-coenzyme A transporter 1; AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN
Target Type
Patented-recorded
Target Bioclass
Transporter and channel
Family
SLC33A transporter family
Subcellular location
Endoplasmic reticulum membrane
Function
Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1. Necessary for O-acetylation of gangliosides.
TTD ID
T11791
Uniprot ID
O00400
DrugMap ID
TTLJKZ0
Ensemble ID
ENST00000359479.7
HGNC ID
HGNC:95
ChEMBL ID
CHEMBL3638338

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C479(0.60); C487(0.60)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 61 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.01  LDD1725  [5]
C055
 Probe Info  		11.63  LDD1752  [5]
C056
 Probe Info  		17.03  LDD1753  [5]
C106
 Probe Info  		29.04  LDD1793  [5]
C107
 Probe Info  		8.17  LDD1794  [5]
C108
 Probe Info  		14.32  LDD1795  [5]
C112
 Probe Info  		22.94  LDD1799  [5]
C130
 Probe Info  		10.85  LDD1812  [5]
C152
 Probe Info  		13.36  LDD1833  [5]
C153
 Probe Info  		21.56  LDD1834  [5]
C169
 Probe Info  		24.42  LDD1849  [5]
C178
 Probe Info  		33.82  LDD1857  [5]
C183
 Probe Info  		5.78  LDD1861  [5]
C201
 Probe Info  		44.94  LDD1877  [5]
C206
 Probe Info  		21.11  LDD1881  [5]
C213
 Probe Info  		14.83  LDD1887  [5]
C218
 Probe Info  		18.90  LDD1892  [5]
C219
 Probe Info  		6.36  LDD1893  [5]
C220
 Probe Info  		25.99  LDD1894  [5]
C225
 Probe Info  		5.70  LDD1898  [5]
C226
 Probe Info  		10.48  LDD1899  [5]
C228
 Probe Info  		17.63  LDD1901  [5]
C231
 Probe Info  		19.29  LDD1904  [5]
C232
 Probe Info  		33.82  LDD1905  [5]
C233
 Probe Info  		10.56  LDD1906  [5]
C234
 Probe Info  		15.56  LDD1907  [5]
C235
 Probe Info  		19.29  LDD1908  [5]
C238
 Probe Info  		16.00  LDD1911  [5]
C240
 Probe Info  		8.40  LDD1913  [5]
C246
 Probe Info  		12.47  LDD1919  [5]
C285
 Probe Info  		39.67  LDD1955  [5]
C286
 Probe Info  		7.84  LDD1956  [5]
C287
 Probe Info  		19.70  LDD1957  [5]
C288
 Probe Info  		17.88  LDD1958  [5]
C289
 Probe Info  		67.18  LDD1959  [5]
C290
 Probe Info  		7.41  LDD1960  [5]
C293
 Probe Info  		45.89  LDD1963  [5]
C296
 Probe Info  		22.47  LDD1966  [5]
C297
 Probe Info  		9.99  LDD1967  [5]
C299
 Probe Info  		18.64  LDD1968  [5]
C305
 Probe Info  		13.93  LDD1974  [5]
C327
 Probe Info  		10.06  LDD1991  [5]
C333
 Probe Info  		7.11  LDD1996  [5]
C338
 Probe Info  		15.14  LDD2001  [5]
C339
 Probe Info  		5.86  LDD2002  [5]
C349
 Probe Info  		9.51  LDD2010  [5]
C357
 Probe Info  		5.43  LDD2018  [5]
C362
 Probe Info  		84.45  LDD2023  [5]
C363
 Probe Info  		52.71  LDD2024  [5]
C364
 Probe Info  		65.80  LDD2025  [5]
C366
 Probe Info  		13.93  LDD2027  [5]
C367
 Probe Info  		8.63  LDD2028  [5]
C383
 Probe Info  		12.38  LDD2042  [5]
C386
 Probe Info  		9.99  LDD2045  [5]
C388
 Probe Info  		40.22  LDD2047  [5]
C407
 Probe Info  		13.83  LDD2064  [5]
C409
 Probe Info  		6.63  LDD2066  [5]
FFF probe11
 Probe Info  		14.63  LDD0471  [6]
FFF probe13
 Probe Info  		20.00  LDD0475  [6]
STS-2
 Probe Info  		N.A.  LDD0138  [7]
OEA-DA
 Probe Info  		20.00  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C479(0.60); C487(0.60)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C479(0.51); C487(0.51)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C479(0.47); C487(0.47)  LDD1105  [1]
 LDCM0230  AC113 HEK-293T C479(1.03); C487(1.00)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C479(1.06); C487(1.05)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C479(0.98); C487(1.03)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C479(1.09); C487(1.17)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C479(0.78); C487(0.86)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C479(0.90); C487(1.04)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C479(0.73); C487(0.83)  LDD0834  [1]
 LDCM0237  AC12 PaTu 8988t C479(0.57); C487(0.57)  LDD1116  [1]
 LDCM0238  AC120 HEK-293T C479(0.77); C487(0.86)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C479(0.69); C487(0.78)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C479(0.66); C487(0.80)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C479(0.61); C487(0.76)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C479(0.76); C487(0.85)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C479(0.71); C487(0.82)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C479(0.59); C487(0.76)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C479(0.63); C487(0.80)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C479(0.90); C487(0.90)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C479(0.74); C487(0.74)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C479(0.79); C487(0.79)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C479(0.83); C487(0.83)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C479(0.89); C487(0.89)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C479(0.74); C487(0.74)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C479(0.76); C487(0.76)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C479(0.96); C487(0.96)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C479(0.85); C487(0.85)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C479(0.75); C487(0.75)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C479(0.83); C487(0.83)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C479(0.71); C487(0.71)  LDD0856  [1]
 LDCM0259  AC14 PaTu 8988t C479(0.86); C487(0.86)  LDD1138  [1]
 LDCM0260  AC140 HEK-293T C479(0.84); C487(0.84)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C479(0.76); C487(0.76)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C479(0.74); C487(0.74)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C479(0.87)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C479(1.27)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C479(1.07)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C479(1.17)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C479(1.00)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C479(0.95)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C479(1.08)  LDD0867  [1]
 LDCM0270  AC15 PaTu 8988t C479(0.68); C487(0.68)  LDD1149  [1]
 LDCM0271  AC150 HEK-293T C479(1.15)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C479(0.93)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C479(0.80)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C479(0.91)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C479(0.82)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C479(0.97)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C479(0.97)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C479(1.40)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C479(0.92); C487(0.92)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C479(0.74); C487(0.74)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C479(0.95); C487(0.95)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C479(0.77); C487(0.77)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C479(1.14); C487(1.14)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C479(0.88); C487(0.88)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C479(1.06); C487(1.06)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C479(0.89); C487(0.89)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C479(1.29); C487(1.29)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C479(1.01); C487(1.01)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C479(0.91); C487(0.91)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C479(0.90); C487(0.90)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C479(0.94); C487(0.94)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C479(0.93); C487(0.93)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C479(1.02); C487(1.02)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C479(0.83); C487(0.83)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C479(0.81); C487(0.81)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C479(0.76); C487(0.76)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C479(0.81); C487(0.81)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C479(0.60); C487(0.60)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C479(1.54); C487(1.54)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C479(1.50); C487(1.50)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C479(1.27); C487(1.27)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C479(1.33); C487(1.33)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C479(1.18); C487(1.18)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C479(0.69); C487(0.69)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C479(0.84); C487(0.84)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C479(1.33); C487(1.33)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C479(1.03); C487(1.03)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C479(1.22); C487(1.22)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C479(1.11); C487(1.11)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C479(0.95); C487(0.95)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C479(1.17); C487(1.17)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C479(0.92); C487(0.92)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C479(0.94); C487(0.94)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C479(0.48); C487(0.48)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C479(0.76); C487(0.76)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C479(0.53); C487(0.53)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C479(2.17); C487(2.17)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C479(1.23); C487(1.23)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C479(0.68); C487(0.68)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C479(0.65); C487(0.65)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C479(0.49); C487(0.49)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C479(0.32); C487(0.32)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C479(0.91); C487(0.89)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C479(0.97); C487(1.09)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C479(0.98); C487(0.83)  LDD0920  [1]
 LDCM0323  AC6 PaTu 8988t C479(0.80); C487(0.80)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C479(1.18); C487(0.89)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C479(0.85); C487(0.81)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C479(1.18); C487(0.87)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C479(0.97); C487(0.84)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C479(1.24); C487(1.10)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C479(0.97); C487(0.81)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C479(1.32); C487(0.72)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C479(1.15); C487(0.78)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C479(1.07)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C479(1.10)  LDD0931  [1]
 LDCM0334  AC7 PaTu 8988t C479(1.20); C487(1.20)  LDD1213  [1]
 LDCM0335  AC70 HEK-293T C479(0.91)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C479(0.83)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C479(0.54)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C479(0.72)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C479(0.73)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C479(0.67)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C479(0.53)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C479(0.64)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C479(0.78)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C479(0.70)  LDD0942  [1]
 LDCM0345  AC8 PaTu 8988t C479(0.89); C487(0.89)  LDD1224  [1]
 LDCM0346  AC80 HEK-293T C479(0.59)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C479(0.62)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C479(0.63)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C479(0.95); C487(1.01)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C479(1.04); C487(1.23)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C479(1.04); C487(1.08)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C479(0.90); C487(0.93)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C479(1.14); C487(1.08)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C479(1.40); C487(1.25)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C479(1.27); C487(1.38)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C479(0.83); C487(1.03)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C479(1.06); C487(1.06)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C479(1.23); C487(1.15)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C479(1.09); C487(1.02)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C479(1.24); C487(1.30)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C479(1.07); C487(1.24)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C479(0.97); C487(1.12)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C479(1.33); C487(1.55)  LDD0962  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C479(0.61); C487(0.61)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C479(0.56); C487(0.56)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C479(0.74); C487(0.74)  LDD1154  [1]
 LDCM0367  CL1 HEK-293T C479(0.84); C487(0.84)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C479(0.95); C487(0.83)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C479(0.69); C487(0.69)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C479(0.81); C487(0.81)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C479(0.82); C487(0.82)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C479(0.40); C487(0.40)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C479(0.74); C487(0.74)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C479(0.86); C487(0.86)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C479(0.55); C487(0.55)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C479(0.61); C487(0.61)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C479(0.55); C487(0.55)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C479(0.75); C487(0.75)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C479(1.01); C487(1.11)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C479(0.69); C487(0.69)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C479(0.79); C487(0.79)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C479(1.09); C487(1.09)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C479(0.69); C487(0.69)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C479(0.92); C487(0.92)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C479(0.81); C487(0.81)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C479(0.80); C487(0.80)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C479(0.47); C487(0.47)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C479(1.10); C487(1.10)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C479(0.96); C487(0.96)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C479(0.93); C487(1.20)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C479(1.34); C487(1.34)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C479(1.30); C487(1.30)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C479(0.97); C487(0.97)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C479(0.63); C487(0.63)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C479(0.62); C487(0.62)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C479(0.74); C487(0.72)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C479(0.74); C487(0.73)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C479(1.01); C487(1.08)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C479(0.95); C487(0.95)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C479(1.05); C487(0.77)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C479(0.73); C487(0.75)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C479(0.87); C487(1.07)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C479(0.82); C487(0.82)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C479(0.69); C487(0.69)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C479(0.72); C487(0.72)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C479(0.81); C487(0.81)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C479(0.81); C487(0.97)  LDD1005  [1]
 LDCM0408  CL20 HCT 116 C479(0.57); C487(0.57)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C479(0.44); C487(0.44)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C479(0.27); C487(0.27)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C479(0.58); C487(0.58)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C479(0.45); C487(0.45)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C479(0.46); C487(0.46)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C479(0.68); C487(0.68)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C479(0.77); C487(0.77)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C479(0.51); C487(0.51)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C479(0.59); C487(0.59)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C479(1.21); C487(0.85)  LDD1016  [1]
 LDCM0419  CL30 HCT 116 C479(0.93); C487(0.93)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C479(0.85); C487(0.85)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C479(0.82); C487(0.82)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C479(0.76); C487(0.76)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C479(0.49); C487(0.49)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C479(0.51); C487(0.51)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C479(0.49); C487(0.49)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C479(0.48); C487(0.48)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C479(0.46); C487(0.46)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C479(1.08); C487(0.96)  LDD1027  [1]
 LDCM0430  CL40 HCT 116 C479(0.61); C487(0.61)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C479(0.53); C487(0.53)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C479(0.31); C487(0.31)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C479(0.44); C487(0.44)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C479(0.52); C487(0.52)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C479(0.56); C487(0.56)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C479(1.11); C487(1.09)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C479(1.07); C487(1.08)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C479(0.93); C487(0.91)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C479(1.12); C487(0.89)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C479(0.84); C487(0.97)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C479(1.03); C487(0.99)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C479(0.75); C487(0.92)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C479(0.90); C487(0.83)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C479(1.46); C487(2.11)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C479(1.20); C487(1.36)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C479(0.85); C487(0.98)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C479(1.03); C487(1.13)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C479(0.84); C487(0.92)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C479(0.88); C487(0.94)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C479(0.95); C487(0.93)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C479(1.08); C487(1.02)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C479(0.99); C487(1.01)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C479(0.80); C487(0.80)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C479(1.02); C487(1.02)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C479(0.73); C487(0.73)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C479(0.58); C487(0.58)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C479(0.99); C487(0.99)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C479(0.42); C487(0.42)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C479(0.58); C487(0.58)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C479(0.66); C487(0.66)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C479(0.83); C487(0.83)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C479(1.04); C487(1.06)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C479(0.76); C487(0.76)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C479(0.60); C487(0.60)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C479(1.19); C487(1.19)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C479(0.68); C487(0.68)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C479(0.62); C487(0.62)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C479(1.38); C487(1.38)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C479(0.83); C487(0.83)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C479(1.16); C487(1.16)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C479(0.78); C487(0.78)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C479(1.18); C487(1.50)  LDD1071  [1]
 LDCM0474  CL80 HCT 116 C479(1.20); C487(1.20)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C479(0.98); C487(0.98)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C479(0.59); C487(0.59)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C479(0.65); C487(0.65)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C479(0.69); C487(0.69)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C479(0.99); C487(0.99)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C479(1.33); C487(1.33)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C479(1.02); C487(1.02)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C479(0.76); C487(0.76)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C479(0.49); C487(0.49)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C479(0.72); C487(1.21)  LDD1082  [1]
 LDCM0485  CL90 HCT 116 C479(1.49); C487(1.49)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C479(0.66); C487(0.66)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C479(0.79); C487(0.79)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C479(0.68); C487(0.68)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C479(0.79); C487(0.79)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C479(0.64); C487(0.64)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C479(0.80); C487(0.80)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C479(0.66); C487(0.66)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C479(0.61); C487(0.61)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C479(0.67); C487(0.67)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C479(0.68); C487(0.68)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C479(0.38); C487(0.38)  LDD0744  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
[14c]Acetylcoa Small molecular drug D0K0FZ
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us8592431, 181 Small molecular drug D0TI5Y
Us8592431, 185 Small molecular drug D0Z5GO
Us8592431, 457 Small molecular drug D0K8EF

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570