Details of the Probe

General Information of Probe

Probe ID
LDPC0562
Probe Name
C339
Synonyms
Z4225969224
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 344.31
Lipid-water partition coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C17H14F2N4O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-5-(2,5-difluorophenyl)-1,2-oxazole-3-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=NOC(=C2)C3=C(C=CC(=C3)F)F
InChI
InChI=1S/C17H14F2N4O2/c1-2-3-6-17(22-23-17)7-8-20-16(24)14-10-15(25-21-14)12-9-11(18)4-5-13(12)19/h1,4-5,9-10H,3,6-8H2,(H,20,24)
InChIKey
USAHAJRHVNJJOD-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

91 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 19.97  LDD2002 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 8.88  LDD2002 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 5.17  LDD2002 
Acid ceramidase (ASAH1) LDTP05905 14.12  LDD2002 
Acylamino-acid-releasing enzyme (APEH) LDTP02693 6.06  LDD2002 
ADP-dependent glucokinase (ADPGK) LDTP11127 8.00  LDD2002 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 11.63  LDD2002 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 5.21  LDD2002 
Antigen peptide transporter 2 (TAP2) LDTP05409 6.15  LDD2002 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 6.06  LDD2002 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 10.41  LDD2002 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 9.13  LDD2002 
ATPase GET3 (GET3) LDTP00836 6.45  LDD2002 
Beta-galactosidase (GLB1) LDTP02837 6.77  LDD2002 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 7.26  LDD2002 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 8.28  LDD2002 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 8.40  LDD2002 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 5.21  LDD2002 
Catechol O-methyltransferase (COMT) LDTP03145 7.21  LDD2002 
Ceramide synthase 2 (CERS2) LDTP10329 21.41  LDD2002 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 12.21  LDD2002 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 22.32  LDD2002 
Cytochrome b5 type B (CYB5B) LDTP00697 29.24  LDD2002 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 12.55  LDD2002 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 8.82  LDD2002 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 5.90  LDD2002 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 9.65  LDD2002 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 10.93  LDD2002 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 5.82  LDD2002 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 10.34  LDD2002 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.34  LDD2002 
Epimerase family protein SDR39U1 (SDR39U1) LDTP16070 6.92  LDD2002 
Epoxide hydrolase 1 (EPHX1) LDTP02175 18.51  LDD2002 
Farnesyl pyrophosphate synthase (FDPS) LDTP02721 5.90  LDD2002 
Ferrochelatase, mitochondrial (FECH) LDTP03198 11.00  LDD2002 
Fumarylacetoacetase (FAH) LDTP02868 6.06  LDD2002 
Helicase-like transcription factor (HLTF) LDTP06139 5.03  LDD2002 
Heme oxygenase 1 (HMOX1) LDTP02359 22.47  LDD2002 
Heme oxygenase 2 (HMOX2) LDTP03540 20.82  LDD2002 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 8.57  LDD2002 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 11.55  LDD2002 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 6.96  LDD2002 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 16.45  LDD2002 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 5.10  LDD2002 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 6.11  LDD2002 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 9.78  LDD2002 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 7.11  LDD2002 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 10.70  LDD2002 
Lysosomal acid phosphatase (ACP2) LDTP02539 7.11  LDD2002 
Lysosomal alpha-glucosidase (GAA) LDTP02486 5.62  LDD2002 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 10.48  LDD2002 
Metalloreductase STEAP3 (STEAP3) LDTP07292 6.92  LDD2002 
Minor histocompatibility antigen H13 (HM13) LDTP09396 8.34  LDD2002 
Mitochondrial intermediate peptidase (MIPEP) LDTP10981 4.96  LDD2002 
Mitofusin-1 (MFN1) LDTP08530 5.66  LDD2002 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 10.70  LDD2002 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 5.17  LDD2002 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 18.64  LDD2002 
NADPH--cytochrome P450 reductase (POR) LDTP02848 8.34  LDD2002 
Nardilysin (NRDC) LDTP00886 7.01  LDD2002 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 17.15  LDD2002 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 5.58  LDD2002 
Palmitoyltransferase ZDHHC20 (ZDHHC20) LDTP07268 6.96  LDD2002 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 7.52  LDD2002 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 5.74  LDD2002 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 6.87  LDD2002 
Pirin (PIR) LDTP00325 7.46  LDD2002 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 6.50  LDD2002 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 7.84  LDD2002 
Presequence protease, mitochondrial (PITRM1) LDTP07003 6.02  LDD2002 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 6.54  LDD2002 
Prostaglandin reductase 3 (PTGR3) LDTP15422 5.74  LDD2002 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 15.35  LDD2002 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 11.08  LDD2002 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 8.63  LDD2002 
Ras-related protein Rab-24 (RAB24) LDTP10020 5.28  LDD2002 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 25.46  LDD2002 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 6.06  LDD2002 
Retinol dehydrogenase 13 (RDH13) LDTP09061 5.54  LDD2002 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 10.41  LDD2002 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 6.54  LDD2002 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 26.54  LDD2002 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 16.11  LDD2002 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 4.96  LDD2002 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 7.52  LDD2002 
Squalene monooxygenase (SQLE) LDTP06142 5.39  LDD2002 
Squalene synthase (FDFT1) LDTP03842 27.10  LDD2002 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 25.99  LDD2002 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 5.50  LDD2002 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 6.68  LDD2002 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 6.54  LDD2002 
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⏷ Show the Full List of 91 Enzyme
68 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 5.86  LDD2002 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 11.79  LDD2002 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 5.82  LDD2002 
Amyloid-beta precursor protein (APP) LDTP02071 5.17  LDD2002 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 9.99  LDD2002 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 15.67  LDD2002 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 5.66  LDD2002 
BRI3-binding protein (BRI3BP) LDTP15648 15.56  LDD2002 
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) LDTP08469 6.82  LDD2002 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 7.57  LDD2002 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 18.77  LDD2002 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 11.31  LDD2002 
Derlin-1 (DERL1) LDTP11245 9.71  LDD2002 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 17.51  LDD2002 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 17.03  LDD2002 
Flotillin-1 (FLOT1) LDTP01366 7.16  LDD2002 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 7.16  LDD2002 
Lysosome membrane protein 2 (SCARB2) LDTP06034 12.73  LDD2002 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 5.70  LDD2002 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 15.67  LDD2002 
Metaxin-1 (MTX1) LDTP05900 8.57  LDD2002 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 6.82  LDD2002 
MICOS complex subunit MIC26 (APOO) LDTP11250 5.10  LDD2002 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 7.57  LDD2002 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 5.28  LDD2002 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 13.00  LDD2002 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 76.64  LDD2002 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD2002 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 6.02  LDD2002 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 6.15  LDD2002 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 6.23  LDD2002 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 4.92  LDD2002 
Mpv17-like protein 2 (MPV17L2) LDTP14952 29.86  LDD2002 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 8.34  LDD2002 
Nucleoporin NDC1 (NDC1) LDTP11213 11.00  LDD2002 
Nucleoporin Nup37 (NUP37) LDTP09203 7.36  LDD2002 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 6.23  LDD2002 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 12.82  LDD2002 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 5.98  LDD2002 
PRA1 family protein 2 (PRAF2) LDTP01060 7.31  LDD2002 
Protein FAM8A1 (FAM8A1) LDTP16190 5.58  LDD2002 
Protein GPR107 (GPR107) LDTP07236 9.32  LDD2002 
Protein GPR108 (GPR108) LDTP12383 7.94  LDD2002 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 5.17  LDD2002 
Protein tweety homolog 3 (TTYH3) LDTP11615 16.34  LDD2002 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 10.27  LDD2002 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 13.55  LDD2002 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 7.78  LDD2002 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 11.63  LDD2002 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 26.35  LDD2002 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 6.73  LDD2002 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 31.56  LDD2002 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 12.73  LDD2002 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 9.13  LDD2002 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 36.76  LDD2002 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 18.25  LDD2002 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 21.71  LDD2002 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 9.71  LDD2002 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 7.52  LDD2002 
Transmembrane protein 126A (TMEM126A) LDTP15948 37.79  LDD2002 
Transmembrane protein 201 (TMEM201) LDTP07058 5.50  LDD2002 
Transmembrane protein 205 (TMEM205) LDTP07667 7.21  LDD2002 
Transmembrane protein 230 (TMEM230) LDTP10065 5.35  LDD2002 
Transmembrane protein 33 (TMEM33) LDTP04787 5.28  LDD2002 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 16.22  LDD2002 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 25.63  LDD2002 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 21.11  LDD2002 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 5.98  LDD2002 
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⏷ Show the Full List of 68 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 12.55  LDD2002 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 8.28  LDD2002 
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54 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 6.82  LDD2002 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 15.14  LDD2002 
Apolipoprotein L2 (APOL2) LDTP11076 58.08  LDD2002 
Centromere protein I (CENPI) LDTP09839 6.23  LDD2002 
Clustered mitochondria protein homolog (CLUH) LDTP14486 16.00  LDD2002 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 5.46  LDD2002 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 22.47  LDD2002 
Dynactin subunit 2 (DCTN2) LDTP05922 8.46  LDD2002 
Dynactin subunit 3 (DCTN3) LDTP01359 7.06  LDD2002 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 10.93  LDD2002 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 37.27  LDD2002 
Ganglioside GM2 activator (GM2A) LDTP02927 6.68  LDD2002 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 5.10  LDD2002 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 12.21  LDD2002 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 11.31  LDD2002 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 5.24  LDD2002 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 9.32  LDD2002 
Kinesin light chain 4 (KLC4) LDTP12591 5.43  LDD2002 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 8.69  LDD2002 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 5.35  LDD2002 
Large proline-rich protein BAG6 (BAG6) LDTP04094 9.92  LDD2002 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 9.85  LDD2002 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 11.31  LDD2002 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 77.71  LDD2002 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 13.27  LDD2002 
Negative elongation factor C/D (NELFCD) LDTP08594 27.67  LDD2002 
Neuferricin (CYB5D2) LDTP15623 5.03  LDD2002 
Nicastrin (NCSTN) LDTP09787 6.54  LDD2002 
Nucleobindin-1 (NUCB1) LDTP05375 7.21  LDD2002 
Nucleobindin-2 (NUCB2) LDTP05160 8.22  LDD2002 
Optic atrophy 3 protein (OPA3) LDTP16006 6.82  LDD2002 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 5.06  LDD2002 
Prelamin-A/C (LMNA) LDTP01932 8.51  LDD2002 
Protein CEBPZOS (CEBPZOS) LDTP18883 14.12  LDD2002 
Protein FAM114A2 (FAM114A2) LDTP16080 10.41  LDD2002 
Protein FAM162A (FAM162A) LDTP10056 11.71  LDD2002 
Protein LYRIC (MTDH) LDTP08224 6.06  LDD2002 
Protein unc-119 homolog B (UNC119B) LDTP00105 14.32  LDD2002 
Reticulocalbin-2 (RCN2) LDTP06097 5.98  LDD2002 
Reticulon-3 (RTN3) LDTP01522 19.16  LDD2002 
Reticulon-4 (RTN4) LDTP12412 9.65  LDD2002 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 11.31  LDD2002 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 4.92  LDD2002 
Small ribosomal subunit protein eS24 (RPS24) LDTP05012 6.36  LDD2002 
Synaptogyrin-2 (SYNGR2) LDTP00859 11.79  LDD2002 
Tetraspanin-6 (TSPAN6) LDTP14458 23.43  LDD2002 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 5.21  LDD2002 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 8.34  LDD2002 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 7.84  LDD2002 
TraB domain-containing protein (TRABD) LDTP19963 9.13  LDD2002 
Transducin beta-like protein 2 (TBL2) LDTP16285 7.16  LDD2002 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 18.25  LDD2002 
Vimentin (VIM) LDTP02297 4.96  LDD2002 
YEATS domain-containing protein 4 (YEATS4) LDTP01638 5.86  LDD2002 
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⏷ Show the Full List of 54 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2002 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587