Details of the Target

General Information of Target

Target ID LDTP06291
Target Name ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)
Gene Name ARL6IP1
Gene ID 23204
Synonyms
ARL6IP; ARMER; KIAA0069; ADP-ribosylation factor-like protein 6-interacting protein 1; ARL-6-interacting protein 1; Aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLIIY
YLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAV
GWWKRLFTLKEEKPKMYFMTMIVSLAAVAWVGQQVHNLLLTYLIVTSLLLLPGLNQHGII
LKYIGMAKREINKLLKQKEKKNE
Target Bioclass
Other
Family
ARL6ip family
Subcellular location
Endomembrane system
Function
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Uniprot ID
Q15041
Ensemble ID
ENST00000304414.12
HGNC ID
HGNC:697

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y183(20.00)  LDD0260  [1]
TH216
 Probe Info  		Y183(20.00)  LDD0259  [1]
ONAyne
 Probe Info  		K188(0.51); K96(10.00)  LDD0274  [2]
BTD
 Probe Info  		C109(2.52)  LDD1700  [3]
Jackson_14
 Probe Info  		2.63  LDD0123  [4]
DBIA
 Probe Info  		C109(1.08)  LDD0531  [5]
ATP probe
 Probe Info  		K114(0.00); K96(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NHS
 Probe Info  		N.A.  LDD0010  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		C109(0.00); H106(0.00)  LDD0217  [11]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.67  LDD1740  [14]
C053
 Probe Info  		6.59  LDD1751  [14]
C055
 Probe Info  		12.73  LDD1752  [14]
C056
 Probe Info  		30.91  LDD1753  [14]
C070
 Probe Info  		9.45  LDD1766  [14]
C072
 Probe Info  		8.57  LDD1768  [14]
C091
 Probe Info  		11.88  LDD1782  [14]
C092
 Probe Info  		20.39  LDD1783  [14]
C094
 Probe Info  		50.91  LDD1785  [14]
C100
 Probe Info  		5.58  LDD1789  [14]
C112
 Probe Info  		22.94  LDD1799  [14]
C134
 Probe Info  		23.10  LDD1816  [14]
C153
 Probe Info  		27.10  LDD1834  [14]
C160
 Probe Info  		7.01  LDD1840  [14]
C161
 Probe Info  		10.27  LDD1841  [14]
C169
 Probe Info  		19.84  LDD1849  [14]
C194
 Probe Info  		13.45  LDD1870  [14]
C198
 Probe Info  		13.00  LDD1874  [14]
C201
 Probe Info  		33.82  LDD1877  [14]
C210
 Probe Info  		45.57  LDD1884  [14]
C218
 Probe Info  		17.15  LDD1892  [14]
C220
 Probe Info  		18.90  LDD1894  [14]
C228
 Probe Info  		18.51  LDD1901  [14]
C238
 Probe Info  		12.38  LDD1911  [14]
C246
 Probe Info  		18.25  LDD1919  [14]
C278
 Probe Info  		81.57  LDD1948  [14]
C282
 Probe Info  		16.56  LDD1952  [14]
C284
 Probe Info  		21.71  LDD1954  [14]
C285
 Probe Info  		20.53  LDD1955  [14]
C287
 Probe Info  		8.88  LDD1957  [14]
C289
 Probe Info  		43.41  LDD1959  [14]
C314
 Probe Info  		15.45  LDD1981  [14]
C338
 Probe Info  		13.09  LDD2001  [14]
C339
 Probe Info  		6.82  LDD2002  [14]
C343
 Probe Info  		33.36  LDD2005  [14]
C346
 Probe Info  		10.41  LDD2007  [14]
C350
 Probe Info  		50.56  LDD2011  [14]
C362
 Probe Info  		76.64  LDD2023  [14]
C363
 Probe Info  		25.11  LDD2024  [14]
C364
 Probe Info  		21.71  LDD2025  [14]
C366
 Probe Info  		7.73  LDD2027  [14]
C367
 Probe Info  		5.82  LDD2028  [14]
C388
 Probe Info  		53.82  LDD2047  [14]
C390
 Probe Info  		26.54  LDD2049  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C109(0.38)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C109(0.50)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C109(1.07)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C109(0.94)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C109(1.20)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C109(0.59)  LDD2132  [3]
 LDCM0214  AC1 HCT 116 C109(1.08)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C109(1.29)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C109(0.95)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C109(1.20)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C109(0.93)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C109(0.97)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C109(1.07)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C109(1.20)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C109(1.07)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C109(1.08)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C109(0.95)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C109(1.18)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C109(1.04)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C109(0.88)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C109(1.00)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C109(0.88)  LDD0827  [5]
 LDCM0237  AC12 HCT 116 C109(1.37)  LDD0554  [5]
 LDCM0246  AC128 HCT 116 C109(1.24)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C109(0.94)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C109(1.32)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C109(1.16)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C109(1.04)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C109(1.06)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C109(1.04)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C109(0.84)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C109(1.07)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C109(0.91)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C109(0.79)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C109(0.98)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C109(1.27)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C109(0.96)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C109(0.83)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C109(1.13)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C109(1.03)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C109(1.21)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C109(1.31)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C109(1.27)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C109(1.33)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C109(1.11)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C109(0.99)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C109(1.41)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C109(1.29)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C109(1.24)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C109(1.16)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C109(1.22)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C109(1.29)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C109(1.55)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C109(1.45)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C109(1.40)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C109(1.02)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C109(0.89)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C109(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C109(1.20)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C109(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C109(0.91)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C109(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C109(1.00)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C109(1.01)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C109(0.78)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C109(0.62)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C109(0.89)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C109(0.80)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C109(0.77)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C109(1.31)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C109(0.71)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C109(0.72)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C109(0.78)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C109(0.76)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C109(0.82)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C109(1.12)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C109(1.00)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C109(1.50)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C109(0.97)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C109(1.02)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C109(1.45)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C109(1.10)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C109(0.85)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C109(0.86)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C109(0.73)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C109(1.25)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C109(1.11)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C109(0.68)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C109(0.54)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C109(0.62)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C109(0.82)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C109(1.45)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C109(0.66)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C109(0.56)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C109(0.60)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C109(0.70)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C109(0.54)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C109(0.63)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C109(0.67)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C109(1.18)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C109(1.15)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C109(1.29)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C109(1.08)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C109(1.25)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C109(1.33)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C109(1.26)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C109(1.43)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C109(1.53)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C109(1.17)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C109(1.15)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C109(1.15)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C109(1.14)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C109(1.43)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C109(1.19)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C109(1.23)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C109(1.54)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C109(1.27)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C109(1.26)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C109(1.38)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C109(1.06)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C109(1.16)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C109(1.24)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C109(1.22)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C109(1.39)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C109(1.08)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C109(1.23)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C109(1.55)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C109(1.37)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C109(0.68)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C109(0.66)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C109(0.75)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C109(0.67)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C109(0.72)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C109(0.73)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C109(0.72)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C109(0.71)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C109(0.70)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C109(0.67)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C109(0.77)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C109(0.85)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C109(0.81)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C109(0.80)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C109(0.84)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C109(0.94)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C109(1.11)  LDD0964  [5]
 LDCM0545  Acetamide MDA-MB-231 C109(1.43)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C109(0.50)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C109(1.24)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C109(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C109(1.29)  LDD0592  [5]
 LDCM0498  BS-3668 MDA-MB-231 C109(0.99)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C109(0.00); H106(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C109(0.66)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C109(0.85)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C109(1.00)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C109(0.97)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C109(1.10)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C109(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C109(1.25)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C109(1.12)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C109(1.03)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C109(1.03)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C109(1.03)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C109(1.29)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C109(0.85)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C109(0.90)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C109(1.22)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C109(0.91)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C109(0.79)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C109(0.72)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C109(0.59)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C109(0.67)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C109(0.72)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C109(0.91)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C109(0.86)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C109(0.91)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C109(0.99)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C109(0.84)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C109(0.67)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C109(0.67)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C109(0.69)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C109(0.76)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C109(1.11)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C109(1.11)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C109(1.32)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C109(1.34)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C109(0.86)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C109(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C109(0.94)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C109(0.91)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C109(0.97)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C109(0.95)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C109(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C109(1.18)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C109(0.86)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C109(0.95)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C109(0.95)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C109(0.84)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C109(0.95)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C109(1.01)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C109(0.79)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C109(0.95)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C109(0.91)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C109(0.87)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C109(1.10)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C109(0.98)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C109(0.91)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C109(0.81)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C109(0.79)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C109(0.94)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C109(0.82)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C109(0.92)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C109(0.89)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C109(0.78)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C109(0.96)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C109(0.86)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C109(0.85)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C109(1.05)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C109(0.86)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C109(0.89)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C109(0.84)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C109(1.02)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C109(1.15)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C109(1.24)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C109(1.21)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C109(1.07)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C109(1.11)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C109(1.23)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C109(1.01)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C109(0.96)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C109(1.15)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C109(1.08)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C109(1.15)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C109(1.32)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C109(1.09)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C109(1.15)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C109(1.03)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C109(1.17)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C109(0.77)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C109(0.98)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C109(1.04)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C109(0.87)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C109(0.90)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C109(1.04)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C109(0.91)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C109(1.04)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C109(0.87)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C109(0.88)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C109(1.18)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C109(0.95)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C109(0.87)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C109(0.85)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C109(0.93)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C109(0.96)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C109(0.63)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C109(0.86)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C109(1.00)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C109(0.91)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C109(0.96)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C109(0.83)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C109(1.05)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C109(1.07)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C109(0.94)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C109(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C109(0.88)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C109(0.92)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C109(1.00)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C109(1.19)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C109(0.86)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C109(0.92)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C109(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C109(1.12)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C109(1.35)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C109(1.10)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C109(1.19)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C109(1.18)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C109(1.18)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C109(1.04)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C109(1.06)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C109(0.92)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C109(3.57)  LDD1702  [3]
 LDCM0625  F8 Ramos C109(1.10)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C109(1.11)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C109(0.19)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C109(1.86)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C109(0.78)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C109(3.70)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C109(3.65)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C109(0.93)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C109(1.82)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C109(0.77)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C109(0.67)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C109(1.06)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C109(1.04)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C109(0.92)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C109(1.05)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C109(1.12)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C109(1.86)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C109(0.85)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C109(1.25)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C109(1.15)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C109(1.91)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C109(2.97)  LDD2188  [16]
 LDCM0107  IAA HeLa H106(0.00); C109(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C109(0.98)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C109(0.99)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C80(2.55)  LDD3310  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C109(1.49)  LDD2102  [3]
 LDCM0109  NEM HeLa C109(0.00); H106(0.00)  LDD0224  [11]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C109(1.06)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C109(1.26)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C109(1.46)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C109(0.11)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C109(0.70)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C109(0.63)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C109(1.59)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C109(0.62)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C109(0.53)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C109(0.41)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C109(1.75)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C109(0.47)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C109(1.00)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C109(0.41)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C109(0.66)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C109(1.05)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C109(1.18)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C109(0.45)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C109(0.32)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C109(0.31)  LDD2116  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C109(1.52)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C109(0.47)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C109(0.19)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C109(1.00)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C109(0.23)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C109(1.11)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C109(0.17)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C109(1.21)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C109(0.58)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C109(1.21)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C109(0.46)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C109(0.41)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C109(1.63)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C109(1.09)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C109(2.52)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C109(1.48)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C109(0.52)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C109(0.39)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C109(1.24)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C109(1.11)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C109(0.92)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C109(0.36)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C109(0.19)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C109(1.37)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C109(0.20)  LDD2151  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C109(0.91)  LDD2207  [18]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.63  LDD0123  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
Threonine--tRNA ligase, mitochondrial (TARS2) Class-II aminoacyl-tRNA synthetase family Q9BW92
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Inositol polyphosphate 5-phosphatase K (INPP5K) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q9BT40
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Protein NDRG4 (NDRG4) NDRG family Q9ULP0
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Sentrin-specific protease 2 (SENP2) Peptidase C48 family Q9HC62
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Serine hydroxymethyltransferase, mitochondrial (SHMT2) SHMT family P34897
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Ras-related protein Rab-33A (RAB33A) Rab family Q14088
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
EH domain-containing protein 3 (EHD3) Dynamin/Fzo/YdjA family Q9NZN3
Elongation factor Tu, mitochondrial (TUFM) Classic translation factor GTPase family P49411
Transporter and channel
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 258 (TMEM258) OST5 family P61165
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-11 (SNX11) Sorting nexin family Q9Y5W9
Sorting nexin-12 (SNX12) Sorting nexin family Q9UMY4
Sorting nexin-15 (SNX15) Sorting nexin family Q9NRS6
Sorting nexin-2 (SNX2) Sorting nexin family O60749
Sorting nexin-3 (SNX3) Sorting nexin family O60493
Sorting nexin-4 (SNX4) Sorting nexin family O95219
Sorting nexin-8 (SNX8) Sorting nexin family Q9Y5X2
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) TIM16/PAM16 family Q9Y3D7
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Ceramide transfer protein (CERT1) . Q9Y5P4
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor A, mitochondrial (TFAM) . Q00059
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgi phosphoprotein 3 (GOLPH3) GOLPH3/VPS74 family Q9H4A6
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) VMA21 family Q3ZAQ7
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) WD repeat PROPPIN family Q9Y4P8
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Mast cell-expressed membrane protein 1 (MCEMP1) . Q8IX19
PRKCA-binding protein (PICK1) . Q9NRD5
Protein TMED8 (TMED8) . Q6PL24
Reticulon-4 (RTN4) . Q9NQC3
StAR-related lipid transfer protein 4 (STARD4) . Q96DR4
Uncharacterized protein C19orf18 (C19orf18) . Q8NEA5
WD repeat and FYVE domain-containing protein 2 (WDFY2) . Q96P53
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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