Details of the Probe

General Information of Probe

Probe ID
LDPC0512
Probe Name
C282
Synonyms
Z4282859941
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 366.4
Lipid-water partition coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H19FN4O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[[4-(4-fluorophenoxy)pyridin-2-yl]methyl]propanamide
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)NCC2=NC=CC(=C2)OC3=CC=C(C=C3)F
InChI
InChI=1S/C20H19FN4O2/c1-2-3-10-20(24-25-20)11-8-19(26)23-14-16-13-18(9-12-22-16)27-17-6-4-15(21)5-7-17/h1,4-7,9,12-13H,3,8,10-11,14H2,(H,23,26)
InChIKey
ZLNBAUQBGOTOSE-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

131 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 15.03  LDD1952 
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 18.77  LDD1952 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 25.46  LDD1952 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 16.11  LDD1952 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 19.84  LDD1952 
Acid ceramidase (ASAH1) LDTP05905 29.04  LDD1952 
ADP-dependent glucokinase (ADPGK) LDTP11127 26.54  LDD1952 
ADP-ribose pyrophosphatase, mitochondrial (NUDT9) LDTP11318 98.36  LDD1952 
ADP-ribosylation factor 5 (ARF5) LDTP05193 14.93  LDD1952 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 44.32  LDD1952 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 16.45  LDD1952 
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) LDTP02264 19.84  LDD1952 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 16.56  LDD1952 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 15.89  LDD1952 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 34.78  LDD1952 
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) LDTP05920 21.56  LDD1952 
Calpain-2 catalytic subunit (CAPN2) LDTP02911 49.18  LDD1952 
Carbohydrate sulfotransferase 12 (CHST12) LDTP12494 18.90  LDD1952 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 70.03  LDD1952 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 32.22  LDD1952 
Catechol O-methyltransferase (COMT) LDTP03145 15.67  LDD1952 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 30.48  LDD1952 
Ceramide glucosyltransferase (UGCG) LDTP06617 32.00  LDD1952 
Ceramide synthase 2 (CERS2) LDTP10329 37.01  LDD1952 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 14.32  LDD1952 
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4) LDTP05638 22.01  LDD1952 
COP9 signalosome complex subunit 3 (COPS3) LDTP13675 16.45  LDD1952 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 25.81  LDD1952 
Copper-transporting ATPase 2 (ATP7B) LDTP03779 16.56  LDD1952 
CTD small phosphatase-like protein 2 (CTDSPL2) LDTP14814 31.12  LDD1952 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 39.40  LDD1952 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 75.58  LDD1952 
Cytochrome b5 type B (CYB5B) LDTP00697 28.84  LDD1952 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 27.47  LDD1952 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 22.16  LDD1952 
DCN1-like protein 5 (DCUN1D5) LDTP11199 99.73  LDD1952 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 22.78  LDD1952 
Delta(24)-sterol reductase (DHCR24) LDTP06375 24.08  LDD1952 
Dihydrofolate reductase (DHFR) LDTP01769 34.30  LDD1952 
DNA polymerase epsilon subunit 2 (POLE2) LDTP04737 14.32  LDD1952 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 22.78  LDD1952 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 32.22  LDD1952 
E3 ubiquitin-protein ligase NEDD4 (NEDD4) LDTP04114 46.85  LDD1952 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 22.78  LDD1952 
Endoplasmic reticulum aminopeptidase 2 (ERAP2) LDTP07503 57.68  LDD1952 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 15.78  LDD1952 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 38.85  LDD1952 
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (MECR) LDTP11271 27.47  LDD1952 
Ethanolamine kinase 1 (ETNK1) LDTP12197 20.53  LDD1952 
Ferrochelatase, mitochondrial (FECH) LDTP03198 27.28  LDD1952 
GTP-binding protein SAR1b (SAR1B) LDTP14231 19.16  LDD1952 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 22.94  LDD1952 
Heme A synthase COX15 (COX15) LDTP07931 18.77  LDD1952 
Heme oxygenase 1 (HMOX1) LDTP02359 40.50  LDD1952 
Heme oxygenase 2 (HMOX2) LDTP03540 52.35  LDD1952 
Hexokinase-2 (HK2) LDTP04531 19.43  LDD1952 
Histone-arginine methyltransferase CARM1 (CARM1) LDTP08352 17.15  LDD1952 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 29.65  LDD1952 
Kinesin-like protein KIF3A (KIF3A) LDTP14033 14.83  LDD1952 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 14.93  LDD1952 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.34  LDD1952 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 21.71  LDD1952 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 16.00  LDD1952 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 41.07  LDD1952 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 23.10  LDD1952 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 29.04  LDD1952 
Lysosomal protective protein (CTSA) LDTP02505 31.56  LDD1952 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 14.12  LDD1952 
Methionine aminopeptidase 1 (METAP1) LDTP04565 14.83  LDD1952 
Methionine aminopeptidase 2 (METAP2) LDTP04375 24.08  LDD1952 
Mitochondrial intermediate peptidase (MIPEP) LDTP10981 20.68  LDD1952 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 26.54  LDD1952 
Mitogen-activated protein kinase 14 (MAPK14) LDTP06547 23.10  LDD1952 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 21.56  LDD1952 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 23.92  LDD1952 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 14.52  LDD1952 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 14.42  LDD1952 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 41.07  LDD1952 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 18.13  LDD1952 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 37.27  LDD1952 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 23.75  LDD1952 
NADPH--cytochrome P450 reductase (POR) LDTP02848 15.89  LDD1952 
Nardilysin (NRDC) LDTP00886 15.67  LDD1952 
NIF3-like protein 1 (NIF3L1) LDTP11648 14.93  LDD1952 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) LDTP03813 15.35  LDD1952 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 29.65  LDD1952 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 17.27  LDD1952 
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) LDTP10101 15.03  LDD1952 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 14.22  LDD1952 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 53.08  LDD1952 
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) LDTP09355 17.27  LDD1952 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 25.11  LDD1952 
Pirin (PIR) LDTP00325 16.11  LDD1952 
Platelet-activating factor acetylhydrolase IB subunit alpha2 (PAFAH1B2) LDTP05078 14.12  LDD1952 
Polyamine-transporting ATPase 13A2 (ATP13A2) LDTP12386 15.67  LDD1952 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 16.80  LDD1952 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 48.50  LDD1952 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 16.80  LDD1952 
Presequence protease, mitochondrial (PITRM1) LDTP07003 16.56  LDD1952 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 17.27  LDD1952 
Prolyl endopeptidase-like (PREPL) LDTP06849 20.82  LDD1952 
Prostaglandin reductase 3 (PTGR3) LDTP15422 14.83  LDD1952 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 44.32  LDD1952 
Proteasome subunit beta type-3 (PSMB3) LDTP04284 16.45  LDD1952 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 19.16  LDD1952 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 40.50  LDD1952 
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) LDTP04925 16.22  LDD1952 
RAC-alpha serine/threonine-protein kinase (AKT1) LDTP03607 17.63  LDD1952 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 19.70  LDD1952 
Retinol dehydrogenase 13 (RDH13) LDTP09061 15.78  LDD1952 
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) LDTP03592 16.22  LDD1952 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 27.67  LDD1952 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 14.93  LDD1952 
Septin-7 (SEPTIN7) LDTP06513 20.97  LDD1952 
Serine protease HTRA2, mitochondrial (HTRA2) LDTP00773 17.51  LDD1952 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 33.36  LDD1952 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 15.24  LDD1952 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 14.52  LDD1952 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 20.53  LDD1952 
Squalene synthase (FDFT1) LDTP03842 14.62  LDD1952 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 16.22  LDD1952 
Thimet oligopeptidase (THOP1) LDTP04542 16.11  LDD1952 
Torsin-1B (TOR1B) LDTP00400 18.13  LDD1952 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 17.03  LDD1952 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 19.29  LDD1952 
tRNA (guanine-N(7)-)-methyltransferase (METTL1) LDTP13140 15.24  LDD1952 
Ubiquitin carboxyl-terminal hydrolase 28 (USP28) LDTP10785 15.35  LDD1952 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 22.01  LDD1952 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 23.26  LDD1952 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 51.98  LDD1952 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 15.35  LDD1952 
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⏷ Show the Full List of 131 Enzyme
88 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 19.43  LDD1952 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 14.93  LDD1952 
Annexin A1 (ANXA1) LDTP02010 33.59  LDD1952 
ATP synthase subunit a (MT-ATP6) LDTP01804 27.86  LDD1952 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 46.85  LDD1952 
BRI3-binding protein (BRI3BP) LDTP15648 44.63  LDD1952 
Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB) LDTP12725 15.89  LDD1952 
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) LDTP12738 25.63  LDD1952 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 18.25  LDD1952 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 99.73  LDD1952 
Derlin-1 (DERL1) LDTP11245 31.34  LDD1952 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 43.71  LDD1952 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 18.64  LDD1952 
Essential MCU regulator, mitochondrial (SMDT1) LDTP11927 18.90  LDD1952 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 24.76  LDD1952 
H(+)/Cl(-) exchange transporter 6 (CLCN6) LDTP04462 29.65  LDD1952 
H(+)/Cl(-) exchange transporter 7 (CLCN7) LDTP04463 22.16  LDD1952 
Integral membrane protein 2B (ITM2B) LDTP13833 15.89  LDD1952 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 21.11  LDD1952 
Lysosome membrane protein 2 (SCARB2) LDTP06034 19.56  LDD1952 
Major facilitator superfamily domain-containing protein 10 (MFSD10) LDTP06198 21.86  LDD1952 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 24.42  LDD1952 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 19.84  LDD1952 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 29.45  LDD1952 
Metaxin-1 (MTX1) LDTP05900 23.26  LDD1952 
MICOS complex subunit MIC26 (APOO) LDTP11250 20.11  LDD1952 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 15.78  LDD1952 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 26.72  LDD1952 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 43.41  LDD1952 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 26.72  LDD1952 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 77.71  LDD1952 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 71.01  LDD1952 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 20.68  LDD1952 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 39.67  LDD1952 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 22.94  LDD1952 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 51.98  LDD1952 
Mpv17-like protein 2 (MPV17L2) LDTP14952 36.76  LDD1952 
Nuclear pore complex protein Nup85 (NUP85) LDTP11310 18.25  LDD1952 
Nucleoporin NDC1 (NDC1) LDTP11213 20.53  LDD1952 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 14.62  LDD1952 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 19.70  LDD1952 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 71.51  LDD1952 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 15.03  LDD1952 
Peroxisomal membrane protein PEX16 (PEX16) LDTP14181 26.35  LDD1952 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 16.56  LDD1952 
Prosaposin (PSAP) LDTP02215 16.00  LDD1952 
Protein ARV1 (ARV1) LDTP11812 29.45  LDD1952 
Protein GPR107 (GPR107) LDTP07236 33.36  LDD1952 
Protein GPR108 (GPR108) LDTP12383 99.73  LDD1952 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 14.12  LDD1952 
Protein tweety homolog 3 (TTYH3) LDTP11615 38.05  LDD1952 
Proton-activated chloride channel (PACC1) LDTP12042 19.03  LDD1952 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 35.02  LDD1952 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 20.82  LDD1952 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 14.12  LDD1952 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 15.24  LDD1952 
Sideroflexin-4 (SFXN4) LDTP07531 40.50  LDD1952 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 22.47  LDD1952 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 17.63  LDD1952 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 43.11  LDD1952 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 20.11  LDD1952 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 17.88  LDD1952 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 14.32  LDD1952 
Stomatin (STOM) LDTP03380 14.83  LDD1952 
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) LDTP10931 14.83  LDD1952 
Surfeit locus protein 4 (SURF4) LDTP00592 18.13  LDD1952 
Syntaxin-5 (STX5) LDTP05780 18.77  LDD1952 
Syntaxin-6 (STX6) LDTP00857 17.63  LDD1952 
Tetraspanin-10 (TSPAN10) LDTP15967 20.82  LDD1952 
Tetraspanin-3 (TSPAN3) LDTP16813 47.50  LDD1952 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 45.57  LDD1952 
Translocator protein (TSPO) LDTP03546 16.11  LDD1952 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 42.22  LDD1952 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 24.42  LDD1952 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 38.05  LDD1952 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 19.29  LDD1952 
Transmembrane emp24 domain-containing protein 9 (TMED9) LDTP11291 19.56  LDD1952 
Transmembrane protein 126A (TMEM126A) LDTP15948 77.17  LDD1952 
Transmembrane protein 160 (TMEM160) LDTP20002 99.73  LDD1952 
Transmembrane protein 230 (TMEM230) LDTP10065 14.22  LDD1952 
Transmembrane protein 87A (TMEM87A) LDTP15481 43.11  LDD1952 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 22.01  LDD1952 
Vacuole membrane protein 1 (VMP1) LDTP10343 22.01  LDD1952 
Vang-like protein 1 (VANGL1) LDTP09288 16.11  LDD1952 
Vezatin (VEZT) LDTP12191 28.05  LDD1952 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 45.57  LDD1952 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 48.84  LDD1952 
Zinc transporter 7 (SLC30A7) LDTP09180 27.86  LDD1952 
------------------------------------------------------------------------------------
⏷ Show the Full List of 88 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 17.51  LDD1952 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Leukocyte surface antigen CD47 (CD47) LDTP05572 17.15  LDD1952 
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90 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60S ribosomal export protein NMD3 (NMD3) LDTP10200 14.93  LDD1952 
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 16.56  LDD1952 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 27.28  LDD1952 
AP-3 complex subunit sigma-1 (AP3S1) LDTP09804 14.42  LDD1952 
Apolipoprotein L2 (APOL2) LDTP11076 55.33  LDD1952 
Armadillo repeat-containing protein 6 (ARMC6) LDTP15101 32.90  LDD1952 
Clustered mitochondria protein homolog (CLUH) LDTP14486 24.42  LDD1952 
COP9 signalosome complex subunit 7a (COPS7A) LDTP13170 16.56  LDD1952 
DNA replication complex GINS protein PSF2 (GINS2) LDTP13802 30.06  LDD1952 
Dymeclin (DYM) LDTP08000 15.89  LDD1952 
Dynactin subunit 2 (DCTN2) LDTP05922 15.56  LDD1952 
Dynactin subunit 3 (DCTN3) LDTP01359 15.67  LDD1952 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 45.57  LDD1952 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 24.25  LDD1952 
ELMO domain-containing protein 2 (ELMOD2) LDTP17659 18.64  LDD1952 
Endoplasmic reticulum resident protein 44 (ERP44) LDTP11144 14.72  LDD1952 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 37.79  LDD1952 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 37.27  LDD1952 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 19.29  LDD1952 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 17.03  LDD1952 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 22.78  LDD1952 
Ganglioside GM2 activator (GM2A) LDTP02927 24.42  LDD1952 
General transcription factor IIF subunit 2 (GTF2F2) LDTP02703 14.72  LDD1952 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 21.56  LDD1952 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 25.28  LDD1952 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 14.12  LDD1952 
HEAT repeat-containing protein 6 (HEATR6) LDTP17313 22.78  LDD1952 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 14.93  LDD1952 
Integral membrane protein GPR180 (GPR180) LDTP19625 14.83  LDD1952 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 30.06  LDD1952 
KIF-binding protein (KIFBP) LDTP10263 14.52  LDD1952 
Kinesin light chain 4 (KLC4) LDTP12591 18.38  LDD1952 
Kinetochore protein Spc24 (SPC24) LDTP09069 17.15  LDD1952 
Large proline-rich protein BAG6 (BAG6) LDTP04094 21.26  LDD1952 
Large ribosomal subunit protein bL28m (MRPL28) LDTP05741 14.42  LDD1952 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 14.62  LDD1952 
Lipase maturation factor 2 (LMF2) LDTP15887 19.56  LDD1952 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 14.32  LDD1952 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 14.32  LDD1952 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 25.46  LDD1952 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 27.86  LDD1952 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 55.33  LDD1952 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 25.28  LDD1952 
Negative elongation factor C/D (NELFCD) LDTP08594 66.26  LDD1952 
Negative elongation factor E (NELFE) LDTP02960 14.62  LDD1952 
Neurochondrin (NCDN) LDTP13093 15.78  LDD1952 
Nucleobindin-1 (NUCB1) LDTP05375 35.02  LDD1952 
Nucleobindin-2 (NUCB2) LDTP05160 99.73  LDD1952 
Nucleolar protein 9 (NOP9) LDTP15283 61.82  LDD1952 
Nurim (NRM) LDTP08606 22.94  LDD1952 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 17.39  LDD1952 
Optic atrophy 3 protein (OPA3) LDTP16006 26.17  LDD1952 
p53 and DNA damage-regulated protein 1 (PDRG1) LDTP16099 20.11  LDD1952 
Paraneoplastic antigen Ma1 (PNMA1) LDTP09119 19.97  LDD1952 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 16.45  LDD1952 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 20.53  LDD1952 
Protein bicaudal D homolog 2 (BICD2) LDTP09410 16.11  LDD1952 
Protein CEBPZOS (CEBPZOS) LDTP18883 30.70  LDD1952 
Protein CREG1 (CREG1) LDTP01279 23.92  LDD1952 
Protein CutA (CUTA) LDTP01075 19.56  LDD1952 
Protein FAM114A2 (FAM114A2) LDTP16080 53.82  LDD1952 
Protein FAM162A (FAM162A) LDTP10056 33.59  LDD1952 
Protein FAM3C (FAM3C) LDTP09773 20.39  LDD1952 
Protein jagunal homolog 1 (JAGN1) LDTP08904 21.41  LDD1952 
Protein LYRIC (MTDH) LDTP08224 15.89  LDD1952 
Protein transport protein Sec16A (SEC16A) LDTP00512 15.24  LDD1952 
Protein unc-119 homolog B (UNC119B) LDTP00105 46.85  LDD1952 
Protein YIF1A (YIF1A) LDTP01494 18.64  LDD1952 
RAD50-interacting protein 1 (RINT1) LDTP07476 15.89  LDD1952 
Receptor expression-enhancing protein 3 (REEP3) LDTP15095 22.78  LDD1952 
Reticulocalbin-2 (RCN2) LDTP06097 15.78  LDD1952 
Reticulon-2 (RTN2) LDTP01167 15.67  LDD1952 
Reticulon-3 (RTN3) LDTP01522 50.56  LDD1952 
Rho GDP-dissociation inhibitor 1 (ARHGDIA) LDTP04510 17.03  LDD1952 
RNA-binding protein 3 (RBM3) LDTP05226 14.32  LDD1952 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 16.00  LDD1952 
Small integral membrane protein 12 (SMIM12) LDTP19859 18.13  LDD1952 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 15.89  LDD1952 
Superkiller complex protein 3 (SKIC3) LDTP07574 19.29  LDD1952 
Superkiller complex protein 8 (SKIC8) LDTP11643 29.04  LDD1952 
Syntaxin-18 (STX18) LDTP13086 23.75  LDD1952 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 32.22  LDD1952 
TraB domain-containing protein (TRABD) LDTP19963 21.56  LDD1952 
Transmembrane emp24 domain-containing protein 4 (TMED4) LDTP08153 17.27  LDD1952 
Transmembrane protein 209 (TMEM209) LDTP18272 15.35  LDD1952 
Trophoblast glycoprotein (TPBG) LDTP05960 27.28  LDD1952 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 31.12  LDD1952 
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) LDTP01163 14.93  LDD1952 
Vacuolar protein-sorting-associated protein 25 (VPS25) LDTP11108 16.56  LDD1952 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 61.39  LDD1952 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1952 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587