Details of the Target

General Information of Target

Target ID LDTP04388
Target Name Palmitoyl-protein thioesterase 1 (PPT1)
Gene Name PPT1
Gene ID 5538
Synonyms
CLN1; PPT; Palmitoyl-protein thioesterase 1; PPT-1; EC 3.1.2.22; Palmitoyl-protein hydrolase 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
IIPFLG
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Palmitoyl-protein thioesterase family
Subcellular location
Lysosome
Function Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
TTD ID
T97740
Uniprot ID
P50897
DrugMap ID
TTSQC14
Ensemble ID
ENST00000449045.7
HGNC ID
HGNC:9325
ChEMBL ID
CHEMBL2331051

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.L202S .
FUOV1 SNV: p.I235T DBIA    Probe Info 
HCT116 Deletion: p.M57WfsTer14 DBIA    Probe Info 
MCC13 SNV: p.M77I .
MFE319 SNV: p.A2T .
NALM6 SNV: p.I256T .
T98G SNV: p.R268L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.66  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [2]
D3
 Probe Info  		4.45  LDD0325  [3]
TH211
 Probe Info  		Y215(15.60)  LDD0260  [4]
C-Sul
 Probe Info  		5.86  LDD0066  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K191(5.00)  LDD0274  [7]
STPyne
 Probe Info  		K165(1.07)  LDD0277  [7]
OPA-S-S-alkyne
 Probe Info  		K174(1.29); K191(1.31)  LDD3494  [8]
Probe 1
 Probe Info  		Y264(6.84)  LDD3495  [9]
P11
 Probe Info  		20.00  LDD0201  [10]
Alkylaryl probe 1
 Probe Info  		5.00  LDD0388  [2]
Propranolol-CA-4PAP
 Probe Info  		4.00  LDD0271  [11]
FBPP2
 Probe Info  		4.10  LDD0054  [12]
IPM
 Probe Info  		C152(3.86)  LDD1702  [13]
Acrolein
 Probe Info  		N.A.  LDD0223  [14]
DBIA
 Probe Info  		C152(1.08); C160(1.08)  LDD0078  [15]
5E-2FA
 Probe Info  		H26(0.00); H158(0.00); H143(0.00)  LDD2235  [16]
ATP probe
 Probe Info  		N.A.  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C128(0.00); C96(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
Lodoacetamide azide
 Probe Info  		C128(0.00); C96(0.00)  LDD0037  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C128(0.00); C96(0.00); C160(0.00); C152(0.00)  LDD2223  [22]
HHS-482
 Probe Info  		Y215(0.68)  LDD2239  [23]
PAL-AfBPP Probe
Click To Hide/Show 186 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		14.32  LDD1711  [24]
C004
 Probe Info  		17.27  LDD1714  [24]
C007
 Probe Info  		6.92  LDD1716  [24]
C008
 Probe Info  		5.86  LDD1717  [24]
C010
 Probe Info  		7.94  LDD1719  [24]
C011
 Probe Info  		7.11  LDD1720  [24]
C022
 Probe Info  		57.28  LDD1728  [24]
C026
 Probe Info  		15.45  LDD1732  [24]
C039
 Probe Info  		6.82  LDD1739  [24]
C040
 Probe Info  		17.51  LDD1740  [24]
C041
 Probe Info  		17.75  LDD1741  [24]
C045
 Probe Info  		8.88  LDD1744  [24]
C049
 Probe Info  		6.59  LDD1747  [24]
C052
 Probe Info  		6.02  LDD1750  [24]
C053
 Probe Info  		8.22  LDD1751  [24]
C055
 Probe Info  		17.75  LDD1752  [24]
C056
 Probe Info  		36.76  LDD1753  [24]
C063
 Probe Info  		49.87  LDD1760  [24]
C064
 Probe Info  		12.73  LDD1761  [24]
C067
 Probe Info  		5.62  LDD1763  [24]
C070
 Probe Info  		26.91  LDD1766  [24]
C071
 Probe Info  		9.92  LDD1767  [24]
C072
 Probe Info  		14.52  LDD1768  [24]
C073
 Probe Info  		5.46  LDD1769  [24]
C082
 Probe Info  		8.40  LDD1774  [24]
C085
 Probe Info  		8.88  LDD1777  [24]
C087
 Probe Info  		38.59  LDD1779  [24]
C089
 Probe Info  		9.71  LDD1781  [24]
C091
 Probe Info  		39.95  LDD1782  [24]
C092
 Probe Info  		60.97  LDD1783  [24]
C094
 Probe Info  		23.59  LDD1785  [24]
C100
 Probe Info  		6.68  LDD1789  [24]
C106
 Probe Info  		78.25  LDD1793  [24]
C107
 Probe Info  		20.68  LDD1794  [24]
C108
 Probe Info  		33.82  LDD1795  [24]
C112
 Probe Info  		79.34  LDD1799  [24]
C115
 Probe Info  		8.88  LDD1802  [24]
C117
 Probe Info  		6.06  LDD1804  [24]
C129
 Probe Info  		10.56  LDD1811  [24]
C130
 Probe Info  		16.00  LDD1812  [24]
C134
 Probe Info  		57.28  LDD1816  [24]
C135
 Probe Info  		23.10  LDD1817  [24]
C139
 Probe Info  		19.29  LDD1821  [24]
C140
 Probe Info  		29.04  LDD1822  [24]
C141
 Probe Info  		30.91  LDD1823  [24]
C143
 Probe Info  		54.95  LDD1825  [24]
C145
 Probe Info  		12.30  LDD1827  [24]
C147
 Probe Info  		13.27  LDD1829  [24]
C149
 Probe Info  		10.63  LDD1830  [24]
C153
 Probe Info  		54.57  LDD1834  [24]
C159
 Probe Info  		31.78  LDD1839  [24]
C160
 Probe Info  		21.41  LDD1840  [24]
C161
 Probe Info  		52.71  LDD1841  [24]
C163
 Probe Info  		20.97  LDD1843  [24]
C164
 Probe Info  		5.31  LDD1844  [24]
C165
 Probe Info  		24.42  LDD1845  [24]
C169
 Probe Info  		29.45  LDD1849  [24]
C170
 Probe Info  		32.90  LDD1850  [24]
C171
 Probe Info  		8.34  LDD1851  [24]
C177
 Probe Info  		15.24  LDD1856  [24]
C178
 Probe Info  		66.72  LDD1857  [24]
C183
 Probe Info  		9.85  LDD1861  [24]
C186
 Probe Info  		39.67  LDD1864  [24]
C187
 Probe Info  		99.73  LDD1865  [24]
C194
 Probe Info  		30.06  LDD1870  [24]
C197
 Probe Info  		17.63  LDD1873  [24]
C198
 Probe Info  		26.17  LDD1874  [24]
C201
 Probe Info  		99.73  LDD1877  [24]
C205
 Probe Info  		8.82  LDD1880  [24]
C206
 Probe Info  		86.22  LDD1881  [24]
C208
 Probe Info  		13.83  LDD1883  [24]
C210
 Probe Info  		41.93  LDD1884  [24]
C211
 Probe Info  		35.51  LDD1885  [24]
C212
 Probe Info  		7.67  LDD1886  [24]
C213
 Probe Info  		55.33  LDD1887  [24]
C218
 Probe Info  		18.13  LDD1892  [24]
C219
 Probe Info  		14.52  LDD1893  [24]
C220
 Probe Info  		65.34  LDD1894  [24]
C221
 Probe Info  		9.32  LDD1895  [24]
C223
 Probe Info  		18.13  LDD1897  [24]
C225
 Probe Info  		25.63  LDD1898  [24]
C226
 Probe Info  		14.52  LDD1899  [24]
C228
 Probe Info  		65.34  LDD1901  [24]
C229
 Probe Info  		19.29  LDD1902  [24]
C231
 Probe Info  		35.26  LDD1904  [24]
C232
 Probe Info  		99.73  LDD1905  [24]
C233
 Probe Info  		30.70  LDD1906  [24]
C234
 Probe Info  		5.78  LDD1907  [24]
C235
 Probe Info  		92.41  LDD1908  [24]
C237
 Probe Info  		8.00  LDD1910  [24]
C239
 Probe Info  		7.52  LDD1912  [24]
C240
 Probe Info  		15.03  LDD1913  [24]
C246
 Probe Info  		44.63  LDD1919  [24]
C249
 Probe Info  		46.21  LDD1922  [24]
C258
 Probe Info  		6.36  LDD1931  [24]
C264
 Probe Info  		52.35  LDD1935  [24]
C265
 Probe Info  		29.65  LDD1936  [24]
C270
 Probe Info  		17.27  LDD1940  [24]
C273
 Probe Info  		12.82  LDD1943  [24]
C277
 Probe Info  		29.45  LDD1947  [24]
C280
 Probe Info  		18.77  LDD1950  [24]
C281
 Probe Info  		6.92  LDD1951  [24]
C282
 Probe Info  		29.65  LDD1952  [24]
C284
 Probe Info  		41.64  LDD1954  [24]
C286
 Probe Info  		12.82  LDD1956  [24]
C287
 Probe Info  		58.49  LDD1957  [24]
C288
 Probe Info  		19.84  LDD1958  [24]
C289
 Probe Info  		39.12  LDD1959  [24]
C293
 Probe Info  		60.55  LDD1963  [24]
C296
 Probe Info  		51.63  LDD1966  [24]
C299
 Probe Info  		8.63  LDD1968  [24]
C302
 Probe Info  		9.25  LDD1971  [24]
C303
 Probe Info  		4.99  LDD1972  [24]
C305
 Probe Info  		32.00  LDD1974  [24]
C307
 Probe Info  		10.56  LDD1975  [24]
C310
 Probe Info  		25.46  LDD1977  [24]
C313
 Probe Info  		16.80  LDD1980  [24]
C314
 Probe Info  		73.01  LDD1981  [24]
C320
 Probe Info  		5.82  LDD1986  [24]
C322
 Probe Info  		6.73  LDD1988  [24]
C326
 Probe Info  		34.54  LDD1990  [24]
C329
 Probe Info  		5.94  LDD1993  [24]
C337
 Probe Info  		5.35  LDD2000  [24]
C338
 Probe Info  		12.21  LDD2001  [24]
C339
 Probe Info  		17.15  LDD2002  [24]
C340
 Probe Info  		5.43  LDD2003  [24]
C343
 Probe Info  		40.79  LDD2005  [24]
C346
 Probe Info  		21.71  LDD2007  [24]
C348
 Probe Info  		33.59  LDD2009  [24]
C349
 Probe Info  		28.25  LDD2010  [24]
C350
 Probe Info  		99.73  LDD2011  [24]
C353
 Probe Info  		7.36  LDD2014  [24]
C354
 Probe Info  		8.28  LDD2015  [24]
C355
 Probe Info  		99.73  LDD2016  [24]
C356
 Probe Info  		29.65  LDD2017  [24]
C357
 Probe Info  		15.56  LDD2018  [24]
C362
 Probe Info  		99.73  LDD2023  [24]
C363
 Probe Info  		99.73  LDD2024  [24]
C364
 Probe Info  		99.73  LDD2025  [24]
C366
 Probe Info  		8.51  LDD2027  [24]
C367
 Probe Info  		5.24  LDD2028  [24]
C373
 Probe Info  		6.68  LDD2033  [24]
C376
 Probe Info  		26.17  LDD2036  [24]
C378
 Probe Info  		11.88  LDD2037  [24]
C380
 Probe Info  		8.28  LDD2039  [24]
C382
 Probe Info  		15.78  LDD2041  [24]
C383
 Probe Info  		41.36  LDD2042  [24]
C385
 Probe Info  		5.43  LDD2044  [24]
C386
 Probe Info  		25.99  LDD2045  [24]
C387
 Probe Info  		8.46  LDD2046  [24]
C388
 Probe Info  		76.64  LDD2047  [24]
C390
 Probe Info  		99.73  LDD2049  [24]
C391
 Probe Info  		21.26  LDD2050  [24]
C393
 Probe Info  		5.06  LDD2052  [24]
C396
 Probe Info  		5.50  LDD2055  [24]
C399
 Probe Info  		21.26  LDD2058  [24]
C403
 Probe Info  		38.32  LDD2061  [24]
C405
 Probe Info  		6.92  LDD2063  [24]
C407
 Probe Info  		18.00  LDD2064  [24]
C408
 Probe Info  		6.41  LDD2065  [24]
C413
 Probe Info  		45.57  LDD2069  [24]
C419
 Probe Info  		32.45  LDD2074  [24]
C420
 Probe Info  		66.72  LDD2075  [24]
C425
 Probe Info  		15.14  LDD2080  [24]
C426
 Probe Info  		17.63  LDD2081  [24]
C428
 Probe Info  		5.03  LDD2083  [24]
C429
 Probe Info  		59.71  LDD2084  [24]
C431
 Probe Info  		99.73  LDD2086  [24]
C433
 Probe Info  		10.93  LDD2088  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe12
 Probe Info  		20.00  LDD0473  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe14
 Probe Info  		20.00  LDD0477  [25]
FFF probe15
 Probe Info  		20.00  LDD0478  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
FFF probe4
 Probe Info  		20.00  LDD0466  [25]
FFF probe7
 Probe Info  		20.00  LDD0483  [25]
FFF probe9
 Probe Info  		20.00  LDD0470  [25]
JN0003
 Probe Info  		20.00  LDD0469  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
A-DA
 Probe Info  		2.06  LDD0144  [27]
BD-F
 Probe Info  		K74(0.00); L86(0.00); N87(0.00); N89(0.00)  LDD0024  [28]
LD-F
 Probe Info  		M77(0.00); I256(0.00); E78(0.00); V80(0.00)  LDD0015  [28]
TM-F
 Probe Info  		E78(0.00); V88(0.00); D79(0.00)  LDD0020  [28]
OEA-DA
 Probe Info  		20.00  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C152(1.07); C160(1.14)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C152(0.92); C160(0.92)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C152(0.91); C160(1.00)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C152(1.07); C160(1.11)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C152(0.98); C160(0.89)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C152(1.33); C160(1.24)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C152(1.17); C160(1.10)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C152(1.11); C160(1.11)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C152(0.97); C160(1.07)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C152(1.22); C160(1.14)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C152(1.01); C160(1.02)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C152(1.08); C160(1.01)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C152(0.80); C160(0.80)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C152(1.02); C160(1.03)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C152(1.02); C160(1.07)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C152(1.28); C160(1.15)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C152(0.83); C160(0.87)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C152(0.91); C160(0.97)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C152(0.80); C160(0.83)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C152(0.83); C160(0.93)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C152(1.04); C160(1.05)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C152(1.00); C160(0.97)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C152(1.07); C160(0.99)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C152(0.94); C160(0.94)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C152(1.05); C160(1.02)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C152(1.06); C160(1.03)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C152(1.05); C160(1.11)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C152(1.03); C160(0.98)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C152(1.05); C160(1.05)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C152(0.88); C160(0.94)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C152(0.81); C160(0.88)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C152(0.89); C160(0.88)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C152(0.70); C160(0.72)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C152(0.49); C160(0.73)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C152(0.45); C160(0.80)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C152(1.02); C160(0.99)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C152(0.75); C160(1.14)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C152(0.69); C160(0.88)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C152(0.98); C160(1.08)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C152(0.94); C160(1.41)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C152(0.72); C160(1.02)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C152(0.95); C160(1.04)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C152(1.34); C160(1.20)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C152(0.86); C160(1.13)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C152(1.02); C160(1.02)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C152(1.10); C160(1.39)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C152(1.07); C160(1.27)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C152(1.18); C160(1.34)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C152(0.65); C160(0.87)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C152(1.08); C160(1.60)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C152(1.01); C160(1.26)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C160(1.12); C152(1.25)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C152(1.07); C160(1.36)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C152(1.24); C160(1.83)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C152(1.18); C160(1.28)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C152(0.92); C160(0.92)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C152(1.25); C160(1.36)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C152(1.49); C160(1.75)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C152(1.24); C160(1.50)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C152(1.38); C160(1.91)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C152(1.15); C160(1.54)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C152(1.33); C160(1.50)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C152(1.23); C160(1.20)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C152(1.39); C160(1.67)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C152(0.82); C160(0.85)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C152(0.73); C160(0.80)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C152(0.66); C160(0.73)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C152(1.14); C160(1.19)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C152(0.82); C160(0.89)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C152(0.73); C160(0.77)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C152(0.91); C160(0.92)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C152(0.88); C160(0.91)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C152(0.89); C160(0.91)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C152(0.90); C160(0.93)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C152(0.92); C160(1.06)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C152(1.00); C160(1.06)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C152(0.97); C160(1.13)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C152(1.08); C160(1.14)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C152(1.16); C160(1.18)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C152(1.24); C160(1.25)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C160(1.17); C152(1.19)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C152(1.21); C160(1.34)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C160(1.25); C152(1.32)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C160(1.23); C152(1.54)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C160(0.93); C152(0.93)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C152(0.98); C160(0.98)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C152(0.73); C160(0.77)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C152(1.20); C160(1.28)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C152(0.99); C160(1.05)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C152(1.22); C160(1.27)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C152(1.05); C160(1.10)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C152(0.89); C160(0.93)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C152(0.91); C160(1.01)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C152(0.76); C160(0.84)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C152(0.90); C160(0.92)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C152(0.83); C160(0.89)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C152(0.90); C160(0.90)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C152(0.71); C160(0.71)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C152(0.83); C160(0.83)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C152(0.94); C160(0.94)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C152(1.18); C160(1.23)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C152(1.01); C160(1.01)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C152(1.08); C160(1.08)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C152(0.90); C160(0.90)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C152(0.97); C160(0.97)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C152(1.16); C160(1.16)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C152(1.02); C160(1.02)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C152(0.71); C160(0.71)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C152(0.94); C160(1.03)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C152(0.96); C160(1.06)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C152(0.98); C160(1.06)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C152(1.00); C160(1.00)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C152(1.04); C160(1.12)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C160(1.02); C152(1.02)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C152(0.91); C160(1.02)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C152(0.98); C160(1.00)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C152(0.90); C160(0.93)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C152(0.99); C160(1.00)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C152(0.93); C160(0.94)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C160(0.98); C152(0.99)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C160(0.85); C152(0.97)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C160(0.85); C152(1.00)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C152(0.93); C160(0.93)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C160(0.97); C152(1.06)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C160(0.88); C152(0.98)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C160(0.96); C152(0.99)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C160(0.94); C152(0.99)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C160(0.87); C152(0.91)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C160(0.94); C152(1.04)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C160(0.83); C152(0.87)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C160(0.87); C152(0.99)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C160(0.86); C152(0.94)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C160(0.86); C152(0.89)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C152(1.02); C160(1.02)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C160(0.78); C152(0.80)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C160(0.80); C152(0.93)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C160(0.84); C152(0.88)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C152(1.06); C160(1.28)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C152(0.93); C160(1.31)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C152(1.06); C160(1.40)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C152(0.87); C160(1.17)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C152(1.02); C160(1.19)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C152(0.86); C160(1.15)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C152(0.89); C160(1.07)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C152(0.85); C160(1.06)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C152(0.95); C160(1.04)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C152(0.93); C160(1.20)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C152(1.05); C160(1.15)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C152(0.93); C160(1.04)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C152(0.99); C160(1.14)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C152(1.06); C160(1.19)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C152(0.93); C160(1.16)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C152(1.04); C160(1.12)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C152(0.96); C160(1.00)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C152(0.92); C160(0.92)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C152(0.82); C160(0.82)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C152(1.08); C160(1.08)  LDD0592  [15]
 LDCM0020  ARS-1620 HCC44 C152(1.08); C160(1.08)  LDD0078  [15]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [10]
 LDCM0367  CL1 HCT 116 C160(0.90); C152(0.98)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C160(0.85); C152(0.89)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C152(1.17); C160(1.21)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C152(1.08); C160(1.08)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C152(0.89); C160(0.89)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C152(0.78); C160(0.78)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C152(0.82); C160(0.82)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C152(0.81); C160(0.87)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C152(0.88); C160(0.89)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C152(0.89); C160(0.97)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C152(0.92); C160(0.98)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C152(0.87); C160(0.89)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C160(0.77); C152(0.79)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C152(0.92); C160(0.93)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C152(0.76); C160(0.79)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C152(0.93); C160(0.94)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C160(1.18); C152(1.27)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C160(1.48); C152(1.81)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C160(1.08); C152(1.17)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C160(1.30); C152(1.50)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C152(1.09); C160(1.13)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C152(0.64); C160(0.73)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C152(0.62); C160(0.74)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C160(0.78); C152(0.83)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C152(0.64); C160(0.72)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C152(1.20); C160(1.20)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C152(1.50); C160(1.50)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C152(0.99); C160(0.99)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C152(0.85); C160(0.85)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C152(0.96); C160(1.05)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C152(1.01); C160(1.06)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C152(1.12); C160(1.22)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C152(0.98); C160(1.02)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C160(0.91); C152(0.94)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C152(0.81); C160(0.82)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C152(0.74); C160(0.77)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C152(0.80); C160(0.80)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C152(0.74); C160(0.74)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C152(0.97); C160(0.97)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C152(1.07); C160(1.07)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C152(0.88); C160(0.89)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C152(0.94); C160(0.94)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C152(0.76); C160(0.76)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C152(1.17); C160(1.17)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C152(1.02); C160(1.02)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C152(1.02); C160(1.02)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C152(0.79); C160(0.79)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C152(1.04); C160(1.04)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C152(1.00); C160(1.00)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C152(0.90); C160(0.90)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C152(0.93); C160(0.93)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C152(0.96); C160(0.93)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C152(0.96); C160(0.96)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C152(0.80); C160(0.84)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C152(0.75); C160(0.73)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C152(0.71); C160(0.68)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C152(0.85); C160(0.82)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C152(0.77); C160(0.73)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C152(0.70); C160(0.70)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C152(0.65); C160(0.63)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C152(0.76); C160(0.73)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C152(0.82); C160(0.82)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C152(0.73); C160(0.70)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C152(0.73); C160(0.72)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C152(0.71); C160(0.68)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C152(0.74); C160(0.68)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C152(0.70); C160(0.67)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C152(0.77); C160(0.76)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C152(1.05); C160(1.09)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C152(0.96); C160(0.97)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C152(0.94); C160(1.00)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C152(0.90); C160(0.90)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C152(0.94); C160(0.93)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C152(0.99); C160(1.05)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C152(0.85); C160(0.91)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C152(1.09); C160(1.11)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C152(1.35); C160(1.23)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C152(1.00); C160(1.06)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C152(1.12); C160(1.09)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C152(1.07); C160(1.06)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C152(1.03); C160(1.02)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C152(0.88); C160(0.91)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C152(0.87); C160(0.95)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C152(0.75); C160(0.81)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C152(1.01); C160(1.03)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C152(1.10); C160(0.80)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C152(1.25); C160(1.22)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C152(1.64); C160(1.56)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C152(1.29); C160(1.28)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C152(1.19); C160(1.14)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C152(1.15); C160(1.11)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C152(1.57); C160(1.38)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C152(2.35); C160(2.13)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C152(1.50); C160(1.45)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C152(0.80); C160(0.80)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C152(1.53); C160(1.44)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C152(1.72); C160(1.34)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C152(1.79); C160(1.63)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C152(0.96); C160(1.03)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C152(1.78); C160(1.54)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C152(1.17); C160(1.17)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C152(1.25); C160(1.25)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C152(1.08); C160(1.08)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C152(1.06); C160(1.06)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C152(0.90); C160(0.89)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C152(1.23); C160(1.23)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C152(1.10); C160(1.10)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C152(0.98); C160(0.98)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C152(0.97); C160(0.97)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C152(0.92); C160(0.92)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C152(1.04); C160(1.04)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C152(1.15); C160(1.15)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C152(1.34); C160(1.34)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C152(1.11); C160(1.11)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C152(1.04); C160(1.04)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C152(0.76); C160(0.80)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C152(0.93); C160(0.93)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C152(1.28); C160(1.18)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C152(1.27); C160(1.21)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C152(1.31); C160(1.23)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C152(1.31); C160(1.24)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C152(1.32); C160(1.25)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C152(1.42); C160(1.32)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C152(1.41); C160(1.33)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C152(0.96); C160(1.03)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C152(1.15); C160(1.22)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C152(1.03); C160(0.82)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C152(3.86)  LDD1702  [13]
 LDCM0468  Fragment33 HCT 116 C152(1.34); C160(1.32)  LDD0785  [15]
 LDCM0427  Fragment51 HCT 116 C152(0.72); C160(0.63)  LDD0744  [15]
 LDCM0022  KB02 HCT 116 C152(2.50); C160(2.50)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C152(4.83); C160(4.83)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C152(2.44); C160(2.44)  LDD0082  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0099  Phenelzine MDA-MB-231 5.00  LDD0388  [2]
 LDCM0098  Propranolol K562 4.00  LDD0271  [11]
 LDCM0084  Ro 48-8071 A-549 2.06  LDD0144  [27]
 LDCM0021  THZ1 HCT 116 C152(1.38); C160(1.38)  LDD2173  [15]
 LDCM0008  Tranylcypromine SH-SY5Y 4.10  LDD0054  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acrosomal protein SP-10 (ACRV1) . P26436
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Palmitic Acid Small molecular drug DB03796
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Plitidepsin Small molecular drug D07QJK
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hexadecanesulfonyl Fluoride . DB02035

References

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2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
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Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
11 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
12 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
28 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402