Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C171  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 27.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 26.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 18.4
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 18.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.3
 LDTP02217  Procathepsin L (CTSL) 15.6
 LDTP02223  Cathepsin B (CTSB) 13.6
 LDTP00185  Deoxyribonuclease-2-alpha (DNASE2) 12.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 12.5
 LDTP00316  Ribonuclease T2 (RNASET2) 10.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 9.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 9.8
 LDTP10888  Legumain (LGMN) 9.4
 LDTP14801  Di-N-acetylchitobiase (CTBS) 8.9
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.9
 LDTP02141  Alpha-galactosidase A (GLA) 8.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.8
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 8.6
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 8.6
 LDTP00282  Beta-mannosidase (MANBA) 8.6
 LDTP12135  Sialate O-acetylesterase (SIAE) 8.6
 LDTP05905  Acid ceramidase (ASAH1) 8.5
 LDTP02260  Beta-glucuronidase (GUSB) 8.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.3
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 8.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 8.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.6
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 7.6
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 7.4
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.3
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 7.2
 LDTP02976  Peptidyl-glycine alpha-amidating monooxygenase (PAM) 6.9
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.8
 LDTP02505  Lysosomal protective protein (CTSA) 6.8
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 6.6
 LDTP02776  Arylsulfatase A (ARSA) 6.5
 LDTP14305  Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) 6.3
 LDTP09764  Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) 6.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 6.1
 LDTP02837  Beta-galactosidase (GLB1) 6.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 5.6
 LDTP03683  N-acetylgalactosamine-6-sulfatase (GALNS) 5.2
 LDTP02643  Uracil-DNA glycosylase (UNG) 5.2
 LDTP08933  Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) 5.1
Transporter and channel
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 17.6
 LDTP11406  Transmembrane protein 59 (TMEM59) 16.8
 LDTP12042  Proton-activated chloride channel (PACC1) 14.8
 LDTP02215  Prosaposin (PSAP) 13.9
 LDTP02071  Amyloid-beta precursor protein (APP) 11.7
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 11.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 10.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 9.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 9.1
 LDTP05218  Low-density lipoprotein receptor-related protein 2 (LRP2) 8.8
 LDTP09838  Sortilin-related receptor (SORL1) 8.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 7.7
 LDTP08327  Osteopetrosis-associated transmembrane protein 1 (OSTM1) 7.3
 LDTP00321  Podocalyxin (PODXL) 7.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 6.6
 LDTP13833  Integral membrane protein 2B (ITM2B) 6.5
 LDTP01829  Low-density lipoprotein receptor (LDLR) 6.3
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 6.1
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 6.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.7
 LDTP01969  Transferrin receptor protein 1 (TFRC) 5.5
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 5.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 7.9
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02775  Interferon gamma receptor 1 (IFNGR1) 8.5
Other
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01279  Protein CREG1 (CREG1) 19.3
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 18.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 13.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 12.4
 LDTP07031  Collectin-12 (COLEC12) 12.0
 LDTP02927  Ganglioside GM2 activator (GM2A) 9.6
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 9.3
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 9.3
 LDTP05215  Very low-density lipoprotein receptor (VLDLR) 8.9
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 8.8
 LDTP11096  Calsyntenin-3 (CLSTN3) 8.0
 LDTP12352  CD320 antigen (CD320) 7.9
 LDTP12256  UPF0606 protein KIAA1549 (KIAA1549) 7.3
 LDTP13114  C-type mannose receptor 2 (MRC2) 6.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 6.4
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 5.9
 LDTP02728  Nidogen-1 (NID1) 5.7
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.7
 LDTP07760  CD109 antigen (CD109) 5.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.4
 LDTP13669  Endothelial protein C receptor (PROCR) 5.4
 LDTP09920  Golgi apparatus protein 1 (GLG1) 5.3
 LDTP06154  Desmocollin-3 (DSC3) 5.2
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 5.1
 LDTP01075  Protein CutA (CUTA) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587