General Information of Target

Target ID LDTP00282
Target Name Beta-mannosidase (MANBA)
Gene Name MANBA
Gene ID 4126
Synonyms
MANB1; Beta-mannosidase; EC 3.2.1.25; Lysosomal beta A mannosidase; Mannanase; Mannase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQD
SYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETD
NMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNF
VRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFD
VVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTG
YNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPA
DSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACA
LYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKD
YVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDC
WNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAG
LHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLN
DIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSV
RVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHE
LLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFS
DNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 2 family
Subcellular location
Lysosome
Function Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Uniprot ID
O00462
Ensemble ID
ENST00000647097.2
HGNC ID
HGNC:6831
ChEMBL ID
CHEMBL3903

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info 
2.11  LDD0054  [1]
DBIA
 Probe Info 
C176(0.88)  LDD0531  [2]
IA-alkyne
 Probe Info 
N.A.  LDD0162  [3]
Lodoacetamide azide
 Probe Info 
C748(0.00); C176(0.00); C800(0.00)  LDD0037  [4]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info 
30.27  LDD1850  [5]
C171
 Probe Info 
8.57  LDD1851  [5]
C197
 Probe Info 
11.00  LDD1873  [5]
C208
 Probe Info 
19.97  LDD1883  [5]
C211
 Probe Info 
9.85  LDD1885  [5]
C223
 Probe Info 
14.83  LDD1897  [5]
C302
 Probe Info 
8.34  LDD1971  [5]
C310
 Probe Info 
19.70  LDD1977  [5]
C425
 Probe Info 
10.78  LDD2080  [5]
VE-P
 Probe Info 
N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C176(0.88)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C176(0.92)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C176(0.85)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C176(1.00)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C176(0.94)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C176(0.78)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C176(1.09)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C176(1.01)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C176(1.06)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C176(0.94)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C176(1.09)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C176(0.89)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C176(0.23)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C176(1.05)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C176(0.82)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C176(1.00)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C176(1.14)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C176(1.06)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C176(1.00)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C176(1.24)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C176(0.96)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C176(1.17)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C176(1.06)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C176(1.22)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C176(0.96)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C176(1.00)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C176(1.33)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C176(1.34)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C176(1.21)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C176(1.10)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C176(1.14)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C176(0.96)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C176(1.02)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C176(1.27)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C176(1.18)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C176(0.93)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C176(1.06)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C176(1.01)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C176(1.11)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C176(1.00)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C176(1.08)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C176(1.08)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C176(0.95)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C176(1.28)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C176(1.02)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C176(1.05)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C176(0.83)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C176(1.02)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C176(0.92)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C176(1.05)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C176(1.24); C800(1.12)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C176(1.05); C800(1.07)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C176(0.90); C800(0.97)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C176(1.18)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C800(0.94); C629(1.21)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C176(0.99); C186(1.04)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C176(0.96); C800(1.05)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C176(1.09); C800(1.01)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C176(1.58); C800(0.98); C629(0.92)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C176(0.85)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C176(0.84)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C176(1.10)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C176(1.20)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C176(0.96)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C176(1.08)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C176(1.16)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C176(0.86)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C176(1.13)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C176(0.94)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C176(0.91)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C176(0.93)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C176(1.04)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C176(1.27)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C176(0.95)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C176(0.98)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C176(0.89)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C176(1.01)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C176(0.92)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C176(1.07)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C176(1.17); C800(1.15)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C176(1.20); C800(1.07)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C176(0.91)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C176(1.17)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C176(1.11)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C176(1.22)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C176(0.98)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C176(0.89)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C176(0.79)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C176(1.02)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C176(0.96)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C176(0.71)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C176(1.20); C800(1.04)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C176(0.63)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C176(0.74)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C176(1.05)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C176(1.18)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C176(1.15)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C176(1.12)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C176(1.02)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C176(0.80)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C176(1.32)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C176(1.58)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C176(1.32); C800(1.10); C629(1.05)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C176(1.33)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C176(1.07)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C176(0.93)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C176(0.77)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C176(1.24)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C176(1.15); C800(1.04)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C800(0.85)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C800(1.11)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C176(1.04); C800(1.13)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C800(0.93)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C800(1.01)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C176(1.24); C800(1.04)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C176(1.01); C800(1.14)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C176(0.96); C800(1.00)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C800(1.00)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C800(1.07); C629(0.94)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C176(1.22); C186(0.71)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C176(1.05); C800(1.08)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C176(1.27); C800(1.02)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C176(1.65); C800(1.11); C629(0.86)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C176(1.00); C800(0.85)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C800(1.04)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C800(0.88)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C176(1.12); C800(1.13)  LDD1621  [7]
 LDCM0419  CL30 HEK-293T C176(1.04); C800(1.00)  LDD1623  [7]
 LDCM0420  CL31 HCT 116 C176(0.94)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C176(1.10)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C176(1.14)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C176(1.03)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C176(1.21)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C176(1.02)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C176(1.03)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C176(1.04)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C800(1.03)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C176(0.90)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C176(1.00)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C176(1.08)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C176(1.06)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C176(1.15)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C176(0.85)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C176(1.14)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C176(1.35)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C176(1.12)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C176(1.18)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C176(1.19); C800(1.20)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C176(1.16)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C176(1.13)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C176(1.18)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C176(0.94)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C176(1.03)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C176(0.90)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C176(1.06)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C176(1.01)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C176(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C176(0.98)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C176(1.08); C800(0.99)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C176(0.94)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C176(1.27)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C176(1.18)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C176(1.13)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C176(1.22)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C176(1.00)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C176(1.05)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C176(1.01)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C176(0.96)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C176(1.28)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C176(1.11); C800(1.03)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C176(0.95)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C176(1.07)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C176(1.02)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C176(1.07)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C176(1.03)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C176(0.88)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C176(0.92)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C176(0.87)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C176(0.82)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C800(0.84); C629(1.34)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C176(0.86)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C176(0.90)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C176(0.73)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C176(0.88)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C176(0.93)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C176(0.86)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C176(0.91)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C176(0.83)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C176(0.96)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C176(0.88)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C176(1.17); C186(0.95)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C176(0.88)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C176(1.04)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C176(0.97)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C176(1.05)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C176(0.90)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C176(1.02)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C176(0.98)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C176(1.00)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C176(1.01)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C176(0.94)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C176(0.96)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C176(1.93)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C800(1.03); C176(0.81)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C800(1.02); C176(1.19)  LDD1497  [7]
 LDCM0024  KB05 HMCB C800(0.90)  LDD3312  [8]
 LDCM0008  Tranylcypromine SH-SY5Y 2.11  LDD0054  [1]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840