Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C208  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 44.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 30.7
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 24.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 23.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 22.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 21.6
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 20.4
 LDTP00282  Beta-mannosidase (MANBA) 20.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 20.0
 LDTP00316  Ribonuclease T2 (RNASET2) 19.0
 LDTP17633  Beta-galactosidase-1-like protein 2 (GLB1L2) 18.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 17.3
 LDTP02141  Alpha-galactosidase A (GLA) 16.9
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 14.5
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.3
 LDTP01372  Carboxypeptidase D (CPD) 14.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 13.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 13.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 13.6
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 11.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 11.4
 LDTP02539  Lysosomal acid phosphatase (ACP2) 11.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 10.9
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 10.5
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 9.6
 LDTP02505  Lysosomal protective protein (CTSA) 9.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.5
 LDTP13751  Exonuclease 1 (EXO1) 7.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 7.4
 LDTP05905  Acid ceramidase (ASAH1) 6.9
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 6.8
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 6.6
 LDTP06370  Ephrin type-A receptor 7 (EPHA7) 6.5
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.5
 LDTP01518  NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) 6.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 6.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 6.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.1
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 6.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 6.0
 LDTP02837  Beta-galactosidase (GLB1) 5.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.7
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 5.3
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.1
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 4.9
Transporter and channel
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 30.7
 LDTP02071  Amyloid-beta precursor protein (APP) 26.5
 LDTP11406  Transmembrane protein 59 (TMEM59) 21.7
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 18.6
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 14.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 14.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 14.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.4
 LDTP01969  Transferrin receptor protein 1 (TFRC) 13.1
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 10.3
 LDTP00310  Syntenin-1 (SDCBP) 10.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 9.6
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 9.2
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 8.9
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 7.7
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 7.7
 LDTP16190  Protein FAM8A1 (FAM8A1) 7.6
 LDTP15481  Transmembrane protein 87A (TMEM87A) 7.6
 LDTP03380  Stomatin (STOM) 7.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.4
 LDTP01427  Slit homolog 2 protein (SLIT2) 7.2
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 6.6
 LDTP02166  Integrin alpha-V (ITGAV) 6.6
 LDTP07236  Protein GPR107 (GPR107) 6.3
 LDTP00433  Neuropilin-1 (NRP1) 6.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.7
 LDTP09288  Vang-like protein 1 (VANGL1) 5.4
 LDTP04462  H(+)/Cl(-) exchange transporter 6 (CLCN6) 5.2
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 5.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 4.9
Immunoglobulin
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01913  HLA class I histocompatibility antigen, B alpha chain (HLA-B) 7.8
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 5.9
 LDTP14280  Roundabout homolog 1 (ROBO1) 5.0
 LDTP14203  Junctional adhesion molecule A (F11R) 4.9
Other
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 18.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 18.3
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 17.5
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 16.8
 LDTP10023  Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) 16.8
 LDTP01973  Ferritin light chain (FTL) 14.5
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 14.4
 LDTP02927  Ganglioside GM2 activator (GM2A) 13.7
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 12.9
 LDTP06134  Protocadherin Fat 1 (FAT1) 12.2
 LDTP14458  Tetraspanin-6 (TSPAN6) 10.8
 LDTP09787  Nicastrin (NCSTN) 10.1
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 9.2
 LDTP05960  Trophoblast glycoprotein (TPBG) 9.0
 LDTP05764  Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) 8.6
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 8.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.8
 LDTP12352  CD320 antigen (CD320) 7.6
 LDTP09920  Golgi apparatus protein 1 (GLG1) 7.5
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 6.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 6.0
 LDTP02443  Calmodulin-3 (CALM3) 5.8
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 5.7
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 5.2
 LDTP13152  DnaJ homolog subfamily B member 11 (DNAJB11) 5.1
 LDTP00887  Calumenin (CALU) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587