Details of the Target

General Information of Target

Target ID LDTP01973
Target Name Ferritin light chain (FTL)
Gene Name FTL
Gene ID 2512
Synonyms
Ferritin light chain; Ferritin L subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Target Bioclass
Other
Family
Ferritin family
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Uniprot ID
P02792
Ensemble ID
ENST00000331825.11
HGNC ID
HGNC:3999

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		7.00  LDD0391  [1]
C-Sul
 Probe Info  		10.70  LDD0066  [2]
STPyne
 Probe Info  		K105(5.82); K106(9.41); K68(1.67)  LDD0277  [3]
m-APA
 Probe Info  		12.88  LDD0403  [4]
BTD
 Probe Info  		C127(0.67)  LDD2106  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C149
 Probe Info  		5.24  LDD1830  [8]
C153
 Probe Info  		18.13  LDD1834  [8]
C170
 Probe Info  		9.51  LDD1850  [8]
C208
 Probe Info  		14.52  LDD1883  [8]
C211
 Probe Info  		8.00  LDD1885  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 12.88  LDD0403  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C127(0.67)  LDD2106  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C127(0.42)  LDD2114  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C127(0.11)  LDD2145  [5]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0392  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferritin heavy chain (FTH1) Ferritin family P02794
Nicotinamide phosphoribosyltransferase (NAMPT) NAPRTase family P43490
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Alpha-synuclein (SNCA) Synuclein family P37840
Syntenin-1 (SDCBP) . O00560
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myogenin (MYOG) . P15173
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Ferritin light chain (FTL) Ferritin family P02792
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Gamma-secretase subunit PEN-2 (PSENEN) PEN-2 family Q9NZ42

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iron Dextran Small molecular drug DB00893
Ferric Pyrophosphate Citrate . DB13995
Sodium Ferric Gluconate Complex . DB09517
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ferric Pyrophosphate Small molecular drug DB09147
Protoporphyrin Small molecular drug DB02285

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587