Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Alkylaryl probe 2  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 71 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP18414  5'-nucleotidase domain-containing protein 2 (NT5DC2) 20.0
 LDTP05905  Acid ceramidase (ASAH1) 20.0
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 20.0
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 20.0
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) 20.0
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL) 20.0
 LDTP01372  Carboxypeptidase D (CPD) 20.0
 LDTP02001  Catalase (CAT) 20.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 20.0
 LDTP12110  Elongator complex protein 3 (ELP3) 20.0
 LDTP01974  Ferritin heavy chain (FTH1) 20.0
 LDTP10888  Legumain (LGMN) 20.0
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 20.0
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 20.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 20.0
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 20.0
 LDTP05793  Methanethiol oxidase (SELENBP1) 20.0
 LDTP13372  N-acetyl-D-glucosamine kinase (NAGK) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP09829  Peroxidasin homolog (PXDN) 20.0
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 20.0
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 20.0
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 20.0
 LDTP15408  Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) 20.0
 LDTP15725  Secernin-2 (SCRN2) 20.0
 LDTP17022  Secernin-3 (SCRN3) 20.0
 LDTP05348  Sterol 26-hydroxylase, mitochondrial (CYP27A1) 20.0
 LDTP13147  Cathepsin Z (CTSZ) 19.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.0
 LDTP12420  Xaa-Pro aminopeptidase 3 (XPNPEP3) 19.0
 LDTP03329  Cathepsin S (CTSS) 18.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 18.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 17.0
 LDTP02883  Alpha-N-acetylgalactosaminidase (NAGA) 17.0
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 17.0
 LDTP02198  Cathepsin D (CTSD) 16.0
 LDTP02918  S-adenosylmethionine decarboxylase proenzyme (AMD1) 16.0
 LDTP11595  Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) 15.0
 LDTP00624  Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) 15.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 15.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.0
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) 15.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 15.0
 LDTP02223  Cathepsin B (CTSB) 14.0
 LDTP07065  Phytanoyl-CoA dioxygenase domain-containing protein 1 (PHYHD1) 14.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 11.0
 LDTP07979  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) 11.0
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 10.0
 LDTP04352  Matrix metalloproteinase-14 (MMP14) 10.0
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 9.0
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC) 9.0
 LDTP02505  Lysosomal protective protein (CTSA) 9.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 9.0
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.0
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) 8.0
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 8.0
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 8.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 7.0
 LDTP07989  Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) 7.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) 6.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 6.0
 LDTP02837  Beta-galactosidase (GLB1) 6.0
 LDTP00285  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) 6.0
 LDTP02888  Aspartate aminotransferase, cytoplasmic (GOT1) 5.0
 LDTP03455  Cytosol aminopeptidase (LAP3) 5.0
 LDTP12803  Dipeptidyl peptidase 3 (DPP3) 5.0
 LDTP05434  Lactoylglutathione lyase (GLO1) 5.0
 LDTP04901  Ras-related protein Rab-14 (RAB14) 5.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 5.0
 LDTP10884  Sialidase-1 (NEU1) 5.0
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 5.0
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05231  Cytochrome c (CYCS) 6.0
 LDTP02215  Prosaposin (PSAP) 5.0
Other
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 20.0
 LDTP00808  Density-regulated protein (DENR) 20.0
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 20.0
 LDTP02085  Plasminogen activator inhibitor 1 (SERPINE1) 20.0
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 13.0
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 12.0
 LDTP00720  Centromere/kinetochore protein zw10 homolog (ZW10) 7.0
 LDTP01973  Ferritin light chain (FTL) 7.0
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 7.0
 LDTP14085  Protein PRRC2C (PRRC2C) 7.0

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.