Details of the Target

General Information of Target

Target ID LDTP12420
Target Name Xaa-Pro aminopeptidase 3 (XPNPEP3)
Gene Name XPNPEP3
Gene ID 63929
Synonyms
Xaa-Pro aminopeptidase 3; X-Pro aminopeptidase 3; EC 3.4.11.9; Aminopeptidase P3; APP3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATSTSTEAKSASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLLDQQELLCGQIAGV
VRCVSDISDSPPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVGFFNFYN
GPVSLAYENCSQEELSTEWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAARIL
QTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGAALP
PNVQIIPVFVTKEEAISLHEFPVEQMTRSLASPAGLQDGSAQHHPKGGSTSALKENATGH
VESMAWTTPDPTSPDEACPDGRKENGCLSGHDLESIRPAGLHNSARGEVLGLSSSLGKEL
VFLQEELDLSEIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKASLSASSSLEPTPPEDT
AISSLRPPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLLLPRLDPGQRG
NKLPTGEQGLDEDVDGVCESHAAPGLECSSGSANCQGAGPSADGISSRLTPAESCMGLVR
MNLYTHCVKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLNGLEVHLKETLPRDEAASTSS
TYNFTHYDRIQSLLMANLPQVATPQDRRFLQAVSLMHSEFAQLPALYEMTVRNASTAVYA
CCNPIQETYFQQLAPAARSSGFPNPQDGAFSLSGKAKQKLLKHGVNLL
Target Bioclass
Enzyme
Family
Peptidase M24B family
Subcellular location
Cytoplasm; Mitochondrion
Function
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.; [Isoform 1]: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
Uniprot ID
Q9NQH7
Ensemble ID
ENST00000357137.9
HGNC ID
HGNC:28052
ChEMBL ID
CHEMBL3831223

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.H147Q .
LN18 SNV: p.I83V .
MEWO SNV: p.P112L .
MOLT4 SNV: p.A463V IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		20.00  LDD0389  [1]
DBIA
 Probe Info  		C334(1.02); C338(1.02)  LDD0593  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Ox-W18
 Probe Info  		N.A.  LDD2175  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		17.03  LDD1752  [7]
C092
 Probe Info  		17.75  LDD1783  [7]
C107
 Probe Info  		10.63  LDD1794  [7]
C185
 Probe Info  		9.13  LDD1863  [7]
C350
 Probe Info  		36.25  LDD2011  [7]
C356
 Probe Info  		8.22  LDD2017  [7]
FFF probe2
 Probe Info  		10.05  LDD0463  [8]
FFF probe3
 Probe Info  		20.00  LDD0465  [8]
FFF probe6
 Probe Info  		20.00  LDD0468  [8]
STS-1
 Probe Info  		N.A.  LDD0136  [9]
STS-2
 Probe Info  		N.A.  LDD0139  [9]
OEA-DA
 Probe Info  		16.82  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C338(1.15)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C338(0.92)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C338(1.00)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C338(1.44)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C338(1.34)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C338(1.05)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C338(1.48)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C338(1.34)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C338(1.76)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C338(1.02)  LDD0823  [2]
 LDCM0227  AC110 HEK-293T C338(1.09)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C338(1.11)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C338(1.24)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C334(1.01)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C334(0.94)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C334(0.98)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C334(0.87)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C334(0.88)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C334(0.88)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C334(0.84)  LDD0834  [2]
 LDCM0238  AC120 HEK-293T C334(0.77)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C334(0.75)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C334(0.70)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C334(0.80)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C334(0.74)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C334(0.79)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C334(0.77)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C334(0.73)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C334(1.13)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C334(0.85)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C334(1.02)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C334(1.08)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C334(1.03)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C334(0.90)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C334(0.96)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C334(0.99)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C334(0.86)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C334(0.87)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C334(0.96)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C334(0.87)  LDD0856  [2]
 LDCM0260  AC140 HEK-293T C334(1.00)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C334(0.90)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C334(0.92)  LDD0860  [2]
 LDCM0276  AC17 HCT 116 C334(1.02); C338(1.02)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C334(0.91); C338(0.91)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C334(0.97); C338(0.97)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C334(0.58); C338(0.58)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C334(0.84); C338(0.84)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C334(0.68); C338(0.68)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C334(0.77); C338(0.77)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C334(0.76); C338(0.76)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C338(0.98)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C338(0.87)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C338(1.26)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C338(2.24)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C338(0.90)  LDD0887  [2]
 LDCM0291  AC30 HEK-293T C338(0.95)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C338(1.09)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C338(1.26)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C338(1.06)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C338(0.92)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C334(0.75); C338(0.75)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C334(1.79); C338(1.79)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C334(0.99); C338(0.99)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C334(1.21); C338(1.21)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C334(1.19); C338(1.19)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C334(1.04); C338(1.04)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C334(1.41); C338(1.41)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C334(1.14); C338(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C334(1.18); C338(1.18)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C334(1.24); C338(1.24)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C334(0.64); C338(0.64)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C334(1.74); C338(1.74)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C334(1.40); C338(1.40)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C334(1.58); C338(1.58)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C334(0.48); C338(0.48)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C334(0.63); C338(0.63)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C334(1.52); C338(1.52)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C334(1.72); C338(1.72)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C334(1.19); C338(1.19)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C334(0.92); C338(0.92)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C334(0.70); C338(0.70)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C334(0.53); C338(0.53)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C334(1.07); C338(1.14)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C334(1.05); C338(1.18)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C334(0.96); C338(1.20)  LDD0920  [2]
 LDCM0324  AC60 HEK-293T C334(0.76); C338(1.47)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C334(0.77); C338(1.39)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C334(0.97); C338(1.30)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C334(0.78); C338(1.23)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C334(0.99); C338(1.47)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C334(0.72); C338(1.35)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C334(0.91); C338(1.43)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C334(0.86); C338(1.31)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C334(1.31); C338(1.31)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C334(1.19); C338(1.19)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C334(0.50); C338(0.50)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C334(0.99); C338(0.99)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C334(0.97); C338(0.97)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C334(0.47); C338(0.47)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C334(0.46); C338(0.46)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C334(0.34); C338(0.34)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C334(0.91); C338(0.91)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C334(1.12); C338(1.12)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C334(1.57); C338(1.57)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C334(1.23); C338(1.23)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C334(1.05); C338(1.05)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C334(0.58); C338(0.58)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C334(0.25); C338(0.25)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C334(1.08)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C334(0.85)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C334(0.87)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C334(0.91)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C334(1.04)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C334(0.90)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C334(0.81)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C334(0.71)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C334(0.93)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C334(0.87)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C334(0.81)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C334(0.83)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C334(0.82)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C334(0.76)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C334(0.74)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C338(1.47)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C338(1.18)  LDD0964  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0374  CL105 HCT 116 C334(0.76); C338(0.76)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C334(0.92); C338(0.92)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C334(0.58); C338(0.58)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C334(0.42); C338(0.42)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C334(0.70); C338(0.70)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C334(0.85); C338(0.85)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C334(0.77); C338(0.77)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C338(1.09)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C338(1.05)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C338(1.01)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C338(0.95)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C338(1.09)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C334(0.30); C338(0.30)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C334(0.61); C338(0.61)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C334(0.66); C338(0.66)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C334(0.83); C338(0.83)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C334(0.74); C338(0.74)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C334(1.39); C338(1.39)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C334(1.40); C338(1.40)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C334(0.76); C338(0.76)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C334(1.10); C338(1.05)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C334(1.07); C338(1.25)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C334(1.13); C338(1.25)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C334(1.01); C338(1.02)  LDD0997  [2]
 LDCM0403  CL16 HCT 116 C334(1.02); C338(1.02)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C334(1.45); C338(1.45)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C334(1.60); C338(1.60)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C334(1.20); C338(1.20)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C334(0.87); C338(0.87)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C334(1.02); C338(1.02)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C334(0.35); C338(0.35)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C334(1.18); C338(1.18)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C334(0.42); C338(0.42)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C334(0.71); C338(0.71)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C334(0.89); C338(0.89)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C334(1.51); C338(1.51)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C334(0.96); C338(0.96)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C334(0.88); C338(0.88)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C334(1.11); C338(1.11)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C334(0.54); C338(0.54)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C334(0.71); C338(0.71)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C334(0.54); C338(0.54)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C334(0.63); C338(0.63)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C334(0.28); C338(0.28)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C334(0.64); C338(0.64)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C334(0.42); C338(0.42)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C334(0.46); C338(0.46)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C334(0.60); C338(0.60)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C334(0.81); C338(0.81)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C334(0.22); C338(0.22)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C334(0.24); C338(0.24)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C334(0.77); C338(0.77)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C334(0.98); C338(0.98)  LDD0752  [2]
 LDCM0427  Fragment51 HCT 116 C334(0.23); C338(0.23)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C492(0.97)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C492(0.96)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C492(0.98)  LDD1502  [11]
 LDCM0109  NEM HeLa N.A.  LDD0224  [5]
 LDCM0099  Phenelzine HEK-293T 4.00  LDD0390  [1]

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402