Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe6  Probe Info 
Probe concentration Probe:200uM; negative probe:200uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cells (K562)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP04689  Adenosine kinase (ADK) 20.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 20.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 20.0
 LDTP02001  Catalase (CAT) 20.0
 LDTP00497  Cyclin-G-associated kinase (GAK) 20.0
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 20.0
 LDTP05171  Dermcidin (DCD) 20.0
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 20.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 20.0
 LDTP04374  Dynamin-2 (DNM2) 20.0
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 20.0
 LDTP13751  Exonuclease 1 (EXO1) 20.0
 LDTP11904  Fructosamine-3-kinase (FN3K) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 20.0
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 20.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 20.0
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) 20.0
 LDTP00751  Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP12420  Xaa-Pro aminopeptidase 3 (XPNPEP3) 20.0
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 17.6
 LDTP06363  Ribosomal protein S6 kinase alpha-2 (RPS6KA2) 16.0
 LDTP10394  Adenosylhomocysteinase 3 (AHCYL2) 14.9
 LDTP04248  Deoxyhypusine synthase (DHPS) 13.9
 LDTP02798  NAD(P)H dehydrogenase [quinone] 1 (NQO1) 13.4
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 13.0
 LDTP07483  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) 12.4
 LDTP03753  Cystathionine beta-synthase (CBS) 12.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 12.0
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) 11.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 11.8
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 11.4
 LDTP05920  Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) 11.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 10.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 10.5
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 8.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 8.6
 LDTP02198  Cathepsin D (CTSD) 8.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 8.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 8.1
 LDTP00886  Nardilysin (NRDC) 8.1
 LDTP03330  Proteasome subunit alpha type-1 (PSMA1) 8.0
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 7.5
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 7.2
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 6.7
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 6.7
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 6.0
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 6.0
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 6.0
 LDTP04256  Glutamate dehydrogenase 2, mitochondrial (GLUD2) 5.9
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 5.9
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 5.8
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.7
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 5.6
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4) 5.3
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) 5.3
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) 5.1
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05900  Metaxin-1 (MTX1) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 12.9
 LDTP04707  Protein SEC13 homolog (SEC13) 9.4
 LDTP02215  Prosaposin (PSAP) 7.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 7.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 6.9
 LDTP03402  Calreticulin (CALR) 6.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 5.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.3
 LDTP09825  Nuclear pore complex protein Nup205 (NUP205) 5.3
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04515  Signal transducer and activator of transcription 2 (STAT2) 20.0
 LDTP02870  Y-box-binding protein 3 (YBX3) 5.8
 LDTP05065  Y-box-binding protein 1 (YBX1) 5.4
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00372  Acyl carrier protein, mitochondrial (NDUFAB1) 20.0
 LDTP01600  BAG family molecular chaperone regulator 4 (BAG4) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP13630  Neudesin (NENF) 20.0
 LDTP11825  Phosducin-like protein 3 (PDCL3) 20.0
 LDTP13906  Polymerase delta-interacting protein 2 (POLDIP2) 20.0
 LDTP01608  Proteasome assembly chaperone 1 (PSMG1) 20.0
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 20.0
 LDTP03397  Replication protein A 70 kDa DNA-binding subunit (RPA1) 12.1
 LDTP14017  Plakophilin-3 (PKP3) 11.6
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 9.6
 LDTP02297  Vimentin (VIM) 8.7
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 8.6
 LDTP00887  Calumenin (CALU) 8.5
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 8.5
 LDTP05904  Tubulin beta-3 chain (TUBB3) 8.3
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 8.3
 LDTP11233  Tubulin beta-6 chain (TUBB6) 8.3
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 8.2
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) 8.2
 LDTP02205  Tubulin beta chain (TUBB) 8.1
 LDTP06097  Reticulocalbin-2 (RCN2) 8.1
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 7.8
 LDTP11238  Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) 7.8
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 7.4
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 7.2
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 7.1
 LDTP03775  RNA-binding protein FUS (FUS) 6.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 6.7
 LDTP05160  Nucleobindin-2 (NUCB2) 6.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.7
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 6.7
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 6.4
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 6.4
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 6.4
 LDTP10684  RNA-binding protein 14 (RBM14) 6.1
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 5.9
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 5.8
 LDTP04935  Prefoldin subunit 3 (VBP1) 5.7
 LDTP00880  A-kinase anchor protein 8 (AKAP8) 5.7
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 5.7
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.7
 LDTP06588  Drebrin (DBN1) 5.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 5.6
 LDTP07888  Protein unc-13 homolog D (UNC13D) 5.4
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 5.3
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 5.3
 LDTP02053  Heat shock protein beta-1 (HSPB1) 5.2
 LDTP14272  Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) 5.2
 LDTP05318  RNA-binding protein EWS (EWSR1) 5.1
 LDTP04395  RNA-binding protein FXR1 (FXR1) 5.1
 LDTP01285  TIP41-like protein (TIPRL) 5.1
 LDTP10271  DAZ-associated protein 1 (DAZAP1) 5.1

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.