Details of the Target

General Information of Target

Target ID LDTP04495
Target Name Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)
Gene Name HNRNPA3
Gene ID 220988
Synonyms
HNRPA3; Heterogeneous nuclear ribonucleoprotein A3; hnRNP A3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGT
LTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPG
AHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTV
DKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRG
GNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQG
GGYGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPY
GGGYGSGGGSGGYGSRRF
Target Bioclass
Other
Subcellular location
Nucleus
Function Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
Uniprot ID
P51991
Ensemble ID
ENST00000392524.7
HGNC ID
HGNC:24941

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.K4NfsTer31 .
A172 Deletion: p.F38YfsTer7 .
A3KAW SNV: p.K57E .
AU565 SNV: p.Q213H DBIA    Probe Info 
COLO792 SNV: p.P5S .
HS936T SNV: p.G254S .
HUH28 SNV: p.R17C DBIA    Probe Info 
LS180 Deletion: p.Q71KfsTer11 .
LS513 SNV: p.Y323C .
SNGM SNV: p.W58G DBIA    Probe Info 
SW756 SNV: p.E23Q .
UACC62 Substitution: p.G219Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		10.00  LDD0450  [2]
A-EBA
 Probe Info  		2.94  LDD0215  [3]
ILS-1
 Probe Info  		2.78  LDD0415  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		6.06  LDD0244  [5]
N1
 Probe Info  		4.44  LDD0242  [5]
TH211
 Probe Info  		Y360(20.00); Y373(20.00); Y364(15.82); Y140(8.80)  LDD0257  [6]
TH216
 Probe Info  		Y188(20.00)  LDD0259  [6]
ONAyne
 Probe Info  		K118(0.00); K127(0.00); K151(0.00)  LDD0273  [7]
Probe 1
 Probe Info  		Y140(77.35); Y145(22.91); Y360(57.62); Y364(10.10)  LDD3495  [8]
BTD
 Probe Info  		C196(2.01)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C94(5.93)  LDD0168  [10]
HHS-482
 Probe Info  		Y360(0.69); Y364(0.90); Y373(1.30)  LDD0285  [11]
HHS-475
 Probe Info  		Y373(0.75); Y360(0.80); Y364(0.87); Y188(1.93)  LDD0264  [12]
HHS-465
 Probe Info  		Y188(10.00); Y360(10.00)  LDD2237  [13]
DBIA
 Probe Info  		C85(0.99); C94(0.99)  LDD0078  [14]
5E-2FA
 Probe Info  		H122(0.00); H26(0.00); H177(0.00); H194(0.00)  LDD2235  [15]
AMP probe
 Probe Info  		N.A.  LDD0200  [16]
ATP probe
 Probe Info  		K134(0.00); K127(0.00); K36(0.00); K187(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C64(0.00); C94(0.00); C85(0.00); C196(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
IPIAA_L
 Probe Info  		C64(0.00); C85(0.00); C196(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C94(0.00); C85(0.00); C64(0.00); C196(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
IPM
 Probe Info  		N.A.  LDD0025  [21]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
TFBX
 Probe Info  		N.A.  LDD0027  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
aONE
 Probe Info  		N.A.  LDD0002  [22]
Compound 10
 Probe Info  		C196(0.00); C64(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
NHS
 Probe Info  		K134(0.00); K29(0.00); K127(0.00); K126(0.00)  LDD0010  [22]
OSF
 Probe Info  		Y360(0.00); Y373(0.00)  LDD0029  [24]
SF
 Probe Info  		K118(0.00); Y188(0.00); K127(0.00); Y360(0.00)  LDD0028  [24]
STPyne
 Probe Info  		K200(0.00); K118(0.00)  LDD0009  [22]
Phosphinate-6
 Probe Info  		C196(0.00); C85(0.00); C94(0.00)  LDD0018  [25]
1c-yne
 Probe Info  		K29(0.00); K127(0.00); K134(0.00); K182(0.00)  LDD0228  [26]
1d-yne
 Probe Info  		N.A.  LDD0357  [26]
Acrolein
 Probe Info  		C196(0.00); H177(0.00); C64(0.00); H194(0.00)  LDD0217  [27]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [27]
Crotonaldehyde
 Probe Info  		C196(0.00); H122(0.00); H194(0.00); C64(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		C196(0.00); C64(0.00); H194(0.00); H177(0.00)  LDD0218  [27]
W1
 Probe Info  		C196(0.00); C64(0.00)  LDD0236  [28]
NAIA_5
 Probe Info  		C64(0.00); C94(0.00); C85(0.00); C196(0.00)  LDD2223  [29]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		14.93  LDD1845  [30]
C232
 Probe Info  		37.01  LDD1905  [30]
C338
 Probe Info  		11.39  LDD2001  [30]
C353
 Probe Info  		5.82  LDD2014  [30]
FFF probe11
 Probe Info  		12.71  LDD0471  [31]
FFF probe12
 Probe Info  		5.12  LDD0473  [31]
FFF probe13
 Probe Info  		14.38  LDD0475  [31]
FFF probe14
 Probe Info  		8.91  LDD0477  [31]
FFF probe2
 Probe Info  		14.89  LDD0463  [31]
FFF probe3
 Probe Info  		13.27  LDD0464  [31]
FFF probe4
 Probe Info  		6.52  LDD0466  [31]
FFF probe6
 Probe Info  		7.21  LDD0468  [31]
JN0003
 Probe Info  		8.90  LDD0469  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
DA-2
 Probe Info  		N.A.  LDD0073  [34]
OEA-DA
 Probe Info  		3.53  LDD0046  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C196(1.32)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C196(1.73)  LDD2152  [9]
 LDCM0025  4SU-RNA HEK-293T C94(5.93)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C64(2.08)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C64(1.49); C85(1.00); C94(0.91)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C64(1.03); C85(1.21); C94(1.21)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C64(1.44); C196(1.86); C85(1.03); C94(0.85)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C64(0.76); C196(0.74); C85(1.36); C94(1.14)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C64(0.78); C196(0.61); C85(1.01); C94(0.96)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C64(0.64); C196(0.33); C85(1.42); C94(1.09)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C64(0.68); C196(0.47); C85(1.42); C94(1.20)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C64(0.65); C196(0.44); C85(1.04); C94(0.91)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C64(0.69); C196(0.44); C85(1.13); C94(1.02)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C64(0.69); C196(0.24); C85(1.70); C94(1.07)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C64(0.73); C196(0.77); C85(0.83); C94(0.81)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C64(0.89); C196(0.74); C85(1.27); C94(1.15)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C64(0.86); C85(1.48); C94(1.42)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C64(0.72); C196(0.58); C85(1.26); C94(0.92)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C64(0.75); C196(0.58); C85(1.86); C94(1.26)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C64(0.69); C196(0.43); C85(1.32); C94(1.07)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C64(0.92); C85(1.03); C94(1.11)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C64(1.19); C85(1.09); C94(1.12)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C64(1.10); C85(0.98); C94(0.97)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C64(1.00); C85(0.79); C94(0.92)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C64(1.11); C85(0.74); C94(1.37)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C64(1.00); C85(0.84); C94(0.87)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C64(0.97); C85(0.72); C94(0.84)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C64(1.05); C85(1.25); C94(1.13)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C64(1.14); C85(1.66); C94(1.43)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C64(1.01); C85(1.13); C94(1.30)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C64(1.04); C85(0.66); C94(0.79)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C64(1.31); C85(1.12); C94(0.94)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C64(1.21); C85(0.93); C94(1.04)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C64(0.96); C85(0.96); C94(0.95)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C64(1.38); C85(1.05); C94(0.95)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C64(1.15); C85(0.78); C94(0.95)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C64(0.64); C85(0.81); C94(0.93)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C64(1.37); C85(0.88); C94(0.91)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C64(1.13); C85(0.74); C94(0.85)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C64(1.83); C85(1.06); C94(1.08)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C64(1.35); C85(0.79); C94(0.83)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C64(1.13); C85(0.91); C94(0.95)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C64(0.89); C85(1.13); C94(1.13)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C64(0.83); C85(0.85); C94(0.93)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C64(1.03); C85(1.07); C94(1.12)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C64(1.30); C85(1.05); C94(0.97)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C64(0.86); C85(1.69); C94(1.52)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C64(0.90); C85(1.06); C94(1.16)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C64(1.05); C85(1.52); C94(1.39)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C64(0.78); C85(1.35); C94(1.36)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C64(0.93); C85(1.52); C94(1.43)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C64(1.33); C85(1.27); C94(1.28)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C64(1.18); C196(0.77); C85(1.15); C94(1.14)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C196(0.48); C64(0.82); C85(1.21); C94(1.25)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C196(0.68); C64(0.94); C94(1.00); C85(1.11)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C196(0.77); C64(0.95); C94(1.11); C85(1.24)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C196(0.37); C64(0.75); C94(1.04); C85(1.13)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C196(0.09); C64(0.51); C94(1.12); C85(1.27)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C196(0.39); C64(0.76); C94(1.34); C85(1.53)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C64(1.04); C94(1.46); C85(1.53)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C196(0.93); C64(1.15); C94(1.16); C85(1.34)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C196(0.74); C85(0.95); C64(0.99); C94(1.10)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C196(0.29); C64(0.72); C94(1.06); C85(1.25)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C196(0.07); C64(0.42); C94(0.91); C85(1.13)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C64(0.88); C196(0.58); C85(1.24); C94(1.13)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C64(1.01); C196(0.52); C85(1.07); C94(1.06)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C64(1.00); C196(0.84); C85(1.25); C94(1.14)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C64(0.88); C196(0.79); C85(1.27); C94(1.09)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C85(1.12); C94(1.17); C64(1.28)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C64(1.18); C94(1.40); C85(1.47)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C64(1.21); C85(1.26); C94(1.30)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C94(1.04); C85(1.08); C64(1.23)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C94(1.15); C85(1.15); C64(1.17)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C94(1.07); C85(1.11); C64(1.27)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C85(1.08); C94(1.11); C64(1.20)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C85(1.04); C94(1.04); C64(1.16)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C85(1.09); C94(1.22); C64(1.26)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C85(0.86); C94(0.88); C64(1.49)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C85(0.83); C94(0.87); C64(0.98)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C94(0.93); C85(0.96); C64(1.01)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C94(0.80); C85(0.81); C64(1.30)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C64(0.84); C85(0.95); C94(1.02)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C94(1.02); C85(1.04); C64(1.20)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C64(0.75); C85(1.04); C94(1.06)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C64(0.86); C85(0.94); C94(0.94)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C64(0.69); C94(1.19); C85(1.20)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C85(1.03); C94(1.05); C64(1.11)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C64(1.14); C94(1.14); C85(1.21)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C85(0.67); C94(0.67); C196(1.19)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C85(0.61); C94(0.61); C196(1.18)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C85(0.63); C94(0.63); C196(1.17)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C85(0.83); C94(0.83); C196(1.38)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C85(0.82); C94(0.82); C196(1.07)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C94(0.97); C64(1.01); C85(1.01)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C196(0.62); C85(0.69); C94(0.69)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C196(0.94); C85(1.08); C94(1.08)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C85(0.81); C94(0.81); C196(0.87)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C85(0.95); C94(0.95); C196(1.21)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C196(0.81); C85(1.25); C94(1.25)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C196(0.55); C85(0.99); C94(0.99)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C85(1.08); C196(1.08); C64(1.09); C94(1.09)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C196(0.94); C85(0.95); C94(1.00); C64(1.01)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C64(1.04); C85(1.07); C94(1.15); C196(1.78)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C196(0.36); C64(1.03); C94(1.36); C85(1.45)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C94(0.94); C64(0.99); C85(1.03)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C196(0.38); C64(1.15); C85(1.33); C94(1.37)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C64(0.98); C85(1.44); C196(1.46); C94(1.57)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C196(0.90); C64(1.07); C94(1.16); C85(1.16)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C196(0.58); C64(0.94); C85(1.26); C94(1.30)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C196(0.54); C64(1.19); C94(1.30); C85(1.39)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C196(0.32); C64(0.90); C85(1.09); C94(1.13)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C196(0.14); C64(0.91); C85(1.60); C94(1.61)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C85(0.88); C94(0.89); C64(1.08)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C64(0.91); C85(1.32); C94(1.54)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C64(0.84); C85(1.23); C94(1.37)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C64(0.86); C94(1.43); C85(1.47)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C94(1.07); C85(1.09); C64(1.33)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C94(0.86); C85(0.90); C64(1.42)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C64(0.96); C85(1.28); C94(1.32)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C85(0.92); C94(0.93); C64(1.14)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C64(0.93); C94(0.98); C85(1.04)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C64(0.91); C85(1.20); C94(1.22)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C94(0.93); C85(1.05); C64(1.32)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C64(0.64); C94(0.85); C85(1.03)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C64(0.76); C196(0.86); C94(0.89); C85(0.89)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C94(0.79); C85(0.84); C196(0.85); C64(0.86)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C64(0.93); C94(1.32); C85(1.39)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C196(0.36); C85(0.56); C64(0.59); C94(0.67)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C85(0.78); C94(0.83); C196(1.01); C64(1.13)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C94(0.67); C85(0.69); C64(0.80); C196(0.88)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C196(0.20); C64(0.39); C85(0.59); C94(0.72)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C196(0.27); C64(0.45); C85(0.76); C94(0.89)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C196(0.14); C64(0.50); C85(0.65); C94(0.72)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C196(0.53); C64(0.61); C85(0.67); C94(0.70)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C64(0.55); C196(0.63); C94(0.84); C85(0.85)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C85(0.78); C94(0.80); C64(1.35); C196(1.67)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C85(0.72); C94(0.76); C64(0.83); C196(1.07)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C64(0.77); C94(1.24); C85(1.33)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C196(0.65); C94(0.73); C85(0.76); C64(0.79)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C85(0.72); C94(0.83); C64(0.84); C196(0.98)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C196(0.13); C64(0.47); C85(0.64); C94(0.71)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C64(1.06); C94(1.12); C85(1.36)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C64(0.95); C94(1.07); C85(1.20)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C94(0.98); C85(1.15); C64(1.26)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C64(1.12); C94(1.27); C85(1.52)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C94(0.84); C85(0.85); C64(1.32)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C94(0.92); C64(1.04); C85(1.10)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C94(1.00); C85(1.10); C64(1.14)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C85(0.87); C94(0.88); C64(1.47)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C64(0.98); C94(1.09); C85(1.30)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C94(0.95); C64(1.04); C85(1.11)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C94(0.86); C85(1.01); C64(1.08)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C94(0.83); C85(0.84); C64(1.41)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C94(1.01); C85(1.18); C64(1.43)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C85(0.99); C94(1.00); C64(1.08)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C94(0.94); C64(0.94); C85(0.95)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C196(0.04); C64(0.32); C94(0.79); C85(1.05)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C64(0.71); C196(0.78); C85(0.86); C94(0.87)  LDD0683  [14]
 LDCM0248  AKOS034007472 HCT 116 C64(1.17); C85(1.28); C94(1.18)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C64(0.92); C94(1.38); C85(1.56)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C64(0.95); C94(1.72); C85(1.75)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C85(0.99); C94(0.99)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C196(0.78)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C64(0.00); C196(0.00); H26(0.00); H177(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C64(20.00); C196(1.00)  LDD2227  [29]
 LDCM0367  CL1 HCT 116 C94(0.86); C85(0.88); C64(0.89)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C64(0.94); C94(0.97); C85(1.02)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C94(0.91); C85(0.93); C64(1.06)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C64(0.84); C94(1.56); C85(1.61)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C64(0.79); C94(1.44); C85(1.61)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C64(1.02); C94(1.15); C85(1.23)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C64(0.99); C85(1.24); C94(1.28)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C64(1.14); C85(1.23); C94(1.23)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C64(0.94); C94(1.40); C85(1.49)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C64(0.98); C85(1.27); C94(1.27)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C64(1.21); C94(1.32); C85(1.38)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C64(1.11); C85(1.12); C94(1.14)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C64(0.80); C94(1.07); C85(1.08)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C64(0.87); C94(1.13); C85(1.18)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C64(1.04); C94(1.34); C85(1.36)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C85(0.85); C94(0.87); C64(0.92)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C64(0.67); C94(1.01); C85(1.08)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C64(0.71); C94(1.09); C85(1.12)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C64(0.70); C94(1.08); C85(1.09)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C85(1.06); C94(1.09); C64(1.16)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C196(0.22); C85(0.81); C94(0.81)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C196(0.85); C85(0.88); C94(0.88)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C196(0.71); C85(0.81); C94(0.81)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C64(0.74); C94(0.99); C85(1.04)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C85(0.73); C94(0.73); C196(0.97)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C196(0.67); C64(1.05); C94(1.20); C85(1.30)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C64(0.87); C196(1.07); C94(1.42); C85(1.68)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C196(0.55); C64(0.90); C85(0.98); C94(1.11)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C196(0.43); C85(0.93); C94(1.00); C64(1.19)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C94(0.87); C85(0.87); C64(1.01)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C64(0.79); C94(0.97); C85(1.02)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C94(0.91); C85(0.93); C64(0.96)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C64(0.80); C85(0.96); C94(1.03)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C64(0.99); C94(1.11); C85(1.14)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C94(0.87); C85(0.89); C64(1.01)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C64(0.76); C94(1.07); C85(1.11)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C64(1.01); C85(1.35); C94(1.36)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C64(0.69); C85(0.94); C94(0.99)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C64(0.96); C85(1.06); C94(1.11)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C64(0.75); C85(1.39); C94(1.41)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C94(0.87); C85(0.89); C64(0.96)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C64(1.02); C85(1.16); C94(1.20)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C64(0.80); C85(1.22); C94(1.25)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C64(1.16); C94(1.31); C85(1.36)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C64(0.80); C85(1.04); C94(1.04)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C64(1.04); C85(1.12); C94(1.14)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C64(0.82); C85(0.84); C94(0.87)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C64(0.69); C85(1.08); C94(1.09)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C64(1.14); C85(1.14); C94(1.16)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C64(1.01); C85(1.04); C94(1.08)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C64(1.09); C85(1.19); C94(1.23)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C64(0.93); C85(0.90); C94(0.90)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C64(1.04); C85(1.34); C94(1.38)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C64(0.71); C85(1.02); C94(1.34)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C64(20.00); C85(1.05); C94(1.12)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C64(1.92); C85(1.00); C94(1.17)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C64(0.50); C85(1.11); C94(1.28)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C64(0.48); C85(1.05); C94(1.35)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C64(0.73); C85(1.04); C94(1.13)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C64(0.31); C85(1.07); C94(1.52)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C64(0.39); C85(1.10); C94(1.16)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C64(0.88); C85(1.06); C94(1.07)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C64(0.70); C85(0.94); C94(1.00)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C64(0.70); C85(1.13); C94(1.20)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C64(0.16); C85(0.98); C94(1.14)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C64(0.23); C85(0.99); C94(1.12)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C64(0.94); C85(1.05); C94(1.09)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C64(0.83); C85(0.93); C94(1.04)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C64(1.23); C85(0.80); C94(0.80)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C64(1.06); C85(1.16); C94(1.14)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C64(1.16); C85(1.17); C94(1.17)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C64(1.01); C85(0.69); C94(0.71)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C64(1.09); C85(0.95); C94(0.91)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C64(1.20); C85(1.05); C94(1.06)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C64(1.23); C85(0.75); C94(0.78)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C64(1.25); C85(0.97); C94(1.00)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C64(0.98); C85(1.42); C94(1.39)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C64(0.98); C85(1.05); C94(0.98)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C64(1.11); C85(0.98); C94(0.99)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C64(0.92); C85(1.39); C94(1.34)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C64(1.08); C85(1.26); C94(1.24)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C64(1.18); C85(0.93); C94(0.94)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C64(1.11); C85(0.98); C94(0.96)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C64(1.18); C85(0.97); C94(0.93)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C64(1.10); C85(0.93); C94(0.88)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C64(1.33); C85(0.81); C94(0.85)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C64(1.37); C85(0.86); C94(1.01)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C64(1.14); C85(1.21); C94(1.19)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C64(1.71); C85(0.84); C94(0.84)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C64(1.36); C85(1.07); C94(0.98)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C64(1.42); C85(1.14); C94(1.17)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C64(1.31); C85(1.22); C94(1.31)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C64(1.03); C85(1.54); C94(1.70)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C64(1.04); C85(1.16); C94(1.14)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C64(1.10); C85(0.99); C94(0.93)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C64(1.05); C85(1.13); C94(1.02)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C64(1.16); C85(1.12); C94(1.10)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C64(0.90); C85(1.26); C94(1.26)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C64(1.10); C85(1.55); C94(1.37)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C64(1.07); C85(1.45); C94(1.52)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C64(1.06); C85(1.14); C94(1.12)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C64(0.73); C85(1.12); C94(1.16)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C64(0.90); C85(1.05); C94(1.06)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C64(0.80); C85(1.16); C94(1.10)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C64(0.62); C85(0.91); C94(0.90)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C64(1.17); C85(1.10); C94(1.04)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C64(1.00); C85(0.97); C94(1.05)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C64(0.71); C85(1.07); C94(1.17)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C64(0.73); C85(1.19); C94(1.20)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C64(0.56); C85(0.93); C94(0.97)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C64(0.98); C85(1.12); C94(1.14)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C64(0.97); C85(1.20); C94(1.06)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C64(0.97); C85(1.05); C94(1.02)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C64(0.79); C85(1.20); C94(1.34)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C64(0.62); C85(1.05); C94(1.06)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C64(0.94); C85(0.99); C94(0.97)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C64(0.95); C85(0.85); C94(0.86)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C64(1.19); C85(1.00); C94(0.99)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C64(1.16); C85(0.90); C94(0.88)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C64(1.15); C85(0.95); C94(0.91)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C64(0.88); C85(1.12); C94(1.10)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C64(0.90); C85(1.10); C94(1.00)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C64(1.03); C85(1.09); C94(0.98)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C64(1.00); C85(1.08); C94(1.08)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C64(1.01); C85(1.07); C94(1.10)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C64(0.99); C85(1.03); C94(1.05)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C196(0.91); C64(1.02); C85(0.98); C94(0.88)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C196(0.58)  LDD1702  [9]
 LDCM0625  F8 Ramos C196(1.62)  LDD2187  [37]
 LDCM0573  Fragment11 Ramos C196(20.00); C64(0.07)  LDD2190  [37]
 LDCM0575  Fragment13 Ramos C196(0.62)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C196(0.49); C64(0.46)  LDD2193  [37]
 LDCM0580  Fragment21 Ramos C196(0.61)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C196(1.32)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C196(1.36)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C196(0.64)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C196(0.62)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C196(0.69)  LDD2200  [37]
 LDCM0468  Fragment33 HCT 116 C64(1.25); C85(1.34); C94(1.26)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C196(1.45)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C196(0.65); C64(2.15)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C64(0.17); C85(0.93); C94(1.15)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C196(0.81)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C196(1.42)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C196(0.60); C64(0.64)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C196(0.51)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y373(0.75); Y360(0.80); Y364(0.87); Y188(1.93)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y360(0.79); Y364(0.80); Y373(0.89); Y188(1.61)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y360(0.47); Y373(0.62); Y364(0.64)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y360(0.84); Y364(0.84); Y373(0.97); Y188(1.43)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y364(0.88); Y188(1.02); Y373(1.03); Y360(1.30)  LDD0268  [12]
 LDCM0107  IAA HeLa H177(0.00); C196(0.00); H194(0.00); H26(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y360(0.69); Y364(0.90); Y373(1.30)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y360(0.56); Y364(0.65); Y373(0.65)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y360(1.20); Y364(1.14); Y373(1.17)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y360(3.33); Y364(2.71); Y373(2.99)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y360(2.00); Y364(2.02); Y373(2.42)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y360(1.16); Y364(1.46); Y373(1.34)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y360(0.34); Y364(0.38); Y373(0.40)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y360(0.89); Y364(0.86); Y373(1.00)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C64(1.31); C85(1.58); C94(1.58)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C64(1.52); C85(1.08); C94(1.08)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C64(1.36); C85(1.13); C94(1.13)  LDD0082  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C196(0.86)  LDD2121  [9]
 LDCM0109  NEM HeLa H177(0.00); H194(0.00); H122(0.00); H26(0.00)  LDD0223  [27]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C196(1.38)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C196(1.58)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C196(1.79)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C196(0.55); C64(0.48)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C196(1.26)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C196(0.72)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C196(1.66)  LDD2099  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C196(1.15)  LDD2101  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C196(1.32)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C196(1.04)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C196(1.35)  LDD2111  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C196(0.67)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C196(0.69)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C196(0.63)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C196(1.73)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C196(0.64)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C196(0.39); C64(0.88)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C196(1.06)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C196(0.45)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C196(1.19)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C196(1.56)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C196(0.73)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C196(1.41)  LDD2129  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C196(0.52)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C196(1.51)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C196(1.71)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C196(1.32)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C196(2.01)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C196(1.22)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C196(0.74)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C196(2.10)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C196(1.82)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C196(1.42)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C196(2.49)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C196(0.52)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C196(0.74)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C196(0.68)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C196(0.42)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C85(1.19); C85(0.89)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C85(1.12); C85(0.86)  LDD2207  [38]
 LDCM0131  RA190 MM1.R C85(1.47); C94(1.47)  LDD0304  [39]
 LDCM0021  THZ1 HCT 116 C85(1.38); C94(1.38); C64(1.37)  LDD2173  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) . P09651

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.