Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C353  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 106 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 39.1
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 33.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 29.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 29.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 26.4
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 23.6
 LDTP01769  Dihydrofolate reductase (DHFR) 23.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 22.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 22.0
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 20.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 19.8
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 18.8
 LDTP01300  Cartilage-associated protein (CRTAP) 18.4
 LDTP04375  Methionine aminopeptidase 2 (METAP2) 18.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 17.8
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 17.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 17.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 16.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 16.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.2
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 15.6
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 15.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 14.9
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 14.5
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 13.9
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 13.4
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 12.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 12.8
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 12.6
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 12.3
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 12.1
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 11.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.9
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 10.8
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 10.5
 LDTP10329  Ceramide synthase 2 (CERS2) 10.3
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 10.1
 LDTP06849  Prolyl endopeptidase-like (PREPL) 9.8
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 9.6
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 9.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 9.4
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 9.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 8.9
 LDTP03001  E3 ubiquitin-protein ligase TRIM21 (TRIM21) 8.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 8.7
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.6
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.2
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 8.1
 LDTP01372  Carboxypeptidase D (CPD) 7.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 7.9
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 7.9
 LDTP06315  Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) 7.8
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 7.8
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 7.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.5
 LDTP16025  Ketosamine-3-kinase (FN3KRP) 7.5
 LDTP04925  Pterin-4-alpha-carbinolamine dehydratase (PCBD1) 7.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.5
 LDTP04689  Adenosine kinase (ADK) 7.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 7.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 7.3
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) 7.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 7.2
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.2
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 7.2
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 7.1
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 7.0
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 7.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.9
 LDTP07581  Aspartate--tRNA ligase, mitochondrial (DARS2) 6.8
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.8
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 6.7
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 6.7
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 6.6
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 6.6
 LDTP10845  E3 ubiquitin-protein ligase UHRF1 (UHRF1) 6.6
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 6.6
 LDTP11494  Neurolysin, mitochondrial (NLN) 6.5
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.5
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 6.4
 LDTP00886  Nardilysin (NRDC) 6.4
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 6.4
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 6.4
 LDTP01641  STAM-binding protein (STAMBP) 6.4
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 6.3
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 6.3
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 6.3
 LDTP01329  Lathosterol oxidase (SC5D) 6.2
 LDTP06427  Translin (TSN) 6.2
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 6.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 6.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 6.0
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 5.9
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 5.9
 LDTP03842  Squalene synthase (FDFT1) 5.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 5.8
 LDTP10249  Metalloendopeptidase OMA1, mitochondrial (OMA1) 5.8
 LDTP06322  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) 5.7
Transporter and channel
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 28.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 19.6
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 17.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 17.4
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 16.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 16.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 14.7
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 14.7
 LDTP07236  Protein GPR107 (GPR107) 13.7
 LDTP01043  Sorting nexin-2 (SNX2) 13.4
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 13.1
 LDTP11245  Derlin-1 (DERL1) 12.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 12.1
 LDTP01804  ATP synthase subunit a (MT-ATP6) 11.5
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 10.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 9.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 9.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 9.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 9.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 8.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 8.3
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 8.3
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 8.1
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 8.1
 LDTP12383  Protein GPR108 (GPR108) 7.7
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 7.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 7.7
 LDTP12451  Integral membrane protein 2C (ITM2C) 7.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 7.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.2
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 7.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.9
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 6.8
 LDTP11250  MICOS complex subunit MIC26 (APOO) 6.5
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 6.3
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.1
 LDTP10885  Sortilin (SORT1) 6.1
 LDTP09987  Secretory carrier-associated membrane protein 4 (SCAMP4) 6.0
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 5.9
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 5.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 5.8
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) 13.6
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 6.8
 LDTP05065  Y-box-binding protein 1 (YBX1) 6.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 8.1
Other
Click to Show/Hide to Show 75 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 26.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 24.6
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 24.4
 LDTP11948  HEAT repeat-containing protein 1 (HEATR1) 19.8
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 19.0
 LDTP11076  Apolipoprotein L2 (APOL2) 17.6
 LDTP05160  Nucleobindin-2 (NUCB2) 16.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 16.8
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 15.1
 LDTP01075  Protein CutA (CUTA) 14.9
 LDTP06097  Reticulocalbin-2 (RCN2) 14.7
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 11.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 10.8
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 10.6
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 10.3
 LDTP13630  Neudesin (NENF) 10.3
 LDTP00887  Calumenin (CALU) 10.1
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 10.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 10.1
 LDTP15714  Mdm2-binding protein (MTBP) 10.1
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 10.0
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 9.4
 LDTP09920  Golgi apparatus protein 1 (GLG1) 9.2
 LDTP05868  Protein unc-119 homolog A (UNC119) 9.1
 LDTP01167  Reticulon-2 (RTN2) 9.0
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 8.8
 LDTP08594  Negative elongation factor C/D (NELFCD) 8.8
 LDTP03775  RNA-binding protein FUS (FUS) 8.8
 LDTP05226  RNA-binding protein 3 (RBM3) 8.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 8.6
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 8.5
 LDTP00986  Syntaxin-10 (STX10) 8.4
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 8.0
 LDTP16193  Craniofacial development protein 1 (CFDP1) 7.8
 LDTP05375  Nucleobindin-1 (NUCB1) 7.8
 LDTP10203  RalBP1-associated Eps domain-containing protein 1 (REPS1) 7.8
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 7.7
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 7.6
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 7.5
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 7.2
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 7.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 7.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 7.0
 LDTP15623  Neuferricin (CYB5D2) 7.0
 LDTP09850  Proline-rich protein PRCC (PRCC) 6.8
 LDTP01259  Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) 6.7
 LDTP05277  Protein SET (SET) 6.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.6
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 6.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 6.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 6.5
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 6.5
 LDTP02345  Retinol-binding protein 1 (RBP1) 6.5
 LDTP04356  Emerin (EMD) 6.3
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 6.3
 LDTP00512  Protein transport protein Sec16A (SEC16A) 6.2
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 6.2
 LDTP10056  Protein FAM162A (FAM162A) 6.1
 LDTP13125  Protein UXT (UXT) 6.1
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 6.1
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 6.1
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 6.1
 LDTP06892  Protein Hikeshi (HIKESHI) 6.1
 LDTP18146  RNA binding motif protein, X-linked-like-1 (RBMXL1) 6.1
 LDTP09870  Signal transducing adapter molecule 1 (STAM) 6.1
 LDTP13604  Hippocalcin-like protein 4 (HPCAL4) 6.0
 LDTP03247  Eukaryotic translation initiation factor 4B (EIF4B) 5.9
 LDTP05318  RNA-binding protein EWS (EWSR1) 5.9
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 5.8
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 5.8
 LDTP05036  Transformer-2 protein homolog beta (TRA2B) 5.8
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 5.7
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 5.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587