Details of the Target

General Information of Target

Target ID LDTP12755
Target Name OCIA domain-containing protein 1 (OCIAD1)
Gene Name OCIAD1
Gene ID 54940
Synonyms
ASRIJ; OCIA; OCIA domain-containing protein 1; Ovarian cancer immunoreactive antigen domain containing 1; Ovarian carcinoma immunoreactive antigen
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQI
RRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGS
KRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL
Target Bioclass
Other
Family
OCIAD1 family
Subcellular location
Endosome
Function
Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes. Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer.
Uniprot ID
Q9NX40
Ensemble ID
ENST00000264312.12
HGNC ID
HGNC:16074

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 Deletion: p.E233KfsTer4 .
LS180 Deletion: p.E233KfsTer4 .
MFE296 Deletion: p.N196IfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		10.16  LDD0196  [1]
TG42
 Probe Info  		12.46  LDD0326  [2]
TH211
 Probe Info  		Y73(20.00); Y87(20.00); Y129(6.22)  LDD0260  [3]
FBP2
 Probe Info  		3.81  LDD0317  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K104(1.63); K195(3.03)  LDD0277  [6]
ONAyne
 Probe Info  		K101(2.78)  LDD0275  [6]
IPM
 Probe Info  		N.A.  LDD0241  [7]
m-APA
 Probe Info  		11.92  LDD0403  [8]
Curcusone 37
 Probe Info  		2.17  LDD0188  [9]
Jackson_14
 Probe Info  		4.55  LDD0123  [10]
AHL-Pu-1
 Probe Info  		C38(3.50)  LDD0170  [11]
Alkyne-RA190
 Probe Info  		5.28  LDD0299  [12]
DBIA
 Probe Info  		C38(0.86)  LDD0078  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
SF
 Probe Info  		Y210(0.00); Y128(0.00); Y129(0.00); Y199(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
AOyne
 Probe Info  		14.30  LDD0443  [21]
NAIA_5
 Probe Info  		C83(0.00); C38(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 92 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.25  LDD0398  [22]
C004
 Probe Info  		6.32  LDD1714  [23]
C022
 Probe Info  		11.71  LDD1728  [23]
C027
 Probe Info  		5.50  LDD1733  [23]
C040
 Probe Info  		15.78  LDD1740  [23]
C041
 Probe Info  		6.73  LDD1741  [23]
C053
 Probe Info  		5.10  LDD1751  [23]
C055
 Probe Info  		16.00  LDD1752  [23]
C056
 Probe Info  		27.86  LDD1753  [23]
C063
 Probe Info  		13.36  LDD1760  [23]
C070
 Probe Info  		9.25  LDD1766  [23]
C082
 Probe Info  		4.99  LDD1774  [23]
C087
 Probe Info  		14.12  LDD1779  [23]
C091
 Probe Info  		14.42  LDD1782  [23]
C092
 Probe Info  		31.56  LDD1783  [23]
C094
 Probe Info  		37.27  LDD1785  [23]
C095
 Probe Info  		5.10  LDD1786  [23]
C100
 Probe Info  		7.89  LDD1789  [23]
C106
 Probe Info  		25.46  LDD1793  [23]
C108
 Probe Info  		8.22  LDD1795  [23]
C112
 Probe Info  		31.34  LDD1799  [23]
C134
 Probe Info  		37.27  LDD1816  [23]
C135
 Probe Info  		10.34  LDD1817  [23]
C139
 Probe Info  		10.41  LDD1821  [23]
C141
 Probe Info  		9.38  LDD1823  [23]
C143
 Probe Info  		24.08  LDD1825  [23]
C153
 Probe Info  		18.90  LDD1834  [23]
C158
 Probe Info  		9.51  LDD1838  [23]
C159
 Probe Info  		9.13  LDD1839  [23]
C160
 Probe Info  		8.22  LDD1840  [23]
C161
 Probe Info  		16.91  LDD1841  [23]
C169
 Probe Info  		30.06  LDD1849  [23]
C178
 Probe Info  		23.59  LDD1857  [23]
C186
 Probe Info  		9.25  LDD1864  [23]
C196
 Probe Info  		11.16  LDD1872  [23]
C201
 Probe Info  		73.01  LDD1877  [23]
C206
 Probe Info  		26.91  LDD1881  [23]
C207
 Probe Info  		21.71  LDD1882  [23]
C210
 Probe Info  		55.33  LDD1884  [23]
C218
 Probe Info  		18.51  LDD1892  [23]
C220
 Probe Info  		18.64  LDD1894  [23]
C228
 Probe Info  		28.44  LDD1901  [23]
C231
 Probe Info  		25.11  LDD1904  [23]
C232
 Probe Info  		52.35  LDD1905  [23]
C234
 Probe Info  		6.87  LDD1907  [23]
C235
 Probe Info  		30.91  LDD1908  [23]
C238
 Probe Info  		18.00  LDD1911  [23]
C243
 Probe Info  		12.04  LDD1916  [23]
C246
 Probe Info  		19.43  LDD1919  [23]
C252
 Probe Info  		8.82  LDD1925  [23]
C265
 Probe Info  		12.91  LDD1936  [23]
C277
 Probe Info  		7.41  LDD1947  [23]
C278
 Probe Info  		75.58  LDD1948  [23]
C282
 Probe Info  		17.39  LDD1952  [23]
C285
 Probe Info  		27.67  LDD1955  [23]
C287
 Probe Info  		9.00  LDD1957  [23]
C288
 Probe Info  		6.19  LDD1958  [23]
C289
 Probe Info  		64.00  LDD1959  [23]
C293
 Probe Info  		25.46  LDD1963  [23]
C296
 Probe Info  		15.78  LDD1966  [23]
C299
 Probe Info  		9.99  LDD1968  [23]
C310
 Probe Info  		7.62  LDD1977  [23]
C314
 Probe Info  		11.71  LDD1981  [23]
C322
 Probe Info  		6.15  LDD1988  [23]
C343
 Probe Info  		13.83  LDD2005  [23]
C348
 Probe Info  		11.96  LDD2009  [23]
C349
 Probe Info  		18.77  LDD2010  [23]
C350
 Probe Info  		57.68  LDD2011  [23]
C353
 Probe Info  		5.74  LDD2014  [23]
C355
 Probe Info  		26.54  LDD2016  [23]
C356
 Probe Info  		9.19  LDD2017  [23]
C362
 Probe Info  		79.89  LDD2023  [23]
C363
 Probe Info  		18.64  LDD2024  [23]
C364
 Probe Info  		24.42  LDD2025  [23]
C366
 Probe Info  		7.57  LDD2027  [23]
C367
 Probe Info  		5.66  LDD2028  [23]
C373
 Probe Info  		5.54  LDD2033  [23]
C382
 Probe Info  		9.19  LDD2041  [23]
C388
 Probe Info  		83.87  LDD2047  [23]
C390
 Probe Info  		41.07  LDD2049  [23]
C403
 Probe Info  		24.25  LDD2061  [23]
C407
 Probe Info  		24.42  LDD2064  [23]
C413
 Probe Info  		14.12  LDD2069  [23]
C431
 Probe Info  		16.91  LDD2086  [23]
FFF probe11
 Probe Info  		20.00  LDD0471  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe4
 Probe Info  		12.12  LDD0466  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
OEA-DA
 Probe Info  		18.99  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C38(3.50)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C38(2.15)  LDD0171  [11]
 LDCM0214  AC1 HCT 116 C38(1.08)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C38(1.47)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C38(1.15)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C38(1.09)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C38(1.22)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C38(1.28)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C38(1.18)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C38(1.20)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C38(1.27)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C38(1.23)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C38(1.19)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C38(1.05)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C38(1.39)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C38(1.10)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C38(1.13)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C38(1.21)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C38(1.21)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C38(1.55)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C38(1.60)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C38(1.38)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C38(1.24)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C38(1.14)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C38(1.26)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C38(1.18)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C38(1.25)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C38(1.19)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C38(1.12)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C38(1.29)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C38(1.13)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C38(1.15)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C38(1.38)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C38(1.54)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C38(1.19)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C38(0.83)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C38(1.12)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C38(0.72)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C38(1.03)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C38(1.12)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C38(1.06)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C38(1.06)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C38(1.03)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C38(1.10)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C38(1.06)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C38(1.11)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C38(1.17)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C38(1.17)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C38(1.06)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C38(0.92)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C38(1.10)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C38(1.17)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C38(1.25)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C38(2.11)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C38(1.23)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C38(1.98)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C38(1.17)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C38(1.23)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C38(1.71)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C38(1.31)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C38(1.16)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C38(1.69)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C38(2.00)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C38(1.21)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C38(0.93)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C38(1.19)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C38(1.04)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C38(1.32)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C38(1.07)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C38(1.00)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C38(1.04)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C38(1.07)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C38(1.05)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C38(1.77)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C38(1.10)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C38(1.00)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C38(1.18)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C38(1.11)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C38(1.12)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C38(1.13)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C38(1.24)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C38(1.26)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C38(1.14)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C38(1.37)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C38(1.10)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C38(1.37)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C38(0.96)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C38(0.93)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C38(1.07)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C38(0.96)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C38(0.89)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C38(1.19)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C38(1.07)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C38(0.97)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C38(1.07)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C38(1.19)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C38(1.02)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C38(0.99)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C38(1.27)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C38(1.14)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C38(1.18)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C38(1.32)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C38(1.11)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C38(1.23)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C38(1.18)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C38(1.18)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C38(1.05)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C38(1.13)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C38(1.08)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C38(1.22)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C38(0.84)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C38(1.50)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C38(1.52)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C38(1.34)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C38(1.36)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C38(1.23)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C38(1.08)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C38(1.31)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C38(1.30)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C38(1.84)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C38(1.75)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C38(1.55)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C38(0.79)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C38(1.20)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C38(1.55)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C38(0.89)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C38(0.97)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C38(1.07)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C38(1.09)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C38(0.96)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C38(1.07)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C38(1.05)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C38(1.29)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C38(1.05)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C38(1.02)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C38(1.35)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C38(1.06)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C38(0.93)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C38(0.91)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C38(1.16)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C38(1.20)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C38(1.20)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C38(1.23)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C38(1.14)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C38(1.20)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C38(1.21)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C38(0.96)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C38(1.21)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C38(1.19)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C38(1.12)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C38(1.10)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C38(1.10)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C38(1.03)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C38(1.36)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C38(1.15)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C38(1.14)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C38(1.23)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C38(1.62)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C38(1.92)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [8]
 LDCM0020  ARS-1620 HCC44 C38(0.86)  LDD0078  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C38(1.46)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C38(1.73)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C38(1.12)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C38(1.46)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C38(1.38)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C38(1.72)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C38(1.09)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C38(1.55)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C38(1.49)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C38(1.29)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C38(1.63)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C38(1.70)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C38(1.53)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C38(1.78)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C38(1.58)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C38(1.09)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C38(1.26)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C38(1.46)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C38(1.48)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C38(1.26)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C38(1.06)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C38(1.29)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C38(1.20)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C38(1.31)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C38(1.10)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C38(1.40)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C38(1.37)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C38(2.22)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C38(1.59)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C38(1.51)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C38(1.48)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C38(1.16)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C38(1.23)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C38(1.45)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C38(1.59)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C38(1.64)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C38(1.23)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C38(1.22)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C38(1.17)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C38(0.86)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C38(1.37)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C38(1.40)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C38(1.80)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C38(1.42)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C38(0.92)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C38(1.01)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C38(1.78)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C38(1.34)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C38(1.11)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C38(1.52)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C38(1.04)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C38(1.11)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C38(1.05)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C38(1.42)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C38(1.41)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C38(2.45)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C38(1.34)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C38(1.15)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C38(1.34)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C38(1.41)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C38(1.84)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C38(1.71)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C38(1.74)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C38(1.21)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C38(1.46)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C38(1.45)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C38(2.16)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C38(1.52)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C38(1.81)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C38(2.06)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C38(1.25)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C38(1.17)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C38(0.98)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C38(1.58)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C38(1.15)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C38(1.40)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C38(1.14)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C38(2.01)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C38(1.05)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C38(1.98)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C38(2.50)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C38(1.11)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C38(1.25)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C38(1.42)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C38(1.47)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C38(1.16)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C38(1.39)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C38(1.45)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C38(1.58)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C38(1.43)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C38(2.04)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C38(1.40)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C38(1.75)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C38(1.79)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C38(1.22)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C38(1.12)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C38(1.44)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C38(1.13)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C38(1.54)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C38(1.41)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C38(1.30)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C38(1.62)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C38(1.10)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C38(1.63)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C38(1.84)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C38(1.10)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C38(1.11)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C38(1.34)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C38(1.57)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C38(2.16)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C38(1.23)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C38(1.33)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C38(1.37)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C38(1.46)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C38(1.48)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C38(1.50)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C38(1.84)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C38(1.20)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C38(1.38)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C38(1.01)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C38(1.44)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C38(1.21)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C38(1.12)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C38(1.23)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C38(1.33)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C38(1.18)  LDD0811  [13]
 LDCM0033  Curcusone1d MCF-7 2.17  LDD0188  [9]
 LDCM0495  E2913 HEK-293T C38(0.95)  LDD1698  [27]
 LDCM0204  EV-97 T cell C38(4.03)  LDD0525  [28]
 LDCM0468  Fragment33 HCT 116 C38(2.13)  LDD0785  [13]
 LDCM0427  Fragment51 HCT 116 C38(1.66)  LDD0744  [13]
 LDCM0107  IAA HeLa H20(0.00); H127(0.00); C38(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C38(1.17)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C38(15.36)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C38(20.00)  LDD0082  [13]
 LDCM0109  NEM HeLa H20(0.00); H127(0.00); H226(0.00)  LDD0227  [20]
 LDCM0131  RA190 MM1.R 5.28  LDD0299  [12]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 4.55  LDD0123  [10]
 LDCM0021  THZ1 HCT 116 C38(1.23)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocyte to macrophage differentiation factor (MMD) ADIPOR family Q15546
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) . P49069
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-7 (ATF7) BZIP family P17544

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
10 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.