General Information of Experiment

Probe Name DR-1  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Lung large cell carcinoma [ICD-11:2C25]
Model Name Human lung large cell carcinoma cells (NCI-H1299)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02198  Cathepsin D (CTSD) 8.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 7.5
 LDTP04992  Ras-related protein Rab-11A (RAB11A) 5.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 5.1
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 4.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 4.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 3.5
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 3.2
 LDTP03145  Catechol O-methyltransferase (COMT) 3.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 2.5
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 2.4
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.3
 LDTP04892  Ras-related protein Rab-2A (RAB2A) 2.1
 LDTP11311  Very long chain fatty acid elongase 1 (ELOVL1) 2.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 2.0
Transporter and channel
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.1
 LDTP03405  Calnexin (CANX) 5.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 4.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 4.2
 LDTP02122  Integrin beta-1 (ITGB1) 4.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 4.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 3.9
 LDTP14661  Transmembrane 4 L6 family member 1 (TM4SF1) 3.6
 LDTP07236  Protein GPR107 (GPR107) 3.4
 LDTP15838  Translocation protein SEC62 (SEC62) 2.8
 LDTP01060  PRA1 family protein 2 (PRAF2) 2.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 2.6
 LDTP00361  Nuclear envelope integral membrane protein 1 (NEMP1) 2.5
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 2.4
 LDTP04187  CD151 antigen (CD151) 2.2
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 2.2
Other
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10924  Prohibitin-2 (PHB2) 7.8
 LDTP12412  Reticulon-4 (RTN4) 6.7
 LDTP10889  Perilipin-2 (PLIN2) 5.5
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 4.3
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 4.2
 LDTP03342  Integrin alpha-3 (ITGA3) 4.2
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 4.1
 LDTP04356  Emerin (EMD) 4.1
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 3.4
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 3.2
 LDTP04041  Melanoma-associated antigen 4 (MAGEA4) 3.0
 LDTP06948  Protein YIF1B (YIF1B) 2.8
 LDTP01021  Perilipin-3 (PLIN3) 2.2
 LDTP10013  Protein YIPF5 (YIPF5) 2.0

References

1 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.