Details of the Target

General Information of Target

Target ID	LDTP03968
Target Name	Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO)
Gene Name	TMPO
Gene ID	7112
Synonyms	LAP2; Lamina-associated polypeptide 2, isoforms beta/gamma; Thymopoietin, isoforms beta/gamma; TP beta/gamma; Thymopoietin-related peptide isoforms beta/gamma; TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin; TP; Splenin; Thymopentin; TP5)]
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL LDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDS DRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKG GPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTG NFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLF VVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
Target Bioclass	Other
Family	LEM family
Subcellular location	Cytoplasm; Nucleus inner membrane
Function	May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Uniprot ID	P42167
Ensemble ID	ENST00000261210.9
HGNC ID	HGNC:11875

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
AGS	SNV: p.I270M	.
CCK81	Deletion: p.T99LfsTer12	.
COLO678	SNV: p.L45P	.
MOLT4	SNV: p.G92S	IA-alkyne Probe Info
NUGC3	Deletion: p.K407RfsTer9	.
SKNSH	SNV: p.S66Y	.
SUPT1	Deletion: p.T99LfsTer12	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 41 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	10.89	LDD0402	[1]
CHEMBL5175495 Probe Info	11.52	LDD0196	[2]
TH211 Probe Info	Y394(8.54)	LDD0260	[3]
TH216 Probe Info	Y394(20.00)	LDD0259	[3]
ONAyne Probe Info	K368(0.00); K303(0.00); K334(0.00)	LDD0273	[4]
Probe 1 Probe Info	Y394(15.88)	LDD3495	[5]
JZ128-DTB Probe Info	N.A.	LDD0462	[6]
BTD Probe Info	C363(0.75)	LDD2089	[7]
AZ-9 Probe Info	10.00	LDD2154	[8]
Jackson_14 Probe Info	2.27	LDD0123	[9]
NAIA_5 Probe Info	C363(0.25)	LDD2228	[10]
HPAP Probe Info	5.10	LDD0062	[11]
EA-probe Probe Info	N.A.	LDD0440	[12]
HHS-475 Probe Info	Y223(0.60); Y127(0.82)	LDD0264	[13]
DBIA Probe Info	C363(0.99)	LDD0078	[14]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[15]
IA-alkyne Probe Info	N.A.	LDD0032	[16]
IPIAA_L Probe Info	N.A.	LDD0031	[17]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[15]
ATP probe Probe Info	N.A.	LDD0035	[18]
JW-RF-010 Probe Info	N.A.	LDD0026	[19]
TFBX Probe Info	N.A.	LDD0027	[19]
WYneO Probe Info	N.A.	LDD0022	[20]
1d-yne Probe Info	K346(0.00); K303(0.00)	LDD0356	[21]
Compound 10 Probe Info	N.A.	LDD2216	[22]
Compound 11 Probe Info	N.A.	LDD2213	[22]
ENE Probe Info	N.A.	LDD0006	[20]
IPM Probe Info	N.A.	LDD0005	[20]
NHS Probe Info	K13(0.00); K389(0.00); K17(0.00); K401(0.00)	LDD0010	[20]
PF-06672131 Probe Info	N.A.	LDD0017	[23]
SF Probe Info	Y394(0.00); Y127(0.00); K323(0.00)	LDD0028	[24]
STPyne Probe Info	K303(0.00); K389(0.00); K13(0.00)	LDD0009	[20]
VSF Probe Info	N.A.	LDD0007	[20]
Phosphinate-6 Probe Info	N.A.	LDD0018	[25]
Ox-W18 Probe Info	N.A.	LDD2175	[26]
1c-yne Probe Info	K17(0.00); K303(0.00)	LDD0228	[21]
Acrolein Probe Info	H304(0.00); H267(0.00); C363(0.00)	LDD0217	[27]
Crotonaldehyde Probe Info	H219(0.00); C363(0.00); H267(0.00)	LDD0219	[27]
Methacrolein Probe Info	N.A.	LDD0218	[27]
W1 Probe Info	N.A.	LDD0236	[28]
TER-AC Probe Info	N.A.	LDD0426	[29]

PAL-AfBPP Probe

Click To Hide/Show 69 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
DR-1 Probe Info	4.12	LDD0398	[30]
C017 Probe Info	7.26	LDD1725	[31]
C022 Probe Info	8.40	LDD1728	[31]
C040 Probe Info	17.63	LDD1740	[31]
C055 Probe Info	17.51	LDD1752	[31]
C056 Probe Info	25.81	LDD1753	[31]
C070 Probe Info	8.51	LDD1766	[31]
C091 Probe Info	16.11	LDD1782	[31]
C092 Probe Info	36.76	LDD1783	[31]
C094 Probe Info	41.64	LDD1785	[31]
C106 Probe Info	19.43	LDD1793	[31]
C112 Probe Info	26.91	LDD1799	[31]
C134 Probe Info	27.10	LDD1816	[31]
C141 Probe Info	9.38	LDD1823	[31]
C143 Probe Info	15.89	LDD1825	[31]
C153 Probe Info	16.56	LDD1834	[31]
C159 Probe Info	10.13	LDD1839	[31]
C160 Probe Info	9.71	LDD1840	[31]
C161 Probe Info	15.35	LDD1841	[31]
C169 Probe Info	24.93	LDD1849	[31]
C187 Probe Info	17.03	LDD1865	[31]
C196 Probe Info	11.71	LDD1872	[31]
C201 Probe Info	45.89	LDD1877	[31]
C210 Probe Info	59.71	LDD1884	[31]
C218 Probe Info	22.63	LDD1892	[31]
C219 Probe Info	5.13	LDD1893	[31]
C220 Probe Info	18.90	LDD1894	[31]
C225 Probe Info	5.28	LDD1898	[31]
C228 Probe Info	28.25	LDD1901	[31]
C231 Probe Info	28.84	LDD1904	[31]
C232 Probe Info	35.51	LDD1905	[31]
C233 Probe Info	11.79	LDD1906	[31]
C234 Probe Info	6.63	LDD1907	[31]
C235 Probe Info	30.27	LDD1908	[31]
C238 Probe Info	11.96	LDD1911	[31]
C243 Probe Info	13.09	LDD1916	[31]
C246 Probe Info	15.67	LDD1919	[31]
C252 Probe Info	9.51	LDD1925	[31]
C264 Probe Info	20.68	LDD1935	[31]
C278 Probe Info	48.84	LDD1948	[31]
C285 Probe Info	30.91	LDD1955	[31]
C287 Probe Info	9.71	LDD1957	[31]
C289 Probe Info	46.21	LDD1959	[31]
C293 Probe Info	20.53	LDD1963	[31]
C296 Probe Info	12.91	LDD1966	[31]
C299 Probe Info	6.45	LDD1968	[31]
C310 Probe Info	8.88	LDD1977	[31]
C339 Probe Info	5.35	LDD2002	[31]
C343 Probe Info	12.47	LDD2005	[31]
C348 Probe Info	11.24	LDD2009	[31]
C349 Probe Info	29.65	LDD2010	[31]
C350 Probe Info	49.18	LDD2011	[31]
C362 Probe Info	99.73	LDD2023	[31]
C363 Probe Info	21.56	LDD2024	[31]
C364 Probe Info	26.17	LDD2025	[31]
C366 Probe Info	12.21	LDD2027	[31]
C367 Probe Info	6.41	LDD2028	[31]
C382 Probe Info	9.38	LDD2041	[31]
C388 Probe Info	60.13	LDD2047	[31]
C390 Probe Info	41.36	LDD2049	[31]
C407 Probe Info	13.83	LDD2064	[31]
FFF probe11 Probe Info	20.00	LDD0471	[32]
FFF probe13 Probe Info	20.00	LDD0475	[32]
FFF probe14 Probe Info	20.00	LDD0477	[32]
FFF probe2 Probe Info	19.11	LDD0463	[32]
FFF probe3 Probe Info	20.00	LDD0464	[32]
FFF probe4 Probe Info	20.00	LDD0466	[32]
JN0003 Probe Info	20.00	LDD0469	[32]
OEA-DA Probe Info	14.83	LDD0046	[33]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C363(0.82)	LDD2142	[7]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C363(1.18)	LDD2112	[7]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C363(1.21)	LDD2117	[7]
LDCM0214	AC1	HCT 116	C363(0.96)	LDD0531	[14]
LDCM0215	AC10	HCT 116	C363(0.90)	LDD0532	[14]
LDCM0216	AC100	HCT 116	C363(0.88)	LDD0533	[14]
LDCM0217	AC101	HCT 116	C363(0.88)	LDD0534	[14]
LDCM0218	AC102	HCT 116	C363(0.91)	LDD0535	[14]
LDCM0219	AC103	HCT 116	C363(1.03)	LDD0536	[14]
LDCM0220	AC104	HCT 116	C363(1.06)	LDD0537	[14]
LDCM0221	AC105	HCT 116	C363(0.94)	LDD0538	[14]
LDCM0222	AC106	HCT 116	C363(0.94)	LDD0539	[14]
LDCM0223	AC107	HCT 116	C363(0.79)	LDD0540	[14]
LDCM0224	AC108	HCT 116	C363(0.73)	LDD0541	[14]
LDCM0225	AC109	HCT 116	C363(0.79)	LDD0542	[14]
LDCM0226	AC11	HCT 116	C363(0.91)	LDD0543	[14]
LDCM0227	AC110	HCT 116	C363(0.95)	LDD0544	[14]
LDCM0228	AC111	HCT 116	C363(0.96)	LDD0545	[14]
LDCM0229	AC112	HCT 116	C363(0.86)	LDD0546	[14]
LDCM0230	AC113	HCT 116	C363(0.95)	LDD0547	[14]
LDCM0231	AC114	HCT 116	C363(1.23)	LDD0548	[14]
LDCM0232	AC115	HCT 116	C363(1.02)	LDD0549	[14]
LDCM0233	AC116	HCT 116	C363(0.98)	LDD0550	[14]
LDCM0234	AC117	HCT 116	C363(0.96)	LDD0551	[14]
LDCM0235	AC118	HCT 116	C363(0.84)	LDD0552	[14]
LDCM0236	AC119	HCT 116	C363(0.91)	LDD0553	[14]
LDCM0237	AC12	HCT 116	C363(0.90)	LDD0554	[14]
LDCM0238	AC120	HCT 116	C363(1.11)	LDD0555	[14]
LDCM0239	AC121	HCT 116	C363(0.97)	LDD0556	[14]
LDCM0240	AC122	HCT 116	C363(0.90)	LDD0557	[14]
LDCM0241	AC123	HCT 116	C363(1.13)	LDD0558	[14]
LDCM0242	AC124	HCT 116	C363(0.96)	LDD0559	[14]
LDCM0243	AC125	HCT 116	C363(0.99)	LDD0560	[14]
LDCM0244	AC126	HCT 116	C363(0.97)	LDD0561	[14]
LDCM0245	AC127	HCT 116	C363(1.02)	LDD0562	[14]
LDCM0246	AC128	HCT 116	C363(0.95)	LDD0563	[14]
LDCM0247	AC129	HCT 116	C363(0.94)	LDD0564	[14]
LDCM0249	AC130	HCT 116	C363(1.14)	LDD0566	[14]
LDCM0250	AC131	HCT 116	C363(1.18)	LDD0567	[14]
LDCM0251	AC132	HCT 116	C363(0.76)	LDD0568	[14]
LDCM0252	AC133	HCT 116	C363(0.82)	LDD0569	[14]
LDCM0253	AC134	HCT 116	C363(0.88)	LDD0570	[14]
LDCM0254	AC135	HCT 116	C363(0.81)	LDD0571	[14]
LDCM0255	AC136	HCT 116	C363(0.83)	LDD0572	[14]
LDCM0256	AC137	HCT 116	C363(0.82)	LDD0573	[14]
LDCM0257	AC138	HCT 116	C363(0.89)	LDD0574	[14]
LDCM0258	AC139	HCT 116	C363(0.83)	LDD0575	[14]
LDCM0259	AC14	HCT 116	C363(0.85)	LDD0576	[14]
LDCM0260	AC140	HCT 116	C363(0.87)	LDD0577	[14]
LDCM0261	AC141	HCT 116	C363(0.92)	LDD0578	[14]
LDCM0262	AC142	HCT 116	C363(0.77)	LDD0579	[14]
LDCM0263	AC143	HCT 116	C363(1.07)	LDD0580	[14]
LDCM0264	AC144	HCT 116	C363(1.14)	LDD0581	[14]
LDCM0265	AC145	HCT 116	C363(1.07)	LDD0582	[14]
LDCM0266	AC146	HCT 116	C363(1.10)	LDD0583	[14]
LDCM0267	AC147	HCT 116	C363(1.18)	LDD0584	[14]
LDCM0268	AC148	HCT 116	C363(1.44)	LDD0585	[14]
LDCM0269	AC149	HCT 116	C363(1.22)	LDD0586	[14]
LDCM0270	AC15	HCT 116	C363(0.92)	LDD0587	[14]
LDCM0271	AC150	HCT 116	C363(1.03)	LDD0588	[14]
LDCM0272	AC151	HCT 116	C363(1.02)	LDD0589	[14]
LDCM0273	AC152	HCT 116	C363(1.21)	LDD0590	[14]
LDCM0274	AC153	HCT 116	C363(1.76)	LDD0591	[14]
LDCM0621	AC154	HCT 116	C363(1.21)	LDD2158	[14]
LDCM0622	AC155	HCT 116	C363(1.25)	LDD2159	[14]
LDCM0623	AC156	HCT 116	C363(1.10)	LDD2160	[14]
LDCM0624	AC157	HCT 116	C363(1.68)	LDD2161	[14]
LDCM0276	AC17	HCT 116	C363(1.27)	LDD0593	[14]
LDCM0277	AC18	HCT 116	C363(1.13)	LDD0594	[14]
LDCM0278	AC19	HCT 116	C363(1.20)	LDD0595	[14]
LDCM0279	AC2	HCT 116	C363(0.91)	LDD0596	[14]
LDCM0280	AC20	HCT 116	C363(1.21)	LDD0597	[14]
LDCM0281	AC21	HCT 116	C363(1.39)	LDD0598	[14]
LDCM0282	AC22	HCT 116	C363(1.16)	LDD0599	[14]
LDCM0283	AC23	HCT 116	C363(1.11)	LDD0600	[14]
LDCM0284	AC24	HCT 116	C363(1.25)	LDD0601	[14]
LDCM0285	AC25	HCT 116	C363(1.08)	LDD0602	[14]
LDCM0286	AC26	HCT 116	C363(1.21)	LDD0603	[14]
LDCM0287	AC27	HCT 116	C363(1.23)	LDD0604	[14]
LDCM0288	AC28	HCT 116	C363(1.28)	LDD0605	[14]
LDCM0289	AC29	HCT 116	C363(1.29)	LDD0606	[14]
LDCM0290	AC3	HCT 116	C363(0.83)	LDD0607	[14]
LDCM0291	AC30	HCT 116	C363(1.14)	LDD0608	[14]
LDCM0292	AC31	HCT 116	C363(1.09)	LDD0609	[14]
LDCM0293	AC32	HCT 116	C363(1.26)	LDD0610	[14]
LDCM0294	AC33	HCT 116	C363(1.25)	LDD0611	[14]
LDCM0295	AC34	HCT 116	C363(1.63)	LDD0612	[14]
LDCM0296	AC35	HCT 116	C363(0.95)	LDD0613	[14]
LDCM0297	AC36	HCT 116	C363(0.85)	LDD0614	[14]
LDCM0298	AC37	HCT 116	C363(0.84)	LDD0615	[14]
LDCM0299	AC38	HCT 116	C363(0.95)	LDD0616	[14]
LDCM0300	AC39	HCT 116	C363(0.96)	LDD0617	[14]
LDCM0301	AC4	HCT 116	C363(0.89)	LDD0618	[14]
LDCM0302	AC40	HCT 116	C363(1.07)	LDD0619	[14]
LDCM0303	AC41	HCT 116	C363(0.93)	LDD0620	[14]
LDCM0304	AC42	HCT 116	C363(1.02)	LDD0621	[14]
LDCM0305	AC43	HCT 116	C363(0.95)	LDD0622	[14]
LDCM0306	AC44	HCT 116	C363(0.97)	LDD0623	[14]
LDCM0307	AC45	HCT 116	C363(1.05)	LDD0624	[14]
LDCM0308	AC46	HCT 116	C363(1.00)	LDD0625	[14]
LDCM0309	AC47	HCT 116	C363(0.99)	LDD0626	[14]
LDCM0310	AC48	HCT 116	C363(0.95)	LDD0627	[14]
LDCM0311	AC49	HCT 116	C363(1.25)	LDD0628	[14]
LDCM0312	AC5	HCT 116	C363(0.83)	LDD0629	[14]
LDCM0313	AC50	HCT 116	C363(1.23)	LDD0630	[14]
LDCM0314	AC51	HCT 116	C363(1.01)	LDD0631	[14]
LDCM0315	AC52	HCT 116	C363(1.03)	LDD0632	[14]
LDCM0316	AC53	HCT 116	C363(1.08)	LDD0633	[14]
LDCM0317	AC54	HCT 116	C363(1.14)	LDD0634	[14]
LDCM0318	AC55	HCT 116	C363(1.31)	LDD0635	[14]
LDCM0319	AC56	HCT 116	C363(1.53)	LDD0636	[14]
LDCM0320	AC57	HCT 116	C363(1.04)	LDD0637	[14]
LDCM0321	AC58	HCT 116	C363(1.16)	LDD0638	[14]
LDCM0322	AC59	HCT 116	C363(1.01)	LDD0639	[14]
LDCM0323	AC6	HCT 116	C363(0.91)	LDD0640	[14]
LDCM0324	AC60	HCT 116	C363(1.08)	LDD0641	[14]
LDCM0325	AC61	HCT 116	C363(0.90)	LDD0642	[14]
LDCM0326	AC62	HCT 116	C363(1.05)	LDD0643	[14]
LDCM0327	AC63	HCT 116	C363(0.99)	LDD0644	[14]
LDCM0328	AC64	HCT 116	C363(1.02)	LDD0645	[14]
LDCM0329	AC65	HCT 116	C363(0.89)	LDD0646	[14]
LDCM0330	AC66	HCT 116	C363(0.93)	LDD0647	[14]
LDCM0331	AC67	HCT 116	C363(0.92)	LDD0648	[14]
LDCM0332	AC68	HCT 116	C363(1.02)	LDD0649	[14]
LDCM0333	AC69	HCT 116	C363(1.11)	LDD0650	[14]
LDCM0334	AC7	HCT 116	C363(0.84)	LDD0651	[14]
LDCM0335	AC70	HCT 116	C363(1.04)	LDD0652	[14]
LDCM0336	AC71	HCT 116	C363(1.01)	LDD0653	[14]
LDCM0337	AC72	HCT 116	C363(1.15)	LDD0654	[14]
LDCM0338	AC73	HCT 116	C363(1.24)	LDD0655	[14]
LDCM0339	AC74	HCT 116	C363(1.28)	LDD0656	[14]
LDCM0340	AC75	HCT 116	C363(1.32)	LDD0657	[14]
LDCM0341	AC76	HCT 116	C363(1.02)	LDD0658	[14]
LDCM0342	AC77	HCT 116	C363(1.16)	LDD0659	[14]
LDCM0343	AC78	HCT 116	C363(0.97)	LDD0660	[14]
LDCM0344	AC79	HCT 116	C363(1.04)	LDD0661	[14]
LDCM0345	AC8	HCT 116	C363(1.02)	LDD0662	[14]
LDCM0346	AC80	HCT 116	C363(1.07)	LDD0663	[14]
LDCM0347	AC81	HCT 116	C363(1.24)	LDD0664	[14]
LDCM0348	AC82	HCT 116	C363(1.14)	LDD0665	[14]
LDCM0349	AC83	HCT 116	C363(1.18)	LDD0666	[14]
LDCM0350	AC84	HCT 116	C363(1.15)	LDD0667	[14]
LDCM0351	AC85	HCT 116	C363(1.08)	LDD0668	[14]
LDCM0352	AC86	HCT 116	C363(1.06)	LDD0669	[14]
LDCM0353	AC87	HCT 116	C363(1.03)	LDD0670	[14]
LDCM0354	AC88	HCT 116	C363(1.10)	LDD0671	[14]
LDCM0355	AC89	HCT 116	C363(1.23)	LDD0672	[14]
LDCM0357	AC90	HCT 116	C363(0.87)	LDD0674	[14]
LDCM0358	AC91	HCT 116	C363(1.25)	LDD0675	[14]
LDCM0359	AC92	HCT 116	C363(1.19)	LDD0676	[14]
LDCM0360	AC93	HCT 116	C363(1.12)	LDD0677	[14]
LDCM0361	AC94	HCT 116	C363(1.08)	LDD0678	[14]
LDCM0362	AC95	HCT 116	C363(1.29)	LDD0679	[14]
LDCM0363	AC96	HCT 116	C363(1.17)	LDD0680	[14]
LDCM0364	AC97	HCT 116	C363(1.23)	LDD0681	[14]
LDCM0365	AC98	HCT 116	C363(1.01)	LDD0682	[14]
LDCM0366	AC99	HCT 116	C363(0.91)	LDD0683	[14]
LDCM0248	AKOS034007472	HCT 116	C363(0.84)	LDD0565	[14]
LDCM0356	AKOS034007680	HCT 116	C363(0.85)	LDD0673	[14]
LDCM0275	AKOS034007705	HCT 116	C363(1.18)	LDD0592	[14]
LDCM0156	Aniline	NCI-H1299	N.A.	LDD0404	[1]
LDCM0020	ARS-1620	HCC44	C363(0.99)	LDD0078	[14]
LDCM0151	AZ-11	HeLa	10.00	LDD2154	[8]
LDCM0630	CCW28-3	231MFP	C363(1.00)	LDD2214	[34]
LDCM0108	Chloroacetamide	HeLa	C363(0.00); H304(0.00); H267(0.00)	LDD0222	[27]
LDCM0367	CL1	HCT 116	C363(0.94)	LDD0684	[14]
LDCM0368	CL10	HCT 116	C363(1.08)	LDD0685	[14]
LDCM0369	CL100	HCT 116	C363(0.92)	LDD0686	[14]
LDCM0370	CL101	HCT 116	C363(0.86)	LDD0687	[14]
LDCM0371	CL102	HCT 116	C363(0.80)	LDD0688	[14]
LDCM0372	CL103	HCT 116	C363(0.98)	LDD0689	[14]
LDCM0373	CL104	HCT 116	C363(1.01)	LDD0690	[14]
LDCM0374	CL105	HCT 116	C363(0.95)	LDD0691	[14]
LDCM0375	CL106	HCT 116	C363(1.27)	LDD0692	[14]
LDCM0376	CL107	HCT 116	C363(1.10)	LDD0693	[14]
LDCM0377	CL108	HCT 116	C363(1.09)	LDD0694	[14]
LDCM0378	CL109	HCT 116	C363(1.18)	LDD0695	[14]
LDCM0379	CL11	HCT 116	C363(1.27)	LDD0696	[14]
LDCM0380	CL110	HCT 116	C363(1.26)	LDD0697	[14]
LDCM0381	CL111	HCT 116	C363(1.28)	LDD0698	[14]
LDCM0382	CL112	HCT 116	C363(1.04)	LDD0699	[14]
LDCM0383	CL113	HCT 116	C363(1.31)	LDD0700	[14]
LDCM0384	CL114	HCT 116	C363(1.07)	LDD0701	[14]
LDCM0385	CL115	HCT 116	C363(1.26)	LDD0702	[14]
LDCM0386	CL116	HCT 116	C363(1.04)	LDD0703	[14]
LDCM0387	CL117	HCT 116	C363(1.23)	LDD0704	[14]
LDCM0388	CL118	HCT 116	C363(0.88)	LDD0705	[14]
LDCM0389	CL119	HCT 116	C363(0.98)	LDD0706	[14]
LDCM0390	CL12	HCT 116	C363(1.44)	LDD0707	[14]
LDCM0391	CL120	HCT 116	C363(0.95)	LDD0708	[14]
LDCM0392	CL121	HCT 116	C363(0.91)	LDD0709	[14]
LDCM0393	CL122	HCT 116	C363(1.04)	LDD0710	[14]
LDCM0394	CL123	HCT 116	C363(1.10)	LDD0711	[14]
LDCM0395	CL124	HCT 116	C363(1.27)	LDD0712	[14]
LDCM0396	CL125	HCT 116	C363(0.88)	LDD0713	[14]
LDCM0397	CL126	HCT 116	C363(0.90)	LDD0714	[14]
LDCM0398	CL127	HCT 116	C363(0.98)	LDD0715	[14]
LDCM0399	CL128	HCT 116	C363(1.01)	LDD0716	[14]
LDCM0400	CL13	HCT 116	C363(1.21)	LDD0717	[14]
LDCM0401	CL14	HCT 116	C363(1.09)	LDD0718	[14]
LDCM0402	CL15	HCT 116	C363(1.20)	LDD0719	[14]
LDCM0403	CL16	HCT 116	C363(1.01)	LDD0720	[14]
LDCM0404	CL17	HCT 116	C363(1.01)	LDD0721	[14]
LDCM0405	CL18	HCT 116	C363(1.24)	LDD0722	[14]
LDCM0406	CL19	HCT 116	C363(1.05)	LDD0723	[14]
LDCM0407	CL2	HCT 116	C363(0.95)	LDD0724	[14]
LDCM0408	CL20	HCT 116	C363(1.07)	LDD0725	[14]
LDCM0409	CL21	HCT 116	C363(1.16)	LDD0726	[14]
LDCM0410	CL22	HCT 116	C363(1.40)	LDD0727	[14]
LDCM0411	CL23	HCT 116	C363(1.11)	LDD0728	[14]
LDCM0412	CL24	HCT 116	C363(1.23)	LDD0729	[14]
LDCM0413	CL25	HCT 116	C363(1.05)	LDD0730	[14]
LDCM0414	CL26	HCT 116	C363(1.10)	LDD0731	[14]
LDCM0415	CL27	HCT 116	C363(0.99)	LDD0732	[14]
LDCM0416	CL28	HCT 116	C363(1.10)	LDD0733	[14]
LDCM0417	CL29	HCT 116	C363(1.12)	LDD0734	[14]
LDCM0418	CL3	HCT 116	C363(0.97)	LDD0735	[14]
LDCM0419	CL30	HCT 116	C363(0.97)	LDD0736	[14]
LDCM0420	CL31	HCT 116	C363(1.16)	LDD0737	[14]
LDCM0421	CL32	HCT 116	C363(1.19)	LDD0738	[14]
LDCM0422	CL33	HCT 116	C363(1.18)	LDD0739	[14]
LDCM0423	CL34	HCT 116	C363(1.30)	LDD0740	[14]
LDCM0424	CL35	HCT 116	C363(1.41)	LDD0741	[14]
LDCM0425	CL36	HCT 116	C363(1.24)	LDD0742	[14]
LDCM0426	CL37	HCT 116	C363(1.38)	LDD0743	[14]
LDCM0428	CL39	HCT 116	C363(1.27)	LDD0745	[14]
LDCM0429	CL4	HCT 116	C363(0.98)	LDD0746	[14]
LDCM0430	CL40	HCT 116	C363(1.25)	LDD0747	[14]
LDCM0431	CL41	HCT 116	C363(1.28)	LDD0748	[14]
LDCM0432	CL42	HCT 116	C363(1.72)	LDD0749	[14]
LDCM0433	CL43	HCT 116	C363(1.70)	LDD0750	[14]
LDCM0434	CL44	HCT 116	C363(1.37)	LDD0751	[14]
LDCM0435	CL45	HCT 116	C363(1.27)	LDD0752	[14]
LDCM0436	CL46	HCT 116	C363(0.92)	LDD0753	[14]
LDCM0437	CL47	HCT 116	C363(0.92)	LDD0754	[14]
LDCM0438	CL48	HCT 116	C363(0.98)	LDD0755	[14]
LDCM0439	CL49	HCT 116	C363(1.18)	LDD0756	[14]
LDCM0440	CL5	HCT 116	C363(1.04)	LDD0757	[14]
LDCM0441	CL50	HCT 116	C363(0.99)	LDD0758	[14]
LDCM0442	CL51	HCT 116	C363(0.95)	LDD0759	[14]
LDCM0443	CL52	HCT 116	C363(0.92)	LDD0760	[14]
LDCM0444	CL53	HCT 116	C363(1.16)	LDD0761	[14]
LDCM0445	CL54	HCT 116	C363(1.00)	LDD0762	[14]
LDCM0446	CL55	HCT 116	C363(1.02)	LDD0763	[14]
LDCM0447	CL56	HCT 116	C363(0.97)	LDD0764	[14]
LDCM0448	CL57	HCT 116	C363(0.94)	LDD0765	[14]
LDCM0449	CL58	HCT 116	C363(0.99)	LDD0766	[14]
LDCM0450	CL59	HCT 116	C363(0.99)	LDD0767	[14]
LDCM0451	CL6	HCT 116	C363(1.02)	LDD0768	[14]
LDCM0452	CL60	HCT 116	C363(1.07)	LDD0769	[14]
LDCM0453	CL61	HCT 116	C363(1.01)	LDD0770	[14]
LDCM0454	CL62	HCT 116	C363(0.94)	LDD0771	[14]
LDCM0455	CL63	HCT 116	C363(0.96)	LDD0772	[14]
LDCM0456	CL64	HCT 116	C363(1.07)	LDD0773	[14]
LDCM0457	CL65	HCT 116	C363(0.99)	LDD0774	[14]
LDCM0458	CL66	HCT 116	C363(1.11)	LDD0775	[14]
LDCM0459	CL67	HCT 116	C363(1.13)	LDD0776	[14]
LDCM0460	CL68	HCT 116	C363(1.05)	LDD0777	[14]
LDCM0461	CL69	HCT 116	C363(1.30)	LDD0778	[14]
LDCM0462	CL7	HCT 116	C363(1.18)	LDD0779	[14]
LDCM0463	CL70	HCT 116	C363(1.11)	LDD0780	[14]
LDCM0464	CL71	HCT 116	C363(0.99)	LDD0781	[14]
LDCM0465	CL72	HCT 116	C363(1.00)	LDD0782	[14]
LDCM0466	CL73	HCT 116	C363(1.01)	LDD0783	[14]
LDCM0467	CL74	HCT 116	C363(1.01)	LDD0784	[14]
LDCM0469	CL76	HCT 116	C363(1.08)	LDD0786	[14]
LDCM0470	CL77	HCT 116	C363(1.04)	LDD0787	[14]
LDCM0471	CL78	HCT 116	C363(1.01)	LDD0788	[14]
LDCM0472	CL79	HCT 116	C363(1.25)	LDD0789	[14]
LDCM0473	CL8	HCT 116	C363(1.30)	LDD0790	[14]
LDCM0474	CL80	HCT 116	C363(1.08)	LDD0791	[14]
LDCM0475	CL81	HCT 116	C363(1.10)	LDD0792	[14]
LDCM0476	CL82	HCT 116	C363(1.32)	LDD0793	[14]
LDCM0477	CL83	HCT 116	C363(1.26)	LDD0794	[14]
LDCM0478	CL84	HCT 116	C363(1.26)	LDD0795	[14]
LDCM0479	CL85	HCT 116	C363(1.13)	LDD0796	[14]
LDCM0480	CL86	HCT 116	C363(1.06)	LDD0797	[14]
LDCM0481	CL87	HCT 116	C363(1.13)	LDD0798	[14]
LDCM0482	CL88	HCT 116	C363(1.12)	LDD0799	[14]
LDCM0483	CL89	HCT 116	C363(1.51)	LDD0800	[14]
LDCM0484	CL9	HCT 116	C363(1.13)	LDD0801	[14]
LDCM0485	CL90	HCT 116	C363(1.04)	LDD0802	[14]
LDCM0486	CL91	HCT 116	C363(1.05)	LDD0803	[14]
LDCM0487	CL92	HCT 116	C363(0.95)	LDD0804	[14]
LDCM0488	CL93	HCT 116	C363(1.04)	LDD0805	[14]
LDCM0489	CL94	HCT 116	C363(0.97)	LDD0806	[14]
LDCM0490	CL95	HCT 116	C363(0.91)	LDD0807	[14]
LDCM0491	CL96	HCT 116	C363(0.93)	LDD0808	[14]
LDCM0492	CL97	HCT 116	C363(0.99)	LDD0809	[14]
LDCM0493	CL98	HCT 116	C363(0.94)	LDD0810	[14]
LDCM0494	CL99	HCT 116	C363(1.00)	LDD0811	[14]
LDCM0634	CY-0357	Hep-G2	C363(0.25)	LDD2228	[10]
LDCM0495	E2913	HEK-293T	C363(0.98)	LDD1698	[35]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C363(2.05)	LDD1702	[7]
LDCM0175	Ethacrynic acid	HeLa	N.A.	LDD0440	[12]
LDCM0625	F8	Ramos	C363(1.22)	LDD2187	[36]
LDCM0572	Fragment10	Ramos	C363(2.70)	LDD2189	[36]
LDCM0573	Fragment11	Ramos	C363(0.22)	LDD2190	[36]
LDCM0574	Fragment12	Ramos	C363(1.64)	LDD2191	[36]
LDCM0575	Fragment13	Ramos	C363(1.22)	LDD2192	[36]
LDCM0576	Fragment14	Ramos	C363(1.72)	LDD2193	[36]
LDCM0579	Fragment20	Ramos	C363(3.28)	LDD2194	[36]
LDCM0580	Fragment21	Ramos	C363(1.04)	LDD2195	[36]
LDCM0582	Fragment23	Ramos	C363(1.11)	LDD2196	[36]
LDCM0578	Fragment27	Ramos	C363(0.93)	LDD2197	[36]
LDCM0586	Fragment28	Ramos	C363(0.68)	LDD2198	[36]
LDCM0588	Fragment30	Ramos	C363(1.27)	LDD2199	[36]
LDCM0589	Fragment31	Ramos	C363(1.20)	LDD2200	[36]
LDCM0590	Fragment32	Ramos	C363(2.61)	LDD2201	[36]
LDCM0468	Fragment33	HCT 116	C363(1.03)	LDD0785	[14]
LDCM0596	Fragment38	Ramos	C363(1.40)	LDD2203	[36]
LDCM0566	Fragment4	Ramos	C363(1.48)	LDD2184	[36]
LDCM0427	Fragment51	HCT 116	C363(1.66)	LDD0744	[14]
LDCM0610	Fragment52	Ramos	C363(1.20)	LDD2204	[36]
LDCM0614	Fragment56	Ramos	C363(1.17)	LDD2205	[36]
LDCM0569	Fragment7	Ramos	C363(2.04)	LDD2186	[36]
LDCM0571	Fragment9	Ramos	C363(2.53)	LDD2188	[36]
LDCM0116	HHS-0101	DM93	Y223(0.60); Y127(0.82)	LDD0264	[13]
LDCM0117	HHS-0201	DM93	Y127(0.62); Y223(0.90)	LDD0265	[13]
LDCM0118	HHS-0301	DM93	Y223(0.62); Y127(0.81)	LDD0266	[13]
LDCM0119	HHS-0401	DM93	Y127(0.64); Y223(0.71)	LDD0267	[13]
LDCM0120	HHS-0701	DM93	Y223(0.23); Y127(0.80)	LDD0268	[13]
LDCM0015	HNE	MDA-MB-231	C363(0.96)	LDD0346	[36]
LDCM0107	IAA	HeLa	H304(0.00); H267(0.00)	LDD0221	[27]
LDCM0179	JZ128	PC-3	N.A.	LDD0462	[6]
LDCM0022	KB02	HCT 116	C363(2.24)	LDD0080	[14]
LDCM0023	KB03	HCT 116	C363(2.02)	LDD0081	[14]
LDCM0024	KB05	HCT 116	C363(3.44)	LDD0082	[14]
LDCM0109	NEM	HeLa	H219(0.00); H304(0.00); H267(0.00)	LDD0223	[27]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C363(0.75)	LDD2089	[7]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C363(1.24)	LDD2100	[7]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C363(1.57)	LDD2105	[7]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C363(0.87)	LDD2106	[7]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C363(0.93)	LDD2108	[7]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C363(0.72)	LDD2114	[7]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C363(0.70)	LDD2141	[7]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C363(0.47)	LDD2150	[7]
LDCM0627	NUDT7-COV-1	HEK-293T	C363(1.26); C363(0.67)	LDD2206	[37]
LDCM0628	OTUB2-COV-1	HEK-293T	C363(1.79); C363(0.84)	LDD2207	[37]
LDCM0014	Panhematin	HEK-293T	5.10	LDD0062	[11]
LDCM0131	RA190	MM1.R	C363(1.47)	LDD0304	[38]
LDCM0016	Ranjitkar_cp1	MDA-MB-231	2.27	LDD0123	[9]
LDCM0021	THZ1	HCT 116	C363(1.12)	LDD2173	[14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Stomatin (STOM)				Band 7/mec-2 family	P27105

Other

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Golgi membrane protein 1 (GOLM1)	GOLM family	Q8NBJ4
Kelch-like protein 6 (KLHL6)	.	Q8WZ60
SH2/SH3 adapter protein NCK1 (NCK1)	.	P16333

References

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3	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
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5	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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16	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
18	Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22. Mass spectrometry data entry: PXD006095 , PXD006096
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24	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
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26	Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6. Mass spectrometry data entry: PXD001377 , PXD005252
27	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Prof. Feng Zhu

Prof. Feng Ni