Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C234  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 39.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 34.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 33.8
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 33.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 21.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 19.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 18.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 17.9
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 17.6
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 17.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 16.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 16.8
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 16.6
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 16.2
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 15.7
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 14.7
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 13.5
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 12.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 12.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 12.2
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 11.9
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 11.8
 LDTP06657  2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) 11.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 11.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.1
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 9.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 9.8
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 9.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 9.4
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.9
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.7
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 8.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 8.6
 LDTP10329  Ceramide synthase 2 (CERS2) 8.3
 LDTP01769  Dihydrofolate reductase (DHFR) 8.2
 LDTP07931  Heme A synthase COX15 (COX15) 8.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 8.2
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 8.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 8.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 8.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 7.8
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 7.6
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.4
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.2
 LDTP09251  Atlastin-2 (ATL2) 7.2
 LDTP00836  ATPase GET3 (GET3) 7.0
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 7.0
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 7.0
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 6.8
 LDTP03145  Catechol O-methyltransferase (COMT) 6.7
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 6.7
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 6.6
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 6.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.6
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 6.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 6.5
 LDTP02505  Lysosomal protective protein (CTSA) 6.4
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 6.2
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 6.1
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.1
 LDTP06343  Serine/threonine-protein phosphatase 2A activator (PTPA) 6.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 5.9
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.8
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 5.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 5.8
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 5.8
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 5.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.7
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 5.7
 LDTP06849  Prolyl endopeptidase-like (PREPL) 5.7
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.6
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 5.6
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 5.6
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 5.6
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 5.6
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 5.5
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 5.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.5
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 5.5
 LDTP10020  Ras-related protein Rab-24 (RAB24) 5.5
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 5.4
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 5.4
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 5.4
Transporter and channel
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 37.8
 LDTP01804  ATP synthase subunit a (MT-ATP6) 31.1
 LDTP07156  Protein wntless homolog (WLS) 28.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 25.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 24.6
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 23.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 22.2
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 21.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 19.8
 LDTP03546  Translocator protein (TSPO) 19.6
 LDTP12383  Protein GPR108 (GPR108) 19.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 18.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 17.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 17.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 16.8
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 16.7
 LDTP15648  BRI3-binding protein (BRI3BP) 16.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 16.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 15.7
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 15.6
 LDTP00592  Surfeit locus protein 4 (SURF4) 14.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 14.7
 LDTP20002  Transmembrane protein 160 (TMEM160) 13.8
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 13.5
 LDTP05900  Metaxin-1 (MTX1) 13.5
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 12.7
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 11.4
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 11.2
 LDTP03952  Reduced folate transporter (SLC19A1) 11.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.6
 LDTP11927  Essential MCU regulator, mitochondrial (SMDT1) 10.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.7
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 9.3
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 9.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 8.8
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 8.5
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 8.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.2
 LDTP07667  Transmembrane protein 205 (TMEM205) 7.9
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 7.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 7.8
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 7.7
 LDTP13833  Integral membrane protein 2B (ITM2B) 7.7
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 7.7
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 7.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 7.5
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 7.3
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 7.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 7.2
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 6.7
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 6.6
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 6.6
 LDTP11812  Protein ARV1 (ARV1) 6.6
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 6.5
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 6.4
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 6.3
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 6.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 6.1
 LDTP12191  Vezatin (VEZT) 5.9
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 5.8
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.8
 LDTP02215  Prosaposin (PSAP) 5.8
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 5.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 5.7
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 5.6
 LDTP07058  Transmembrane protein 201 (TMEM201) 5.6
 LDTP10065  Transmembrane protein 230 (TMEM230) 5.4
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 5.4
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 8.3
Other
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 66.3
 LDTP10056  Protein FAM162A (FAM162A) 32.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 26.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 22.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 21.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 18.1
 LDTP16006  Optic atrophy 3 protein (OPA3) 18.0
 LDTP05160  Nucleobindin-2 (NUCB2) 17.0
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 15.9
 LDTP01494  Protein YIF1A (YIF1A) 14.3
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 13.0
 LDTP14939  Membralin (TMEM259) 12.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 12.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.2
 LDTP05868  Protein unc-119 homolog A (UNC119) 11.6
 LDTP01522  Reticulon-3 (RTN3) 11.2
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 10.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.3
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 10.2
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 9.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 9.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 9.3
 LDTP08224  Protein LYRIC (MTDH) 9.2
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 8.9
 LDTP13630  Neudesin (NENF) 8.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.6
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 8.3
 LDTP13086  Syntaxin-18 (STX18) 8.3
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 8.3
 LDTP19963  TraB domain-containing protein (TRABD) 8.1
 LDTP10357  RUS family member 1 (RUSF1) 8.0
 LDTP00875  Striatin (STRN) 8.0
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 7.9
 LDTP01652  Centrosomal protein 43 (CEP43) 7.7
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 7.6
 LDTP05765  Translation initiation factor eIF2B subunit epsilon (EIF2B5) 7.2
 LDTP18272  Transmembrane protein 209 (TMEM209) 7.1
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 6.9
 LDTP07655  Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) 6.9
 LDTP12412  Reticulon-4 (RTN4) 6.9
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 6.6
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 6.5
 LDTP05041  Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) 6.4
 LDTP00887  Calumenin (CALU) 6.4
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 6.2
 LDTP16078  Heme-binding protein 1 (HEBP1) 6.0
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 6.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 6.0
 LDTP06097  Reticulocalbin-2 (RCN2) 5.9
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 5.9
 LDTP01711  Protein ecdysoneless homolog (ECD) 5.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 5.9
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 5.7
 LDTP01638  YEATS domain-containing protein 4 (YEATS4) 5.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.6
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 5.6
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 5.5
 LDTP06406  Protein SSXT (SS18) 5.5
 LDTP08094  Wings apart-like protein homolog (WAPL) 5.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587