Details of the Target

General Information of Target

Target ID LDTP07931
Target Name Heme A synthase COX15 (COX15)
Gene Name COX15
Gene ID 1355
Synonyms
Heme A synthase COX15; HAS; EC 1.17.99.9; Cytochrome c oxidase assembly protein COX15 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSL
PSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAE
FQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGM
KGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWT
SLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESW
IPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTL
LALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK
Target Bioclass
Enzyme
Family
COX15/CtaA family
Subcellular location
Mitochondrion membrane
Function
Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Uniprot ID
Q7KZN9
Ensemble ID
ENST00000016171.6
HGNC ID
HGNC:2263

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.W102Ter .
HUH7 SNV: p.S292C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K173(10.00)  LDD0277  [2]
HPAP
 Probe Info  		3.14  LDD0062  [3]
DBIA
 Probe Info  		C76(0.80)  LDD0531  [4]
AOyne
 Probe Info  		13.90  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 58 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		15.14  LDD1728  [6]
C027
 Probe Info  		10.27  LDD1733  [6]
C055
 Probe Info  		19.84  LDD1752  [6]
C056
 Probe Info  		28.25  LDD1753  [6]
C063
 Probe Info  		11.96  LDD1760  [6]
C091
 Probe Info  		19.56  LDD1782  [6]
C092
 Probe Info  		32.45  LDD1783  [6]
C094
 Probe Info  		45.57  LDD1785  [6]
C100
 Probe Info  		5.90  LDD1789  [6]
C106
 Probe Info  		33.82  LDD1793  [6]
C107
 Probe Info  		6.06  LDD1794  [6]
C108
 Probe Info  		11.31  LDD1795  [6]
C112
 Probe Info  		36.76  LDD1799  [6]
C143
 Probe Info  		13.18  LDD1825  [6]
C153
 Probe Info  		33.59  LDD1834  [6]
C169
 Probe Info  		44.02  LDD1849  [6]
C178
 Probe Info  		48.17  LDD1857  [6]
C201
 Probe Info  		43.71  LDD1877  [6]
C206
 Probe Info  		17.27  LDD1881  [6]
C225
 Probe Info  		5.66  LDD1898  [6]
C228
 Probe Info  		36.00  LDD1901  [6]
C229
 Probe Info  		8.00  LDD1902  [6]
C231
 Probe Info  		32.22  LDD1904  [6]
C232
 Probe Info  		99.73  LDD1905  [6]
C233
 Probe Info  		13.74  LDD1906  [6]
C234
 Probe Info  		8.22  LDD1907  [6]
C235
 Probe Info  		36.00  LDD1908  [6]
C246
 Probe Info  		16.34  LDD1919  [6]
C264
 Probe Info  		42.52  LDD1935  [6]
C278
 Probe Info  		64.89  LDD1948  [6]
C282
 Probe Info  		18.77  LDD1952  [6]
C285
 Probe Info  		20.39  LDD1955  [6]
C287
 Probe Info  		12.64  LDD1957  [6]
C289
 Probe Info  		36.25  LDD1959  [6]
C293
 Probe Info  		19.56  LDD1963  [6]
C296
 Probe Info  		14.83  LDD1966  [6]
C307
 Probe Info  		8.46  LDD1975  [6]
C310
 Probe Info  		16.34  LDD1977  [6]
C343
 Probe Info  		31.12  LDD2005  [6]
C348
 Probe Info  		10.70  LDD2009  [6]
C349
 Probe Info  		15.89  LDD2010  [6]
C350
 Probe Info  		41.93  LDD2011  [6]
C362
 Probe Info  		52.35  LDD2023  [6]
C376
 Probe Info  		12.73  LDD2036  [6]
C382
 Probe Info  		9.92  LDD2041  [6]
C388
 Probe Info  		45.25  LDD2047  [6]
C390
 Probe Info  		41.07  LDD2049  [6]
C426
 Probe Info  		14.03  LDD2081  [6]
C431
 Probe Info  		15.89  LDD2086  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0464  [7]
JN0003
 Probe Info  		20.00  LDD0469  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
OEA-DA
 Probe Info  		20.00  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C76(0.80)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C31(1.28)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C31(1.08)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C31(1.16)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C31(1.12)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C31(1.15)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C31(1.30)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C31(1.03)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C31(0.83)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C31(1.03)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C31(0.98)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C31(1.00)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C31(0.96)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C31(1.40)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C31(1.54)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C31(1.58)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C31(1.01); C76(0.74)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C31(1.41); C76(0.83)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C31(1.30); C76(0.74)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C31(3.28); C76(0.83)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C31(1.63); C76(0.61)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C31(1.43); C76(0.59)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C31(1.56); C76(0.55)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C31(1.23)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C31(1.60); C76(0.58)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C31(1.31); C76(0.51)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C31(1.42); C76(0.52)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C31(1.62); C76(0.47)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C31(1.48); C76(0.54)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C31(1.47); C76(0.47)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C31(1.41); C76(0.41)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C31(2.62); C76(0.45)  LDD0843  [4]
 LDCM0259  AC14 HEK-293T C31(1.32)  LDD0857  [4]
 LDCM0263  AC143 HEK-293T C31(1.17); C76(0.96)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C31(1.14); C76(0.89)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C31(1.05); C76(1.00)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C31(1.24); C76(1.00)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C31(1.55); C76(1.04)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C31(1.13); C76(0.84)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C31(1.03); C76(0.93)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C31(1.24)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C31(0.90); C76(0.95)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C31(1.08); C76(0.89)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C31(1.27); C76(0.94)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C31(1.04); C76(0.90)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C31(1.24); C76(1.07)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C31(1.12); C76(0.93)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C31(1.49); C76(1.08)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C31(1.62); C76(1.14)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C76(0.93)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C76(0.95)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C76(0.82)  LDD1517  [11]
 LDCM0279  AC2 HCT 116 C76(0.76)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C76(1.06)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C76(0.73)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C76(0.82)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C76(1.02)  LDD1522  [11]
 LDCM0285  AC25 HEK-293T C76(0.42)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C76(0.48)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C76(0.50)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C76(0.54)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C76(0.99)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C76(1.10)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C76(0.71)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C76(0.48)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C76(0.48)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C76(0.79)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C76(0.61)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C31(0.90)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C31(1.18)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C31(0.89)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C31(1.02)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C31(0.98)  LDD0898  [4]
 LDCM0301  AC4 HCT 116 C76(0.85)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C31(1.22)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C31(0.99)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C31(0.81)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C31(0.96)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C31(1.06)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C31(0.99)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C31(1.14)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C31(1.10)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C31(1.50)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C31(1.12)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C76(1.22)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C31(1.20)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C31(1.32)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C31(1.38)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C31(1.25)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C31(1.25)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C31(1.50)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C31(1.14)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C76(1.08)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C76(1.25)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C76(1.02)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C31(1.31)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C76(0.85)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C76(0.81)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C76(0.97)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C76(1.15)  LDD1566  [11]
 LDCM0334  AC7 HEK-293T C31(1.19)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C31(1.61)  LDD0943  [4]
 LDCM0349  AC83 HEK-293T C31(1.08)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C31(0.89)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C31(1.04)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C31(1.39)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C31(0.98)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C31(1.30)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C31(1.38)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C31(1.46)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C31(1.29)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C31(1.56)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C31(1.07)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C31(1.41)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C31(1.48)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C31(1.33)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C31(2.34)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C31(0.90)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C31(0.89)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C31(1.28)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C31(1.52)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C31(1.82)  LDD0873  [4]
 LDCM0367  CL1 HCT 116 C76(1.09)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C76(0.71)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C76(0.99)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C31(1.44)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C31(1.47)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C31(1.56)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C31(1.71)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C76(0.81)  LDD1578  [11]
 LDCM0376  CL107 HEK-293T C76(0.98)  LDD1580  [11]
 LDCM0378  CL109 HEK-293T C76(0.89)  LDD1582  [11]
 LDCM0379  CL11 HCT 116 C76(0.76)  LDD0696  [4]
 LDCM0381  CL111 HEK-293T C76(0.94)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C76(0.76)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C76(0.43)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C76(0.80)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C76(0.56)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C76(0.58)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C31(1.08)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C31(0.98)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C31(0.96)  LDD0987  [4]
 LDCM0390  CL12 HCT 116 C76(0.87)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C31(0.90)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C31(1.28)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C31(1.12)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C31(1.25)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C31(1.15)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C76(1.67)  LDD1600  [11]
 LDCM0398  CL127 HEK-293T C76(1.07)  LDD1602  [11]
 LDCM0400  CL13 HCT 116 C76(0.59)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C76(0.79)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C76(0.75)  LDD0719  [4]
 LDCM0404  CL17 HEK-293T C76(1.29)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C76(1.14)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C76(1.00)  LDD1610  [11]
 LDCM0407  CL2 HCT 116 C76(1.17)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C76(1.14)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C76(1.00)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C76(1.10)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C76(1.32)  LDD1615  [11]
 LDCM0413  CL25 HEK-293T C76(0.89)  LDD1617  [11]
 LDCM0415  CL27 HEK-293T C76(0.91)  LDD1619  [11]
 LDCM0417  CL29 HEK-293T C76(1.16)  LDD1621  [11]
 LDCM0418  CL3 HCT 116 C76(1.05)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C76(0.97)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C76(0.71)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C76(0.40)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C76(0.56)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C76(0.61)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C76(0.67)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C76(0.62)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C76(0.62)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C76(0.57)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C76(0.70)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C76(0.53)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C76(0.61)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C76(0.67)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C76(0.58)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C76(0.53)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C76(0.43)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C31(0.99)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C31(0.87)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C31(1.10)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C31(1.14)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C76(1.10)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C31(0.96)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C31(1.21)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C31(0.92)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C31(1.09)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C31(1.02)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C31(0.95)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C31(0.94)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C31(1.13)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C31(0.98)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C31(1.19)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C76(0.71)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C31(1.14)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C31(1.13); C76(0.87)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C31(1.02); C76(0.57)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C31(1.13); C76(0.55)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C31(0.76); C76(0.61)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C31(1.83); C76(0.60)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C31(1.08); C76(0.52)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C31(0.97); C76(0.60)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C31(0.94); C76(0.59)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C31(1.22); C76(0.50)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C76(0.73)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C31(0.78); C76(0.58)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C31(0.95); C76(0.58)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C31(1.24); C76(0.78)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C31(0.90); C76(0.50)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C31(1.87); C76(0.34)  LDD1065  [4]
 LDCM0469  CL76 HCT 116 C76(0.85)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C76(0.94)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C76(0.97)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C76(0.90)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C76(0.81)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C76(0.75)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C76(0.97)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C76(0.90)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C76(1.00)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C76(1.02)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C76(1.43)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C76(1.06)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C76(0.92)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C76(0.89)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C76(1.03)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C76(0.98)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C76(1.09)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C76(0.99)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C76(1.21)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C76(0.81)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C76(0.73)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C76(0.82)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C76(1.06)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C76(0.89)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C76(0.83)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C76(0.73)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C76(1.00)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C31(1.49); C76(0.40)  LDD1066  [4]
 LDCM0427  Fragment51 HCT 116 C76(0.60)  LDD0744  [4]
 LDCM0014  Panhematin HEK-293T 3.14  LDD0062  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxiredoxin-6 (PRDX6) Peroxiredoxin family P30041

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402