Details of the Probe

General Information of Probe

Probe ID
LDPC0320
Probe Name
C063
Synonyms
Z4225970074
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 335.4
Lipid-water partition coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H21N5O
IUPAC Name
(1R,2R)-N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-(1-methylindazol-3-yl)cyclopropane-1-carboxamide
Canonical SMILES
CN1C2=CC=CC=C2C(=N1)C3CC3C(=O)NCCC4(N=N4)CCC#C
InChI
InChI=1S/C19H21N5O/c1-3-4-9-19(22-23-19)10-11-20-18(25)15-12-14(15)17-13-7-5-6-8-16(13)24(2)21-17/h1,5-8,14-15H,4,9-12H2,2H3,(H,20,25)/t14-,15-/m1/s1
InChIKey
NPHIPFVSXULONT-HUUCEWRRSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

137 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 12.47  LDD1760 
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 11.00  LDD1760 
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 21.11  LDD1760 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 14.72  LDD1760 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 17.15  LDD1760 
5'-nucleotidase domain-containing protein 2 (NT5DC2) LDTP18414 10.13  LDD1760 
Acid ceramidase (ASAH1) LDTP05905 13.83  LDD1760 
Adenosine deaminase (ADA) LDTP01803 19.16  LDD1760 
Adenosine kinase (ADK) LDTP04689 20.97  LDD1760 
ADP-dependent glucokinase (ADPGK) LDTP11127 19.29  LDD1760 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 13.93  LDD1760 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 19.16  LDD1760 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 22.94  LDD1760 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 13.00  LDD1760 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 9.92  LDD1760 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 21.71  LDD1760 
ATP-dependent RNA helicase A (DHX9) LDTP05550 13.36  LDD1760 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 14.52  LDD1760 
Beta-galactosidase (GLB1) LDTP02837 16.91  LDD1760 
Beta-galactosidase-1-like protein 2 (GLB1L2) LDTP17633 9.92  LDD1760 
Beta-glucuronidase (GUSB) LDTP02260 11.88  LDD1760 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 24.59  LDD1760 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 27.86  LDD1760 
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) LDTP05920 11.08  LDD1760 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 20.25  LDD1760 
Cartilage-associated protein (CRTAP) LDTP01300 12.13  LDD1760 
Catechol O-methyltransferase (COMT) LDTP03145 12.82  LDD1760 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 15.14  LDD1760 
Ceramide glucosyltransferase (UGCG) LDTP06617 13.55  LDD1760 
Ceramide synthase 1 (CERS1) LDTP03394 15.67  LDD1760 
Ceramide synthase 2 (CERS2) LDTP10329 17.03  LDD1760 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 20.25  LDD1760 
Choline kinase alpha (CHKA) LDTP03787 10.93  LDD1760 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 36.00  LDD1760 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 44.32  LDD1760 
Cytochrome b5 type B (CYB5B) LDTP00697 36.25  LDD1760 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 15.78  LDD1760 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 23.75  LDD1760 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 12.55  LDD1760 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 20.25  LDD1760 
Delta(24)-sterol reductase (DHCR24) LDTP06375 21.26  LDD1760 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 12.13  LDD1760 
Diacylglycerol lipase-beta (DAGLB) LDTP09095 10.85  LDD1760 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 9.78  LDD1760 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 13.64  LDD1760 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 16.80  LDD1760 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 17.27  LDD1760 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 11.63  LDD1760 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 10.13  LDD1760 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 13.45  LDD1760 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 23.59  LDD1760 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 20.68  LDD1760 
Flavin reductase (NADPH) (BLVRB) LDTP03511 21.11  LDD1760 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 9.78  LDD1760 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 10.70  LDD1760 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 12.04  LDD1760 
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) LDTP15879 20.11  LDD1760 
Heme A synthase COX15 (COX15) LDTP07931 11.96  LDD1760 
Heme oxygenase 1 (HMOX1) LDTP02359 30.91  LDD1760 
Heme oxygenase 2 (HMOX2) LDTP03540 35.75  LDD1760 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 13.93  LDD1760 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 10.85  LDD1760 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 28.25  LDD1760 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 11.16  LDD1760 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 18.25  LDD1760 
Lathosterol oxidase (SC5D) LDTP01329 13.00  LDD1760 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.82  LDD1760 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 55.33  LDD1760 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 17.88  LDD1760 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 40.50  LDD1760 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 9.85  LDD1760 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 10.34  LDD1760 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 20.68  LDD1760 
Lysosomal acid phosphatase (ACP2) LDTP02539 13.55  LDD1760 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 25.46  LDD1760 
Lysosomal protective protein (CTSA) LDTP02505 19.97  LDD1760 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 15.67  LDD1760 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 27.67  LDD1760 
Minor histocompatibility antigen H13 (HM13) LDTP09396 19.56  LDD1760 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 10.48  LDD1760 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 16.80  LDD1760 
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (PIGL) LDTP16258 10.70  LDD1760 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 13.55  LDD1760 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 17.15  LDD1760 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 23.92  LDD1760 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 11.47  LDD1760 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 26.54  LDD1760 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 68.12  LDD1760 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 9.92  LDD1760 
NADPH--cytochrome P450 reductase (POR) LDTP02848 12.30  LDD1760 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 14.12  LDD1760 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 49.87  LDD1760 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 14.12  LDD1760 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 14.03  LDD1760 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 14.32  LDD1760 
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) LDTP07620 17.51  LDD1760 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 9.78  LDD1760 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 12.82  LDD1760 
Phospholipase A2 group XV (PLA2G15) LDTP09088 14.22  LDD1760 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 12.73  LDD1760 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 21.86  LDD1760 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 16.34  LDD1760 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 14.93  LDD1760 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 10.13  LDD1760 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 11.39  LDD1760 
Prostaglandin reductase 3 (PTGR3) LDTP15422 43.71  LDD1760 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 11.08  LDD1760 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 18.64  LDD1760 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 14.42  LDD1760 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 11.24  LDD1760 
Protein O-GlcNAcase (OGA) LDTP00988 12.73  LDD1760 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 28.64  LDD1760 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 13.83  LDD1760 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 16.11  LDD1760 
Rab-like protein 3 (RABL3) LDTP06986 10.56  LDD1760 
Ras-related protein Rab-11B (RAB11B) LDTP06501 14.03  LDD1760 
Receptor-type tyrosine-protein phosphatase F (PTPRF) LDTP02499 9.78  LDD1760 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 17.63  LDD1760 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 30.70  LDD1760 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 21.86  LDD1760 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 10.85  LDD1760 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 37.79  LDD1760 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 16.80  LDD1760 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 15.78  LDD1760 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 12.04  LDD1760 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 18.00  LDD1760 
Squalene monooxygenase (SQLE) LDTP06142 12.82  LDD1760 
Squalene synthase (FDFT1) LDTP03842 22.94  LDD1760 
Sulfhydryl oxidase 2 (QSOX2) LDTP07813 11.71  LDD1760 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 9.78  LDD1760 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 11.00  LDD1760 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 19.16  LDD1760 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 15.45  LDD1760 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 10.85  LDD1760 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 11.31  LDD1760 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 26.54  LDD1760 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 12.64  LDD1760 
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⏷ Show the Full List of 137 Enzyme
107 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 13.27  LDD1760 
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) LDTP01601 12.04  LDD1760 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 20.82  LDD1760 
Amyloid-beta precursor protein (APP) LDTP02071 14.93  LDD1760 
Anoctamin-10 (ANO10) LDTP12704 14.22  LDD1760 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 13.09  LDD1760 
ATP synthase subunit a (MT-ATP6) LDTP01804 42.22  LDD1760 
ATP synthase subunit e, mitochondrial (ATP5ME) LDTP14717 10.06  LDD1760 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 34.78  LDD1760 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 10.34  LDD1760 
BRI3-binding protein (BRI3BP) LDTP15648 20.97  LDD1760 
Cell division cycle protein 20 homolog (CDC20) LDTP05662 14.12  LDD1760 
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) LDTP08469 9.99  LDD1760 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 16.56  LDD1760 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 99.04  LDD1760 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 13.55  LDD1760 
Derlin-1 (DERL1) LDTP11245 20.11  LDD1760 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 42.81  LDD1760 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 46.21  LDD1760 
Essential MCU regulator, mitochondrial (SMDT1) LDTP11927 50.21  LDD1760 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 15.67  LDD1760 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 12.04  LDD1760 
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) LDTP04227 21.71  LDD1760 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 10.06  LDD1760 
H(+)/Cl(-) exchange transporter 7 (CLCN7) LDTP04463 14.03  LDD1760 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 13.83  LDD1760 
Importin-9 (IPO9) LDTP10663 12.38  LDD1760 
Intermembrane lipid transfer protein VPS13A (VPS13A) LDTP10769 15.45  LDD1760 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 14.93  LDD1760 
Lysosome membrane protein 2 (SCARB2) LDTP06034 36.76  LDD1760 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 9.99  LDD1760 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 26.91  LDD1760 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 13.27  LDD1760 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 21.86  LDD1760 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 29.65  LDD1760 
Metaxin-1 (MTX1) LDTP05900 23.10  LDD1760 
Metaxin-2 (MTX2) LDTP01217 9.92  LDD1760 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 19.70  LDD1760 
MICOS complex subunit MIC26 (APOO) LDTP11250 11.16  LDD1760 
MICOS complex subunit MIC60 (IMMT) LDTP06660 10.13  LDD1760 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 13.09  LDD1760 
Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) LDTP07439 14.32  LDD1760 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 13.74  LDD1760 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 11.39  LDD1760 
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) LDTP08279 17.15  LDD1760 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 17.15  LDD1760 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 11.63  LDD1760 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD1760 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 34.54  LDD1760 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 25.81  LDD1760 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 15.35  LDD1760 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 20.97  LDD1760 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 13.18  LDD1760 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 11.08  LDD1760 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 30.48  LDD1760 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 10.34  LDD1760 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 12.04  LDD1760 
Mpv17-like protein 2 (MPV17L2) LDTP14952 44.32  LDD1760 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 12.55  LDD1760 
Nucleoporin NDC1 (NDC1) LDTP11213 15.56  LDD1760 
Pannexin-1 (PANX1) LDTP10754 10.13  LDD1760 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 10.70  LDD1760 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 99.73  LDD1760 
PRA1 family protein 2 (PRAF2) LDTP01060 11.00  LDD1760 
Prosaposin (PSAP) LDTP02215 23.43  LDD1760 
Protein ARV1 (ARV1) LDTP11812 10.78  LDD1760 
Protein GPR107 (GPR107) LDTP07236 29.65  LDD1760 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 11.24  LDD1760 
Protein spinster homolog 1 (SPNS1) LDTP11844 28.84  LDD1760 
Protein tweety homolog 3 (TTYH3) LDTP11615 32.90  LDD1760 
Protein wntless homolog (WLS) LDTP07156 21.56  LDD1760 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 13.93  LDD1760 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 12.91  LDD1760 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 19.70  LDD1760 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 22.01  LDD1760 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 10.63  LDD1760 
Sideroflexin-4 (SFXN4) LDTP07531 10.13  LDD1760 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 21.56  LDD1760 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 15.35  LDD1760 
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) LDTP02544 10.48  LDD1760 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 16.22  LDD1760 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 36.76  LDD1760 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 15.45  LDD1760 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 16.91  LDD1760 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 12.47  LDD1760 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 32.90  LDD1760 
Stomatin (STOM) LDTP03380 10.56  LDD1760 
Surfeit locus protein 4 (SURF4) LDTP00592 14.22  LDD1760 
Tetraspanin-3 (TSPAN3) LDTP16813 36.00  LDD1760 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 37.01  LDD1760 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 41.64  LDD1760 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 19.97  LDD1760 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 15.45  LDD1760 
Transmembrane protein 126A (TMEM126A) LDTP15948 17.39  LDD1760 
Transmembrane protein 160 (TMEM160) LDTP20002 29.45  LDD1760 
Transmembrane protein 199 (TMEM199) LDTP08881 17.03  LDD1760 
Transmembrane protein 205 (TMEM205) LDTP07667 14.03  LDD1760 
Transmembrane protein 230 (TMEM230) LDTP10065 13.64  LDD1760 
Transmembrane protein 245 (TMEM245) LDTP15979 17.88  LDD1760 
Transmembrane protein 59 (TMEM59) LDTP11406 19.70  LDD1760 
Transmembrane protein 87A (TMEM87A) LDTP15481 11.24  LDD1760 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 19.16  LDD1760 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 10.13  LDD1760 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 46.85  LDD1760 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 45.25  LDD1760 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 13.09  LDD1760 
Zinc transporter 7 (SLC30A7) LDTP09180 30.27  LDD1760 
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⏷ Show the Full List of 107 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 10.56  LDD1760 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 12.13  LDD1760 
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1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 14.52  LDD1760 
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4 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 12.21  LDD1760 
HLA class I histocompatibility antigen, B alpha chain (HLA-B) LDTP01913 10.85  LDD1760 
HLA class I histocompatibility antigen, C alpha chain (HLA-C) LDTP02491 11.39  LDD1760 
Neogenin (NEO1) LDTP09907 11.39  LDD1760 
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103 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) LDTP00223 14.42  LDD1760 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 12.47  LDD1760 
Apolipoprotein L2 (APOL2) LDTP11076 52.71  LDD1760 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 12.64  LDD1760 
Calmodulin-3 (CALM3) LDTP02443 16.80  LDD1760 
Calumenin (CALU) LDTP00887 17.63  LDD1760 
CCR4-NOT transcription complex subunit 9 (CNOT9) LDTP09813 11.88  LDD1760 
Centrin-2 (CETN2) LDTP03926 36.76  LDD1760 
Centromere protein H (CENPH) LDTP11883 9.85  LDD1760 
Clustered mitochondria protein homolog (CLUH) LDTP14486 17.51  LDD1760 
Coiled-coil domain-containing protein 167 (CCDC167) LDTP12956 10.34  LDD1760 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 13.00  LDD1760 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 42.81  LDD1760 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 10.63  LDD1760 
Dymeclin (DYM) LDTP08000 10.63  LDD1760 
Dynactin subunit 3 (DCTN3) LDTP01359 13.45  LDD1760 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 12.64  LDD1760 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 16.00  LDD1760 
Emerin (EMD) LDTP04356 12.55  LDD1760 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 28.05  LDD1760 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 26.17  LDD1760 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 14.52  LDD1760 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 31.56  LDD1760 
Galectin-3-binding protein (LGALS3BP) LDTP05558 10.63  LDD1760 
Ganglioside GM2 activator (GM2A) LDTP02927 18.13  LDD1760 
Glucose-induced degradation protein 4 homolog (GID4) LDTP08517 10.63  LDD1760 
Golgi apparatus protein 1 (GLG1) LDTP09920 11.08  LDD1760 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 25.11  LDD1760 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 15.78  LDD1760 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 9.78  LDD1760 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 11.63  LDD1760 
HIG1 domain family member 1A, mitochondrial (HIGD1A) LDTP13797 36.50  LDD1760 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 13.18  LDD1760 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 16.80  LDD1760 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 20.39  LDD1760 
Large proline-rich protein BAG6 (BAG6) LDTP04094 11.24  LDD1760 
Large ribosomal subunit protein mL40 (MRPL40) LDTP12395 17.51  LDD1760 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 24.42  LDD1760 
Large ribosomal subunit protein mL64 (GADD45GIP1) LDTP09297 40.50  LDD1760 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 12.73  LDD1760 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 37.53  LDD1760 
Mediator of RNA polymerase II transcription subunit 24 (MED24) LDTP01225 13.18  LDD1760 
MICOS complex subunit MIC27 (APOOL) LDTP07718 9.85  LDD1760 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 12.73  LDD1760 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 26.72  LDD1760 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 12.04  LDD1760 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 99.73  LDD1760 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 56.49  LDD1760 
Molybdenum cofactor biosynthesis protein 1 (MOCS1) LDTP12884 13.64  LDD1760 
Neudesin (NENF) LDTP13630 10.63  LDD1760 
Neuferricin (CYB5D2) LDTP15623 16.80  LDD1760 
Neurofilament light polypeptide (NEFL) LDTP02180 13.45  LDD1760 
Nucleobindin-1 (NUCB1) LDTP05375 65.80  LDD1760 
Nucleobindin-2 (NUCB2) LDTP05160 38.32  LDD1760 
Nurim (NRM) LDTP08606 26.54  LDD1760 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 13.36  LDD1760 
Optic atrophy 3 protein (OPA3) LDTP16006 32.22  LDD1760 
Oxysterol-binding protein-related protein 3 (OSBPL3) LDTP11930 12.91  LDD1760 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 24.42  LDD1760 
Polyadenylate-binding protein-interacting protein 2 (PAIP2) LDTP11044 12.55  LDD1760 
Prelamin-A/C (LMNA) LDTP01932 11.71  LDD1760 
PRELI domain-containing protein 1, mitochondrial (PRELID1) LDTP13807 28.25  LDD1760 
Prohibitin-2 (PHB2) LDTP10924 12.55  LDD1760 
Protein CEBPZOS (CEBPZOS) LDTP18883 26.54  LDD1760 
Protein FAM114A2 (FAM114A2) LDTP16080 25.28  LDD1760 
Protein FAM162A (FAM162A) LDTP10056 27.10  LDD1760 
Protein FAM177A1 (FAM177A1) LDTP15398 11.55  LDD1760 
Protein FAM3C (FAM3C) LDTP09773 24.93  LDD1760 
Protein Hook homolog 2 (HOOK2) LDTP10255 15.03  LDD1760 
Protein jagunal homolog 1 (JAGN1) LDTP08904 20.97  LDD1760 
Protein LYRIC (MTDH) LDTP08224 11.00  LDD1760 
Protein SET (SET) LDTP05277 14.93  LDD1760 
Protein unc-119 homolog B (UNC119B) LDTP00105 10.63  LDD1760 
Protein YIF1A (YIF1A) LDTP01494 14.32  LDD1760 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 11.39  LDD1760 
Reticulocalbin-2 (RCN2) LDTP06097 22.32  LDD1760 
Reticulon-3 (RTN3) LDTP01522 23.10  LDD1760 
Reticulon-4 (RTN4) LDTP12412 16.68  LDD1760 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 12.73  LDD1760 
RNA-binding protein FUS (FUS) LDTP03775 10.63  LDD1760 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 11.71  LDD1760 
Small integral membrane protein 12 (SMIM12) LDTP19859 15.35  LDD1760 
Superkiller complex protein 3 (SKIC3) LDTP07574 11.16  LDD1760 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 19.84  LDD1760 
Synaptogyrin-2 (SYNGR2) LDTP00859 14.22  LDD1760 
Syntaxin-10 (STX10) LDTP00986 16.68  LDD1760 
Syntaxin-18 (STX18) LDTP13086 17.88  LDD1760 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 12.30  LDD1760 
Tetraspanin-6 (TSPAN6) LDTP14458 34.54  LDD1760 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 17.63  LDD1760 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 10.70  LDD1760 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 19.16  LDD1760 
TraB domain-containing protein (TRABD) LDTP19963 11.96  LDD1760 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 13.36  LDD1760 
Transcription initiation protein SPT3 homolog (SUPT3H) LDTP01236 10.13  LDD1760 
Transformer-2 protein homolog beta (TRA2B) LDTP05036 9.78  LDD1760 
Transmembrane protein 209 (TMEM209) LDTP18272 28.44  LDD1760 
Trophoblast glycoprotein (TPBG) LDTP05960 11.63  LDD1760 
U6 snRNA-associated Sm-like protein LSm3 (LSM3) LDTP04979 10.93  LDD1760 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 22.47  LDD1760 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 38.59  LDD1760 
Vacuolar protein sorting-associated protein 52 homolog (VPS52) LDTP08766 10.70  LDD1760 
Vimentin (VIM) LDTP02297 18.00  LDD1760 
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⏷ Show the Full List of 103 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1760 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587